{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:21:20Z","timestamp":1790108480406,"version":"4.0.1"},"reference-count":85,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,7,5]],"date-time":"2020-07-05T00:00:00Z","timestamp":1593907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2019\/35\/B\/NZ7\/01165"],"award-info":[{"award-number":["2019\/35\/B\/NZ7\/01165"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The incidence of bladder cancer (BC) is increasing, and although current therapeutic approaches are effective in many cases, recurrence of BC is common. Therefore, it seems necessary to search not only for novel therapeutic approaches, but also for new therapeutic agents. Natural polyphenols, such as curcumin (CUR) and epigallocatechin gallate (EGCG), possess remarkable antitumor activity. Their biochemical mechanisms of action include regulation of signaling pathways, modeling of proteins involved in apoptosis and cell cycle inhibition, angiogenesis, and the proliferation, migration and adhesion of tumor cells. Both compounds also present antioxidant, anti-inflammatory, antibacterial and antiviral properties. CUR has been considered a promising candidate for the treatment of cystic fibrosis, Alzheimer\u2019s disease or malaria, whereas EGCG can play a supportive role in the treatment of obesity, metabolic and neurodegenerative diseases. The review summarizes the latest research on the role of CUR and EGCG in the treatment of BC. In particular, the effects of CUR and EGCG, and their prospects for use in BC therapy, their inhibition of cancer development and their prevention of multidrug resistance, are described. The literature\u2019s data indicate the possibility of achieving the effect of synergism of both polyphenols in BC therapy, which has been observed so far in the treatment of ovarian, breast and prostate cancer.<\/jats:p>","DOI":"10.3390\/cancers12071801","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T09:49:11Z","timestamp":1594028951000},"page":"1801","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Role of Curcumin and (\u2212)-Epigallocatechin-3-O-Gallate in Bladder Cancer Treatment: A Review"],"prefix":"10.3390","volume":"12","author":[{"given":"Ludwika","family":"Piwowarczyk","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5106-5937","authenticated-orcid":false,"given":"Maciej","family":"Stawny","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3583-0752","authenticated-orcid":false,"given":"Dariusz T.","family":"Mlynarczyk","sequence":"additional","affiliation":[{"name":"Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6734-3671","authenticated-orcid":false,"given":"Izabela","family":"Muszalska-Kolos","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5705-5414","authenticated-orcid":false,"given":"Tomasz","family":"Goslinski","sequence":"additional","affiliation":[{"name":"Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Jeli\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Saginala, K., Barsouk, A., Aluru, J.S., Rawla, P., Padala, S.A., and Barsouk, A. (2020). Epidemiology of Bladder Cancer. Med. Sci., 8.","DOI":"10.3390\/medsci8010015"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Mandelli, G.E., Missale, F., Bresciani, D., Gatta, L.B., Scapini, P., Caveggion, E., Roca, E., Bugatti, M., Monti, M., and Cristinelli, L. (2020). Tumor Infiltrating Neutrophils Are Enriched in Basal-Type Urothelial Bladder Cancer. Cells, 9.","DOI":"10.3390\/cells9020291"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.eururo.2011.03.017","article-title":"EAU Guidelines on Non-Muscle-Invasive Urothelial Carcinoma of the Bladder, the 2011 Update","volume":"59","author":"Babjuk","year":"2011","journal-title":"Eur. Urol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1053\/j.seminoncol.2012.08.007","article-title":"New Therapeutic Challenges in Advanced Bladder Cancer","volume":"39","author":"Bellmunt","year":"2012","journal-title":"Semin. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Niedzwiecki, A., Roomi, M.W., Kalinovsky, T., and Rath, M. (2016). Anticancer Efficacy of Polyphenols and Their Combinations. Nutrients, 8.","DOI":"10.3390\/nu8090552"},{"key":"ref_6","first-page":"39","article-title":"Curcumin and Epigallocatechin Gallate Inhibit the Cancer Stem Cell Phenotype via Down-regulation of STAT3\u2013NF\u03baB signaling","volume":"35","author":"Chung","year":"2015","journal-title":"Anticancer Res."},{"key":"ref_7","first-page":"1131","article-title":"Synergism from Sequenced Combinations of Curcumin and Epigallocatechin-3-gallate with Cisplatin in the Killing of Human Ovarian Cancer Cells","volume":"31","author":"Yunos","year":"2011","journal-title":"Anticancer Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1080\/01635581.2017.1359322","article-title":"In vitro Biological Effects of Sulforaphane (SFN), Epigallocatechin-3-gallate (EGCG), and Curcumin on Breast Cancer Cells: A Systematic Review of the Literature","volume":"69","author":"Gianfredi","year":"2017","journal-title":"Nutr. Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"5231","DOI":"10.21873\/anticanres.13720","article-title":"Chemoprevention of Prostate Cancer by Natural Agents: Evidence from Molecular and Epidemiological Studies","volume":"39","author":"Mokbel","year":"2019","journal-title":"Anticancer Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1002\/cam4.1979","article-title":"Hope and challenge: Precision medicine in bladder cancer","volume":"8","author":"Su","year":"2019","journal-title":"Cancer Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s11864-013-0271-3","article-title":"New Treatments for Bladder Cancer: When Will We Make Progress?","volume":"15","author":"Nadal","year":"2014","journal-title":"Curr. Treat. Options Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ucl.2015.02.002","article-title":"Trimodality Therapy in Bladder Cancer","volume":"42","author":"Premo","year":"2015","journal-title":"Urol. Clin. North Am."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"17022","DOI":"10.1038\/nrdp.2017.22","article-title":"Bladder Cancer","volume":"3","author":"Sanli","year":"2017","journal-title":"Nat. Rev. Dis. Primer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/med.20188","article-title":"Curcumin and its analogues: Potential anticancer agents","volume":"30","author":"Agrawal","year":"2010","journal-title":"Med. Res. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jtcme.2016.05.005","article-title":"Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives\u2014A review","volume":"7","author":"Amalraj","year":"2016","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Hewlings, S., and Kalman, D. (2017). Curcumin: A Review of Its\u2019 Effects on Human Health. Foods, 6.","DOI":"10.3390\/foods6100092"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1208\/s12248-015-9811-z","article-title":"Therapeutic Applications of Curcumin Nanoformulations","volume":"17","author":"Yallapu","year":"2015","journal-title":"AAPS J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1208\/s12248-012-9432-8","article-title":"Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials","volume":"15","author":"Gupta","year":"2013","journal-title":"AAPS J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/advances\/nmx011","article-title":"The Problem of Curcumin and Its Bioavailability: Could Its Gastrointestinal Influence Contribute to Its Overall Health-Enhancing Effects?","volume":"9","author":"Lopresti","year":"2018","journal-title":"Adv. Nutr."},{"key":"ref_20","first-page":"2895","article-title":"Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions","volume":"21","author":"Cheng","year":"2001","journal-title":"Anticancer Res."},{"key":"ref_21","unstructured":"European Medicines Agency (2020, April 07). European Union Herbal Monograph on Curcuma longa L.. Available online: https:\/\/www.ema.europa.eu\/en\/documents\/herbal-monograph\/draft-european-union-herbal-monograph-curcuma-longa-l-c-domestica-valeton-rhizome-revision-1_en.pdf."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1207\/s15327914nc5502_2","article-title":"Curcumin content of turmeric and curry powders","volume":"55","author":"Tayyem","year":"2006","journal-title":"Nutr. Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/mp700113r","article-title":"Bioavailability of Curcumin: Problems and Promises","volume":"4","author":"Anand","year":"2007","journal-title":"Mol. Pharm."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1021\/acs.jafc.6b04815","article-title":"Physical and Chemical Stability of Curcumin in Aqueous Solutions and Emulsions: Impact of pH, Temperature, and Molecular Environment","volume":"65","author":"Kharat","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1039\/c9pp00375d","article-title":"Curcumin derivatives as photosensitizers in photodynamic therapy: Photophysical properties and in vitro studies with prostate cancer cells","volume":"19","author":"Kazantzis","year":"2020","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1089\/pho.2014.3805","article-title":"Effects of Photodynamic Therapy with Blue Light and Curcumin as Mouth Rinse for Oral Disinfection: A Randomized Controlled Trial","volume":"32","author":"Leite","year":"2014","journal-title":"Photomed. Laser Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ccr.2015.09.001","article-title":"Metal complexes of curcumin and curcumin derivatives for molecular imaging and anticancer therapy","volume":"307","author":"Schubert","year":"2016","journal-title":"Coord. Chem. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1749-8546-5-13","article-title":"Beneficial effects of green tea: A literature review","volume":"5","author":"Chacko","year":"2010","journal-title":"Chin. