{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:01:59Z","timestamp":1782918119555,"version":"3.54.5"},"reference-count":266,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,5,30]],"date-time":"2021-05-30T00:00:00Z","timestamp":1622332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Human papillomavirus (HPV) infection remains one of the most prominent cancer-causing DNA viruses, contributing to approximately 5% of human cancers. While association between HPV and cervical cancers has been well-established, evidence on the attribution of head and neck cancers (HNC) to HPV have been increasing in recent years. Among the cancer-causing HPV genotypes, HPV16 and 18 remain the major contributors to cancers across the globe. Nonetheless, the distribution of HPV genotypes in ethnically, geographically, and socio-economically diverse East, Southeast, and South Asia may differ from other parts of the world. In this review, we garner and provide updated insight into various aspects of HPV reported in recent years (2015\u20132021) in these regions. We included: (i) the HPV genotypes detected in normal cancers of the uterine cervix and head and neck, as well as the distribution of the HPV genotypes by geography and age groups; (ii) the laboratory diagnostic methods and treatment regimens used within these regions; and (iii) the oncogenic properties of HPV prototypes and their variants contributing to carcinogenesis. More importantly, we also unveil the similarities and discrepancies between these aspects, the areas lacking study, and the challenges faced in HPV studies.<\/jats:p>","DOI":"10.3390\/cancers13112691","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:22:15Z","timestamp":1622420535000},"page":"2691","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Current Updates on Cancer-Causing Types of Human Papillomaviruses (HPVs) in East, Southeast, and South Asia"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1040-5285","authenticated-orcid":false,"given":"Chichao","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Microbiology, The Chinese University of Hong Kong, Hong Kong SAR 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2978-4147","authenticated-orcid":false,"given":"Sile","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The Chinese University of Hong Kong, Hong Kong SAR 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The Chinese University of Hong Kong, Hong Kong SAR 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8577-1298","authenticated-orcid":false,"given":"Zigui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The Chinese University of Hong Kong, Hong Kong SAR 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6360-4608","authenticated-orcid":false,"given":"Paul K. S.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The Chinese University of Hong Kong, Hong Kong SAR 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9772-2971","authenticated-orcid":false,"given":"Siaw Shi","family":"Boon","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The Chinese University of Hong Kong, Hong Kong SAR 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.virol.2013.07.020","article-title":"The E1 proteins","volume":"445","author":"Bergvall","year":"2013","journal-title":"Virology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6169","DOI":"10.1128\/jvi.70.9.6169-6179.1996","article-title":"Transcriptional and replicational activation functions in the bovine papillomavirus type 1 E2 protein are encoded by different structural determinants","volume":"70","author":"Abroi","year":"1996","journal-title":"J. Virol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1128\/JVI.78.4.2142-2151.2004","article-title":"The viral E4 protein is required for the completion of the cottontail rabbit papillomavirus productive cycle in vivo","volume":"78","author":"Peh","year":"2004","journal-title":"J. Virol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.virol.2013.07.008","article-title":"The E4 protein; Structure, function and patterns of expression","volume":"445","author":"Doorbar","year":"2013","journal-title":"Virology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/0092-8674(90)90409-8","article-title":"The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53","volume":"63","author":"Scheffner","year":"1990","journal-title":"Cell"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0092-8674(93)90384-3","article-title":"The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53","volume":"75","author":"Scheffner","year":"1993","journal-title":"Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.virol.2013.04.013","article-title":"The papillomavirus