{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:27:10Z","timestamp":1774682830375,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>(1) Background: T-cell lymphoblastic lymphoma (T-LBL) is extremely rare and highly aggressive, with no practical risk model defined yet. The prognostic value of T-LBL immunological subtypes is still a matter of controversy. (2) Methods: We re-evaluated 49 subsequent adult T-LBL patients treated according to the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia (GMALL) protocols, 05\/93 (n = 20) and T-LBL 1\/2004 (n = 29), 85.7% of which achieved complete remission (CR). (3) Results: The 5\/10-year overall survival (OS) and event-free survival (EFS) were 62%\/59% and 48%\/43%, respectively. In 96% of patients, flow cytometry analyses defining the WHO 2008 immunophenotypes were available. Cortical, early\/pro-T\/CD2(\u2212), early\/pre-T\/CD2(+), and mature subtypes were identified in 59.5%, 19%, 15%, and 6.5% of patients, respectively. Overall, 20% of patients had the early T-cell precursor (ETP)-LBL immunophenotype, as proposed by the WHO 2017 classification. For the early\/pro-T\/CD2(\u2212) subtype, the five-year OS and EFS were 13% and 13%, while for all the other, non-pro-T subtypes, they were 69% and 67%. By multivariate analysis, only CD2(\u2212) status and age &gt; 35 years emerged as strong, independent factors influencing OS and EFS, while the risk of CR failure was influenced by age only (&gt;35 years). (4) Conclusions: ETP was non-significant for OS, unless an ultra-high-risk pro-T\/CD2(\u2212) subtype was concerned.<\/jats:p>","DOI":"10.3390\/cancers13081911","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T12:11:00Z","timestamp":1618488660000},"page":"1911","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic Value of the Immunological Subtypes of Adolescent and Adult T-Cell Lymphoblastic Lymphoma; an Ultra-High-Risk Pro-T\/CD2(\u2212) Subtype"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7318-1031","authenticated-orcid":false,"given":"Beata","family":"Ostrowska","sequence":"first","affiliation":[{"name":"Department of Lymphoid Malignancies, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3478-8014","authenticated-orcid":false,"given":"Grzegorz","family":"Rymkiewicz","sequence":"additional","affiliation":[{"name":"Flow Cytometry Laboratory, Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6139-1234","authenticated-orcid":false,"given":"Magdalena","family":"Chechlinska","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Blachnio","sequence":"additional","affiliation":[{"name":"Flow Cytometry Laboratory, Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Domanska-Czyz","sequence":"additional","affiliation":[{"name":"Department of Lymphoid Malignancies, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zbigniew","family":"Bystydzienski","sequence":"additional","affiliation":[{"name":"Flow Cytometry Laboratory, Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Romejko-Jarosinska","sequence":"additional","affiliation":[{"name":"Department of Lymphoid Malignancies, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Borysiuk","sequence":"additional","affiliation":[{"name":"Flow Cytometry Laboratory, Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Rybski","sequence":"additional","affiliation":[{"name":"Department, of Mathematical Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Michalski","sequence":"additional","affiliation":[{"name":"Department, of Mathematical Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4247-2674","authenticated-orcid":false,"given":"Jan","family":"Walewski","sequence":"additional","affiliation":[{"name":"Department of Lymphoid Malignancies, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"key":"ref_1","unstructured":"Swerdlow, S.H., Campo, E., and Harris, N.L. (2008). T lymphoblastic leukaemia\/lymphoma. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, IARC. [4th ed.]."},{"key":"ref_2","unstructured":"Swerdlow, S.H., Campo, E., and Harris, N.L. (2017). T lymphoblastic leukaemia\/lymphoma. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, Revised, IARC. [4th ed.]."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1038\/sj.leu.2403095","article-title":"Adult lymphoblastic lymphoma: A retrospective analysis of 92 patients under 61 years included in the LNH87\/93 trials","volume":"17","author":"Lepretre","year":"2003","journal-title":"Leukemia"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.exphem.2017.04.002","article-title":"Adult T-type lymphoblastic lymphoma: Treatment advances and prognostic indicators","volume":"51","author":"Lepretre","year":"2017","journal-title":"Exp. Hematol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4379","DOI":"10.1182\/blood-2002-01-0110","article-title":"Outcome of adult patients with T-lymphoblastic lymphoma treated according to protocols for acute lymphoblastic leukemia","volume":"99","author":"Hoelzer","year":"2002","journal-title":"Blood"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1182\/blood-2003-12-4428","article-title":"Outcome with the hyper-CVAD regimens in lymphoblastic lymphoma","volume":"104","author":"Thomas","year":"2004","journal-title":"Blood"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00277-011-1252-x","article-title":"Results of a lymphoblastic leukemia-like chemotherapy program with risk-adapted mediastinal irradiation and stem cell transplantation for adult patients with lymphoblastic lymphoma","volume":"91","author":"Cortelazzo","year":"2012","journal-title":"Ann. Hematol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1200\/JCO.2015.61.5385","article-title":"Pediatric-Like Acute Lymphoblastic Leukemia Therapy in Adults With Lymphoblastic Lymphoma: The GRAALL-LYSA LL03 Study","volume":"34","author":"Lepretre","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1182\/blood.V124.21.370.370","article-title":"Favorable Outcome in a Large Cohort of Prospectively Treated Adult Patients with T-Lymphoblastic Lymphoma (T-LBL) Despite Slowly Evolving Complete Remission Assessed By Conventional Radiography","volume":"124","author":"Wolf","year":"2014","journal-title":"Blood"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.clml.2017.05.016","article-title":"Prognostic Factors and Outcomes of Adult Lymphoblastic Lymphoma in the United States","volume":"17","year":"2017","journal-title":"Clin. Lymphoma Myeloma Leuk."