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5813793","DOI":"10.1155\/2017\/5813793","article-title":"Therapeutic Potential of Epigallocatechin Gallate Nanodelivery Systems","volume":"2017","author":"Granja","year":"2017","journal-title":"BioMed Res. Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnutbio.2016.01.002","article-title":"Stability of (\u2212)-epigallocatechin gallate and its activity in liquid formulations and delivery systems","volume":"37","author":"Krupkova","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Zheng, J., Li, Y., Xu, D.-P., Li, S., Chen, Y.-M., and Li, H.-B. (2016). Natural Polyphenols for Prevention and Treatment of Cancer. Nutrients, 8.","DOI":"10.3390\/nu8080515"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3892\/ijmm.2017.3024","article-title":"Formulation and characterization of EGCG for the treatment of superficial bladder cancer","volume":"40","author":"Dettlaff","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Cai, Z.-Y., Li, X.-M., Liang, J.-P., Xiang, L.-P., Wang, K.-R., Shi, Y.-L., Yang, R., Shi, M., Ye, J.-H., and Lu, J.-L. (2018). Bioavailability of Tea Catechins and Its Improvement. Molecules, 23.","DOI":"10.3390\/molecules23092346"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1158\/1940-6207.CAPR-16-0167","article-title":"A Phase II Randomized, Double-blind, Presurgical Trial of Polyphenon E in Bladder Cancer Patients to Evaluate Pharmacodynamics and Bladder Tissue Biomarkers","volume":"10","author":"Gee","year":"2017","journal-title":"Cancer Prev. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"19112","DOI":"10.1038\/s41598-019-55619-4","article-title":"A novel and green nanoparticle formation approach to forming low-crystallinity curcumin nanoparticles to improve curcumin\u2019s bioaccessibility","volume":"9","author":"Ubeyitogullari","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.2147\/IJN.S132434","article-title":"Liposomal curcumin and its application in cancer","volume":"12","author":"Feng","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.foodhyd.2014.07.011","article-title":"Preparation and characterization of nanoemulsion encapsulating curcumin","volume":"43","author":"Sari","year":"2015","journal-title":"Food Hydrocoll."},{"key":"ref_38","first-page":"10564","article-title":"Curcumin combined with exposure to visible light blocks bladder cancer cell adhesion and migration by an integrin dependent mechanism","volume":"23","author":"Mani","year":"2019","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"6374940","DOI":"10.1155\/2019\/6374940","article-title":"The Antitumor Effect of Curcumin in Urothelial Cancer Cells Is Enhanced by Light Exposure In Vitro","volume":"2019","author":"Roos","year":"2019","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Buss, S., Dobra, J., Goerg, K., Hoffmann, S., Kippenberger, S., Kaufmann, R., Hofmann, M., and Bernd, A. (2013). Visible Light Is a Better Co-Inducer of Apoptosis for Curcumin-Treated Human Melanoma Cells than UVA. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0079748"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.7150\/jca.17176","article-title":"Photodynamic Treatment of Oral Squamous Cell Carcinoma Cells with Low Curcumin Concentrations","volume":"8","author":"Beyer","year":"2017","journal-title":"J. Cancer"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.3109\/14756366.2015.1101091","article-title":"The biological effects of vanadyl curcumin and vanadyl diacetylcurcumin complexes: The effect on structure, function and oxidative stability of the peroxidase enzyme, antibacterial activity and cytotoxic effect","volume":"31","author":"Hamidi","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/s00775-015-1295-x","article-title":"Investigating the effect of gallium curcumin and gallium diacetylcurcumin complexes on the structure, function and oxidative stability of the peroxidase enzyme and their anticancer and antibacterial activities","volume":"20","author":"Jahangoshaei","year":"2015","journal-title":"J. Biol. Inorg. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"9547","DOI":"10.2147\/IJN.S225172","article-title":"Development And In Vitro Characterization Of Bladder Tumor Cell Targeted Lipid-Coated Polyplex For Dual Delivery Of Plasmids And Small Molecules","volume":"14","author":"Samaddar","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"9634902","DOI":"10.1155\/2018\/9634902","article-title":"Curcumin as Treatment for Bladder Cancer: A Preclinical Study of Cyclodextrin-Curcumin Complex and BCG as Intravesical Treatment in an Orthotopic Bladder Cancer Rat Model","volume":"2018","author":"Falke","year":"2018","journal-title":"BioMed Res. Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.3892\/ijo.2017.4097","article-title":"Melatonin potentiates the antitumor effect of curcumin by inhibiting IKK\u03b2\/NF-\u03baB\/COX-2 signaling pathway","volume":"51","author":"Shrestha","year":"2017","journal-title":"Int. J. Oncol."