E7 proteins","volume":"445","author":"Roman","year":"2013","journal-title":"Virology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.virol.2013.05.006","article-title":"The E5 proteins","volume":"445","author":"DiMaio","year":"2013","journal-title":"Virology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.virol.2013.05.038","article-title":"The papillomavirus major capsid protein L1","volume":"445","author":"Buck","year":"2013","journal-title":"Virology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.virol.2013.04.017","article-title":"L2, the minor capsid protein of papillomavirus","volume":"445","author":"Wang","year":"2013","journal-title":"Virology"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Graham, S.V. (2017). Keratinocyte differentiation-dependent human papillomavirus gene regulation. Viruses, 9.","DOI":"10.3390\/v9090245"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"D499","DOI":"10.1093\/nar\/gkw879","article-title":"The papillomavirus episteme: A major update to the papillomavirus sequence database","volume":"45","author":"Li","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.virol.2004.03.033","article-title":"Classification of papillomaviruses","volume":"324","author":"Fauquet","year":"2004","journal-title":"Virology"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Chen, Z., DeSalle, R., Schiffman, M., Herrero, R., Wood, C.E., Ruiz, J.C., Clifford, G.M., Chan, P.K.S., and Burk, R.D. (2018). Niche adaptation and viral transmission of human papillomaviruses from archaic hominins to modern humans. PLoS Pathog., 14.","DOI":"10.1371\/journal.ppat.1007352"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.3389\/fmicb.2019.02093","article-title":"Non-human primate papillomaviruses share similar evolutionary histories and niche adaptation as the human counterparts","volume":"10","author":"Chen","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1155\/2007\/942650","article-title":"Human papillomaviruses and non-melanoma skin cancer: Basic virology and clinical manifestations","volume":"23","author":"Nindl","year":"2007","journal-title":"Dis. Markers"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"21039","DOI":"10.1038\/srep21039","article-title":"Prevalence of HPV infection among 28,457 Chinese women in Yunnan Province, southwest China","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ijgo.2015.06.027","article-title":"Characteristics of HPV prevalence in Sichuan Province, China","volume":"131","author":"Chen","year":"2015","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12985-019-1239-0","article-title":"Characteristics of human papillomaviruses distribution in Guizhou Province, China","volume":"16","author":"Chen","year":"2019","journal-title":"Virol. J."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Yan, L., Yang, J., Long, X., and Zhou, D. (2020). Epidemiological characteristics of human pap-illomavirus (HPV) in different groups of women in Chongqing, China. Jpn. J. Infect. Dis.","DOI":"10.7883\/yoken.JJID.2020.635"},{"key":"ref_21","first-page":"1460","article-title":"Prevalence and genotyping of human papillomavirus infection in females in Hainan province","volume":"26","author":"Zhang","year":"2015","journal-title":"Hainan Med. J."},{"key":"ref_22","first-page":"246","article-title":"Results\u2019 analysis of human papillomavirus determination of 9810 patients in Liuzhou, Guangxi","volume":"34","author":"Cai","year":"2019","journal-title":"Lab. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.1177\/0300060519870918","article-title":"Positivity and prevalence of human papillomavirus among a large population of women in southeastern China","volume":"47","author":"Liu","year":"2019","journal-title":"J. Int. Med. Res."},{"key":"ref_24","first-page":"25","article-title":"Prevalence of human papillomavirus infection and type distribution among Uyghur females in Xinjiang, northwest China","volume":"20","author":"Yan","year":"2020","journal-title":"Oncol. Lett."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1002\/jmv.24248","article-title":"Prevalence and genotype distribution of cervical human papillomavirus (HPV) among women in urban Tianjin, China","volume":"87","author":"Chen","year":"2015","journal-title":"J. Med. Virol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1080\/21645515.2019.1689743","article-title":"Prevalence, genotype distribution and risk factors of cervical HPV infection in Yangqu, China: A population-based survey of 10086 women","volume":"16","author":"Yang","year":"2020","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/jmv.24888","article-title":"Prevalence of human papillomavirus infection in women in the autonomous region of Inner Mongolia: A population-based study of a Chinese ethnic minority","volume":"90","author":"Wang","year":"2018","journal-title":"J. Med. Virol."