{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:29:06Z","timestamp":1790141346506,"version":"4.0.1"},"reference-count":137,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,7,19]],"date-time":"2020-07-19T00:00:00Z","timestamp":1595116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008730","name":"Kreftforeningen","doi-asserted-by":"publisher","award":["182609"],"award-info":[{"award-number":["182609"]}],"id":[{"id":"10.13039\/100008730","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The acute phase reaction is a systemic response to acute or chronic inflammation. The serum level of C-reactive protein (CRP) is the only acute phase biomarker widely used in routine clinical practice, including its uses for prognostics and therapy monitoring in cancer patients. Although Interleukin 6 (IL6) is a main trigger of the acute phase reactions, a series of acute phase reactants can contribute (e.g., other members in IL6 family or IL1 subfamily, and tumor necrosis factor \u03b1). However, the experience from patients receiving intensive chemotherapy for hematological malignancies has shown that, besides CRP, other biomarkers (e.g., cytokines, soluble cytokine receptors, soluble adhesion molecules) also have altered systemic levels as a part of the acute phase reaction in these immunocompromised patients. Furthermore, CRP and white blood cell counts can serve as a dual prognostic predictor in solid tumors and hematological malignancies. Recent studies also suggest that biomarker profiles as well as alternative inflammatory mediators should be further developed to optimize the predictive utility in cancer patients. Finally, the experience from allogeneic stem cell transplantation suggests that selected acute phase reactants together with specific markers of organ damages are useful for predicting or diagnosing graft versus host disease. Acute phase proteins may also be useful to identify patients (at risk of) developing severe immune-mediated toxicity after anticancer immunotherapy. To conclude, future studies of acute phase predictors in human malignancies should not only investigate the conventional inflammatory mediators (e.g., CRP, white blood cell counts) but also combinations of novel inflammatory parameters with specific markers of organ damages.<\/jats:p>","DOI":"10.3390\/cancers12071966","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T06:38:55Z","timestamp":1595313535000},"page":"1966","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Combined C-Reactive Protein and Novel Inflammatory Parameters as a Predictor in Cancer\u2014What Can We Learn from the Hematological Experience?"],"prefix":"10.3390","volume":"12","author":[{"given":"\u00d8ystein","family":"Bruserud","sequence":"first","affiliation":[{"name":"Section for Hematology, Institute of Clinical Science, Faculty of Medicine, University of Bergen, 5007 Bergen, Norway"},{"name":"Section for Hematology, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene Hersvik","family":"Aarstad","sequence":"additional","affiliation":[{"name":"Section for Hematology, Institute of Clinical Science, Faculty of Medicine, University of Bergen, 5007 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tor Henrik Anderson","family":"Tvedt","sequence":"additional","affiliation":[{"name":"Section for Hematology, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJM199902113400607","article-title":"Acute-phase proteins and other systemic responses to inflammation","volume":"340","author":"Gabay","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1749-6632.1982.tb22124.x","article-title":"The phenomenon of the acute phase response","volume":"389","author":"Kushner","year":"1982","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"ofv098","DOI":"10.1093\/ofid\/ofv098","article-title":"Acute phase reactants in infections: Evidence-Based review and a guide for clinicians","volume":"2","author":"Markanday","year":"2015","journal-title":"Open Forum Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1631\/jzus.2005.B1045","article-title":"Acute phase reaction and acute phase proteins","volume":"6","author":"Gruys","year":"2005","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1034\/j.1600-0757.2000.2230103.x","article-title":"Acute-phase reactants in infections and inflammatory diseases","volume":"23","author":"Ebersole","year":"2000","journal-title":"Periodontol. 2000"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s00391-015-0938-4","article-title":"C-reactive protein and the acute phase reaction in geriatric patients","volume":"48","author":"Bertsch","year":"2015","journal-title":"Z Gerontol. Geriatr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"754","DOI":"10.3389\/fimmu.2018.00754","article-title":"Role of C-Reactive Protein at Sites of Inflammation and Infection","volume":"9","author":"Sproston","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1161\/01.CIR.0000131160.94926.6E","article-title":"C-reactive protein promotes monocyte chemoattractant protein-1 - mediated chemotaxis through upregulating CC chemokine receptor 2 expression in human monocytes","volume":"109","author":"Han","year":"2004","journal-title":"Circulation"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Boncler, M., Wu, Y., and Watala, C. (2019). The multiple faces of C-Reactive Protein-Physiological and pathophysiological implications in cardiovascular disease. Molecules, 