{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T01:51:26Z","timestamp":1771379486283,"version":"3.50.1"},"reference-count":126,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Health, Czech Republic","award":["MMCI 00209805"],"award-info":[{"award-number":["MMCI 00209805"]}]},{"name":"National Oncology Institute, Bratislava, Slovakia","award":["20191111\/SVKNOI\/3"],"award-info":[{"award-number":["20191111\/SVKNOI\/3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Recurrent nasopharyngeal carcinoma represents an extremely challenging therapeutic situation. Given the vulnerability of the already pretreated neurological structures surrounding the nasopharynx, any potential salvage retreatment option bears a significant risk of severe complications that result in high treatment-related morbidity, quality of life deterioration, and even mortality. Yet, with careful patient selection, long-term survival may be achieved after local retreatment in a subgroup of patients with local or regional relapse of nasopharyngeal cancer. Early detection of the recurrence represents the key to therapeutic success, and in the case of early stage disease, several curative treatment options can be offered to the patient, albeit with minimal support in prospective clinical data. In this article, an up-to-date review of published evidence on modern surgical and radiation therapy treatment options is summarized, including currently recommended treatment modifications of both therapeutic approaches during the coronavirus disease 2019 pandemic.<\/jats:p>","DOI":"10.3390\/cancers12123510","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T08:59:15Z","timestamp":1606294755000},"page":"3510","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Recurrent Nasopharyngeal Cancer: Critical Review of Local Treatment Options Including Recommendations during the COVID-19 Pandemic"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6372-3295","authenticated-orcid":false,"given":"Michaela","family":"Svajdova","sequence":"first","affiliation":[{"name":"Department of Radiation and Clinical Oncology, Central Military Hospital\u2014Teaching Hospital Ruzomberok, 034 01 Ruzomberok, Slovakia"},{"name":"Department of Radiation Oncology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian","family":"Sicak","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology and Head and Neck Surgery, Central Military Hospital\u2014Teaching Hospital, 034 01 Ruzomberok, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavol","family":"Dubinsky","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, East Slovakia Oncology Institute, 041 91 Kosice, Slovakia"},{"name":"Faculty of Health, Catholic University Ruzomberok, 034 01 Ruzomberok, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8591-5941","authenticated-orcid":false,"given":"Marek","family":"Slavik","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic"},{"name":"Department of Radiation Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Slampa","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7288-8975","authenticated-orcid":false,"given":"Tomas","family":"Kazda","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Masaryk Memorial Cancer Institute, 656 53 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. 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