},{"key":"ref_28","first-page":"947","article-title":"Genotyping of human papillomavirus from 26.385 cases of cervical cells in Hebei","volume":"30","author":"Xu","year":"2018","journal-title":"Chin. J. Microecol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-019-4313-8","article-title":"Characteristics of women infected with human papillomavirus in a tertiary hospital in Beijing China, 2014\u20132018","volume":"19","author":"Ma","year":"2019","journal-title":"BMC Infect. Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bmjopen-2016-014135","article-title":"Prevalence characteristics of cervical human papillomavirus (HPV) genotypes in the Taizhou area, China: A cross-sectional study of 37.967 women from the general population","volume":"7","author":"Xu","year":"2017","journal-title":"BMJ Open"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12985-020-01352-8","article-title":"Prevalence characteristics of cervical human papillomavirus (HPV) infection in the Zhoupu District, Shanghai City, China","volume":"17","author":"Li","year":"2020","journal-title":"Virol. J."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Jiang, L., Tian, X., Peng, D., Zhang, L., Xie, F., Bi, C., Wang, R., Wang, J., and Qi, D. (2019). HPV prevalence and genotype distribution among women in Shandong Province, China: Analysis of 94.489 HPV genotyping results from Shandong\u2019s largest independent pathology laboratory. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0210311"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jiph.2017.01.011","article-title":"Prevalence of human papillomavirus infection among 71.435 women in Jiangxi Province, China","volume":"10","author":"Zhong","year":"2017","journal-title":"J. Infect. Public Health"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12985-019-1175-z","article-title":"Distribution of human papillomavirus infection: A population-based study of cervical samples from Jiangsu Province","volume":"16","author":"Zhang","year":"2019","journal-title":"Virol. J."},{"key":"ref_35","first-page":"1","article-title":"Epidemiology of humanpapilloma virus infection among women in Fujian, China","volume":"18","author":"Wu","year":"2017","journal-title":"BMC Public Health"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/jmv.25365","article-title":"Cervical human papillomavirus among 19.753 women attending gynecological department of a major comprehensive hospital in north Anhui China 2013\u20132016: Implication for cervical cancer screening and prevention","volume":"91","author":"Liu","year":"2019","journal-title":"J. Med. Virol."},{"key":"ref_37","first-page":"235","article-title":"Analysis of the current situation of human ppilloma virus infection among 12.459 women in Changsha City","volume":"5","author":"Li","year":"2015","journal-title":"Anti Tumor Pharm."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e22581","DOI":"10.1002\/jcla.22581","article-title":"Distribution characteristics of different human papillomavirus genotypes in women in Wuhan, China","volume":"32","author":"Xiang","year":"2018","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.4238\/2015.May.22.15","article-title":"Prevalence and genotype distribution of human papillomavirus in women in the Henan Province","volume":"14","author":"Zhi","year":"2015","journal-title":"Genet. Mol. Res."},{"key":"ref_40","first-page":"1589","article-title":"Epidemiological status of cervical HPV infection in women in Shaanxi province","volume":"28","author":"Zhang","year":"2017","journal-title":"Chin. J. Woman Child Health Res."},{"key":"ref_41","unstructured":"Ji, H. (2016). The Analysis of Human Papillomavirus Genotype of Han, Tibetan and Hui Women Living in Qinghai Area, Qinghai University."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1002\/jmv.24029","article-title":"Prevalence and genotype distribution of human papillomavirus infection in asymptomatic women in Liaoning province, China","volume":"87","author":"Xue","year":"2015","journal-title":"J. Med. Virol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0230640","article-title":"HPV genotypic spectrum in Jilin province, China, where non-vaccine-covered HPV53 and 51 are prevalent, exhibits a bimodal agespecific pattern","volume":"15","author":"Hao","year":"2020","journal-title":"PLoS ONE"},{"key":"ref_44","first-page":"223","article-title":"Analysis of HPV typing results in 24.597 women screened for cervical cancer in Heilongjiang Province","volume":"7","author":"Ma","year":"2019","journal-title":"Chin. J. Clin. Lab. Manag."