{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:35:31Z","timestamp":1787027731780,"version":"build-2736575974"},"reference-count":190,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:00:00Z","timestamp":1597190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01-CA217797"],"award-info":[{"award-number":["P01-CA217797"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cancer Center Support Grant through the University of Iowa Holden Comprehensive Cancer Center","award":["P30-CA086862"],"award-info":[{"award-number":["P30-CA086862"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Historically, patients with localized soft tissue sarcomas (STS) of the extremities would undergo limb amputation. It was subsequently determined that the addition of radiation therapy (RT) delivered prior to (neoadjuvant) or after (adjuvant) a limb-sparing surgical resection yielded equivalent survival outcomes to amputation in appropriate patients. Generally, neoadjuvant radiation offers decreased volume and dose of high-intensity radiation to normal tissue and increased chance of achieving negative surgical margins\u2014but also increases wound healing complications when compared to adjuvant radiotherapy. This review elaborates on the current neoadjuvant\/adjuvant RT approaches, wound healing complications in STS, and the potential application of novel radioprotective agents to minimize radiation-induced normal tissue toxicity.<\/jats:p>","DOI":"10.3390\/cancers12082258","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T09:14:49Z","timestamp":1597223689000},"page":"2258","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective Agents"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9795-1424","authenticated-orcid":false,"given":"Cameron M.","family":"Callaghan","sequence":"first","affiliation":[{"name":"Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USA"},{"name":"Holden Comprehensive Cancer Center and Department of Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. M.","family":"Hasibuzzaman","sequence":"additional","affiliation":[{"name":"Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USA"},{"name":"Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA 52422, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel N.","family":"Rodman","sequence":"additional","affiliation":[{"name":"Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USA"},{"name":"Department of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica E.","family":"Goetz","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kranti A.","family":"Mapuskar","sequence":"additional","affiliation":[{"name":"Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Petronek","sequence":"additional","affiliation":[{"name":"Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J.","family":"Steinbach","sequence":"additional","affiliation":[{"name":"Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin J.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey F.","family":"Pulliam","sequence":"additional","affiliation":[{"name":"Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA 52422, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell C.","family":"Coleman","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1185-5448","authenticated-orcid":false,"given":"Varun V.","family":"Monga","sequence":"additional","affiliation":[{"name":"Holden Comprehensive Cancer Center and Department of Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed M.","family":"Milhem","sequence":"additional","affiliation":[{"name":"Holden Comprehensive Cancer Center and Department of Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas R.","family":"Spitz","sequence":"additional","affiliation":[{"name":"Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan G.","family":"Allen","sequence":"additional","affiliation":[{"name":"Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USA"},{"name":"Holden Comprehensive Cancer Center and Department of Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA 52422, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.14694\/EdBook_AM.2014.34.244","article-title":"Radiotherapy for soft tissue sarcoma: 50 years of change and improvement","volume":"34","author":"Wang","year":"2014","journal-title":"Am. 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