{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:46:05Z","timestamp":1790696765885,"version":"4.1.0"},"reference-count":32,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Purpose: To assess the potential added value of FDG-PET\/CT radiomics for the characterization of pheochromocytomas (PHEO) and their genetic orientation prior to surgery and genetic testing. Methods: This retrospective monocentric study, included 49 patients (52 tumors) that underwent both FDG-PET\/CT and MIBG scan before surgery. A germline mutation was secondarily identified in 13 patients in one of the genes related to Cluster 1 (n = 4) or Cluster 2 (n = 9). No mutation was identified in 32 patients and 4 did not have genetic testing. Correlation between several PET-based biomarkers, including SUVmax, metabolic tumor volume (MTV), total lesion glycolysis (TLG) and textural features, and biochemical and genetic features were analyzed. Results: Sensitivity of FDG-PET\/CT alone was 92%, and 98% when combined to MIBG. The SUVmax was significantly higher for mutated tumors classified in Cluster 1 than in Cluster 2 (p = 0.002) or for tumors with no identified mutations (p = 0.04). MTV and TLG of the tumors with the most intense uptake discriminated mutated Cluster 2 from sporadic tumors, but not from Cluster 1 tumors. Textural features combined with MTV led to better differentiation between sporadic and mutated tumors (p &lt; 0.05). Conclusion: FDG-PET\/CT is useful for preoperative characterization of PHEO, and when combined with radiomics biomarkers, provides evidences for a genetic predisposition.<\/jats:p>","DOI":"10.3390\/cancers12092424","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T09:56:58Z","timestamp":1598435818000},"page":"2424","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Usefulness of FDG-PET\/CT-Based Radiomics for the Characterization and Genetic Orientation of Pheochromocytomas Before Surgery"],"prefix":"10.3390","volume":"12","author":[{"given":"Catherine","family":"Ansquer","sequence":"first","affiliation":[{"name":"Nuclear Medicine Department, University Hospital of Nantes, Place Alexis Ricordeau, 44093 Nantes, France"},{"name":"Universit\u00e9 de Nantes, CNRS, INSERM, CRCINA, 44007 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Drui","sequence":"additional","affiliation":[{"name":"Endocrinology Department, University Hospital of Nantes, Boulevard Jacques Monod, 44092 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Miralli\u00e9","sequence":"additional","affiliation":[{"name":"Digestive and Endocrine Surgery Department (CCDE), Institut des Maladies de l\u2019Appareil Digestif (IMAD), University Hospital of Nantes, Place Alexis Ricordeau, 44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Renaudin-Autain","sequence":"additional","affiliation":[{"name":"Anatomopathology Department, University Hospital of Nantes, Place Alexis Ricordeau, 44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Denis","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, University Hospital of Nantes, Place Alexis Ricordeau, 44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4816-670X","authenticated-orcid":false,"given":"Anne-Paule","family":"Gimenez-Roqueplo","sequence":"additional","affiliation":[{"name":"Genetic Department, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital Europ\u00e9en Georges Pompidou, 75015 Paris, France"},{"name":"Universit\u00e9 de Paris, INSERM, PARCC, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Leux","sequence":"additional","affiliation":[{"name":"Medical Information Department, University Hospital of Nantes, Place Alexis Ricordeau, 44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederique","family":"Toulgoat","sequence":"additional","affiliation":[{"name":"Radiology Department, University Hospital of Nantes, Place Alexis Ricordeau, 44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Kraeber-Bod\u00e9r\u00e9","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, University Hospital of Nantes, Place Alexis Ricordeau, 44093 Nantes, France"},{"name":"Universit\u00e9 de Nantes, CNRS, INSERM, CRCINA, 44007 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6932-7322","authenticated-orcid":false,"given":"Thomas","family":"Carlier","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, University Hospital of Nantes, Place Alexis Ricordeau, 44093 Nantes, France"},{"name":"Universit\u00e9 de Nantes, CNRS, INSERM, CRCINA, 44007 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1210\/jc.2014-1498","article-title":"Pheochromocytoma and paraganglioma: An endocrine society clinical practice guideline","volume":"99","author":"Lenders","year":"2014","journal-title":"J. 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