},{"key":"ref_45","first-page":"1","article-title":"Prevalence of human papillomavirus infection and its correlation with age and cervical cytology results in Hong Kong","volume":"15","author":"Chau","year":"2018","journal-title":"J. Hong Kong Inst. Med. Lab. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"104","DOI":"10.15430\/JCP.2016.21.2.104","article-title":"Human papillomavirus prevalence and type distribution among 968 women in South Korea","volume":"21","author":"So","year":"2016","journal-title":"J. Cancer Prev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3802\/jgo.2018.29.e14","article-title":"Prevalence of human papillomavirus genotypes and precancerous cervical lesions in a screening population in the republic of Korea, 2014\u20132016","volume":"29","author":"Ouh","year":"2018","journal-title":"J. Gynecol. Oncol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3343\/alm.2017.37.5.426","article-title":"Human papillomavirus genotype distribution among 18.815 Women in 13 Korean cities and relationship with cervical cytology findings","volume":"37","author":"Nah","year":"2017","journal-title":"Ann. Lab. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijid.2018.09.018","article-title":"Human papillomavirus genotyping among women with cervical abnormalities in Ulaanbaatar, Mongolia","volume":"77","author":"Tsedenbal","year":"2018","journal-title":"Int. J. Infect. Dis."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Imai, H., Nakao, H., Shinohara, H., Watarai, M., Matsumoto, N., Yamagishi, T., Saito, M., and Kitamura, T. (2015). Prevalence, potential predictors, and genotype-specific prevalence of human papillomavirus infection among sexually active students in Japan. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0132462"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/jmv.24323","article-title":"Population-based study for human papillomavirus (HPV) infection in young women in Japan: A multicenter study by the Japanese human papillomavirus disease education research survey group (J-HERS)","volume":"88","author":"Sasagawa","year":"2016","journal-title":"J. Med. Virol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/odi.13221","article-title":"The prevalence of oral high-risk HPV infection in Indonesian oral squamous cell carcinoma patients","volume":"26","author":"Purwanto","year":"2020","journal-title":"Oral Dis."},{"key":"ref_53","first-page":"2807","article-title":"High prevalence of human papillomavirus types 56 and 70 identified in the native populations of Sabah, Malaysia","volume":"19","author":"Sainei","year":"2018","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"20171268","DOI":"10.1042\/BSR20171268","article-title":"Prevalence and type distribution of human papillomavirus (HPV) in Malaysian women with and without cervical cancer: An updated estimate","volume":"38","author":"Tan","year":"2018","journal-title":"Biosci. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1136\/sextrans-2017-053320","article-title":"Prevalence and sociodemographic correlates of cervicovaginal human papillomavirus (HPV) carriage in a cross-sectional, multiethnic, community-based female Asian population","volume":"94","author":"Khoo","year":"2018","journal-title":"Sex. Transm. Infect."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Marks, M.A., Gupta, S., Liaw, K.-L., Tadesse, A., Kim, E., Phongnarisorn, C., Wootipoom, V., Yuenyao, P., Vipupinyo, C., and Rugpao, S. (2015). Prevalence and correlates of HPV among women attending family-planning clinics in Thailand. BMC Infect. Dis., 15.","DOI":"10.1186\/s12879-015-0886-z"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13027-015-0001-5","article-title":"Genotypic distribution of human papillomavirus (HPV) and cervical cytology findings in 5906 Thai women undergoing cervical cancer screening programs","volume":"10","author":"Kantathavorn","year":"2015","journal-title":"Infect. Agent. Cancer"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/aogs.13036","article-title":"Prevalence of human papillomavirus infection among women in rural Nepal","volume":"96","author":"Shakya","year":"2017","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Thapa, N., Maharjan, M., Shrestha, G., Maharjan, N., Petrini, M.A., Zuo, N., He, C., Yang, J., Xu, M., and Ge, C. (2018). Prevalence and type-specific distribution of human papillomavirus infection among women in mid-western rural, Nepal\u2014A population-based study. BMC Infect. Dis., 18.","DOI":"10.1186\/s12879-018-3175-9"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1177\/0956462414552813","article-title":"Prevalence