{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T07:36:44Z","timestamp":1783409804068,"version":"3.54.6"},"reference-count":50,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T00:00:00Z","timestamp":1598745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Although most of the analyses included transverse colon cancers (TCC) among right colon cancer (RCC), it is not completely clear if they present total similarities with RCC or if they have their specific features. Therefore, we present an observational study to evaluate clinicopathological characteristics and survival data of patients with TCC. Methods: We retrospectively reviewed 450 RCC, of whom 97 stages I\u2013IV TCC were included in this multicenter study; clinicopathological and molecular parameters were analyzed to identify prognostic factors for disease-free survival (DFS) and overall survival (OS). Results: Most of TCC cases were male (61%), with \u226470 years old (62%), and good performance status (ECOG PS 0, 68%). According to WHO classification, 41 (49%) and 40 (48%) tumors were classified as well to moderate and poorly\/undifferentiated respectively, regardless of mucinous component (30%). About molecular data, 8 (26%), 45 (63%), and 14 (24%) were MSI-H, KRAS wild-type, and BRAF V600E mutant, respectively. With a median follow-up of 34 months, there were 29 and 50 disease recurrences and deaths respectively. Charlson comorbidity index \u22655 was a significant prognostic factor for DFS (HR = 7.67, 95% CI 2.27\u201325.92). Colon obstruction\/perforation (HR = 2.65, 95% CI 1.01\u20137.01), and BRAF mutant (HR = 3.03, 95% CI 0.97\u20139.50) cases showed a worst, despite not statistically significant, DFS. Whereas for OS, at the multivariate model, only tumor grade differentiation (HR = 5.26, 95% CI 1.98\u201314.01) and BRAF mutation status (3.71, 95% CI 1.07\u201312.89) were independent prognostic factors. Conclusions: Poorly\/undifferentiated tumor grade and BRAF V600E mutation are independent prognostic factors for OS in TCC. Further prospective clinical trials are needed to better define TCC treatment in order to improve patient outcome.<\/jats:p>","DOI":"10.3390\/cancers12092457","type":"journal-article","created":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T06:06:22Z","timestamp":1598767582000},"page":"2457","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of Prognostic Factors for Survival in Transverse Colon Cancer"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5339-8348","authenticated-orcid":false,"given":"Michela","family":"Roberto","sequence":"first","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Oncology Unit, Sant\u2019 Andrea Hospital, Sapienza University of Rome, 00187 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Arrivi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Oncology Unit, Sant\u2019 Andrea Hospital, Sapienza University of Rome, 00187 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Lo Bianco","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Oncology Unit, Sant\u2019 Andrea Hospital, Sapienza University of Rome, 00187 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Cascinu","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Oncology and Hematology, University Hospital of Modena, 41125 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Gelsomino","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Oncology and Hematology, University Hospital of Modena, 41125 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Caputo","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Oncology and Hematology, University Hospital of Modena, 41125 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisida","family":"Cerma","sequence":"additional","affiliation":[{"name":"Division of Oncology, Department of Oncology and Hematology, University Hospital of Modena, 41125 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5435-1218","authenticated-orcid":false,"given":"Michele","family":"Ghidini","sequence":"additional","affiliation":[{"name":"Oncology Unit, Oncology Department, ASST of Cremona, 26100 Cremona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Ratti","sequence":"additional","affiliation":[{"name":"Oncology Unit, Oncology Department, ASST of Cremona, 26100 Cremona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Pizzo","sequence":"additional","affiliation":[{"name":"Oncology Unit, Oncology Department, ASST of Cremona, 26100 Cremona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Ficorella","sequence":"additional","affiliation":[{"name":"Medical Oncology, St. Salvatore Hospital, University of L\u2019Aquila, Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4629-7762","authenticated-orcid":false,"given":"Alessandro","family":"Parisi","sequence":"additional","affiliation":[{"name":"Medical Oncology, St. Salvatore Hospital, University of L\u2019Aquila, Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1209-5735","authenticated-orcid":false,"given":"Alessio","family":"Cortellini","sequence":"additional","affiliation":[{"name":"Medical Oncology, St. Salvatore Hospital, University of L\u2019Aquila, Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Urbano","sequence":"additional","affiliation":[{"name":"Department of Radiology, Oncology and Pathology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Letizia","family":"Calandrella","sequence":"additional","affiliation":[{"name":"Department of Radiology, Oncology and Pathology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Dell\u2019Aquila","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Campus Bio-Medico University of Rome, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Minelli","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Campus Bio-Medico University of Rome, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5654-9225","authenticated-orcid":false,"given":"Claudia Angela Maria","family":"Fulgenzi","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Campus Bio-Medico University of Rome, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica","family":"Gariazzo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Oncology Unit, Sant\u2019 Andrea Hospital, Sapienza University of Rome, 00187 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1013-8460","authenticated-orcid":false,"given":"Andrea","family":"Montori","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, UOC Anatomia Patologica, Sant\u2019 Andrea Hospital, Sapienza University of Rome, 00187 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Pilozzi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, UOC Anatomia Patologica, Sant\u2019 Andrea Hospital, Sapienza University of Rome, 00187 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Di Girolamo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sant\u2019Andrea University Hospital, 00187 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Marchetti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Oncology Unit, Sant\u2019 Andrea Hospital, Sapienza University of Rome, 00187 Rome, Italy"},{"name":"Department of Radiology, Oncology and Pathology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Mazzuca","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Oncology Unit, Sant\u2019 Andrea Hospital, Sapienza University of Rome, 00187 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.14740\/gr1062w","article-title":"Difference Between Left-Sided and Right-Sided Colorectal Cancer: A 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