{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:59:26Z","timestamp":1782827966014,"version":"3.54.5"},"reference-count":109,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007436","name":"Torben og Alice Frimodts Fond","doi-asserted-by":"publisher","award":["."],"award-info":[{"award-number":["."]}],"id":[{"id":"10.13039\/501100007436","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007444","name":"Einar Willumsen Foundation","doi-asserted-by":"publisher","award":["."],"award-info":[{"award-number":["."]}],"id":[{"id":"10.13039\/100007444","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008249","name":"Frimodt-Heineke Fonden","doi-asserted-by":"publisher","award":["."],"award-info":[{"award-number":["."]}],"id":[{"id":"10.13039\/501100008249","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department of Hematology, Zealand University Hospital, Roskilde, Denmark","award":["."],"award-info":[{"award-number":["."]}]},{"name":"Departmental funds at UTHSCSA, USA","award":["."],"award-info":[{"award-number":["."]}]},{"name":"Health Sciences Research Foundation, Region Zealand, Denmark","award":["."],"award-info":[{"award-number":["."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Elevated body mass index (BMI) is a global health problem, leading to enhanced mortality and the increased risk of several cancers including essential thrombocythemia (ET), a subtype of the Philadelphia-chromosome negative myeloproliferative neoplasms (MPN). Furthermore, evidence states that BMI is associated with the severity of symptom burden among cancer patients. MPN patients often suffer from severe symptom burden. The purpose of this study was to examine whether deviations from a normal BMI in an MPN population are associated with higher symptom burden and reduced quality of life (QoL). A combined analysis of two large cross-sectional surveys, the Danish Population-based Study, MPNhealthSurvey (n = 2044), and the international Fatigue Study (n = 1070), was performed. Symptoms and QoL were assessed using the validated Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF). Analysis of covariance was used to estimate the effects of different BMI categories on symptom scores while adjusting for age, sex, and MPN subtype. A U-shaped association between BMI and Total Symptom Burden was observed in both datasets with significantly higher mean scores for underweight and obese patients relative to normal weight (mean difference: underweight 5.51 (25.8%), p = 0.006; obese 5.70 (26.6%) p &lt; 0.001). This is an important finding, as BMI is a potentially modifiable factor in the care of MPN patients.<\/jats:p>","DOI":"10.3390\/cancers12082202","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T09:41:21Z","timestamp":1596706881000},"page":"2202","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Body Mass Index and Total Symptom Burden in Myeloproliferative Neoplasms Discovery of a U-shaped Association"],"prefix":"10.3390","volume":"12","author":[{"given":"Sarah Friis","family":"Christensen","sequence":"first","affiliation":[{"name":"Department of Hematology, Zealand University Hospital, 4000 Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn Marie","family":"Scherber","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, UT Health San Antonio MD Anderson Cancer Center, San Antonio, TX 78229, USA"},{"name":"Hematologic Malignancies, Incyte Corporation, Wilmington, DE 19803, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Brochmann","sequence":"additional","affiliation":[{"name":"Department of Hematology, Zealand University Hospital, 4000 Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Goros","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, UT Health San Antonio, San Antonio, TX 78229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Gelfond","sequence":"additional","affiliation":[{"name":"Department of Population Health Sciences, UT Health San Antonio, San Antonio, TX 78229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christen Lykkegaard","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Hematology, University Hospital of Copenhagen at Rigshospitalet, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esben Meulengracht","family":"Flachs","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, 2400 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Mesa","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, UT Health San Antonio MD Anderson Cancer Center, San Antonio, TX 78229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1478-7954-10-22","article-title":"National, regional, and global trends in adult overweight and obesity prevalences","volume":"10","author":"Stevens","year":"2012","journal-title":"Popul. 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