of Trichomonas vaginalis, Chlamydia trachomatis, Neisseria gonorrhoeae and human papillomavirus in a sexual health clinic setting in urban Sri Lanka","volume":"26","author":"Samarawickrema","year":"2015","journal-title":"Int. J. STD AIDS"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/jmv.25331","article-title":"Prevalence characteristics of single and multiple HPV infections in women with cervical cancer and precancerous lesions in Beijing, China","volume":"91","author":"Li","year":"2019","journal-title":"J. Med. Virol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MD.0000000000002555","article-title":"Prevalence of human papillomavirus genotypes among women with high-grade cervical lesions in Beijing, China","volume":"95","author":"Xiao","year":"2016","journal-title":"Medicine"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/jmv.24094","article-title":"Prevalence of human papillomavirus and its genotype among 1336 invasive cervical cancer patients in Hunan province, central south China","volume":"87","author":"Wang","year":"2015","journal-title":"J. Med. Virol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcla.22708","article-title":"Prevalence and distribution of human papillomavirus genotypes among women with high-grade squamous intraepithelial lesion and invasive cervical cancer in Ganzhou, China","volume":"33","author":"Liao","year":"2019","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jiph.2017.06.012","article-title":"The distribution of human papillomavirus genotypes in cervical cancer and intraepithelial neoplasia lesions among Chinese women in Yunnan Province","volume":"11","author":"Yuanyue","year":"2018","journal-title":"J. Infect. Public Health"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Lau, Y.M., Cheung, T.H., Yeo, W., Mo, F., Yu, M.Y., Lee, K.M., Ho, W.C.S., Yeung, A.C.M., Law, P.T.Y., and Chan, P.K.S. (2015). Prognostic implication of human papillomavirus types and species in cervical cancer patients undergoing primary treatment. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0122557"},{"key":"ref_67","first-page":"293","article-title":"Prevalence and attribution of high-risk HPV in different histological types of cervical cancer","volume":"54","author":"Wang","year":"2019","journal-title":"Chin. J. Obstet. Gynecol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1002\/jmv.25553","article-title":"Clustering patterns of type-type combination in multiple genotypes infections of human papillomavirus in cervical adenocarcinoma","volume":"91","author":"Dong","year":"2019","journal-title":"J. Med. Virol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1007\/s00404-020-05787-w","article-title":"Prevalence and distribution of human papillomavirus genotypes in cervical intraepithelial neoplasia in China: A meta-analysis","volume":"302","author":"Zhang","year":"2020","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"15386","DOI":"10.18632\/oncotarget.24169","article-title":"Prevalence of human papillomavirus genotypes and relative risk of cervical cancer in China: A systematic review and metaanalysis","volume":"9","author":"Xu","year":"2018","journal-title":"Oncotarget"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/ijc.33251","article-title":"Role of human papillomavirus status after conization for high-grade cervical intraepithelial neoplasia","volume":"148","author":"Huang","year":"2021","journal-title":"Int. J. Cancer"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3802\/jgo.2019.30.e52","article-title":"Human papillomavirus genotype-specific risk in cervical carcinogenesis","volume":"30","author":"So","year":"2019","journal-title":"J. Gynecol. Oncol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ygyno.2017.11.003","article-title":"Prognostic value of pre-treatment human papilloma virus DNA status in cervical cancer","volume":"148","author":"Chong","year":"2018","journal-title":"Gynecol. Oncol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1111\/cas.14445","article-title":"Human papillomavirus genotype contribution to cervical cancer and precancer: Implications for screening and vaccination in Japan","volume":"111","author":"Onuki","year":"2020","journal-title":"Cancer Sci."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Khunamornpong, S., Settakorn, J., Sukpan, K., Suprasert, P., Srisomboon, J., Intaraphet, S., and Siriaunkgul, S. (2016). Genotyping for human papillomavirus (HPV) 16\/18\/52\/58 has a higher performance than HPV16\/18 genotyping in triaging women with positive high-risk HPV test in Northern Thailand. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0158184"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-017-3900-6","article-title":"Cervical cytology and human papillomavirus among asymptomatic healthy volunteers in Vientiane, Lao PDR","volume":"17","author":"Takamatsu","year":"2017","journal-title":"BMC Cancer"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-016-2136-4","article-title":"HPV genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India","volume":"17","author":"Senapati","year":"2017","journal-title":"BMC Infect. Dis."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"8187","DOI":"10.7314\/APJCP.2015.16.18.8187","article-title":"Detection of high-risk human papillomaviruses in the prevention of cervical cancer in India","volume":"16","author":"Baskaran","year":"2016","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13027-018-0176-7","article-title":"Human papillomavirus genotype distribution in cervical cancer biopsies from Nepalese women","volume":"13","author":"Sah","year":"2018","journal-title":"Infect. Agent. Cancer"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-14-116","article-title":"Human papillomavirus prevalence and type-distribution in women with cervical lesions: A cross-sectional study in Sri Lanka","volume":"14","author":"Karunaratne","year":"2014","journal-title":"BMC Cancer"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.31557\/APJCP.2020.21.6.1679","article-title":"Characteristics and impact of HPV-associated p16 expression on head and neck squamous cell carcinoma in Thai patients","volume":"21","author":"Jiarpinitnun","year":"2020","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_82","first-page":"2192","article-title":"High risk HPV detection by RNAscope in situ hybridization combined with Cdc2 protein expression by immunohistochemistry for prognosis of oropharyngeal squamous cell carcinoma","volume":"13","author":"Yang","year":"2020","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Ni, G., Huang, K., Luan, Y., Cao, Z., Chen, S., Ma, B., Yuan, J., Wu, X., Chen, G., and Wang, T. (2019). Human papillomavirus infection among head and neck squamous cell carcinomas in southern China. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0221045"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.oooo.2016.06.006","article-title":"Low prevalence of transcriptionally active human papilloma virus in Indian patients with HNSCC and leukoplakia","volume":"122","author":"Bhosale","year":"2016","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"86730","DOI":"10.18632\/oncotarget.13502","article-title":"High-risk HPV genotypes and P16INK4a expression in a cohort of head and neck squamous cell carcinoma patients in Singapore","volume":"7","author":"Tan","year":"2016","journal-title":"Oncotarget"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/lary.25728","article-title":"Human papillomavirus infection on initiating synchronous esophageal neoplasia in patients with head and neck cancer","volume":"126","author":"Wang","year":"2016","journal-title":"Laryngoscope"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00430-017-0502-5","article-title":"Human papilloma virus (HPV) infection leads to the development of head and neck lesions but offers better prognosis in malignant Indian patients","volume":"206","author":"Sarkar","year":"2017","journal-title":"Med. Microbiol. Immunol."},{"key":"ref_88","first-page":"1325","article-title":"Detection of human papilloma virus and risk factors among patients with head and neck squamous cell carcinoma attending a tertiary referral centre in South India","volume":"19","author":"Bandhary","year":"2018","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/ijc.30712","article-title":"Role of mucosal high-risk human papillomavirus types in head and neck cancers in central India","volume":"141","author":"Gheit","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/cam4.983","article-title":"Characterization of key transcription factors as molecular signatures of HPV-positive and HPV-negative oral cancers","volume":"6","author":"Verma","year":"2017","journal-title":"Cancer Med."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s13193-016-0559-4","article-title":"Human papilloma virus in oral cavity cancer and relation to change in quality of life following treatment\u2014A pilot study from Northern India","volume":"7","author":"Singh","year":"2016","journal-title":"Indian J. Surg. Oncol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4103\/2278-330X.195337","article-title":"Detection of human papilloma virus in potentially malignant and malignant lesions of the oral cavity and a study of associated risk factors","volume":"5","author":"Bijina","year":"2016","journal-title":"South Asian J. Cancer"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/odi.12382","article-title":"Detection of active human papilloma virus-16 in head and neck cancers of Asian North Indian patients","volume":"22","author":"Sannigrahi","year":"2016","journal-title":"Oral Dis."