24.","DOI":"10.3390\/molecules24112062"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1365-2141.1995.tb05309.x","article-title":"Serum concentrations of E-selectin, P-selectin, ICAM-1 and interleukin 6 in acute leukaemia patients with chemotherapy-induced leucopenia and bacterial infections","volume":"91","author":"Bruserud","year":"1995","journal-title":"Br. J. Haematol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1600-0609.1993.tb00156.x","article-title":"Cytokine mediators of septic infections in the normal and granulocytopenic host","volume":"50","author":"Waage","year":"1993","journal-title":"Eur. J. Haematol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3109\/10428199609054849","article-title":"Serum levels of adhesion molecules and cytokines in patients with acute leukaemia","volume":"23","author":"Bruserud","year":"1996","journal-title":"Leuk. Lymphoma"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1600-0609.1997.tb01686.x","article-title":"Interleukin 4 responses in acute leukaemia patients with severe chemotherapy-induced leucopenia","volume":"59","author":"Bruserud","year":"1997","journal-title":"Eur. J. Haematol."},{"key":"ref_14","first-page":"231","article-title":"Hematopoietic growth factors in patients receiving intensive chemotherapy for malignant disorders: Studies of granulocyte-colony stimulating factor (G-CSF), granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-3 (IL-3) and Flt-3 ligand (Flt3L)","volume":"12","author":"Bruserud","year":"2001","journal-title":"Eur. Cytokine Netw."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1365-2141.2004.05350.x","article-title":"Significance of the CC chemokine RANTES in patients with haematological malignancy: Results from a prospective observational study","volume":"128","author":"Ellis","year":"2005","journal-title":"Br. J. Haematol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00277-011-1339-4","article-title":"Evaluation of circulating soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) to predict risk profile, response to antimicrobial therapy, and development of complications in patients with chemotherapy- associated febrile neutropenia: A pilot study","volume":"91","author":"Kwofie","year":"2012","journal-title":"Ann. Hematol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jiac.2016.04.002","article-title":"Diagnostic value of levels of presepsin (soluble CD14-subtype) in febrile neutropenia in patients with hematological disorders","volume":"22","author":"Koh","year":"2016","journal-title":"J. Infect. Chemother."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.transci.2011.10.019","article-title":"Comparative levels of macrophage migration inhibitory factor, procalcitonin, osteoprotegerin, interleukin-8, hs-C reactive protein, D-dimer in febrile neutropenia, newly diagnosed cancer patients, and infectious fever","volume":"46","author":"Bilgir","year":"2012","journal-title":"Transfus. Apher. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e241","DOI":"10.1097\/MPH.0b013e31824e498d","article-title":"Predictive value of interleukin-5 and monocyte chemotactic protein-1 for bacteremia in children with febrile neutropenia","volume":"34","author":"Aquino","year":"2012","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/MPH.0b013e3180308770","article-title":"The diagnostic value of C-reactive protein, interleukin-8, and monocyte chemotactic protein in risk stratification of febrile neutropenic children with hematologic malignancies","volume":"29","author":"Moneer","year":"2007","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1080\/10428194.2019.1617859","article-title":"MMP-10 and TIMP-1 as indicators of severe sepsis in adult hematological patients with febrile neutropenia","volume":"60","author":"Becker","year":"2019","journal-title":"Leuk. Lymphoma"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1007\/s12185-016-2175-z","article-title":"Serum concentrations of apoptosis-associated molecules in septic children with leukemia, neutropenia and fever","volume":"105","author":"Perez","year":"2017","journal-title":"Int. J. Hematol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1179\/102453311X13127324303434","article-title":"Serum levels of endothelium-derived endocan are increased in patients with untreated acute myeloid leukemia","volume":"16","author":"Hatfield","year":"2011","journal-title":"Hematology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/09537109976301","article-title":"Serum levels of thrombopoietin and stem cell factor in acute leukemia patients with chemotherapy-induced cytopenia and complicating infections","volume":"10","author":"Foss","year":"1999","journal-title":"Platelets"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3389\/fimmu.2018.00691","article-title":"Inflammatory mediator profiles differ in sepsis patients with and without bacteremia","volume":"9","author":"Mosevoll","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s00011-019-01269-1","article-title":"Regulation of C-reactive protein conformation in inflammation","volume":"68","author":"Yao","year":"2019","journal-title":"Inflamm. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1515\/hsz-2015-0149","article-title":"C-reactive protein and inflammation: Conformational changes affect function","volume":"396","author":"Wu","year":"2015","journal-title":"Biol. