{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:59:39Z","timestamp":1790690379845,"version":"4.1.0"},"reference-count":80,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:00:00Z","timestamp":1612396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","award":["No number"],"award-info":[{"award-number":["No number"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The Epstein\u2013Barr virus (EBV) is associated with angioimmunoblastic T cell lymphoma (AITL) in more than 80% of cases. Few studies have focused on this association and it is not clear now what role the virus plays in this pathology. We used next-generation sequencing (NGS) to study EBV transcriptome in 14 AITLs compared to 21 other lymphoma samples and 11 cell lines including 4 lymphoblastoid cell lines (LCLs). Viral transcripts were recovered using capture probes and sequencing was performed on Illumina. Bam-HI A rightward transcripts (BARTs) were the most latency transcripts expressed in AITLs, suggesting they may play a role in this pathology. Thus, BARTs, already described as highly expressed in carcinoma cells, are also very present in AITLs and other lymphomas. They were poorly expressed in cell lines other than LCLs. AITLs showed a latency IIc, with BNLF2a gene expression. For most AITLs, BCRF1, which encodes a homologous protein of human interleukin 10, vIL-10, was in addition expressed. This co-expression can contribute to immune escape and survival of infected cells. Considering these results, it can be assumed that EBV plays a pathogenic role in AITLs.<\/jats:p>","DOI":"10.3390\/cancers13040610","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T12:02:10Z","timestamp":1612440130000},"page":"610","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Comprehensive Epstein-Barr Virus Transcriptome by RNA-Sequencing in Angioimmunoblastic T Cell Lymphoma (AITL) and Other Lymphomas"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6658-4342","authenticated-orcid":false,"given":"Nader","family":"Bayda","sequence":"first","affiliation":[{"name":"Microbiology Department, UMR CNRS 7276, INSERM U1262, Faculty of Pharmacy, 87025 Limoges, France"},{"name":"Department of Infectious Disease Control, Faculty of Public Health, Jinan University, Tripoli 1300, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2967-8670","authenticated-orcid":false,"given":"Valentin","family":"Tilloy","sequence":"additional","affiliation":[{"name":"National Reference Center for Herpesviruses, Bioinformatics, Centre de Biologie Recherche et Sant\u00e9, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2419-8974","authenticated-orcid":false,"given":"Alain","family":"Chaunavel","sequence":"additional","affiliation":[{"name":"Pathology Department, Centre de Biologie Recherche et Sant\u00e9, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Racha","family":"Bahri","sequence":"additional","affiliation":[{"name":"Microbiology Department, UMR CNRS 7276, INSERM U1262, Faculty of Pharmacy, 87025 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad Adnan","family":"Halabi","sequence":"additional","affiliation":[{"name":"Microbiology Department, UMR CNRS 7276, INSERM U1262, Faculty of Pharmacy, 87025 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6223-2454","authenticated-orcid":false,"given":"Jean","family":"Feuillard","sequence":"additional","affiliation":[{"name":"Biological Hematology Department, UMR CNRS 7276, INSERM U1262, Centre de Biologie Recherche et Sant\u00e9, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Jaccard","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department, UMR CNRS 7276, INSERM U1262, University Hospital Dupuytren, 87042 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4092-7164","authenticated-orcid":false,"given":"Sylvie","family":"Ranger-Rogez","sequence":"additional","affiliation":[{"name":"Microbiology Department, UMR CNRS 7276, INSERM U1262, Faculty of Pharmacy, 87025 Limoges, France"},{"name":"Virology Department, UMR CNRS 7276, INSERM U1262, Centre de Biologie Recherche et Sant\u00e9, 87000 Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virol.2006.10.009","article-title":"Lineage Structures in the Genome Sequences of Three Epstein-Barr Virus Strains","volume":"359","author":"McGeoch","year":"2007","journal-title":"Virology"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Smatti, M.K., Al-Sadeq, D.W., Ali, N.H., Pintus, G., Abou-Saleh, H., and Nasrallah, G.K. (2018). Epstein\u2013Barr Virus Epidemiology, Serology, and Genetic Variability of LMP-1 Oncogene Among Healthy Population: An Update. Front. Oncol., 8.","DOI":"10.3389\/fonc.2018.00211"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Arvin, A., Campadelli-Fiume, G., Mocarski, E., Moore, P.S., Roizman, B., Whitley, R., and Yamanishi, K. (2007). Introduction to the human \u03b3-herpesviruses. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis, Cambridge University Press.","DOI":"10.1017\/CBO9780511545313"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Wang, C., Li, D., Zhang, L., Jiang, S., Liang, J., Narita, Y., Hou, I., Zhong, Q., Zheng, Z., and Xiao, H. (2019). RNA Sequencing Analyses of Gene Expression during Epstein-Barr Virus Infection of Primary B Lymphocytes. J. Virol., 93.","DOI":"10.1128\/JVI.00226-19"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"10700","DOI":"10.1128\/JVI.01204-06","article-title":"Methylation Status of the Epstein-Barr Virus (EBV) BamHI W Latent Cycle Promoter and Promoter Activity: Analysis with Novel EBV-Positive Burkitt and Lymphoblastoid Cell Lines","volume":"80","author":"Hutchings","year":"2006","journal-title":"J. Virol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1038\/emm.2014.84","article-title":"Epstein-Barr Virus Latent Genes","volume":"47","author":"Kang","year":"2015","journal-title":"Exp. Mol. Med."},{"key":"ref_7","first-page":"40","article-title":"Epstein\u2013Barr Virus-Associated B-Cell Lymphoproliferative Disorders and Lymphomas: A Review","volume":"52","author":"Salas","year":"2020","journal-title":"Pathology"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Arvin, A., Campadelli-Fiume, G., Mocarski, E., Moore, P.S., Roizman, B., Whitley, R., and Yamanishi, K. (2007). EBV gene expression and regulation. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis, Cambridge University Press.","DOI":"10.1017\/CBO9780511545313"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1053\/j.seminoncol.2014.12.030","article-title":"Epstein-Barr Virus-Associated Lymphomas","volume":"42","author":"Grywalska","year":"2015","journal-title":"Semin. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jim.2012.08.008","article-title":"Simultaneous Detection of the Two Main Proliferation Driving EBV Encoded Proteins, EBNA-2 and LMP-1 in Single B Cells","volume":"385","author":"Rasul","year":"2012","journal-title":"J. Immunol. Methods"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e23035","DOI":"10.4161\/onci.23035","article-title":"EBV Genome Carrying B Lymphocytes That Express the Nuclear Protein EBNA-2 but Not LMP-1: Type IIb Latency","volume":"2","author":"Klein","year":"2013","journal-title":"Oncoimmunology"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Price, A.M., and Luftig, M.A. (2015). To Be or Not IIb: A Multi-Step Process for Epstein-Barr Virus Latency Establishment and Consequences for B Cell Tumorigenesis. PLoS Pathog., 11.","DOI":"10.1371\/journal.ppat.1004656"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Messinger, J.E., Dai, J., Stanland, L.J., Price, A.M., and Luftig, M.A. (2019). Identification of Host Biomarkers of Epstein-Barr Virus Latency IIb and Latency III. mBio, 10.","DOI":"10.1128\/mBio.01006-19"},{"key":"ref_14","first-page":"237","article-title":"Epstein-Barr Virus Lytic Cycle Reactivation","volume":"391","author":"McKenzie","year":"2015","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1128\/JVI.06537-11","article-title":"Identification of New Viral Genes and Transcript Isoforms during Epstein-Barr Virus Reactivation Using RNA-Seq","volume":"86","author":"Concha","year":"2012","journal-title":"J. Virol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"6146","DOI":"10.1128\/JVI.00013-12","article-title":"Functions of the Epstein-Barr Virus EBNA1 Protein in Viral Reactivation and Lytic Infection","volume":"86","author":"Sivachandran","year":"2012","journal-title":"J. Virol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"6010","DOI":"10.1158\/0008-5472.CAN-19-0615","article-title":"Integrated Pan-Cancer Map of EBV-Associated Neoplasms Reveals Functional Host-Virus Interactions","volume":"79","author":"Chakravorty","year":"2019","journal-title":"Cancer Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"713","DOI":"10.3389\/fonc.2019.00713","article-title":"The Global Landscape of EBV-Associated