},{"key":"ref_94","first-page":"EC04","article-title":"Analysis of human papilloma virus 16\/18 dna and its correlation with p16 expression in oral cavity squamous cell carcinoma in North-Eastern India: A chromogenic in-situ hybridization based study","volume":"9","author":"Jitani","year":"2015","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4103\/0975-5950.183857","article-title":"Human papillomavirus 16 and 18 in squamous cell carcinoma of oral cavity and sexual practices: A pilot study at a Tertiary Care Hospital of North India","volume":"6","author":"Parshad","year":"2015","journal-title":"Natl. J. Maxillofac. Surg."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"7077","DOI":"10.7314\/APJCP.2015.16.16.7077","article-title":"Do human papilloma viruses play any role in oral squamous cell carcinoma in North Indians","volume":"16","author":"Singh","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13027-015-0007-z","article-title":"A shifting paradigm in the aetiology of oral and pharyngeal cancer in Sri Lanka: A case-control study providing serologic evidence for the role of oncogenic HPV types 16 and 18","volume":"10","author":"Gunasekera","year":"2015","journal-title":"Infect. Agent. Cancer"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1017\/S0022215118000361","article-title":"Correlation of human papillomavirus infection and clinical parameters with five-year survival in oral squamous cell carcinoma","volume":"132","author":"Ali","year":"2018","journal-title":"J. Laryngol. Otol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ijid.2018.02.003","article-title":"Human papilloma virus 16\/18: Fabricator of trouble in oral squamous cell carcinoma","volume":"69","author":"Baig","year":"2018","journal-title":"Int. J. Infect. Dis."},{"key":"ref_100","first-page":"e8601","article-title":"p16 Immunohistochemical expression in head and neck squamous cell carcinoma: Association with prognostic parameters","volume":"12","author":"Hashmi","year":"2020","journal-title":"Cureus"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Shaikh, M.H., Khan, A.I., Sadat, A., Chowdhury, A.H., Jinnah, S.A., Gopalan, V., Lam, A.K., Clarke, D.T.W., McMillan, N.A.J., and Johnson, N.W. (2017). Prevalence and types of high-risk human papillomaviruses in head and neck cancers from Bangladesh. BMC Cancer, 17.","DOI":"10.1186\/s12885-017-3789-0"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Kumar, R., Rai, A.K., Das, D., Das, R., Kumar, R.S., Sarma, A., Sharma, S., Kataki, A.C., and Ramteke, A. (2015). Alcohol and tobacco increases risk of high risk HPV infection in head and neck cancer patients: Study from North-East region of India. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0140700"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Albano, P.M., Holzinger, D., Salvador, C., Orosa, J., Racelis, S., Lea\u00f1o, M., Sanchez, D., Angeles, L.M., Halec, G., and Schmitt, M. (2017). Low prevalence of human papillomavirus in head and neck squamous cell carcinoma in the northwest region of the Philippines. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0172240"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/7498706","article-title":"HPV infection and prognostic factors of tongue squamous cell carcinoma in different ethnic groups from geographically closed cohort in Xinjiang, China","volume":"2016","author":"Zhang","year":"2016","journal-title":"Biochem. Res. Int."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/4980396","article-title":"Prevalence of sexually transmitted infections among married women in rural Nepal","volume":"2018","author":"Shakya","year":"2018","journal-title":"Infect. Dis. Obstet. Gynecol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.1016\/S2214-109X(19)30482-6","article-title":"Estimates of incidence and mortality of cervical cancer in 2018: A worldwide analysis","volume":"8","author":"Arbyn","year":"2020","journal-title":"Lancet Glob. Health"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/ijc.31937","article-title":"Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods","volume":"144","author":"Ferlay","year":"2019","journal-title":"Int. J. Cancer"},{"key":"ref_108","unstructured":"Bruni, L., Albero, G., Serrano, B., Mena, M., Gomez, D., Munoz, J., Bosch, F., and de Sanjose, S. (2019). Human Papillomavirus and Related Disease in the World, ICO\/IARC Information Centre on Papillomavirus (HPV) and Cancer."