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1189\/jlb.0111032","article-title":"C-reactive protein-derived peptide 201-206 inhibits neutrophil adhesion to endothelial cells and platelets through CD32","volume":"90","author":"Zhang","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1161\/ATVBAHA.107.157016","article-title":"Human C-reactive protein activates monocyte-derived dendritic cells and induces dendritic cell-mediated T-cell activation","volume":"28","author":"Bult","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3389\/fimmu.2018.00372","article-title":"C-Reactive protein impairs dendritic cell development, maturation, and function: Implications for peripheral tolerance","volume":"9","author":"Jimenez","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_31","first-page":"665","article-title":"Polymorphism of structural forms of C-reactive protein","volume":"9","author":"Wang","year":"2002","journal-title":"Int. J. Mol. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5461","DOI":"10.3892\/mmr.2016.5922","article-title":"Presence of multimeric isoforms of human C-reactive protein in tissues and blood","volume":"14","author":"Li","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1074\/jbc.M109.044495","article-title":"C-reactive protein exists in an NaCl concentration-dependent pentamer-decamer equilibrium in physiological buffer","volume":"285","author":"Okemefuna","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1161\/01.RES.0000163015.67711.AB","article-title":"Activation of inflammation and coagulation after infusion of C-reactive protein in humans","volume":"96","author":"Bisoendial","year":"2005","journal-title":"Circ. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.3389\/fimmu.2018.01089","article-title":"pCRP-mCRP Dissociation Mechanisms as Potential Targets for the Development of Small-Molecule Anti-Inflammatory Chemotherapeutics","volume":"9","author":"Caprio","year":"2018","journal-title":"Front Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"Blasco","year":"2013","journal-title":"Cell"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"166","DOI":"10.18632\/aging.100444","article-title":"Inflammaging: Disturbed interplay between autophagy and inflammasomes","volume":"4","author":"Salminen","year":"2012","journal-title":"Aging (Albany NY)"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Tvedt, T.H.A., Melve, G.K., Tsykunova, G., Ahmed, A.B., Brenner, A.K., and Bruserud, \u00d8. (2018). Immunological heterogeneity of healthy peripheral blood stem cell donors-effects of granulocyte colony-stimulating factor on inflammatory responses. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19102886"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Barron, E., Lara, J., White, M., and Mathers, J.C. (2015). Blood-borne biomarkers of mortality risk: Systematic review of cohort studies. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0127550"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.atherosclerosis.2017.02.003","article-title":"Hs-CRP and all-cause, cardiovascular, and cancer mortality risk: A meta-analysis","volume":"259","author":"Li","year":"2017","journal-title":"Atherosclerosis"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1001\/archinte.162.20.2333","article-title":"Cardiovascular Health Study. Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: Results from the cardiovascular health study","volume":"162","author":"Walston","year":"2002","journal-title":"Arch. Intern Med."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Shrotriya, S., Walsh, D., Bennani-Baiti, N., Thomas, S., and Lorton, C. (2015). C-Reactive protein is an important biomarker for prognosis tumor recurrence and treatment response in adult solid tumors: A Systematic Review. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0143080"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.critrevonc.2017.06.002","article-title":"The role of the systemic inflammatory response in predicting outcomes in patients with advanced inoperable cancer: Systematic review and meta-analysis","volume":"116","author":"Dolan","year":"2017","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.2147\/OTT.S137002","article-title":"The prognostic value of C-reactive protein\/albumin ratio in human malignancies: An updated meta-analysis","volume":"10","author":"Xu","year":"2017","journal-title":"Onco Targets Ther."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.ctrv.2012.08.003","article-title":"The systemic inflammation-based Glasgow Prognostic Score: A decade of experience in patients with cancer","volume":"39","author":"McMillan","year":"2013","journal-title":"Cancer Treat Rev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"209","DOI":"10.5301\/JBM.2011.8872","article-title":"Prognostic role of C-reactive protein in breast cancer: A systematic review and meta-analysis","volume":"26","author":"Han","year":"2011","journal-title":"Int. J. Biol. Markers"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Yi, J.H., Wang, D., Li, Z.Y., Hu, J., Niu, X.F., and Liu, X.L. (2014). C-reactive protein as a prognostic factor for human osteosarcoma: A meta-analysis and literature review. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0094632"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e8463","DOI":"10.1097\/MD.0000000000008463","article-title":"Prognostic role of C-reactive protein in patients with nasopharyngeal carcinoma: A meta-analysis and literature review","volume":"96","author":"Fang","year":"2017","journal-title":"Medicine"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"441","DOI":"10.5301\/tj.5000522","article-title":"Baseline C-reactive protein level predicts survival of early-stage lung cancer: Evidence from a systematic review and meta-analysis","volume":"102","author":"Leuzzi","year":"2016","journal-title":"Tumori J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e13505","DOI":"10.1097\/MD.0000000000013505","article-title":"The prognostic value of C-reactive protein to albumin ratio in patients with lung cancer","volume":"97","author":"Deng","year":"2018","journal-title":"Medicine"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/hpb.12355","article-title":"Prognostic significance of pre-operative C-reactive protein and the neutrophil-lymphocyte ratio in resectable pancreatic cancer: A systematic review","volume":"17","author":"Stevens","year":"2015","journal-title":"HPB"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.3748\/wjg.v21.i9.2807","article-title":"Prognostic significance of neutrophil to lymphocyte ratio in pancreatic cancer: A meta-analysis","volume":"21","author":"Yang","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.2147\/OTT.S154162","article-title":"Prognostic value of platelet-to-lymphocyte ratio in pancreatic cancer: A comprehensive meta-analysis of 17 cohort studies","volume":"11","author":"Zhou","year":"2018","journal-title":"Onco Targets Ther."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2147\/TCRM.S70954","article-title":"Prognostic role of serum C-reactive protein in esophageal cancer: A systematic review and meta-analysis","volume":"11","author":"Huang","year":"2015","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/ags3.12294","article-title":"Prognostic significance of systemic inflammatory markers in esophageal cancer: Systematic review and meta-analysis","volume":"4","author":"Ishibashi","year":"2019","journal-title":"Ann. Gastroenterol. Surg."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1559325819889814","DOI":"10.1177\/1559325819889814","article-title":"C-Reactive Protein to albumin ratio in colorectal cancer: A Meta-Analysis of prognostic value","volume":"17","author":"Zhou","year":"2019","journal-title":"Dose Response"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/codi.12700","article-title":"Is C-reactive protein useful in prognostication for colorectal cancer? A systematic review","volume":"16","author":"Pathak","year":"2014","journal-title":"Colorectal Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.7314\/APJCP.2014.15.8.3369","article-title":"Prognostic significance of C-reactive protein in urological cancers: A systematic review and meta-analysis","volume":"15","author":"Dai","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.eururo.2014.07.033","article-title":"Inflammatory biomarkers and bladder cancer prognosis: A systematic review","volume":"66","author":"Rava","year":"2014","journal-title":"Eur. Urol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Mori, K., Miura, N., Mostafaei, H., Quhal, F., Motlagh, R.S., Lysenko, I., Kimura, S., Egawa, S., Karakiewicz, P.I., and Shariat, S.F. (2020). Prognostic value of preoperative hematologic biomarkers in urothelial carcinoma of the bladder treated with radical cystectomy: A systematic review and meta-analysis. Int. J. Clin. Oncol.","DOI":"10.1007\/s10147-020-01690-1"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00432-010-0951-3","article-title":"Prognostic role of systemic inflammatory response in renal cell carcinoma: A systematic review and meta-analysis","volume":"137","author":"Wu","year":"2011","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.urolonc.2013.07.016","article-title":"The prognostic value of C-reactive protein in renal cell carcinoma: A systematic review and meta-analysis","volume":"32","author":"Hu","year":"2014","journal-title":"Urol. Oncol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"467","DOI":"10.4103\/1008-682X.123686","article-title":"Prognostic role of C-reactive protein in prostate cancer: A systematic review and meta-analysis","volume":"16","author":"Liu","year":"2014","journal-title":"Asian J. Androl."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1159\/000369545","article-title":"Prognostic impact of C-reactive protein in metastatic prostate cancer: A systematic review and meta-analysis","volume":"37","author":"Rocha","year":"2014","journal-title":"Oncol. Res. Treat"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1442-2042.2012.03121.x","article-title":"Role of C-reactive protein in urological cancers: A useful biomarker for predicting outcomes","volume":"20","author":"Saito","year":"2013","journal-title":"Int. J. Urol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3904\/kjim.2016.054","article-title":"Myeloma prognostic index at diagnosis might be a prognostic marker in patients newly diagnosed with multiple myeloma","volume":"32","author":"Kim","year":"2017","journal-title":"Korean J. Intern. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e22032","DOI":"10.1002\/jcla.22032","article-title":"The Predictive Role of the Neutrophil\/Lymphocyte Ratio in Survival with Multiple Myeloma: A Single Center Experience","volume":"31","author":"Onec","year":"2017","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Witte, H.M., Bonorden, B., Riecke, A., Biersack, H., Steinestel, K., Merz, H., Feller, A.C., Bernard, V., Fetscher, S., and Von Bubnoff, N. (2020). The Glasgow Prognostic Score at diagnosis is a predictor of clinical outcome in patients with multiple myeloma undergoing autologous haematopoietic stem cell transplantation. Cancers, 12.","DOI":"10.3390\/cancers12040921"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e154","DOI":"10.1016\/S2352-3026(18)30220-5","article-title":"A clinical prediction model for outcome and therapy delivery in transplant-ineligible patients with myeloma (UK Myeloma Research Alliance Risk Profile): A development and validation study","volume":"6","author":"Cook","year":"2019","journal-title":"Lancet Haematol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/sj.bjc.6603329","article-title":"Preoperative elevation of serum C\u2014Reactive protein is predictive for prognosis in myeloma bone disease after surgery","volume":"95","author":"Goldschmidt","year":"2006","journal-title":"Br. J. Cancer"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/ajh.24352","article-title":"Reduction in C-reactive protein indicates successful targeting of the IL-1\/IL-6 axis resulting in improved survival in early stage multiple myeloma","volume":"91","author":"Lust","year":"2016","journal-title":"Am. J. Hematol."},{"key":"ref_72","unstructured":"Aarstad, H.H., Gudbrandsdottir, G., Hjelle, K.M., Bostad, L., Bruserud, \u00d8, Tvedt, T.H., and Beisland, C. The Biological Context of Serum C-Reactive Protein as a Prognostic Marker in Renal Cell Carcinoma; Studies of the Acute Phase Cytokine Profile. Personal communication."},{"key":"ref_73","unstructured":"Aarstad, H.H., Emblem Moe, S.E., Lybak, S., Bruserud, \u00d8, Aarstad, H.J., and Tvedt, T.H. The Acute Phase Reaction and Its Prognostic Impact in Patients with Head and Neck Squamous Cell Cell Carcinoma: Single Biomarkers Including C-Reactive Protein Versus Biomarker Profiles. Personal communication."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1182\/blood-2016-08-733196","article-title":"Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel","volume":"129","author":"Estey","year":"2017","journal-title":"Blood"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.bbmt.2019.10.015","article-title":"Role of age and hematopoietic cell transplantation-specific comorbidity index in myelodysplastic patients undergoing an allotransplant: A retrospective study from the chronic malignancies working party of the european group for blood and marrow transplantation","volume":"26","author":"Porcher","year":"2020","journal-title":"Biol. Blood Marrow Transpl."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e14474","DOI":"10.1097\/MD.0000000000014474","article-title":"Pretransplant C-reactive protein as a prognostic marker in allogeneic stem cell transplantation: A PRISMA-compliant meta-analysis","volume":"98","author":"Wu","year":"2019","journal-title":"Medicine"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Tvedt, T.H., Lie, S.A., Reikvam, H., Rye, K.P., Lind\u00e5s, R., Gedde-Dahl, T., Ahmed, A.B., and Bruserud, \u00d8. (2016). Pretransplant Levels of CRP and Interleukin-6 Family Cytokines; Effects on Outcome after Allogeneic Stem Cell Transplantation. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17111823"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.bbmt.2011.10.007","article-title":"The pretransplantation serum cytokine profile in allogeneic stem cell recipients differs from healthy individuals, and various profiles are associated with different risks of posttransplantation complications","volume":"18","author":"Reikvam","year":"2012","journal-title":"Biol. Blood Marrow Transpl."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.bbmt.2008.02.008","article-title":"Preengraftment serum C-reactive protein (CRP) value may predict acute graft-versus-host disease and nonrelapse mortality after allogeneic hematopoietic stem cell transplantation","volume":"14","author":"Fuji","year":"2008","journal-title":"Biol. Blood Marrow Transpl."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2217\/bmm-2016-0244","article-title":"Association between C-reactive protein levels in the first 1-3 days post-transplant and allogeneic immune reactions","volume":"11","author":"Chen","year":"2017","journal-title":"Biomark Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.bbmt.2016.03.010","article-title":"Peritransplant serum albumin decline predicts subsequent severe acute graft-versus-host disease after mucotoxic myeloablative conditioning","volume":"22","author":"Rashidi","year":"2016","journal-title":"Biol. Blood Marrow Transpl."