{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:36:55Z","timestamp":1778740615019,"version":"3.51.4"},"reference-count":46,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T00:00:00Z","timestamp":1610236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health &quot;5x1000&quot; + European Institute of Oncology Foundation","award":["no number"],"award-info":[{"award-number":["no number"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: the aim of this paper is to quantify multidisciplinary team meeting (MDT) impact on the decisional clinical pathway of thoracic cancer patients, assessing the modification rate of the initial out-patient evaluation. Methods: the impact of MDT was classified as follows: confirmation: same conclusions as out-patient hypothesis; modification: change of out-patient hypothesis; implementation: definition of a clear clinical track\/conclusion for patients that did not receive any clinical hypothesis; further exams required: the findings that emerged in the MDT meeting require further exams. Results: one thousand consecutive patients evaluated at MDT meetings were enrolled. Clinical settings of patients were: early stage lung cancer (17.4%); locally advanced lung cancer (27.4%); stage IV lung cancer (9.8%); mesothelioma (1%); metastases to the lung from other primary tumors (4%); histologically proven or suspected recurrence from previous lung cancer (15%); solitary pulmonary nodule (19.2%); mediastinal tumors (3.4%); other settings (2.8%). Conclusions: MDT meetings impact patient management in oncologic thoracic surgery by modifying the out-patient clinical hypothesis in 10.6% of cases; the clinical settings with the highest decisional modification rates are \u201csolitary pulmonary nodule\u201d and \u201cproven or suspected recurrence\u201d with modification rates of 14.6% and 13.3%, respectively.<\/jats:p>","DOI":"10.3390\/cancers13020228","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T19:55:56Z","timestamp":1610308556000},"page":"228","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Impact of Multidisciplinary Team Meetings on Patient Management in Oncologic Thoracic Surgery: A Single-Center Experience"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5945-1576","authenticated-orcid":false,"given":"Francesco","family":"Petrella","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, IRCCS European Institute of Oncology, 20141 Milan, Italy"},{"name":"Department of Oncology and Hemato-Oncology, Universit\u00e0 degli Studi di Milano, 20141 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Radice","sequence":"additional","affiliation":[{"name":"Department of Biostatistcs, IRCCS European Institute of Oncology, 20141 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Guarize","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, IRCCS European Institute of Oncology, 20141 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaia","family":"Piperno","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, IRCCS European Institute of Oncology, 20141 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiano","family":"Rampinelli","sequence":"additional","affiliation":[{"name":"Department of Radiology, IRCCS European Institute of Oncology, 20141 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"de Marinis","sequence":"additional","affiliation":[{"name":"Department of Thoracic Oncology, IRCCS European Institute of Oncology, 20141 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Spaggiari","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, IRCCS European Institute of Oncology, 20141 Milan, Italy"},{"name":"Department of Oncology and Hemato-Oncology, Universit\u00e0 degli Studi di Milano, 20141 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Specchia, M.L., Frisicale, E.M., and Carini, E. (2020). The impact of tumor board on cancer care: Evidence from an umbrella review. BMC Health Serv. Res., 20.","DOI":"10.1186\/s12913-020-4930-3"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Lesslie, M., and Parikh, J.R. (2017). Implementing a Multidisciplinary Tumor Board in the Community Practice Setting. Diagnostic, 7.","DOI":"10.3390\/diagnostics7040055"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.lungcan.2018.07.032","article-title":"Does presentation at multidisciplinary team meetings improve lung cancer survival? Findings from a consecutive cohort study","volume":"124","author":"Stone","year":"2018","journal-title":"Lung Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.cllc.2018.01.006","article-title":"Survival outcomes among lung cancer patients treated using a multidisciplinary team approach","volume":"19","author":"Bilfinger","year":"2018","journal-title":"Clin. Lung Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5112","DOI":"10.1002\/cncr.26149","article-title":"Do multidisciplinary team meetings make a difference in the management of lung cancer?","volume":"117","author":"Boxer","year":"2011","journal-title":"Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ctrv.2015.11.007","article-title":"The impact of multidisciplinary team meetings on patient assessment, management and outcomes in oncology settings: A systematic review of the literature","volume":"42","author":"Pillay","year":"2016","journal-title":"Cancer Treat. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e298","DOI":"10.1111\/ajco.12192","article-title":"Impact of the lung oncology multidisciplinary team meetings on the management of patients with cancer","volume":"12","author":"Ung","year":"2016","journal-title":"Asia Pac. J. Clin. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1445-5994.2006.01237.x","article-title":"Analysis of multidisciplinary lung cancer practice","volume":"37","author":"Conron","year":"2007","journal-title":"Intern. Med. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"88","DOI":"10.21037\/tlcr.2018.01.02","article-title":"Pragmatic trial of a multidisciplinary lung cancer care model in a community healthcare setting: Study design, implementation evaluation, and baseline clinical results","volume":"7","author":"Smeltzer","year":"2018","journal-title":"Transl. Lung Cancer Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/ajco.13166","article-title":"The challenge of putting principles into practice: Resource tensions and real-world constraints in multidisciplinary oncology team meetings","volume":"15","author":"Lamprell","year":"2019","journal-title":"Asia Pac. J. Clin. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/resp.12459","article-title":"Multidisciplinary lung cancer meetings: Improving the practice of radiation oncology and facing future challenges","volume":"20","author":"Campbell","year":"2015","journal-title":"Respirology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/resp.13307","article-title":"Consensus minimum data set for lung cancer multidisciplinary teams: Results of a Delphi process","volume":"23","author":"Stone","year":"2018","journal-title":"Respirology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/jncimonographs\/lgq010","article-title":"The Organization of Multidisciplinary Care Teams: Modeling internal and external influences on Cancer care quality","volume":"40","author":"Fennell","year":"2010","journal-title":"J. Natl. Cancer Inst. Monogr."},{"key":"ref_14","first-page":"378","article-title":"A multidisciplinary approach to the management of urologic malignancies: Does it influence diagnostic and treatment decisions?","volume":"29","author":"Kurpad","year":"2011","journal-title":"Urol. Oncol. Semin. Orig. Investig."},{"key":"ref_15","unstructured":"American College of Chest Physicians, and Health and Science Policy Committee (2003). Diagnosis and management of lung cancer: ACCP evidence-based guidelines. Chest, 123, 1S\u201319S."},{"key":"ref_16","unstructured":"Cancer Council Australia (2020, October 08). Clinical Practice Guidelines for the Prevention, Diagnosis and Management of Lung Cancer. Cancer Council Australia, Available online: http:\/\/www.nhmrc.gov.au\/publications\/subjects\/cancer.htm."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"The Lung Cancer Working Party of the British Thoracic Society Standards of Care Committee (1998). BTS recommendations to respiratory physicians for organising the care of patients with lung cancer. The Lung Cancer Working Party of the British Thoracic Society Standards of Care Committee. Thorax, 53, S1\u2013S8.","DOI":"10.1136\/thx.53.suppl_1.S1"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.lungcan.2008.01.008","article-title":"Systematic review of multidisciplinary teams in the management of lung cancer","volume":"60","author":"Coory","year":"2008","journal-title":"Lung Cancer"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/sj.bjc.6602825","article-title":"An evaluation of the impact of a multidisciplinary team, in a single centre, on treatment and survival in patients with inoperable non-smallcell lung cancer","volume":"93","author":"Forrest","year":"2005","journal-title":"Br. J. Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Price, A., Kerr, G., Gregor, A., Ironside, J., and Little, F. (2002). The impact of multidisciplinary teams and site specialisation on the use of radiotherapy in elderly people with non-small cell lung cancer (NSCLC). Radiother. Oncol., 64.","DOI":"10.1016\/S0167-8140(02)82554-3"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0169-5002(03)00358-1","article-title":"The pathway study: Results of a pilot feasibility study in patients suspected of having lung carcinoma investigated in a conventional chest clinic setting compared to a centralised two-stop pathway","volume":"42","author":"Murray","year":"2003","journal-title":"Lung Cancer"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.lungcan.2004.03.010","article-title":"The beneficial effects of specialist thoracic surgery on the resection rate for non-small-cell lung cancer","volume":"46","author":"Waller","year":"2004","journal-title":"Lung Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1200\/jop.2005.1.3.84","article-title":"Cancer patient survival improvement is correlated with the opening of a community cancer centre: Comparisons with intramural and extramural benchmarks","volume":"1","author":"Dillman","year":"2005","journal-title":"J. Oncol. Pract."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.otohns.2010.07.020","article-title":"A prospective study of the clinical impact of a multidisciplinary head and neck tumor board","volume":"143","author":"Wheless","year":"2010","journal-title":"Otolaryngol. Head Neck"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1080\/08858190802189014","article-title":"Tumor board: More than treatment planning: A 1-year prospective survey","volume":"23","author":"Gatcliffe","year":"2008","journal-title":"J. Cancer Educ."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ijsu.2005.06.006","article-title":"Improving outcomes in urological cancers: The impact of \u201cmultidisciplinary team meetings\u201d","volume":"3","author":"Acher","year":"2005","journal-title":"Int. J. Surg."