{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:49:42Z","timestamp":1760233782092,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI15\/02252"],"award-info":[{"award-number":["PI15\/02252"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI15\/02252"],"award-info":[{"award-number":["PI15\/02252"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SAMID network","award":["RD12\/0026\/0016"],"award-info":[{"award-number":["RD12\/0026\/0016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>High prevalence of placental-derived complications, such as preeclampsia and intrauterine growth restriction, has been reported in women with breast cancer (BC) treated with chemotherapy during pregnancy (PBC-CHT). Aim: To ascertain whether PBC-CHT is associated with an imbalance of angiogenic factors, surrogate markers for placental insufficiency, that could explain perinatal outcomes. Methods: Prospective study between 2012 and 2016 in a single institution. Soluble fms-like tyrosine kinase (sFlt-1), placental growth factor (PlGF), and soluble endoglin (sEng) in maternal blood were assessed throughout pregnancy in 12 women with BC and 215 controls. Results: Cancer patients were treated with doxorubicin-based regimes and with taxanes. Ten PBC-CHT (83%) developed obstetrical complications. At the end of the third trimester, significantly higher levels of sFlt-1; sFlt-1\/PGF ratio, and sEng levels were observed in BC women as compared to controls. Moreover; there was a significant correlation between plasma levels of sFlt-1 and the number of chemotherapy cycles administered. Besides, more chemotherapy cycles correlated with lower birthweight and head circumference at birth. Conclusions: Women with BC treated during pregnancy showed an antiangiogenic state compatible with placental insufficiency. Angiogenic factors could be useful in the clinical obstetric management of these patients; although further studies will be required to guide clinical decision-making.<\/jats:p>","DOI":"10.3390\/cancers13040923","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T12:40:16Z","timestamp":1614084016000},"page":"923","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evolution of Angiogenic Factors in Pregnant Patients with Breast Cancer Treated with Chemotherapy"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8296-5065","authenticated-orcid":false,"given":"Cristina","family":"Saura","sequence":"first","affiliation":[{"name":"Medical Oncology Department, Vall d\u2019Hebron University Hospital, Vall d\u2019Hebr\u00f3n Institute of Oncology (VHIO), 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Maternal and Child Health and Development Network (SAMID), RD12\/0026\/16 and RD16\/0022\/0015, Institute of Health Carlos III, 28029 Madrid, Spain"},{"name":"Biochemistry and Molecular Biology Research Centre for Nanomedicine, Vall d\u2019Hebron Research Institute, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebr\u00f3n Institute of Oncology (VHIO), 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology Research Centre for Nanomedicine, Vall d\u2019Hebron Research Institute, 08035 Barcelona, Spain"},{"name":"Center for Biomedical Research on Rare Diseases (CIBERER), 08028 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Dienstmann","sequence":"additional","affiliation":[{"name":"Oncology Data Science (ODysSey), Vall d\u2019Hebr\u00f3n Institute of Oncology (VHIO), 08028 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3932-0170","authenticated-orcid":false,"given":"Fiorella","family":"Ru\u00edz-Pace","sequence":"additional","affiliation":[{"name":"Oncology Data Science (ODysSey), Vall d\u2019Hebr\u00f3n Institute of Oncology (VHIO), 08028 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Concepci\u00f3","family":"C\u00e9spedes","sequence":"additional","affiliation":[{"name":"Pediatrics Department, Vall d\u2019Hebron University Hospital, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngeles","family":"Pe\u00f1uelas","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Vall d\u2019Hebron University Hospital, Vall d\u2019Hebr\u00f3n Institute of Oncology (VHIO), 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7623-1583","authenticated-orcid":false,"given":"Javier","family":"Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Vall d\u2019Hebr\u00f3n Institute of Oncology (VHIO), International Breast Cancer Center, Quiron Group, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Llurba","sequence":"additional","affiliation":[{"name":"Maternal and Child Health and Development Network (SAMID), RD12\/0026\/16 and RD16\/0022\/0015, Institute of Health Carlos III, 28029 Madrid, Spain"},{"name":"Department of Obstetrics, Maternal-Fetal Medicine Unit, Santa Creu i Sant Pau University Hospital, Universitat Aut\u00f2noma de Barcelona, 08025 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9591-7430","authenticated-orcid":false,"given":"Octavi","family":"C\u00f3rdoba","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, Hospital Universitari Son Espases, 07120 Palma, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria de les Illes Balears (IdISBa), 07120 Palma, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/AOG.0b013e3181b19154","article-title":"Increasing incidence of pregnancy-associated breast cancer in Sweden","volume":"114","author":"Andersson","year":"2009","journal-title":"Obstet. 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