{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:48:33Z","timestamp":1791485313196,"version":"4.3.4"},"reference-count":55,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T00:00:00Z","timestamp":1599436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: The aim of this study was to analyze patients diagnosed, staged and treated for orbital and eyelid B-cell lymphoma (OEL). Methods: One hundred and forty-one cases of OEL were included in this study. Primary endpoints were to analyze the histopathologic findings, the main risk factors and the type of treatment and to correlate them with recurrence of OEL. The secondary endpoint was to determine the progression-free survival (PFS) time. Results: Extranodal marginal zone B-cell lymphoma was the most frequent subtype (66%), followed by small lymphocytic lymphoma (12.7%), diffuse large B-cell lymphoma (DLBCL) (9.2%), follicular lymphoma (6.6%), mantle cell lymphoma (4.3%) and Burkitt lymphoma (1.2%). The probability of relapse was influenced by the histopathologic subtype DLBCL (OR = 7.7, 95% CI 1.8\u201332.3) and treatment with chemotherapy (OR = 14.9, 95% CI 2.6\u201383.7). Multivariate analysis showed that the histopathologic subtype DLBCL and chemotherapy treatment retained statistical significance for a poorer PFS, with hazard ratios of 8.581 (p = 0.0112) and 9.239 (p = 0.0094), respectively. Conclusions: Five lymphoma subtypes were found in patients with OEL. The histopathologic subtype and the type of treatment were found to be the main factors influencing treatment outcome.<\/jats:p>","DOI":"10.3390\/cancers12092538","type":"journal-article","created":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T09:18:16Z","timestamp":1599470296000},"page":"2538","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Orbital and Eyelid B-Cell Lymphoma: A Multicenter Retrospective Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Gustavo","family":"Savino","sequence":"first","affiliation":[{"name":"UOC Oncologia Oculare, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy"},{"name":"Istituto di Oftalmologia, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Midena","sequence":"additional","affiliation":[{"name":"UOC Oncologia Oculare, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy"},{"name":"Istituto di Oftalmologia, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6812-1210","authenticated-orcid":false,"given":"Maria Antonietta","family":"Blasi","sequence":"additional","affiliation":[{"name":"UOC Oncologia Oculare, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy"},{"name":"Istituto di Oftalmologia, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remo","family":"Battendieri","sequence":"additional","affiliation":[{"name":"UOC Oncologia Oculare, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Grimaldi","sequence":"additional","affiliation":[{"name":"Moorfields Eye Hospital NHS Foundation Trust, London EC1V 2PD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3754-7486","authenticated-orcid":false,"given":"Martina","family":"Maceroni","sequence":"additional","affiliation":[{"name":"UOC Oncologia Oculare, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, Italy"},{"name":"Istituto di Oftalmologia, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto","family":"Tranfa","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienza, della Riproduzione e di Odontostomatologia, Centro di Patologia Orbitaria. Universit\u00e0 \u201cFederico II\u201d di Napoli, 80138 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6044-7486","authenticated-orcid":false,"given":"Pasquale","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienza, della Riproduzione e di Odontostomatologia, Centro di Patologia Orbitaria. Universit\u00e0 \u201cFederico II\u201d di Napoli, 80138 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3231-1930","authenticated-orcid":false,"given":"Vittoria","family":"Lanni","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienza, della Riproduzione e di Odontostomatologia, Centro di Patologia Orbitaria. Universit\u00e0 \u201cFederico II\u201d di Napoli, 80138 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Iuliano","sequence":"additional","affiliation":[{"name":"Dipartimento di Neuroscienza, della Riproduzione e di Odontostomatologia, Centro di Patologia Orbitaria. 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