},{"key":"ref_27","first-page":"1321","article-title":"Impact of a weekly multidisciplinary tumor board conference on the management of women with gynecologic malignancies","volume":"20","author":"Greer","year":"2010","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1002\/cncr.22266","article-title":"Changes in surgical management resulting from case review at a breast cancer multidisciplinary tumor board","volume":"107","author":"Newman","year":"2006","journal-title":"Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1093\/ejcts\/ezaa005","article-title":"Lung cancer surgery in oligometastatic patients: Outcome and survival","volume":"57","author":"Casiraghi","year":"2020","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S1569-9293(02)00058-0","article-title":"Multiple chondromatous hamartomas of the lung","volume":"1","author":"Bini","year":"2002","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.surge.2010.07.010","article-title":"Predicting prolonged air leak after standard pulmonary lobectomy: Computed tomography assessment and risk factors stratification","volume":"9","author":"Petrella","year":"2011","journal-title":"Surgeon"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.ejcts.2009.01.011","article-title":"Which factors affect pulmonary function after lung metastasectomy?","volume":"35","author":"Petrella","year":"2009","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1053\/j.semtcvs.2017.02.001","article-title":"Salvage Surgery after Definitive Chemoradiotherapy for Non\u2013small Cell Lung Cancer","volume":"29","author":"Casiraghi","year":"2017","journal-title":"Semin. Thorac. Cardiovasc. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/00003072-200307000-00003","article-title":"Somatostatin Receptor Scintigraphy for Bronchial Carcinoid Follow-Up","volume":"28","author":"Fanti","year":"2003","journal-title":"Clin. Nucl. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1177\/1066896906290657","article-title":"A primary pure yolk sac tumor of the lung exhibiting CDX-2 immunoreactivity and increased serum levels of alkaline phosphatase intestinal isoenzyme","volume":"14","author":"Pelosi","year":"2006","journal-title":"Int. J. Surg. Pathol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Klarenbeek, S.E., Schuurbiers-Siebers, O.C.J., van den Heuvel, M.M., Prokop, M., and Tummers, M. (2020). Barriers and Facilitators for Implementation of a Computerized Clinical Decision Support System in Lung Cancer Multidisciplinary Team Meetings\u2014A Qualitative Assessment. Biology, 10.","DOI":"10.3390\/biology10010009"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"100291","DOI":"10.1016\/j.ejro.2020.100291","article-title":"Contribution of FDG-PET\/CT to the management of esophageal cancer patients at multidisciplinary tumor board conferences","volume":"7","author":"Shashi","year":"2020","journal-title":"Eur. J. Radiol. Open"},{"key":"ref_38","first-page":"S24","article-title":"How to treat venous thromboembolism (TVE) in cancer patients: Ten years of multidisciplinary team meetings (MDTM) at Saint-Louis Hospital","volume":"45","author":"Crichi","year":"2020","journal-title":"J. Med. Vasc."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Graetz, D.E., Chen, Y., Devidas, M., Antillon-Klussmann, F., Fu, L., Quintero, K., Fuentes-Alabi, S.L., Gassant, P.Y., Kaye, E.C., and Baker, J.N. (2020). Interdisciplinary care of pediatric oncology patients in Central America and the Caribbean. Cancer.","DOI":"10.1002\/cncr.33339"},{"key":"ref_40","first-page":"100073","article-title":"Medicolegal Considerations in Multidisciplinary Cancer Care","volume":"1","author":"Karas","year":"2020","journal-title":"JTO Clin. Res. Rep."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Zhao, S., Qi, W., and Chen, J. (2020). Role of a multidisciplinary team in administering radiotherapy for esophageal cancer. BMC Cancer, 20.","DOI":"10.1186\/s12885-020-07467-z"},{"key":"ref_42","first-page":"125","article-title":"Examining the Potential Relationship between Multidisciplinary Team Meetings and Patient Survival in Pediatric Oncology Settings: A Systematic Review","volume":"102","author":"Dijkstra","year":"2020","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1308\/rcsann.2020.0212","article-title":"Refocusing cancer multidisciplinary team meetings in the United Kingdom: Comparing urology with other specialties","volume":"103","author":"Warner","year":"2021","journal-title":"Ann. R. Coll. Surg. Engl."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.21037\/tlcr.2019.11.28","article-title":"Accuracy of lung cancer staging in the multidisciplinary team setting","volume":"9","author":"Liam","year":"2020","journal-title":"Transl. Lung Cancer Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.21037\/tlcr-19-441","article-title":"Looking through the eyes of the multidisciplinary team: The design and clinical evaluation of a decision support system for lung cancer care","volume":"9","author":"Pluyter","year":"2020","journal-title":"Transl. Lung Cancer Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.athoracsur.2013.10.032","article-title":"Stem cell transplantation effectively occludes bronchopleural fistula in an animal model","volume":"97","author":"Petrella","year":"2014","journal-title":"Ann. Thorac. Surg."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/13\/2\/228\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:09:22Z","timestamp":1760159362000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/13\/2\/228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,10]]},"references-count":46,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,1]]}},"alternative-id":["cancers13020228"],"URL":"https:\/\/doi.org\/10.3390\/cancers13020228","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,10]]}}}