{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T03:12:16Z","timestamp":1789269136259,"version":"build-2803163510"},"reference-count":35,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C16420\/A18066"],"award-info":[{"award-number":["C16420\/A18066"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Eve Appeal Charity","award":["C16420\/A18066"],"award-info":[{"award-number":["C16420\/A18066"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Unselected population-based personalised ovarian cancer (OC) risk assessment combining genetic\/epidemiology\/hormonal data has not previously been undertaken. We aimed to perform a feasibility study of OC risk stratification of general population women using a personalised OC risk tool followed by risk management. Volunteers were recruited through London primary care networks. Inclusion criteria: women \u226518 years. Exclusion criteria: prior ovarian\/tubal\/peritoneal cancer, previous genetic testing for OC genes. Participants accessed an online\/web-based decision aid along with optional telephone helpline use. Consenting individuals completed risk assessment and underwent genetic testing (BRCA1\/BRCA2\/RAD51C\/RAD51D\/BRIP1, OC susceptibility single-nucleotide polymorphisms). A validated OC risk prediction algorithm provided a personalised OC risk estimate using genetic\/lifestyle\/hormonal OC risk factors. Population genetic testing (PGT)\/OC risk stratification uptake\/acceptability, satisfaction, decision aid\/telephone helpline use, psychological health and quality of life were assessed using validated\/customised questionnaires over six months. Linear-mixed models\/contrast tests analysed impact on study outcomes. Main outcomes: feasibility\/acceptability, uptake, decision aid\/telephone helpline use, satisfaction\/regret, and impact on psychological health\/quality of life. In total, 123 volunteers (mean age = 48.5 (SD = 15.4) years) used the decision aid, 105 (85%) consented. None fulfilled NHS genetic testing clinical criteria. OC risk stratification revealed 1\/103 at \u226510% (high), 0\/103 at \u22655%\u2013&lt;10% (intermediate), and 100\/103 at &lt;5% (low) lifetime OC risk. Decision aid satisfaction was 92.2%. The telephone helpline use rate was 13% and the questionnaire response rate at six months was 75%. Contrast tests indicated that overall depression (p = 0.30), anxiety (p = 0.10), quality-of-life (p = 0.99), and distress (p = 0.25) levels did not jointly change, while OC worry (p = 0.021) and general cancer risk perception (p = 0.015) decreased over six months. In total, 85.5\u201398.7% were satisfied with their decision. Findings suggest population-based personalised OC risk stratification is feasible and acceptable, has high satisfaction, reduces cancer worry\/risk perception, and does not negatively impact psychological health\/quality of life.<\/jats:p>","DOI":"10.3390\/cancers12051241","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T10:53:59Z","timestamp":1589540039000},"page":"1241","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Population Study of Ovarian Cancer Risk Prediction for Targeted Screening and Prevention"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4081-6883","authenticated-orcid":false,"given":"Faiza","family":"Gaba","sequence":"first","affiliation":[{"name":"Wolfson Institute of Preventative Medicine, Barts CRUK Cancer Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK"},{"name":"Department of Gynaecological Oncology, St Bartholomew\u2019s Hospital, Barts Health NHS Trust, London EC1A 7BE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg","family":"Blyuss","sequence":"additional","affiliation":[{"name":"School of Physics, Astronomy and Mathematics, University of Hertfordshire, College Lane, Hatfield AL10 9AB, UK"},{"name":"Department of Paediatrics and Paediatric Infectious Diseases, Sechenov First Moscow State Medical University, Moscow 119146, Russia"},{"name":"Department of Applied Mathematics, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod 603098, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7475-0096","authenticated-orcid":false,"given":"Xinting","family":"Liu","sequence":"additional","affiliation":[{"name":"Wolfson Institute of Preventative Medicine, Barts CRUK Cancer Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivam","family":"Goyal","sequence":"additional","affiliation":[{"name":"Wolfson Institute of Preventative Medicine, Barts CRUK Cancer Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant","family":"Lahoti","sequence":"additional","affiliation":[{"name":"Wolfson Institute of Preventative Medicine, Barts CRUK Cancer Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhivya","family":"Chandrasekaran","sequence":"additional","affiliation":[{"name":"Wolfson Institute of Preventative Medicine, Barts CRUK Cancer Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK"},{"name":"Department of Gynaecological Oncology, St Bartholomew\u2019s Hospital, Barts Health NHS Trust, London EC1A 7BE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida","family":"Kurzer","sequence":"additional","affiliation":[{"name":"Department of Gynaecological Oncology, St Bartholomew\u2019s Hospital, Barts Health NHS Trust, London EC1A 7BE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatinderpal","family":"Kalsi","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Cancer, Elizabeth Garrett Anderson Institute for Women\u2019s Health, University College London, London WC1E 6AU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8427-724X","authenticated-orcid":false,"given":"Saskia","family":"Sanderson","sequence":"additional","affiliation":[{"name":"Department of Behavioural Science and Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Lanceley","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Cancer, Elizabeth Garrett Anderson Institute for Women\u2019s Health, University College London, London WC1E 6AU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munaza","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department Clinical Genetics, North East Thames Regional Genetics Unit, Great Ormond Street Hospital, London WC1N 3JH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Side","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Gentry-Maharaj","sequence":"additional","affiliation":[{"name":"Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, 90 High Holborn, London WC1V 6LJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Wallis","sequence":"additional","affiliation":[{"name":"West Midlands Regional Genetics Laboratory, Birmingham Women\u2019s NHS Foundation Trust, Birmingham B15 2TG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wallace","sequence":"additional","affiliation":[{"name":"Manchester Centre for Genomic Medicine, 6th Floor Saint Marys Hospital, Oxford Rd, Manchester M13 9WL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Waller","sequence":"additional","affiliation":[{"name":"Cancer Prevention Group, King\u2019s College London, Great Maze Pond, London SE1 9RT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Luccarini","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-1214","authenticated-orcid":false,"given":"Joe","family":"Dennis","sequence":"additional","affiliation":[{"name":"Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Laboratory, Worts Causeway, Cambridge CB1 8RN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Dunning","sequence":"additional","affiliation":[{"name":"Centre for Cancer 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Tropical Medicine, London WC1E 7HT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3708-1732","authenticated-orcid":false,"given":"Usha","family":"Menon","sequence":"additional","affiliation":[{"name":"Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, 90 High Holborn, London WC1V 6LJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Health, University of New South Wales, Australia, Level 1, Chancellery Building, Sydney 2052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3381-5057","authenticated-orcid":false,"given":"Ranjit","family":"Manchanda","sequence":"additional","affiliation":[{"name":"Wolfson Institute of Preventative Medicine, Barts CRUK Cancer Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK"},{"name":"Department of Gynaecological Oncology, St Bartholomew\u2019s Hospital, Barts Health NHS Trust, London EC1A 7BE, UK"},{"name":"Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, 90 High Holborn, London WC1V 6LJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1001\/jama.2017.7112","article-title":"Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers","volume":"317","author":"Kuchenbaecker","year":"2017","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Yang, X., Song, H., Leslie, G., Engel, C., Hahnen, E., Auber, B., Horv\u00e1th, J., Kast, K., Niederacher, D., and Turnbull, C. 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