Tumors","volume":"9","author":"Rickinson","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e361","DOI":"10.3324\/haematol.2015.126300","article-title":"Angioimmunoblastic T-Cell Lymphoma Is the Most Common T-Cell Lymphoma in Two Distinct French Information Data Sets","volume":"100","author":"Parrens","year":"2015","journal-title":"Haematologica"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1038\/s41375-020-0990-y","article-title":"Advances in Understanding of Angioimmunoblastic T-Cell Lymphoma","volume":"34","author":"Chiba","year":"2020","journal-title":"Leukemia"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1200\/JCO.2008.16.4558","article-title":"International T-Cell Lymphoma Project International Peripheral T-Cell and Natural Killer\/T-Cell Lymphoma Study: Pathology Findings and Clinical Outcomes","volume":"26","author":"Vose","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1200\/JCO.2011.37.3647","article-title":"Clinicopathologic Characteristics of Angioimmunoblastic T-Cell Lymphoma: Analysis of the International Peripheral T-Cell Lymphoma Project","volume":"31","author":"Federico","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1182\/blood.V80.7.1804.1804","article-title":"Heterogeneous Epstein-Barr Virus Infection Patterns in Peripheral T-Cell Lymphoma of Angioimmunoblastic Lymphadenopathy Type","volume":"80","author":"Anagnostopoulos","year":"1992","journal-title":"Blood"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5893","DOI":"10.4081\/hr.2015.5893","article-title":"Angioimmunoblastic T-Cell Lymphoma Presenting with an Acute Serologic Epstein-Barr Virus Profile","volume":"7","author":"Beer","year":"2015","journal-title":"Hematol. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1365-2141.2007.06725.x","article-title":"Frequent Occurrence of B-Cell Lymphomas in Angioimmunoblastic T-Cell Lymphoma and Proliferation of Epstein-Barr Virus-Infected Cells in Early Cases","volume":"138","author":"Willenbrock","year":"2007","journal-title":"Br. J. Haematol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1309\/VD2D-98ME-MB3F-WH34","article-title":"Composite Angioimmunoblastic T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma: A Case Report and Review of the Literature","volume":"118","author":"Xu","year":"2002","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1309\/6UTX-GVC0-12ND-JJEU","article-title":"Epstein-Barr Virus-Associated B-Cell Lymphoproliferative Disorders in Angloimmunoblastic T-Cell Lymphoma and Peripheral T-Cell Lymphoma, Unspecified","volume":"117","author":"Zettl","year":"2002","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1080\/10428190701245138","article-title":"Angioimmunoblastic T-Cell Lymphoma: Immune Modulation as a Therapeutic Strategy","volume":"48","author":"Dunleavy","year":"2007","journal-title":"Leuk. Lymph."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Nakhoul, H., Lin, Z., Wang, X., Roberts, C., Dong, Y., and Flemington, E. (2019). High-Throughput Sequence Analysis of Peripheral T-Cell Lymphomas Indicates Subtype-Specific Viral Gene Expression Patterns and Immune Cell Microenvironments. mSphere, 4.","DOI":"10.1128\/mSphere.00248-19"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1128\/JVI.74.7.3082-3092.2000","article-title":"Structure and Coding Content of CST (BART) Family RNAs of Epstein-Barr Virus","volume":"74","author":"Smith","year":"2000","journal-title":"J. Virol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1128\/jvi.44.3.1088-1091.1982","article-title":"The B95-8 Isolate of Epstein-Barr Virus Arose from an Isolate with a Standard Genome","volume":"44","author":"Skare","year":"1982","journal-title":"J. Virol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11684-016-0436-0","article-title":"Comprehensive Profiling of EBV Gene Expression in Nasopharyngeal Carcinoma through Paired-End Transcriptome Sequencing","volume":"10","author":"Hu","year":"2016","journal-title":"Front. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"8509","DOI":"10.1128\/JVI.00315-08","article-title":"The Epstein-Barr Virus LF2 Protein Inhibits Viral Replication","volume":"82","author":"Calderwood","year":"2008","journal-title":"J. Virol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0042-6822(90)90302-8","article-title":"Sequence and Transcription of Raji Epstein-Barr Virus DNA Spanning the B95-8 Deletion Region","volume":"179","author":"Parker","year":"1990","journal-title":"Virology."