{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T06:32:08Z","timestamp":1772001128595,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,4,5]],"date-time":"2020-04-05T00:00:00Z","timestamp":1586044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondo de Investigacion Sanitaria (FIS), Instituto de Salud Carlos III","award":["PI17\/313"],"award-info":[{"award-number":["PI17\/313"]}]},{"name":"ACCIO-CIDEM, Generalitat de Catalunya","award":["RD08-2-0035"],"award-info":[{"award-number":["RD08-2-0035"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>MYC rearrangements usually confer aggressive biological behavior to large B-cell lymphomas. In this study, we aimed to evaluate the relevance of LMO2 detection to the clinical approach to these tumors. First, the ability of LMO2 loss of expression to recognize the presence of MYC rearrangements was evaluated. A series of 365 samples obtained from 351 patients, including 28 Burkitt lymphoma, 230 diffuse large B-cell lymphoma, 30 high-grade B-cell lymphoma with MYC and BCL2\/BCL6 rearrangements, eight high-grade B-cell lymphoma-NOS, 43 transformed diffuse large B-cell lymphoma, and 26 high-grade follicular lymphomas was analyzed. Among the CD10-positive tumors prospectively analyzed in whole tissue sections, LMO2 negative expression obtained values of 88% sensitivity, 94% specificity, and 93% accuracy, proving the utility of LMO2 to screen MYC rearrangements. In addition, survival analyses were performed in a series of 155 patients. As per univariate analyses, the prognosis relevance of LMO2 was as useful as that of the diagnostic categories, MYC rearrangements, and MYC immunohistochemistry. Multivariate models revealed that both LMO2 (hazard ratio 0.51 p = 0.02) and IPI (hazard ratio 1.67 p &lt; 0.005) were independent variables predicting overall survival. Finally, MYC and LMO2 mRNA expression were analyzed in a small group of cases. Taken together, these findings show the interest of LMO2 testing in large B-cell lymphomas.<\/jats:p>","DOI":"10.3390\/cancers12040884","type":"journal-article","created":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T03:58:39Z","timestamp":1586231919000},"page":"884","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical Interest of LMO2 Testing for the Diagnosis of Aggressive Large B-Cell Lymphomas"],"prefix":"10.3390","volume":"12","author":[{"given":"Ivonne","family":"Vazquez","sequence":"first","affiliation":[{"name":"Department of Pathology, Hematopathology Section, Hospital del Mar, Institute of Investigacions Mediques-IMIM, Universitat Autonoma de Barcelona, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Papaleo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hematopathology Section, Hospital del Mar, Institute of Investigacions Mediques-IMIM, Universitat Autonoma de Barcelona, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Pathology-IdiPAZ, Hospital Universitario La Paz, 28046 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9988-5977","authenticated-orcid":false,"given":"Marta","family":"Salido","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hematopathology Section, Hospital del Mar, Institute of Investigacions Mediques-IMIM, Universitat Autonoma de Barcelona, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4652-4825","authenticated-orcid":false,"given":"Antonio","family":"Salar","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hospital del Mar, Institute of Investigacions Mediques-IMIM, Universitat Autonoma de Barcelona, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Health and Experimental Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7934-9130","authenticated-orcid":false,"given":"Xavier","family":"Calvo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hematopathology Section, Hospital del Mar, Institute of Investigacions Mediques-IMIM, Universitat Autonoma de Barcelona, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5236-5085","authenticated-orcid":false,"given":"Luis","family":"Colomo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hematopathology Section, Hospital del Mar, Institute of Investigacions Mediques-IMIM, Universitat Autonoma de Barcelona, 08003 Barcelona, Spain"},{"name":"Department of Health and Experimental Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cell.2012.08.033","article-title":"c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells","volume":"151","author":"Nie","year":"2012","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cell.2012.03.003","article-title":"MYC on the path to cancer","volume":"149","author":"Dang","year":"2012","journal-title":"Cell"},{"key":"ref_3","first-page":"575","article-title":"Understanding MYC -driven aggressive B-cell lymphomas: Pathogenesis and classification","volume":"122","author":"Ott","year":"2016","journal-title":"Ann. 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