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s12185-012-1229-0","article-title":"Differing impacts of pretransplant serum ferritin and C-reactive protein levels on the incidence of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation","volume":"97","author":"Sakamoto","year":"2013","journal-title":"Int. J. Hematol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.jcyt.2018.02.366","article-title":"The healthy donor profile of immunoregulatory soluble mediators is altered by stem cell mobilization and apheresis","volume":"20","author":"Melve","year":"2018","journal-title":"Cytotherapy"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3389\/fimmu.2018.00845","article-title":"Peripheral blood stem cell mobilization in healthy donors by granulocyte colony-stimulating factor causes preferential mobilization of lymphocyte subsets","volume":"9","author":"Melve","year":"2018","journal-title":"Front Immunol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1080\/17474086.2018.1511420","article-title":"Immunological heterogeneity of healthy peripheral blood stem cell donors-Preharvesting donor characteristics, additional heterogeneity induced by granulocyte colony-stimulating factor and possible importance for outcome after allotransplantation","volume":"11","author":"Bruserud","year":"2018","journal-title":"Expert Rev. Hematol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.bbmt.2017.10.025","article-title":"C-Reactive protein levels at diagnosis of acute graft-versus-host disease predict steroid-refractory disease, treatment-related mortality, and overall survival after allogeneic hematopoietic stem cell transplantation","volume":"24","author":"Minculescu","year":"2018","journal-title":"Biol. Blood Marrow Transpl."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s00277-020-04015-4","article-title":"Serum albumin and C-reactive protein as significant predictors of non-relapse mortality in lower gastrointestinal graft-versus-host disease","volume":"99","author":"Chung","year":"2020","journal-title":"Ann. Hematol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1182\/blood-2008-07-167098","article-title":"A biomarker panel for acute graft-versus-host disease","volume":"113","author":"Paczesny","year":"2009","journal-title":"Blood"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3854","DOI":"10.1182\/blood-2012-01-403063","article-title":"Acute graft-versus-host disease biomarkers measured during therapy can predict treatment outcomes: A blood and marrow transplant clinical trials network study","volume":"119","author":"Levine","year":"2012","journal-title":"Blood"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1182\/blood-2018-01-822957","article-title":"MAGIC biomarkers predict long-term outcomes for steroid-resistant acute GVHD","volume":"131","author":"Renteria","year":"2018","journal-title":"Blood"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1182\/bloodadvances.2019000791","article-title":"The MAGIC algorithm probability is a validated response biomarker of treatment of acute graft-versus-host disease","volume":"3","author":"Srinagesh","year":"2019","journal-title":"Blood Adv."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Aziz, M.D., Shah, J., Kapoor, U., Dimopoulos, C., Anand, S., Augustine, A., Ayuk, F., Chaudhry, M., Chen, Y.B., and Choe, H.K. (2020). Disease risk and GVHD biomarkers can stratify patients for risk of relapse and nonrelapse mortality post hematopoietic cell transplant. Leukemia.","DOI":"10.1038\/s41375-020-0726-z"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"5244","DOI":"10.2174\/0929867326666190325095853","article-title":"Immunosuppression and Immunotargeted Therapy in Acute Myeloid Leukemia\u2014The potential use of checkpoint inhibitors in combination with other treatments","volume":"26","author":"Leufven","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/bjc.2017.274","article-title":"Predicting response and toxicity to immune checkpoint inhibitors using routinely available blood and clinical markers","volume":"117","author":"Hopkins","year":"2017","journal-title":"Br. J. Cancer"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1158\/1078-0432.CCR-15-1136","article-title":"Nivolumab in resected and unresectable metastatic melanoma: Characteristics of immune- related adverse events and association with outcomes","volume":"22","author":"Kim","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1200\/JCO.2014.57.4756","article-title":"Vitiligo-like depigmentation in patients with stage III-IV melanoma receiving immunotherapy and its association with survival: A systematic review and meta-analysis","volume":"33","author":"Teulings","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"6681","DOI":"10.1158\/1078-0432.CCR-07-0187","article-title":"Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade","volume":"13","author":"Downey","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1200\/JCO.2015.66.1389","article-title":"Safety profile of nivolumab monotherapy: A pooled analysis of patients with advanced melanoma","volume":"35","author":"Weber","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1001\/jamadermatol.2015.2707","article-title":"Association of vitiligo with tumor response in patients with metastatic melanoma treated with pembrolizumab","volume":"152","author":"Hua","year":"2016","journal-title":"JAMA Dermatol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1093\/annonc\/mdw016","article-title":"Baseline neutrophils and derived neutrophil-to-lymphocyte ratio: Prognostic relevance in metastatic melanoma patients receiving ipilimumab","volume":"27","author":"Ferrucci","year":"2016","journal-title":"Ann. Oncol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/bjd.14155","article-title":"High neutrophil to lymphocyte ratio measured before starting ipilimumab treatment is associated with reduced overall survival in patients with melanoma","volume":"174","author":"Zaragoza","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00262-014-1545-8","article-title":"Immunological and biological changes during ipilimumab treatment and their potential correlation with