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/1097-0142(196902)23:2<281::AID-CNCR2820230205>3.0.CO;2-#","article-title":"Hetero- Transplantation of Human Cell Lines from Burkitt\u2019s Tumors and Acute Leukemia into Newborn Rats","volume":"23","author":"Southam","year":"1969","journal-title":"Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jviromet.2016.12.007","article-title":"Quantitative Multi-Target RNA Profiling in Epstein-Barr Virus Infected Tumor Cells","volume":"241","author":"Greijer","year":"2017","journal-title":"J. Virol. Methods"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/ijc.2910100108","article-title":"Sensitivity of Epstein-Barr Virus (EBV) Producer and Non-Producer Human Lymphoblastoid Cell Lines to Superinfection with EB-Virus","volume":"10","author":"Klein","year":"1972","journal-title":"Int. J. Cancer."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1743-422X-3-43","article-title":"Quantitative Profiling of Housekeeping and Epstein-Barr Virus Gene Transcription in Burkitt Lymphoma Cell Lines Using an Oligonucleotide Microarray","volume":"3","author":"Bernasconi","year":"2006","journal-title":"Virol. J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1073\/pnas.80.7.1987","article-title":"Chromosome Site for Epstein-Barr Virus DNA in a Burkitt Tumor Cell Line and in Lymphocytes Growth-Transformed in Vitro","volume":"80","author":"Henderson","year":"1983","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1128\/jvi.1.5.1045-1051.1967","article-title":"Immunofluorescence and Herpes-Type Virus Particles in the P3HR-1 Burkitt Lymphoma Cell Line","volume":"1","author":"Hinuma","year":"1967","journal-title":"J. Virol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1002\/cam4.1311","article-title":"Antitumor Effects of Duvelisib on Epstein-Barr Virus-Associated Lymphoma Cells","volume":"7","author":"Kawada","year":"2018","journal-title":"Cancer Med."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Chelouah, S., Cochet, E., Couv\u00e9, S., Balkaran, S., Robert, A., May, E., Ogryzko, V., and Wiels, J. (2018). New Interactors of the Truncated EBNA-LP Protein Identified by Mass Spectrometry in P3HR1 Burkitt\u2019s Lymphoma Cells. Cancers, 10.","DOI":"10.3390\/cancers10010012"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nrc1452","article-title":"Epstein-Barr Virus: 40 Years On","volume":"4","author":"Young","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"ref_44","first-page":"547","article-title":"Morphological and Virological Investigations on Cultured Burkitt Tumor Lymphoblasts (Strain Raji)","volume":"37","author":"Epstein","year":"1966","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"7309","DOI":"10.1128\/jvi.69.11.7309-7314.1995","article-title":"The Lytic Cycle of Epstein-Barr Virus in the Nonproducer Raji Line Can Be Rescued by the Expression of a 135-Kilodalton Protein Encoded by the BALF2 Open Reading Frame","volume":"69","author":"Decaussin","year":"1995","journal-title":"J. Virol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/0042-6822(88)90546-6","article-title":"Sequence Analysis of Raji Epstein-Barr Virus DNA","volume":"164","author":"Hatfull","year":"1988","journal-title":"Virology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1038\/leu.2009.91","article-title":"STAT3 Transcription Factor Is Constitutively Activated and Is Oncogenic in Nasal-Type NK\/T-Cell Lymphoma","volume":"23","author":"Coppo","year":"2009","journal-title":"Leukemia"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1046\/j.1365-2141.2003.04359.x","article-title":"Common Cytological and Cytogenetic Features of Epstein-Barr Virus (EBV)-Positive Natural Killer (NK) Cells and Cell Lines Derived from Patients with Nasal T\/NK-Cell Lymphomas, Chronic Active EBV Infection and Hydroa Vacciniforme-like Eruptions","volume":"121","author":"Zhang","year":"2003","journal-title":"Br. J. Haematol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1002\/ijc.22139","article-title":"Concomitant Increase of LMP1 and CD25 (IL-2-Receptor Alpha) Expression Induced by IL-10 in the EBV-Positive NK Lines SNK6 and KAI3","volume":"119","author":"Takahara","year":"2006","journal-title":"Int. J. Cancer"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/ijc.25969","article-title":"Monocytes Enhance Cell Proliferation and LMP1 Expression of Nasal Natural Killer\/T-Cell Lymphoma Cells by Cell Contact-Dependent Interaction through Membrane-Bound