{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T15:24:02Z","timestamp":1774538642629,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T00:00:00Z","timestamp":1598140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015755","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","doi-asserted-by":"publisher","award":["18PI03"],"award-info":[{"award-number":["18PI03"]}],"id":[{"id":"10.13039\/501100015755","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The identification of high-risk groups of gastric (GC) and pancreatic adenocarcinoma (PC) due to a hereditary basis could imply a benefit in the affected families by establishing personalized preventive strategies. We aimed at assessing the diagnostic yield of GC\/PC hereditary syndromes in individuals evaluated based on specific clinical criteria. In total, 77 unrelated individuals (45 from GC group\/32 from PC group) were recruited: 51 (66.2%) cancer diagnosis \u226460 years, 3 (4%) with personal history of GC\/PC and other cancer and 23 (29.8%) due to family history. Immunohistochemical analysis of DNA mismatch repair proteins was performed in 38 (49.3%) available tumors, being pathological in one (2%) GC. A genetic analysis was performed if clinical criteria of hereditary syndrome were fulfilled, identifying a mutation in 10\/22 (45.5%) families [7\/16 (43.7%) with GC and 3\/6 (50%) with PC] and 19 (24.7%) fulfilled criteria of familial cancer. Diagnosis of cancer &lt;40 years and personal history of other cancers were independent risk factors of a hereditary syndrome [OR:11.3 (95%IC 1.9\u201367); p = 0.007 and OR:17.4 (95% IC 2.5\u2013119.9); p = 0.004; respectively]. The selection of patients based on clinical criteria leads to high diagnostic yield, detecting a causative germline mutation in almost half of the cases; therefore, both meticulous genetic counseling and use of multi-gen panels is crucial.<\/jats:p>","DOI":"10.3390\/cancers12092386","type":"journal-article","created":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T21:28:06Z","timestamp":1598218086000},"page":"2386","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Genetic Counseling for Hereditary Gastric and Pancreatic Cancer in High-Risk Gastrointestinal Cancer Clinics: An Effective Strategy"],"prefix":"10.3390","volume":"12","author":[{"given":"Joan","family":"Llach","sequence":"first","affiliation":[{"name":"Gastroenterology Department, Hospital Cl\u00ednic de Barcelona, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Institut d\u2019Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Moreno","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Cl\u00ednic de Barcelona, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Institut d\u2019Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariadna","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Cl\u00ednic de Barcelona, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Institut d\u2019Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9748-1212","authenticated-orcid":false,"given":"Cristina","family":"Herrera-Pariente","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Cl\u00ednic de Barcelona, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Institut d\u2019Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Oca\u00f1a","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Cl\u00ednic de Barcelona, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Institut d\u2019Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3063-0110","authenticated-orcid":false,"given":"Miriam","family":"Cuatrecasas","sequence":"additional","affiliation":[{"name":"Pathology Department, Centre for Biomedical Diagnosis, Hospital Cl\u00ednic, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liseth","family":"Rivero-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Cl\u00ednic de Barcelona, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Institut d\u2019Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebeca","family":"Moreira","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Cl\u00ednic de Barcelona, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Institut d\u2019Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mireia","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Cl\u00ednic de Barcelona, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Institut d\u2019Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3675-312X","authenticated-orcid":false,"given":"Gerhard","family":"Jung","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Cl\u00ednic de Barcelona, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Institut d\u2019Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Pellis\u00e9","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Cl\u00ednic de Barcelona, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Institut d\u2019Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8431-2033","authenticated-orcid":false,"given":"Antoni","family":"Castells","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Cl\u00ednic de Barcelona, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Institut d\u2019Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesc","family":"Balaguer","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Cl\u00ednic de Barcelona, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Institut d\u2019Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabela","family":"Carballal","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Cl\u00ednic de Barcelona, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Institut d\u2019Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4518-8591","authenticated-orcid":false,"given":"Leticia","family":"Moreira","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Cl\u00ednic de Barcelona, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Institut d\u2019Investigacions Biomediques August Pi i Sunyer, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,23]]},"reference":[{"key":"ref_1","first-page":"613","article-title":"Development of indicators to evaluate colorectal cancer prevention programs in the high-risk population. 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Assoc."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/12\/9\/2386\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:05:28Z","timestamp":1760177128000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/12\/9\/2386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,23]]},"references-count":30,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9]]}},"alternative-id":["cancers12092386"],"URL":"https:\/\/doi.org\/10.3390\/cancers12092386","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,23]]}}}