clinical response and survival in patients with advanced melanoma","volume":"63","author":"Simeone","year":"2014","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00262-018-2258-1","article-title":"Soluble CTLA-4 as a favorable predictive biomarker in metastatic melanoma patients treated with ipilimumab: An Italian melanoma intergroup study","volume":"68","author":"Pistillo","year":"2019","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Hopkins, A.M., Kichenadasse, G., Garrett-Mayer, E., Karapetis, C.S., Rowland, A., and Sorich, M.J. (2020). Development and validation of a prognostic model for patients with advanced lung cancer treated with the immune checkpoint inhibitor atezolizumab. Clin. Cancer Res.","DOI":"10.1158\/1078-0432.CCR-19-2968"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s11523-019-00660-6","article-title":"Predictive Impact of peripheral blood markers and C-Reactive protein in nivolumab therapy for metastatic renal cell carcinoma","volume":"14","author":"Ishihara","year":"2019","journal-title":"Target Oncol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12032-019-1255-3","article-title":"Impact of early inflammatory cytokine elevation after commencement of PD-1 inhibitors to predict efficacy in patients with non-small cell lung cancer","volume":"36","author":"Ozawa","year":"2019","journal-title":"Med. Oncol."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Formica, V., Morelli, C., Patrikidou, A., Murias, C., Butt, S., Nardecchia, A., Lucchetti, J., Renzi, N., Shiu, K.K., and Coselli, M. (2020). Gastric Inflammatory Prognostic Index (GIPI) in patients with metastatic gastro-esophageal Junction\/Gastric Cancer treated with PD-1\/PD-L1 Immune checkpoint inhibitors. Target Oncol.","DOI":"10.1007\/s11523-020-00723-z"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1158\/2159-8290.CD-16-0040","article-title":"Identification of Predictive Biomarkers for cytokine release syndrome after chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia","volume":"6","author":"Teachey","year":"2016","journal-title":"Cancer Discov."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12967-018-1467-x","article-title":"Sex and interleukin-6 are prognostic factors for autoimmune toxicity following treatment with anti-CTLA4 blockade","volume":"16","author":"Valpione","year":"2018","journal-title":"J. Transl. Med."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Davila, M.L., Riviere, I., Wang, X., Bartido, S., Park, J., Curran, K., Chung, S.S., Stefanski, J., Borquez-Ojeda, O., and Olszewska, M. (2014). Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Sci. Transl. Med., 224ra25.","DOI":"10.1126\/scitranslmed.3008226"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1007\/s00432-019-03002-1","article-title":"C-reactive protein as an early marker of immune-related adverse events","volume":"145","author":"Abolhassani","year":"2019","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s40425-017-0300-z","article-title":"Society for Immunotherapy of Cancer Toxicity Management Working Group. Managing toxicities associated with immune checkpoint inhibitors: Consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group","volume":"5","author":"Puzanov","year":"2017","journal-title":"J. Immunother. Cancer"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Wu, H., Shi, J., Luo, Y., Li, X., Lan, J., Ni, W., Lu, Y., Chen, L., and Tan, Y. (2020). Ruxolitinib combined with etanercept Induce a rapid response to Corticosteroid-refractory Severe acute graft versus host disease after allogeneic stem cell transplantation: Results of a multi-center prospective study. Am. J. Hematol.","DOI":"10.1002\/ajh.25898"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Modemann, F., Ayuk, F., Wolschke, C., Christopeit, M., Janson, D., Von Pein, U.M., and Kr\u00f6ger, N. (2020). Ruxolitinib plus extracorporeal photopheresis (ECP) for steroid refractory acute graft-versus-host disease of lower GI-tract after allogeneic stem cell transplantation leads to increased regulatory T cell level. Bone Marrow Transpl.","DOI":"10.1038\/s41409-020-0952-z"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1056\/NEJMoa1917635","article-title":"REACH2 Trial Group. Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host Disease","volume":"382","author":"Zeiser","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3109\/10408363.2011.599831","article-title":"Elevated C-reactive protein in the diagnosis, prognosis, and cause of cancer","volume":"48","author":"Allin","year":"2011","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1200\/JCO.2016.71.7017","article-title":"Guideline for the management of fever and neutropenia in children with cancer and hematopoietic Stem-Cell transplantation recipients: 2017 Update","volume":"35","author":"Lehrnbecher","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s00277-019-03622-0","article-title":"Management of sepsis in neutropenic cancer patients: 2018 guidelines from the Infectious Diseases Working Party (AGIHO) and Intensive Care Working Party (iCHOP) of the German Society of Hematology and Medical Oncology (DGHO)","volume":"98","author":"Kochanek","year":"2019","journal-title":"Ann. Hematol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1007\/s00277-017-3098-3","article-title":"Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)","volume":"96","author":"Heinz","year":"2017","journal-title":"Ann. Hematol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/MPH.0000000000001468","article-title":"Frequency and determinants of invasive fungal infections in children with solid and hematologic malignancies in a nonallogeneic stem cell transplantation setting: A Narrative Review","volume":"41","author":"Ruijters","year":"2019","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/QCO.0000000000000502","article-title":"Invasive fungal disease and cytomegalovirus infection: Is there an association?","volume":"31","author":"Yong","year":"2018","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.emc.2018.06.009","article-title":"Infectious disease emergencies in oncology patients","volume":"36","author":"Cantwell","year":"2018","journal-title":"Emerg Med. Clin. N. Am."