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Therefore, reliable preclinical models are crucial for research and development of efficacious treatments for this condition. To date, a number of animal models have attempted to reproduce as accurately as possible the complexity of the tumor microenvironment of human peritoneal carcinomatosis. These include: Syngeneic tumor cell lines, human xenografts, patient-derived xenografts, genetically induced tumors, and 3D scaffold biomimetics. Each experimental model has its own strengths and limitations, all of which can influence the subsequent translational results concerning anticancer and immunomodulatory drugs under exploration. This review highlights the current status of peritoneal carcinomatosis mouse models for preclinical development of anticancer drugs or immunotherapeutic agents.<\/jats:p>","DOI":"10.3390\/cancers13050963","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T21:16:53Z","timestamp":1614287813000},"page":"963","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Mouse Models of Peritoneal Carcinomatosis to Develop Clinical Applications"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6534-7705","authenticated-orcid":false,"given":"\u00c1ngela","family":"Bella","sequence":"first","affiliation":[{"name":"Program of Immunology and Immunotherapy, Cima Universidad de Navarra, 31008 Pamplona, Spain"},{"name":"Navarra Institute for Health Research (IDISNA), 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7423-2352","authenticated-orcid":false,"given":"Claudia Augusta","family":"Di Trani","sequence":"additional","affiliation":[{"name":"Program of Immunology and Immunotherapy, Cima Universidad de Navarra, 31008 Pamplona, Spain"},{"name":"Navarra Institute for Health Research (IDISNA), 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2119-3967","authenticated-orcid":false,"given":"Myriam","family":"Fern\u00e1ndez-Sendin","sequence":"additional","affiliation":[{"name":"Program of Immunology and Immunotherapy, Cima Universidad de Navarra, 31008 Pamplona, Spain"},{"name":"Navarra Institute for Health Research (IDISNA), 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leire","family":"Arrizabalaga","sequence":"additional","affiliation":[{"name":"Program of Immunology and Immunotherapy, Cima Universidad de Navarra, 31008 Pamplona, Spain"},{"name":"Navarra Institute for Health Research (IDISNA), 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assunta","family":"Cirella","sequence":"additional","affiliation":[{"name":"Program of Immunology and Immunotherapy, Cima Universidad de Navarra, 31008 Pamplona, Spain"},{"name":"Navarra Institute for Health Research (IDISNA), 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7339-4464","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Teijeira","sequence":"additional","affiliation":[{"name":"Program of Immunology and Immunotherapy, Cima Universidad de Navarra, 31008 Pamplona, Spain"},{"name":"Navarra Institute for Health Research (IDISNA), 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Medina-Echeverz","sequence":"additional","affiliation":[{"name":"Bavarian Nordic GmbH, Fraunhoferstrasse 13, 82152 Planegg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1360-348X","authenticated-orcid":false,"given":"Ignacio","family":"Melero","sequence":"additional","affiliation":[{"name":"Program of Immunology and Immunotherapy, Cima Universidad de Navarra, 31008 Pamplona, Spain"},{"name":"Navarra Institute for Health Research (IDISNA), 31008 Pamplona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), 28029 Madrid, Spain"},{"name":"Department of Oncology, Cl\u00ednica Universidad de Navarra, 31008 Pamplona, Spain"},{"name":"Department of Immunology and Immunotherapy, Cl\u00ednica Universidad de Navarra, 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7410-1865","authenticated-orcid":false,"given":"Pedro","family":"Berraondo","sequence":"additional","affiliation":[{"name":"Program of Immunology and Immunotherapy, Cima Universidad de Navarra, 31008 Pamplona, Spain"},{"name":"Navarra Institute for Health Research (IDISNA), 31008 Pamplona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer (CIBERONC), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9364-474X","authenticated-orcid":false,"given":"Fernando","family":"Aranda","sequence":"additional","affiliation":[{"name":"Program of Immunology and Immunotherapy, Cima Universidad de Navarra, 31008 Pamplona, Spain"},{"name":"Navarra Institute for Health Research (IDISNA), 31008 Pamplona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.3748\/wjg.v19.i41.6979","article-title":"Peritoneal carcinomatosis","volume":"19","author":"Coccolini","year":"2013","journal-title":"World J. 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