},{"key":"ref_47","first-page":"515","article-title":"Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells","volume":"53","author":"Zhang","year":"2018","journal-title":"Int. J. Oncol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1010428317702548","DOI":"10.1177\/1010428317702548","article-title":"Curcumin inhibits bladder cancer progression via regulation of \u03b2-catenin expression","volume":"39","author":"Shi","year":"2017","journal-title":"Tumor Biol."},{"key":"ref_49","first-page":"6869","article-title":"The modulation study of multiple drug resistance in bladder cancer by curcumin and resveratrol","volume":"18","author":"Cho","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1007\/s11255-019-02210-5","article-title":"MicroRNA-1246 regulates the radio-sensitizing effect of curcumin in bladder cancer cells via activating P53","volume":"51","author":"Xu","year":"2019","journal-title":"Int. Urol. Nephrol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1142\/S0192415X18500714","article-title":"Curcumin Suppresses microRNA-7641-Mediated Regulation of p16 Expression in Bladder Cancer","volume":"46","author":"Wang","year":"2018","journal-title":"Am. J. Chin. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e3066","DOI":"10.1038\/cddis.2017.452","article-title":"Curcumin reversed chronic tobacco smoke exposure induced urocystic EMT and acquisition of cancer stem cells properties via Wnt\/\u03b2-catenin","volume":"8","author":"Liang","year":"2017","journal-title":"Cell Death Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.bbrc.2017.08.158","article-title":"Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway","volume":"493","author":"Wang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.3892\/ol.2017.6205","article-title":"Antitumor effects of curcumin in human bladder cancer in vitro","volume":"14","author":"Shi","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1080\/1061186X.2017.1306535","article-title":"Curcumin inhibits urothelial tumor development by suppressing IGF2 and IGF2-mediated PI3K\/AKT\/mTOR signaling pathway","volume":"25","author":"Tian","year":"2017","journal-title":"J. Drug Target."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3892\/ijo.2017.3887","article-title":"Curcumin reverses benzidine-induced epithelial-mesenchymal transition via suppression of ERK5\/AP-1 in SV-40 immortalized human urothelial cells","volume":"50","author":"Liu","year":"2017","journal-title":"Int. J. Oncol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"63870","DOI":"10.18632\/oncotarget.11563","article-title":"Curcumin potentiates antitumor activity of cisplatin in bladder cancer cell lines via ROS-mediated activation of ERK1\/2","volume":"7","author":"Park","year":"2016","journal-title":"Oncotarget"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.etp.2015.12.003","article-title":"Curcumin reverses benzidine-induced cell proliferation by suppressing ERK1\/2 pathway in human bladder cancer T24 cells","volume":"68","author":"Sun","year":"2016","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_59","first-page":"4503","article-title":"Inhibition of tobacco smoke-induced bladder MAPK activation and epithelial-mesenchymal transition in mice by curcumin","volume":"8","author":"Liang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_60","first-page":"884","article-title":"The effect of curcumin on bladder tumor in rat model","volume":"21","author":"Pan","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_61","first-page":"3225","article-title":"Concentration- Dependent Effects of Curcumin on 5-Fluorouracil Efficacy in Bladder Cancer Cells","volume":"18","author":"Afsharmoghadam","year":"2017","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.2147\/OTT.S130653","article-title":"Bisdemethoxycurcumin in combination with \u03b1-PD-L1 antibody boosts immune response against bladder cancer","volume":"10","author":"Shao","year":"2017","journal-title":"OncoTargets Ther."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.3892\/or.2015.4537","article-title":"Theracurmin\u00ae efficiently inhibits the growth of human prostate and bladder cancer cells via induction of apoptotic cell death and cell cycle arrest","volume":"35","author":"Kang","year":"2016","journal-title":"Oncol. Rep."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Lee, H.-Y., Chen, Y.-J., Chang, W.-A., Li, W.-M., Ke, H.-L., Wu, W.-J., and Kuo, P.-L. (2019). Effects of Epigallocatechin Gallate (EGCG) on Urinary Bladder Urothelial Carcinoma\u2015Next-Generation Sequencing and Bioinformatics Approaches. Medicina, 55.","DOI":"10.3390\/medicina55120768"},{"key":"ref_65","first-page":"425","article-title":"(-)-Epigallocatechin-3-gallate inhibits bladder cancer stem cells via suppression of sonic hedgehog pathway","volume":"42","author":"Sun","year":"2019","journal-title":"Oncol. Rep."