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3109\/0284186X.2014.889850","article-title":"Treatment outcome in T-cell lymphoblastic lymphoma in adults\u2014A population-based study from the Swedish Lymphoma Registry","volume":"53","author":"Ellin","year":"2014","journal-title":"Acta Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5136","DOI":"10.1182\/blood-2009-08-231217","article-title":"T-cell acute lymphoblastic leukemia in adults: Clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII\/ECOG 2993)","volume":"114","author":"Marks","year":"2009","journal-title":"Blood"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1182\/blood-2015-08-661702","article-title":"Early T-cell precursor acute lymphoblastic leukemia\/lymphoma (ETP-ALL\/LBL) in adolescents and adults: A high-risk subtype","volume":"127","author":"Jain","year":"2016","journal-title":"Blood"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1182\/blood.V114.22.324.324","article-title":"Successful Subtype Oriented Treatment Strategies in Adult T-All; Results of 744 Patients Treated in Three Consecutive GMALL Studies","volume":"114","author":"Hoelzer","year":"2009","journal-title":"Blood"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3324\/haematol.2019.226985","article-title":"Tandem autologous hematopoietic stem cell transplantation for treatment of adult T-cell lymphoblastic lymphoma: A multiple center prospective study in China","volume":"106","author":"Liu","year":"2021","journal-title":"Haematologica"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S1470-2045(08)70314-0","article-title":"Early T-cell precursor leukaemia: A subtype of very high-risk acute lymphoblastic leukaemia","volume":"10","author":"Mullighan","year":"2009","journal-title":"Lancet Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1200\/JCO.2016.71.8585","article-title":"Early Response-Based Therapy Stratification Improves Survival in Adult Early Thymic Precursor Acute Lymphoblastic Leukemia: A Group for Research on Adult Acute Lymphoblastic Leukemia Study","volume":"35","author":"Bond","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e294","DOI":"10.3324\/haematol.2019.225078","article-title":"Unique clinico-biological, genetic and prognostic features of adult early T-cell precursor acute lymphoblastic leukemia","volume":"105","author":"Genesca","year":"2020","journal-title":"Haematologica"},{"key":"ref_19","first-page":"2040620720929475","article-title":"Early precursor T-cell acute lymphoblastic leukemia: Current paradigms and evolving concepts","volume":"11","author":"Papadantonakis","year":"2020","journal-title":"Ther. Adv. Hematol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/modpathol.2017.186","article-title":"A comprehensive flow-cytometry-based immunophenotypic characterization of Burkitt-like lymphoma with 11q aberration","volume":"31","author":"Rymkiewicz","year":"2018","journal-title":"Mod. Pathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1309\/AJCPATRQWANW2O3N","article-title":"Cytogenetic and flow cytometry evaluation of Richter syndrome reveals MYC, CDKN2A, IGH alterations with loss of CD52, CD62L and increase of CD71 antigen expression as the most frequent recurrent abnormalities","volume":"143","author":"Woroniecka","year":"2015","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_22","first-page":"30","article-title":"Pro-T cell ALL\/LBL: An ultra-high risk CD2-negative disease subtype in adults defined by flow cytometry","volume":"102","author":"Ostrowska","year":"2017","journal-title":"Haematologica"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1182\/blood.V114.22.3928.3928","article-title":"Fine Needle Aspiration Biopsy with Flow Cytometry is a Reliable Method for Defining Immunophenotype of Prognostic Value in T Lymphoblastic Lymphoma","volume":"114","author":"Ostrowska","year":"2009","journal-title":"Blood"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"G\u00f6kbuget, N., Arnold, R., B\u00f6hme, A., Fietkau, R., Freund, M., Ganser, A., Kneba, M., Lipp, T., Ludwig, W.-D., and Maschmeyer, G. (2008). Treatment of Adult ALL According to Protocols of the German Multicenter Study Group for Adult ALL (GMALL). Acute Leukemias, Springer.","DOI":"10.1007\/978-3-540-72304-2_13"},{"key":"ref_25","first-page":"3931","article-title":"Value of immunophenotype in intensively treated adult acute lymphoblastic leukemia: Cancer and leukemia Group B study 8364","volume":"93","author":"Czuczman","year":"1999","journal-title":"Blood"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1182\/blood-2002-09-2913","article-title":"CALM-AF10 is a common fusion transcript in T-ALL and is specific to the TCRgammadelta lineage","volume":"102","author":"Asnafi","year":"2003","journal-title":"Blood"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1182\/blood-2004-09-3666","article-title":"Impact of TCR status and genotype on outcome in adult T-cell acute lymphoblastic leukemia: A LALA-94 study","volume":"105","author":"Asnafi","year":"2005","journal-title":"Blood"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1158\/1078-0432.CCR-07-1927","article-title":"T cell receptor genotyping and HOXA\/TLX1 expression define three T lymphoblastic lymphoma subsets which might affect clinical outcome","volume":"14","author":"Baleydier","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/339312a0","article-title":"CD2-mediated adhesion facilitates T lymphocyte antigen recognition function","volume":"339","author":"Moingeon","year":"1989","journal-title":"Nature"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1182\/blood-2002-07-2206","article-title":"CD2 engagement induces dendritic cell activation: Implications for immune surveillance and T-cell activation","volume":"102","author":"Crawford","year":"2003","journal-title":"Blood"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/13\/8\/1911\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:48:28Z","timestamp":1760161708000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/13\/8\/1911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,15]]},"references-count":30,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,4]]}},"alternative-id":["cancers13081911"],"URL":"https:\/\/doi.org\/10.3390\/cancers13081911","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,15]]}}}