{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:09:06Z","timestamp":1783105746333,"version":"3.54.6"},"reference-count":55,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Region Zealand Health Scientific Research Foundation;","award":["."],"award-info":[{"award-number":["."]}]},{"DOI":"10.13039\/501100006442","name":"Faculty of Health and Medical Sciences, University of Copenhagen","doi-asserted-by":"publisher","award":[","],"award-info":[{"award-number":[","]}],"id":[{"id":"10.13039\/501100006442","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Trigon Foundation","award":[","],"award-info":[{"award-number":[","]}]},{"name":"the Andersen-Isted Foundation","award":["."],"award-info":[{"award-number":["."]}]},{"name":"the Fabrikant Einar Willumsens Mindelegat","award":["."],"award-info":[{"award-number":["."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>An association between hematological cancers and inflammatory bowel disease (IBD) has previously been suggested, but the risk of IBD in patients with myeloproliferative neoplasms (MPNs) is unknown. We conducted a nationwide population-based cohort study using Danish registries, to estimate the risk of IBD in individuals diagnosed with essential thrombocythemia, polycythemia vera, myelofibrosis or unclassifiable MPN during 1994\u20132013. MPN patients were matched 1:10 with sex- and age-matched comparisons. Everyone was followed until a diagnosis of IBD, death\/emigration, or 31 December 2013. The risk of IBD overall and according to MPN subtype was calculated using Cox regression and presented as hazard ratios (HRs) with 95% confidence intervals (CI). Of 8207 MPN patients followed for 45,232 person-years, 80 were diagnosed with IBD (61 ulcerative colitis, 19 Crohn\u2019s disease). The rate of IBD per 1000 person-years was 1.8 (95% CI:1.4\u20132.2) in patients vs. 0.8 (95% CI:0.7\u20130.8) in comparisons, and the absolute 10-year risk of IBD was 0.8% (95% CI:0.6\u20131.0) in patients vs. 0.4% (95% CI:0.4\u20130.5) in comparisons. The HR of IBD was 2.4 (95% CI:2.1\u20132.9) with similar HRs for ulcerative colitis and Crohn\u2019s disease. MPN subtype risks varied from 2.1 (95% CI:1.6\u20132.7) to 2.8 (95% CI:2.1\u20133.7). Our unselected cohort study showed a more than 2-fold increased risk of IBD in MPN patients.<\/jats:p>","DOI":"10.3390\/cancers12092700","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T08:18:01Z","timestamp":1600676281000},"page":"2700","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Risk of Inflammatory Bowel Disease in Patients with Chronic Myeloproliferative Neoplasms: A Danish Nationwide Cohort Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1511-6749","authenticated-orcid":false,"given":"Marie","family":"Bak","sequence":"first","affiliation":[{"name":"Department of Haematology, Zealand University Hospital, University of Copenhagen, 4000 Roskilde, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tine","family":"Jess","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Research, Statens Serum Institut, 2300 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esben Meulengracht","family":"Flachs","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Bispebjerg Hospital, University of Copenhagen, 2400 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Dorthe","family":"Zwisler","sequence":"additional","affiliation":[{"name":"Danish Knowledge Centre for Rehabilitation and Palliative Care, University of Southern Denmark and Odense University Hospital, 5800 Nyborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4134-1173","authenticated-orcid":false,"given":"Knud","family":"Juel","sequence":"additional","affiliation":[{"name":"National Institute of Public Health, University of Southern Denmark, 1455 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Frederiksen","sequence":"additional","affiliation":[{"name":"Department of Haematology, Odense University Hospital, 5000 Odense, Denmark"},{"name":"Department of Clinical Epidemiology, Aarhus University Hospital, 8200 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nri3661","article-title":"Cytokines in inflammatory bowel disease","volume":"14","author":"Neurath","year":"2014","journal-title":"Nat. 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