IL-15","volume":"130","author":"Ishii","year":"2012","journal-title":"Int. J. Cancer"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1002\/j.1460-2075.1989.tb08404.x","article-title":"EBV Gene Expression in an NPC-Related Tumour","volume":"8","author":"Hitt","year":"1989","journal-title":"EMBO J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.1128\/jvi.65.11.6252-6259.1991","article-title":"Expression of the Epstein-Barr Virus BamHI a Fragment in Nasopharyngeal Carcinoma: Evidence for a Viral Protein Expressed in Vivo","volume":"65","author":"Gilligan","year":"1991","journal-title":"J. Virol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0092-8674(79)90008-4","article-title":"Epstein-Barr Virus RNA in Burkitt Tumor Tissue","volume":"16","author":"Dambaugh","year":"1979","journal-title":"Cell"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.3389\/fonc.2019.01120","article-title":"Epstein-Barr Virus BART Long Non-Coding RNAs Function as Epigenetic Modulators in Nasopharyngeal Carcinoma","volume":"9","author":"Verhoeven","year":"2019","journal-title":"Front Oncol"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Strong, M.J., Xu, G., Coco, J., Baribault, C., Vinay, D.S., Lacey, M.R., Strong, A.L., Lehman, T.A., Seddon, M.B., and Lin, Z. (2013). Differences in Gastric Carcinoma Microenvironment Stratify According to EBV Infection Intensity: Implications for Possible Immune Adjuvant Therapy. PLoS Pathog., 9.","DOI":"10.1371\/journal.ppat.1003341"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"11256","DOI":"10.1128\/JVI.01492-15","article-title":"Host Gene Expression Is Regulated by Two Types of Noncoding RNAs Transcribed from the Epstein-Barr Virus BamHI a Rightward Transcript Region","volume":"89","author":"Marquitz","year":"2015","journal-title":"J. Virol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.semcancer.2011.12.001","article-title":"The Role of MiRNAs and EBV BARTs in NPC","volume":"22","author":"Marquitz","year":"2012","journal-title":"Semin. Cancer Biol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1099\/vir.0.006551-0","article-title":"Epstein-Barr Virus BART Gene Expression","volume":"90","author":"Bodelon","year":"2009","journal-title":"J. Gen. Virol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Cai, X., Sch\u00e4fer, A., Lu, S., Bilello, J.P., Desrosiers, R.C., Edwards, R., Raab-Traub, N., and Cullen, B.R. (2006). Epstein-Barr Virus MicroRNAs Are Evolutionarily Conserved and Differentially Expressed. PLoS Pathog., 2.","DOI":"10.1371\/journal.ppat.0020023"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1128\/JVI.01689-08","article-title":"Identification of Novel Epstein-Barr Virus MicroRNA Genes from Nasopharyngeal Carcinomas","volume":"83","author":"Zhu","year":"2009","journal-title":"J. Virol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1128\/JVI.74.6.2550-2557.2000","article-title":"The Epstein-Barr Virus Pol Catalytic Subunit Physically Interacts with the BBLF4-BSLF1-BBLF2\/3 Complex","volume":"74","author":"Fujii","year":"2000","journal-title":"J. Virol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1038\/s41598-019-39706-0","article-title":"Interpretation of EBV Infection in Pan-Cancer Genome Considering Viral Life Cycle: LiEB (Life Cycle of Epstein-Barr Virus)","volume":"9","author":"Song","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Kheir, F., Zhao, M., Strong, M.J., Yu, Y., Nanbo, A., Flemington, E.K., Morris, G.F., Reiss, K., Li, L., and Lin, Z. (2019). Detection of Epstein-Barr Virus Infection in Non-Small Cell Lung Cancer. Cancers, 11.","DOI":"10.3390\/cancers11060759"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"10110","DOI":"10.1128\/JVI.01110-15","article-title":"Latent Expression of the Epstein-Barr Virus (EBV)-Encoded Major Histocompatibility Complex Class I TAP Inhibitor, BNLF2a, in EBV-Positive Gastric Carcinomas","volume":"89","author":"Strong","year":"2015","journal-title":"J. Virol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Jochum, S., Moosmann, A., Lang, S., Hammerschmidt, W., and Zeidler, R. (2012). The EBV Immunoevasins VIL-10 and BNLF2a Protect Newly Infected B Cells from Immune Recognition and Elimination. PLoS Pathog., 8.","DOI":"10.1371\/journal.ppat.1002704"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.4049\/jimmunol.0803218","article-title":"Specific Targeting of the EBV Lytic Phase Protein BNLF2a to the Transporter Associated with Antigen Processing Results in Impairment of HLA Class I-Restricted Antigen Presentation","volume":"182","author":"Horst","year":"2009","journal-title":"J. Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Croft, N.P., Shannon-Lowe, C., Bell, A.I., Horst, D., Kremmer, E., Ressing, M.E., Wiertz, E.J.H.J., Middeldorp, J.M., Rowe, M., and Rickinson, A.B. (2009). Stage-Specific Inhibition of MHC Class I Presentation by the Epstein-Barr Virus BNLF2a Protein during Virus Lytic Cycle. PLoS Pathog., 5.","DOI":"10.1371\/journal.ppat.1000490"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"6104054","DOI":"10.1155\/2017\/6104054","article-title":"IL-10: A Multifunctional Cytokine in Viral Infections","volume":"2017","author":"Rojas","year":"2017","journal-title":"J. Immunol. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.3389\/fimmu.2018.02198","article-title":"Epstein Barr Virus Interleukin 10 Suppresses Anti-Inflammatory Phenotype in Human Monocytes","volume":"9","author":"Jog","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Borozan, I., Zapatka, M., Frappier, L., and Ferretti, V. (2018). Analysis of Epstein-Barr Virus Genomes and Expression Profiles in Gastric Adenocarcinoma. J. Virol., 92.","DOI":"10.1128\/JVI.00330-18"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Hooykaas, M.J.G., Kruse, E., Wiertz, E.J.H.J., and Lebbink, R.J. (2016). Comprehensive Profiling of Functional Epstein-Barr Virus MiRNA Expression in Human Cell Lines. BMC Genom., 17.","DOI":"10.1186\/s12864-016-2978-6"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"8619","DOI":"10.1038\/sj.onc.1207905","article-title":"Epstein\u2013Barr Virus (EBV) LMP2A Mediates B-Lymphocyte Survival through Constitutive Activation of the Ras\/PI3K\/Akt Pathway","volume":"23","author":"Portis","year":"2004","journal-title":"Oncogene"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.virol.2016.10.015","article-title":"Epstein-Barr Virus Latent Membrane Protein 2A (LMP2A) Enhances IL-10 Production through the Activation of Bruton\u2019s Tyrosine Kinase and STAT3","volume":"500","author":"Incrocci","year":"2017","journal-title":"Virology"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"8479","DOI":"10.1073\/pnas.90.18.8479","article-title":"Epstein-Barr Virus-Coded BHRF1 Protein, a Viral Homologue of Bcl-2, Protects Human B Cells from Programmed Cell Death","volume":"90","author":"Henderson","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Altmann, M., and Hammerschmidt, W. (2005). Epstein-Barr Virus Provides a New Paradigm: A Requirement for the Immediate Inhibition of Apoptosis. PLoS Biol., 3.","DOI":"10.1371\/journal.pbio.0030404"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Bernhardt, K., Haar, J., Tsai, M.-H., Poirey, R., Feederle, R., and Delecluse, H.-J. (2016). A Viral MicroRNA Cluster Regulates the Expression of PTEN, P27 and of a Bcl-2 Homolog. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1005405"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s00430-018-0570-1","article-title":"Molecular Mechanisms of EBV-Driven Cell Cycle Progression and Oncogenesis","volume":"208","author":"Yin","year":"2019","journal-title":"Med. Microbiol. Immunol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/289300a0","article-title":"Cyclosporin A Promotes Spontaneous Outgrowth in Vitro of Epstein-Barr Virus-Induced B-Cell Lines","volume":"289","author":"Bird","year":"1981","journal-title":"Nature"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1099\/0022-1317-68-8-2069","article-title":"Detection of Epstein-Barr Virus Strain Variants in Lymphoblastoid Cell Lines \u201cspontaneously\u201d Derived from Patients with Rheumatoid Arthritis, Infectious Mononucleosis and Normal Controls","volume":"68","author":"Sculley","year":"1987","journal-title":"J. Gen. Virol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","article-title":"The 2016 Revision of the World Health Organization Classification of Lymphoid Neoplasms","volume":"127","author":"Swerdlow","year":"2016","journal-title":"Blood"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/13\/4\/610\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:19:55Z","timestamp":1760159995000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/13\/4\/610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,4]]},"references-count":80,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["cancers13040610"],"URL":"https:\/\/doi.org\/10.3390\/cancers13040610","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,4]]}}}