{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:24:31Z","timestamp":1760239471860,"version":"build-2065373602"},"reference-count":48,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T00:00:00Z","timestamp":1605916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Malignant pleural mesothelioma (MPM) is an aggressive tumor with median survival of 12 months and limited effective treatments. The scope of this study was to study the relationship between blood DNA methylation (DNAm) and overall survival (OS) aiming at a noninvasive prognostic test. We investigated a cohort of 159 incident asbestos exposed MPM cases enrolled in an Italian area with high incidence of mesothelioma. Considering 12 months as a cut-off for OS, epigenome-wide association study (EWAS) revealed statistically significant (p value = 7.7 \u00d7 10\u22129) OS-related differential methylation of a single-CpG (cg03546163), located in the 5\u2032UTR region of the FKBP5 gene. This is an independent marker of prognosis in MPM patients with a better performance than traditional inflammation-based scores such as lymphocyte-to-monocyte ratio (LMR). Cases with DNAm &lt; 0.45 at the cg03546163 had significantly poor survival compared with those showing DNAm \u2265 0.45 (mean: 243 versus 534 days; p value&lt; 0.001). Epigenetic changes at the FKBP5 gene were robustly associated with OS in MPM cases. Our results showed that blood DNA methylation levels could be promising and dynamic prognostic biomarkers in MPM.<\/jats:p>","DOI":"10.3390\/cancers12113470","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T08:18:23Z","timestamp":1606119503000},"page":"3470","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["DNA Methylation of FKBP5 as Predictor of Overall Survival in Malignant Pleural Mesothelioma"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6080-0718","authenticated-orcid":false,"given":"Giovanni","family":"Cugliari","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Catalano","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4400-1817","authenticated-orcid":false,"given":"Simonetta","family":"Guarrera","sequence":"additional","affiliation":[{"name":"Italian Institute for Genomic Medicine, IIGM, 10060 Candiolo, Italy"},{"name":"Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Allione","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Casalone","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5494-2218","authenticated-orcid":false,"given":"Alessia","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Grosso","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, SS. 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Antonio e Biagio General Hospital, 15122 Alessandria, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2312-1342","authenticated-orcid":false,"given":"Dario","family":"Mirabelli","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, Italy"},{"name":"Interdepartmental Center for Studies on Asbestos and Other Toxic Particulates \u201cG. Scansetti\u201d, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6413-5471","authenticated-orcid":false,"given":"Corrado","family":"Magnani","sequence":"additional","affiliation":[{"name":"Unit of Medical Statistics, Department of Translational Medicine, University of Piemonte Orientale, 28100 Novara, Italy"},{"name":"Cancer Epidemiology Unit, CPO-Piemonte, 28100 Novara, Italy"},{"name":"Interdepartmental Center for Studies on Asbestos and Other Toxic Particulates \u201cG. Scansetti\u201d, University of Turin, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irma","family":"Dianzani","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy"},{"name":"Interdepartmental Center for Studies on Asbestos and Other Toxic Particulates \u201cG. 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Scansetti\u201d, University of Turin, 10126 Turin, Italy"},{"name":"Medical Genetics Unit, AOU Citt\u00e0 della Salute e della Scienza, 10126 Turin, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1093\/carcin\/bgt166","article-title":"Molecular pathogenesis of malignant mesothelioma","volume":"34","author":"Sekido","year":"2013","journal-title":"Carcinogenesis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fonc.2018.00091","article-title":"New Perspectives on Diagnosis and Therapy of Malignant Pleural Mesothelioma","volume":"8","author":"Rossini","year":"2018","journal-title":"Front. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Furuya, S., Chimed-Ochir, O., Takahashi, K., David, A., and Takala, J. (2018). Global Asbestos Disaster. Int. J. Environ. Res. 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