{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:15:53Z","timestamp":1780582553900,"version":"3.54.1"},"reference-count":183,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004252","name":"Qatar University","doi-asserted-by":"publisher","award":["QUHI-CMED-19\/20-1, QUCG-CMED-20\/21-2, GCC-2017-002 QU\/KU and QUCG-CMED-20\/21-2"],"award-info":[{"award-number":["QUHI-CMED-19\/20-1, QUCG-CMED-20\/21-2, GCC-2017-002 QU\/KU and QUCG-CMED-20\/21-2"]}],"id":[{"id":"10.13039\/501100004252","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Human coronaviruses, especially SARS-CoV-2, are emerging pandemic infectious diseases with high morbidity and mortality in certain group of patients. In general, SARS-CoV-2 causes symptoms ranging from the common cold to severe conditions accompanied by lung injury, acute respiratory distress syndrome in addition to other organs\u2019 destruction. The main impact upon SARS-CoV-2 infection is damage to alveolar and acute respiratory failure. Thus, lung cancer patients are identified as a particularly high-risk group for SARS-CoV-2 infection and its complications. On the other hand, it has been reported that SARS-CoV-2 spike (S) protein binds to angiotensin-converting enzyme 2 (ACE-2), that promotes cellular entry of this virus in concert with host proteases, principally transmembrane serine protease 2 (TMPRSS2). Today, there are no vaccines and\/or effective drugs against the SARS-CoV-2 coronavirus. Thus, manipulation of key entry genes of this virus especially in lung cancer patients could be one of the best approaches to manage SARS-CoV-2 infection in this group of patients. We herein provide a comprehensive and up-to-date overview of the role of ACE-2 and TMPRSS2 genes, as key entry elements as well as therapeutic targets for SARS-CoV-2 infection, which can help to better understand the applications and capacities of various remedial approaches for infected individuals, especially those with lung cancer.<\/jats:p>","DOI":"10.3390\/cancers12082186","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T15:13:18Z","timestamp":1596640398000},"page":"2186","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["SARS-CoV-2 Infection and Lung Cancer: Potential Therapeutic Modalities"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8627-3186","authenticated-orcid":false,"given":"Ishita","family":"Gupta","sequence":"first","affiliation":[{"name":"College of Medicine, QU Health, Qatar University, 2713 Doha, Qatar"},{"name":"Biomedical Research Center, Qatar University, 2713 Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5859-3804","authenticated-orcid":false,"given":"Balsam","family":"Rizeq","sequence":"additional","affiliation":[{"name":"College of Medicine, QU Health, Qatar University, 2713 Doha, Qatar"},{"name":"Biomedical Research Center, Qatar University, 2713 Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3868-0318","authenticated-orcid":false,"given":"Eyad","family":"Elkord","sequence":"additional","affiliation":[{"name":"Qatar Biomedical Research Institute &amp; 4Hamad Bin Khalifa University, 34110 Doha, Qatar"},{"name":"Biomedical Research Center, School of Science, Engineering and Environment, University of Salford, Manchester M5 4WT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9743-7265","authenticated-orcid":false,"given":"Semir","family":"Vranic","sequence":"additional","affiliation":[{"name":"College of Medicine, QU Health, Qatar University, 2713 Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4452-3439","authenticated-orcid":false,"given":"Ala-Eddin","family":"Al Moustafa","sequence":"additional","affiliation":[{"name":"College of Medicine, QU Health, Qatar University, 2713 Doha, Qatar"},{"name":"Biomedical Research Center, Qatar University, 2713 Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/ijc.31937","article-title":"Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods","volume":"144","author":"Ferlay","year":"2019","journal-title":"Int. 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