{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:32:01Z","timestamp":1789882321209,"version":"4.0.1"},"reference-count":36,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T00:00:00Z","timestamp":1622246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Primary gastrointestinal T\/NK cell lymphoma (GI-TNKL) is an uncommon and heterogeneous group of lymphoid malignancies. We aimed to investigate their subtype distribution, clinicopathologic characteristics, and clinical outcomes. A total of 38 GI-TNKL cases and their clinical and pathological characteristics were analyzed. GI-TNKL occurred in adults with a median patient age in the sixth decade of life and showed a slight male predominance. The most common histologic type was extranodal NK\/T-cell lymphoma, nasal type (ENKTL; 34.2%), followed by monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL; 31.6%), intestinal T-cell lymphoma, NOS (ITCL, NOS, 18.4%), anaplastic large cell lymphoma, ALK-negative (ALCL, ALK-; 13.2%). The small intestine was the primary affected region. More than 90% of patients complained of various GI symptoms and cases with advanced Lugano stage, high IPI score, or bowel perforation that required emergent operation were not uncommon. GI-TNKL also showed aggressive behavior with short progression-free survival and overall survival. This thorough clinical and pathological descriptive analysis will be helpful for accurate understanding, diagnosis, and treatment.<\/jats:p>","DOI":"10.3390\/cancers13112679","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:22:15Z","timestamp":1622420535000},"page":"2679","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Primary Gastrointestinal T\/NK Cell Lymphoma"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9439-0446","authenticated-orcid":false,"given":"Eun Kyung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pathology, National Health Insurance Service Ilsan Hospital, Goyang 10444, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Health Insurance Service Ilsan Hospital, Goyang 10444, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Ick","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Och","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1046\/j.1365-2559.2003.01659.x","article-title":"Clinicopathological analysis of 143 primary malignant lymphomas in the small and large intestines based on the new WHO classification","volume":"43","author":"Kohno","year":"2003","journal-title":"Histopathology"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kim, S.J., Choi, C.W., Mun, Y.-C., Oh, S.Y., Kang, H.J., Lee, S.I., Won, J.H., Kim, M.K., Kwon, J.H., and Kim, J.S. 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