{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T13:02:48Z","timestamp":1793278968059,"version":"4.5.0"},"reference-count":66,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2015R1D1A1A09057839"],"award-info":[{"award-number":["2015R1D1A1A09057839"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017M3A9E4065331"],"award-info":[{"award-number":["2017M3A9E4065331"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Cancer cachexia is a multifactorial systemic inflammation disease caused by complex interactions between the tumor and host tissues via soluble factors. However, whether cancer cachexia affects the bone marrow, in particular the hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), remains unclear. Here, we investigated the bone marrow and bone in a cancer cachexia animal model generated by transplanting Lewis lung carcinoma cells. The number of bone marrow mononuclear cells (BM-MNCs) started to significantly decrease in the cancer cachectic animal model prior to the discernable loss of muscle and fat. This decrease in BM-MNCs was associated with myeloid skewing in the circulation and the expansion of hematopoietic progenitors in the bone marrow. Bone loss occurred in the cancer cachexia animal model and accompanied the decrease in the bone marrow MSCs that play important roles in both supporting HSCs and maintaining bone homeostasis. Glucocorticoid signaling mediated the decrease in bone marrow MSCs in the cancer cachectic environment. The cancer cachexia environment also skewed the differentiation of the bone marrow MSCs toward adipogenic fate via JAK\/STAT as well as glucocorticoid signaling. Our results suggest that the bone loss induced in cancer cachexia is associated with the depletion and the impaired differentiation capacity of the bone marrow MSCs.<\/jats:p>","DOI":"10.3390\/cancers13051059","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T21:24:01Z","timestamp":1614720241000},"page":"1059","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Bone Marrow Homeostasis Is Impaired via JAK\/STAT and Glucocorticoid Signaling in Cancer Cachexia Model"],"prefix":"10.3390","volume":"13","author":[{"given":"Jinyeong","family":"Yu","sequence":"first","affiliation":[{"name":"Graduate School of Biotechnology, Kyung Hee University, Yongin 17104, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghyuk","family":"Choi","sequence":"additional","affiliation":[{"name":"Graduate School of Biotechnology, Kyung Hee University, Yongin 17104, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aran","family":"Park","sequence":"additional","affiliation":[{"name":"Graduate School of Biotechnology, Kyung Hee University, Yongin 17104, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungbeom","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghyun","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngjae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinok","family":"Noh","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kil Yeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, Kyung Hee University, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Hoon","family":"Maeng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Sook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul 02447, Korea"},{"name":"East-West Medical Research Institute, Kyung Hee University, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nrc3829","article-title":"Cancer cachexia: Understanding the molecular basis","volume":"14","author":"Argiles","year":"2014","journal-title":"Nat. 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