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jim.2018.06.003","article-title":"Standardization of sampling and sample preparation for analysis of human monocyte subsets in peripheral blood","volume":"461","author":"Rundgren","year":"2018","journal-title":"J. Immunol. Methods"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.3389\/fimmu.2019.01786","article-title":"The Endless Saga of Monocyte Diversity","volume":"10","author":"Ugel","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Boyette, L.B., Macedo, C., Hadi, K., Elinoff, B.D., Walters, J.T., Ramaswami, B., Chalasani, G., Taboas, J.M., Lakkis, F.G., and Metes, D.M. (2017). Phenotype, function, and differentiation potential of human monocyte subsets. PLoS ONE, 26.","DOI":"10.1371\/journal.pone.0176460"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/JLB.4RI0818-311R","article-title":"Monocyte heterogeneity and functions in cancer. Version 2","volume":"106","author":"Olingy","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Lim, H.X., Kim, T.S., and Poh, C.L. (2020). Understanding the differentiation, expansion, recruitment and suppressive activities of myeloid-derived suppressor cells in cancers. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103599"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"e12883","DOI":"10.1111\/sji.12883","article-title":"Pattern of human monocyte subpopulations in health and disease","volume":"92","author":"Szymczak","year":"2020","journal-title":"Scand J. Immunol."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Rundgren, I.M., Ersv\u00e6r, E., Ahmed, A.B., Ryningen, A., and Bruserud, \u00d8. (2019). Circulating monocyte subsets in multiple myeloma patients receiving autologous stem cell transplantation - A study of the preconditioning status and the course until posttransplant reconstitution for a consecutive group of patients. BMC Immunol., 20.","DOI":"10.1186\/s12865-019-0323-y"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Rundgrenm, I.M., Ersv\u00e6r, E., Ahmed, A.B., Ryningen, A., and Bruserud, \u00d8. (2020). A Pilot Study of Circulating monocyte subsets in patients treated with stem cell transplantation for high-risk hematological malignancies. Medicina, 56.","DOI":"10.3390\/medicina56010036"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Rundgren, I.M., Ryningen, A., Anderson Tvedt, T.H., Bruserud, \u00d8., and Ersv\u00e6r, E. (2020). Immunomodulatory drugs alter the metabolism and the extracellular release of soluble mediators by normal monocytes. Molecules, 25.","DOI":"10.3390\/molecules25020367"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1056\/NEJMra1609337","article-title":"Acute Graft-versus-Host Disease\u2014Biologic Process, prevention, and therapy","volume":"377","author":"Zeiser","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"102944","DOI":"10.1016\/j.critrevonc.2020.102944","article-title":"Comparative efficacy of 20 graft-versus-host disease prophylaxis therapies for patients after hematopoietic stem-cell transplantation: A multiple-treatments network meta-analysis","volume":"150","author":"Lv","year":"2020","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Zappavigna, S., Cossu, A.M., Grimaldi, A., Bocchetti, M., Ferraro, G.A., Nicoletti, G.F., Filosa, R., and Caraglia, M. (2020). Anti-Inflammatory drugs as anticancer agents. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072605"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1053\/j.seminoncol.2015.09.010","article-title":"Mechanisms of nonsteroidal anti-inflammatory drugs in cancer prevention","volume":"43","author":"Umar","year":"2016","journal-title":"Semin. Oncol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1158\/1940-6207.CAPR-16-0209","article-title":"Targeting inflammation in cancer prevention and therapy","volume":"12","author":"Todoric","year":"2016","journal-title":"Cancer Prev. Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nrclinonc.2015.105","article-title":"Inflammation and cancer: Advances and new agents","volume":"12","author":"Crusz","year":"2015","journal-title":"Nat. Rev. Clin. Oncol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/12\/7\/1966\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:49:50Z","timestamp":1760176190000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/12\/7\/1966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,19]]},"references-count":137,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,7]]}},"alternative-id":["cancers12071966"],"URL":"https:\/\/doi.org\/10.3390\/cancers12071966","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,19]]}}}