{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:40:47Z","timestamp":1790534447608,"version":"4.1.0"},"reference-count":61,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007391","name":"Association pour la Recherche sur le Cancer","doi-asserted-by":"publisher","award":["PGA1 RF20170205386"],"award-info":[{"award-number":["PGA1 RF20170205386"]}],"id":[{"id":"10.13039\/100007391","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Infrastructure Program eCellFrance","award":["ANR-11-INSB-005"],"award-info":[{"award-number":["ANR-11-INSB-005"]}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["PLBIO-18-060"],"award-info":[{"award-number":["PLBIO-18-060"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Follicular lymphoma (FL), the most frequent indolent non-Hodgkin\u2019s B cell lymphoma, is considered as a prototypical centrocyte-derived lymphoma, dependent on a specific microenvironment mimicking the normal germinal center (GC). In agreement, several FL genetic alterations affect the crosstalk between malignant B cells and surrounding cells, including stromal cells and follicular helper T cells (Tfh). In our study, we sought to deconvolute this complex FL supportive synapse by comparing the transcriptomic profiles of GC B cells, Tfh, and stromal cells, isolated from normal versus FL tissues, in order to identify tumor-specific pathways. In particular, we highlighted a high expression of IL-6 and IL-7 in FL B cells that could favor the activation of FL Tfh overexpressing IFNG, able in turn to stimulate FL B cells without triggering MHC (major histocompatibility) class II expression. Moreover, the glycoprotein clusterin was found up-regulated in FL stromal cells and could promote FL B cell adhesion. Finally, besides its expression on Tfh, CD200 was found overexpressed on tumor B cells and could contribute to the induction of the immunosuppressive enzyme indoleamine-2,3 dioxygenase by CD200R-expressing dendritic cells. Altogether our findings led us to outline the contribution of major signals provided by the FL microenvironment and their interactions with malignant FL B cells.<\/jats:p>","DOI":"10.3390\/cancers12102865","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T10:43:48Z","timestamp":1601894628000},"page":"2865","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Integrative Analysis of Cell Crosstalk within Follicular Lymphoma Cell Niche: Towards a Definition of the FL Supportive Synapse"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3978-2209","authenticated-orcid":false,"given":"C\u00e9line","family":"Pangault","sequence":"first","affiliation":[{"name":"UMR_S 1236, Univ Rennes, INSERM, \u00c9tablissement Fran\u00e7ais du Sang (EFS) Bretagne, LabEx IGO, F-35000 Rennes, France"},{"name":"Laboratoire H\u00e9matologie, Centre Hospitalier 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Launay","sequence":"additional","affiliation":[{"name":"Service H\u00e9matologie Clinique, Centre Hospitalier Yves Le Fol, F-22000 Saint Brieuc, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Lamy","sequence":"additional","affiliation":[{"name":"UMR_S 1236, Univ Rennes, INSERM, \u00c9tablissement Fran\u00e7ais du Sang (EFS) Bretagne, LabEx IGO, F-35000 Rennes, France"},{"name":"Service H\u00e9matologie Clinique, Centre Hospitalier Universitaire de Rennes, F-35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Fest","sequence":"additional","affiliation":[{"name":"UMR_S 1236, Univ Rennes, INSERM, \u00c9tablissement Fran\u00e7ais du Sang (EFS) Bretagne, LabEx IGO, F-35000 Rennes, France"},{"name":"Laboratoire H\u00e9matologie, Centre Hospitalier Universitaire de Rennes, F-35000 Rennes, 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