{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:47:08Z","timestamp":1760233628126,"version":"build-2065373602"},"reference-count":99,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The National Centre for Research and Development (NCBiR, Poland)","award":["LIDER\/016\/275\/L-5\/13\/NCBR\/2014"],"award-info":[{"award-number":["LIDER\/016\/275\/L-5\/13\/NCBR\/2014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Follicular lymphoma (FL) represents the major subtype of indolent B-cell non-Hodgkin lymphomas (B-NHLs) and results from the malignant transformation of mature B-cells in lymphoid organs. Although gene expression and genomic studies have identified multiple disease driving gene aberrations, only a few proteomic studies focused on the protein level. The present work aimed to examine the proteomic profiles of follicular lymphoma vs. normal B-cells obtained by fine-needle aspiration biopsy (FNAB) to gain deep insight into the most perturbed pathway of FL. The cells of interest were purified by magnetic-activated cell sorting (MACS). High-throughput proteomic profiling was performed using liquid chromatography-tandem mass spectrometry (LC-MS\/MS) and allowed to identify of 6724 proteins in at least 75% of each group of samples. The \u2018Total Protein Approach\u2019 (TPA) was applied to the absolute quantification of proteins in this study. We identified 1186 differentially abundant proteins (DAPs) between FL and control samples, causing an extensive remodeling of several molecular pathways, including the B-cell receptor signaling pathway, cellular adhesion molecules, and PPAR pathway. Additionally, the construction of protein\u2013protein interactions networks (PPINs) and identification of hub proteins allowed us to indicate the key player proteins for FL pathology. Finally, ICAM1, CD9, and CD79B protein expression was validated in an independent cohort by flow cytometry (FCM), and the results were consistent with the mass spectrometry (MS) data.<\/jats:p>","DOI":"10.3390\/cancers13040630","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T08:33:48Z","timestamp":1612514028000},"page":"630","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Large-Scale Proteomic Analysis of Follicular Lymphoma Reveals Extensive Remodeling of Cell Adhesion Pathway and Identifies Hub Proteins Related to the Lymphomagenesis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9005-9695","authenticated-orcid":false,"given":"Kamila","family":"Du\u015b-Szachniewicz","sequence":"first","affiliation":[{"name":"Department of Pathology, Wroc\u0142aw Medical University, Marcinkowskiego 1, 50-368 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3478-8014","authenticated-orcid":false,"given":"Grzegorz","family":"Rymkiewicz","sequence":"additional","affiliation":[{"name":"Flow Cytometry Laboratory, Department of Pathology and Laboratory Diagnostics, Maria Sk\u0142odowska-Curie National Research Institute of Oncology, Roentgen 5, 02-781 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil Kumar","family":"Agrawal","sequence":"additional","affiliation":[{"name":"2nd Department of General and Oncological Surgery, Wroc\u0142aw Medical University, Borowska 213, 50-556 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"Ko\u0142odziej","sequence":"additional","affiliation":[{"name":"Division of Pathology, Soko\u0142owski Hospital Wa\u0142brzych, Soko\u0142owskiego 4, 58-309 Wa\u0142brzych, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek R.","family":"Wi\u015bniewski","sequence":"additional","affiliation":[{"name":"Biochemical Proteomics Group, Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1023\/A:1008265532487","article-title":"Epidemiology of the non-Hodgkin\u2019s lymphomas: Distributions of the major subtypes differ by geographic locations. 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