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"12261","DOI":"10.18632\/oncotarget.24301","article-title":"EGCG inhibited bladder cancer T24 and 5637 cell proliferation and migration via PI3K\/AKT pathway","volume":"9","author":"Luo","year":"2018","journal-title":"Oncotarget"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jnutbio.2016.12.004","article-title":"EGCG inhibited bladder cancer SW780 cell proliferation and migration both in vitro and in vivo via down-regulation of NF-\u03baB and MMP-9","volume":"41","author":"Luo","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.3892\/etm.2017.4981","article-title":"Epigallocatechin gallate inhibits the growth and promotes the apoptosis of bladder cancer cells","volume":"14","author":"Feng","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.3892\/mmr.2017.6111","article-title":"Effect and mechanism of resveratrol on drug resistance in human bladder cancer cells","volume":"15","author":"Wang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Wang, S., Lei, T., and Zhang, M. (2016). The Reversal Effect and Its Mechanisms of Tetramethylpyrazine on Multidrug Resistance in Human Bladder Cancer. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0157759"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3892\/ijo.2013.2174","article-title":"Epigallocatechin-3-gallate prevents tumor cell implantation\/growth in an experimental rat bladder tumor model","volume":"44","author":"Jankun","year":"2014","journal-title":"Int. J. Oncol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nrc.2016.138","article-title":"Cell cycle proteins as promising targets in cancer therapy","volume":"17","author":"Otto","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.7150\/ijbs.33710","article-title":"Potential Mechanisms of Action of Curcumin for Cancer Prevention: Focus on Cellular Signaling Pathways and miRNAs","volume":"15","author":"Wang","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/jcb.20070","article-title":"Mitogen-activated protein kinases modulate H2O2-induced apoptosis in primary rat alveolar epithelial cells","volume":"92","author":"Carvalho","year":"2004","journal-title":"J. Cell. Biochem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"111512","DOI":"10.1016\/j.ejmech.2019.07.015","article-title":"Curcumin as tyrosine kinase inhibitor in cancer treatment","volume":"181","author":"Golonko","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"a006098","DOI":"10.1101\/cshperspect.a006098","article-title":"Signal Transduction in Cancer","volume":"5","author":"Sever","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"5416923","DOI":"10.1155\/2018\/5416923","article-title":"Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment","volume":"2018","author":"Phi","year":"2018","journal-title":"Stem. Cells Int."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/mc.22300","article-title":"Sonic hedgehog (Shh) signaling promotes tumorigenicity and stemness via activation of epithelial-to-mesenchymal transition (EMT) in bladder cancer","volume":"55","author":"Islam","year":"2016","journal-title":"Mol. Carcinog."},{"key":"ref_79","first-page":"6211","article-title":"Identification of genes and pathways associated with MDR in MCF-7\/MDR breast cancer cells by RNA-seq analysis","volume":"17","author":"Yang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.phymed.2018.09.169","article-title":"Modulation of multidrug resistant in cancer cells by EGCG, tannic acid and curcumin","volume":"50","author":"Li","year":"2018","journal-title":"Phytomedicine"},{"key":"ref_81","first-page":"5162","article-title":"Curcumin reverses doxorubicin resistance via inhibition the efflux function of ABCB4 in doxorubicin-resistant breast cancer cells","volume":"19","author":"Wen","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"33572","DOI":"10.1039\/C7RA02994B","article-title":"Curcumin re-sensitizes multidrug resistant (MDR) breast cancer to cisplatin through inducing autophagy by decreasing CCAT1 expression","volume":"7","author":"Lv","year":"2017","journal-title":"RSC Adv."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s12029-018-00186-6","article-title":"Curcumin and Gastric Cancer: A Review on Mechanisms of Action","volume":"50","author":"Hassanalilou","year":"2019","journal-title":"J. Gastrointest. Cancer"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.3892\/etm.2014.1662","article-title":"Resveratrol reverses multidrug resistance in human breast cancer doxorubicin-resistant cells","volume":"7","author":"Huang","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.tifs.2019.09.017","article-title":"The effects and mechanisms of epigallocatechin-3-gallate on reversing multidrug resistance in cancer","volume":"93","author":"Zhang","year":"2019","journal-title":"Trends Food Sci. 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