{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:03:55Z","timestamp":1791669835897,"version":"4.3.4"},"reference-count":64,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:00:00Z","timestamp":1583193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>In this article, we aimed to discuss the role of total laryngectomy (TL) in the management of patients with larynx cancer (LC) in the era of organ preservation. Before the 1990s, TL followed by radiotherapy (RT) was the standard treatment for patients with locally advanced LC. Over the last 30 years, various types of larynx preservation (LP) programs associating induction or concurrent chemotherapy (CT) with RT have been developed, with the aim of treating locally advanced LC patients while preserving the larynx and its functions. Overall, more than two-thirds of patients included in a LP program will not require total laryngectomy (TL) and will preserve a functional larynx. However, despite these advances, the larynx is the only tumor site in the upper aero-digestive tract for which prognosis has not improved during recent decades. Indeed, none of these LP protocols have shown any survival advantage compared to primary radical surgery, and it appears that certain LC patients do not benefit from an LP program. This is the case for patients with T4a LC (extra-laryngeal tumor extension through the thyroid cartilage) or with poor pretreatment laryngeal function and for whom primary TL is still the preferred therapeutic option. Moreover, TL is the standard salvage therapy for patients with recurrent tumor after an LP protocol.<\/jats:p>","DOI":"10.3390\/cancers12030584","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T13:06:23Z","timestamp":1583240783000},"page":"584","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Current Role of Total Laryngectomy in the Era of Organ Preservation"],"prefix":"10.3390","volume":"12","author":[{"given":"Alexandre","family":"Bozec","sequence":"first","affiliation":[{"name":"Institut Universitaire de la Face et du Cou, Centre Antoine Lacassagne, Universit\u00e9 C\u00f4te d\u2019Azur, 06103 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorian","family":"Culi\u00e9","sequence":"additional","affiliation":[{"name":"Institut Universitaire de la Face et du Cou, Centre Antoine Lacassagne, Universit\u00e9 C\u00f4te d\u2019Azur, 06103 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Poissonnet","sequence":"additional","affiliation":[{"name":"Institut Universitaire de la Face et du Cou, Centre Antoine Lacassagne, Universit\u00e9 C\u00f4te d\u2019Azur, 06103 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Dassonville","sequence":"additional","affiliation":[{"name":"Institut Universitaire de la Face et du Cou, Centre Antoine Lacassagne, Universit\u00e9 C\u00f4te d\u2019Azur, 06103 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000381717","article-title":"Update on Head and Neck Cancer: Current Knowledge on Epidemiology, Risk Factors, Molecular Features and Novel Therapies","volume":"89","author":"Pezzuto","year":"2015","journal-title":"Oncology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.coms.2018.06.001","article-title":"Epidemiology and Demographics of the Head and Neck Cancer Population","volume":"30","author":"Cohen","year":"2018","journal-title":"Oral Maxillofac. 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