{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T11:39:01Z","timestamp":1776944341427,"version":"3.51.4"},"reference-count":28,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Aims: It is largely unknown whether cancer patients seen in routine care show ventricular arrhythmias in 24 h electrocardiograms (ECGs), and whether when they are detected they carry prognostic relevance. Methods and Results: We included 261 consecutive cancer patients that were referred to the department of cardiology for 24 h ECG examination and 35 healthy controls of similar age and sex in the analysis. To reduce selection bias, cancer patients with known left ventricular ejection fraction &lt;45% were not included in the analysis. Non\u2013sustained ventricular tachycardia (NSVT) episodes of either \u22653 and \u22654 beats duration were more frequent in cancer patients than controls (17% vs. 0%, p = 0.0008; 10% vs. 0%, p = 0.016). Premature ventricular contractions (PVCs)\/24 h were not more frequent in cancer patients compared to controls (median (IQR), 26 (2\u2013360) vs. 9 (1\u201343), p = 0.06; \u226520 PVCs 53% vs. 37%, p = 0.07). During follow-up, (up to 7.2 years, median 15 months) of the cancer patients, 158 (61%) died (1-\/3-\/5-year mortality rates: 45% [95%CI 39\u201351%], 66% [95%CI 59\u201373%], 73% [95%CI 64\u201382%]). Both non-sustained ventricular tachycardia of \u22654 beats and \u226520 PVCs\/24 h independently predicted mortality in univariate and multivariate survival analyses, adjusted for all other univariate predictors of mortality as well as relevant clinical factors, including cancer stage and type, performance status (ECOG), prior potentially cardiotoxic anti-cancer drug therapy, coronary artery disease, potassium concentration, and haemoglobin (multivariate adjusted hazard ratios: NSVT \u22654 beats [HR 1.76, p = 0.022], \u226520 PVCs\/24 h [HR 1.63, p &lt; 0.0064]). Conclusions: NSVT \u22654 beats and \u226520 PVCs\/day seen in routine 24 h ECGs of patients with cancer carry prognostic relevance.<\/jats:p>","DOI":"10.3390\/cancers13102303","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T10:59:12Z","timestamp":1620817152000},"page":"2303","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Spontaneous Non-Sustained Ventricular Tachycardia and Premature Ventricular Contractions and Their Prognostic Relevance in Patients with Cancer in Routine Care"],"prefix":"10.3390","volume":"13","author":[{"given":"Annemarie","family":"Albrecht","sequence":"first","affiliation":[{"name":"Department of Cardiology (CVK), Charit\u00e9 Universit\u00e4tsmedizin Berlin, 13353 Berlin, Germany"},{"name":"Berlin Institute of Health Center for Regenerative Therapies (BCRT), 13353 Berlin, Germany"},{"name":"German Centre for Cardiovascular Research (DZHK) Partner Site Berlin, 13353 Berlin, Germany"},{"name":"Department of Cardiology (CBF), Charit\u00e9 Universit\u00e4tsmedizin Berlin, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4100-4361","authenticated-orcid":false,"given":"Jan","family":"Porthun","sequence":"additional","affiliation":[{"name":"Department of Health Sciences in Gj\u00f8vik, Norwegian University of Science and Technology, Campus Gj\u00f8vik (NTNU-Gj\u00f8vik), 2815 Gj\u00f8vik, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Eucker","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Cancer Immunology, Campus Benjamin Franklin, Charit\u00e9 University Medicine Berlin, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Coats","sequence":"additional","affiliation":[{"name":"IRCCS, San Raffaele, 00163 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"von Haehling","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology, Heart Center G\u00f6ttingen, University of G\u00f6ttingen Medical Center, Georg-August-University, 37073 G\u00f6ttingen, Germany"},{"name":"German Center for Cardiovascular Medicine (DZHK), Partner Site G\u00f6ttingen, 37099 G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Pezzutto","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Benjamin Franklin Campus, Charit\u00e9 University of Medicine Berlin, 12203 Berlin, Germany"},{"name":"Berlin Institute for Health Charit\u00e9 and Max-Delbr\u00fcck Center, Campus Buch, Building 42-53, Lindenberger Weg 80, 13125 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5715-2959","authenticated-orcid":false,"given":"Mahir","family":"Karakas","sequence":"additional","affiliation":[{"name":"Clinic for General and Interventional Cardiology, University Heart Center Hamburg, 20246 Hamburg, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Hamburg\/Kiel\/L\u00fcbeck, 20246 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanno","family":"Riess","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Charit\u00e9\u2014Campus Virchow-Klinikum (CVK), 13353 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8485-1958","authenticated-orcid":false,"given":"Ulrich","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Cancer Immunology, Campus Benjamin Franklin, Charit\u00e9 University Medicine Berlin, 12203 Berlin, Germany"},{"name":"Max-Delbr\u00fcck-Center for Molecular Medicine, 13125 Berlin, Germany"},{"name":"German Cancer Consortium (DKTK) &amp; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Landmesser","sequence":"additional","affiliation":[{"name":"German Centre for Cardiovascular Research (DZHK) Partner Site Berlin, 13353 Berlin, Germany"},{"name":"Department of Cardiology (CBF), Charit\u00e9 Universit\u00e4tsmedizin Berlin, 12203 Berlin, Germany"},{"name":"Berlin Institute of Health (BIH), 13353 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilhelm","family":"Haverkamp","sequence":"additional","affiliation":[{"name":"Department of Cardiology (CVK), Charit\u00e9 Universit\u00e4tsmedizin Berlin, 13353 Berlin, Germany"},{"name":"Berlin Institute of Health Center for Regenerative Therapies (BCRT), 13353 Berlin, Germany"},{"name":"German Centre for Cardiovascular Research (DZHK) Partner Site Berlin, 13353 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Anker","sequence":"additional","affiliation":[{"name":"Department of Cardiology (CVK), Charit\u00e9 Universit\u00e4tsmedizin Berlin, 13353 Berlin, Germany"},{"name":"Berlin Institute of Health Center for Regenerative Therapies (BCRT), 13353 Berlin, Germany"},{"name":"German Centre for Cardiovascular Research (DZHK) Partner Site Berlin, 13353 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Anker","sequence":"additional","affiliation":[{"name":"Berlin Institute of Health Center for Regenerative Therapies (BCRT), 13353 Berlin, Germany"},{"name":"German Centre for Cardiovascular Research (DZHK) Partner Site Berlin, 13353 Berlin, Germany"},{"name":"Department of Cardiology (CBF), Charit\u00e9 Universit\u00e4tsmedizin Berlin, 12203 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/1097-0142(197402)33:2<568::AID-CNCR2820330236>3.0.CO;2-2","article-title":"Proceedings: Cause of death in cancer patients","volume":"33","author":"Inagaki","year":"1974","journal-title":"Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/jnci\/85.12.979","article-title":"Noncancer deaths in white adult cancer patients","volume":"85","author":"Brown","year":"1993","journal-title":"J. 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