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Loya, A., Serrano, B., Rasheed, F., Tous, S., Hassan, M., Clavero, O., Raza, M., de Sanjos\u00e9, S., Bosch, F., and Alemany, L. (2016). Human papillomavirus genotype distribution in invasive cervical cancer in Pakistan. Cancers, 8.","DOI":"10.3390\/cancers8080072"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.31557\/APJCP.2019.20.11.3269","article-title":"Prevalence of human papilloma virus sub genotypes following head and neck squamous cell carcinomas in Asian continent, a systematic review article","volume":"20","author":"Bukhari","year":"2019","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_111","unstructured":"(2010). Human Papillomavirus Laboratory Manual, World Health Organization. [1st ed.]."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12985-018-1003-x","article-title":"HPV-16, HPV-58, and HPV-33 are the most carcinogenic HPV genotypes in Southwestern China and their viral loads are associated with severity of premalignant lesions in the cervix","volume":"15","author":"Long","year":"2018","journal-title":"Virol. J."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/cncr.31031","article-title":"Human papillomavirus and World Health Organization type III nasopharyngeal carcinoma: Multicenter study from an endemic area in Southern China","volume":"124","author":"Huang","year":"2018","journal-title":"Cancer"},{"key":"ref_114","first-page":"1505","article-title":"Clinical efficacy of cryotherapy combined with interferon in the treatment of chronic cervicitis complicated with HPV infection","volume":"30","author":"Su","year":"2017","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Le, H.H.L., Bi, X., Ishizaki, A., van Le, H., Nguyen, T.V., and Ichimura, H. (2019). Low concordance of oral and genital HPV infection among male patients with sexually transmitted infections in Vietnam. BMC Infect. Dis., 19.","DOI":"10.1186\/s12879-019-4175-0"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1038\/emi.2016.118","article-title":"Human papillomavirus prevalence and associated factors in women and men in south China: A population-based study","volume":"5","author":"Wei","year":"2016","journal-title":"Emerg. Microbes Infect."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/OLQ.0000000000000564","article-title":"Genital human papillomavirus infection in Indian HIV-seropositive men who have sex with men","volume":"44","author":"Raghavendran","year":"2017","journal-title":"Sex. Transm. Dis."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e117","DOI":"10.1017\/S0950268818003205","article-title":"Prevalence and genotypes of anal human papillomavirus infection among HIV-positive vs. HIV-negative men in Taizhou, China","volume":"147","author":"Liu","year":"2019","journal-title":"Epidemiol. Infect."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/jmv.25255","article-title":"Prevalence and distribution of cervical human papillomavirus genotypes in women with cytological results from Sichuan province, China","volume":"91","author":"Li","year":"2019","journal-title":"J. Med. Virol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jcv.2019.03.005","article-title":"Liquid biopsy of HPV DNA in cervical cancer","volume":"114","author":"Cheung","year":"2019","journal-title":"J. Clin. Virol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"e17087","DOI":"10.1097\/MD.0000000000017087","article-title":"Characteristics of carcinogenic HPV genotypes in North China Plain and the association with cervical lesions","volume":"98","author":"Liu","year":"2019","journal-title":"Medicine"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.tjog.2019.05.008","article-title":"Comparison of detection rate of high risk HPV infection between self-collected HPV testing and clinician-collected HPV testing in cervical cancer screening","volume":"58","author":"Nutthachote","year":"2019","journal-title":"Taiwan.J. Obstet. Gynecol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1097\/NCC.0000000000000241","article-title":"Evaluation of the impact of human papillomavirus DNA self-sampling on the uptake of cervical cancer screening","volume":"39","author":"Wong","year":"2016","journal-title":"Cancer Nurs."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"e3910","DOI":"10.7717\/peerj.3910","article-title":"Comparison of human papillomavirus (HPV) detection in urine and cervical swab samples using the HPV GenoArray diagnostic assay","volume":"5","author":"Nilyanimit","year":"2017","journal-title":"PeerJ"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12985-017-0744-2","article-title":"Evaluation of the performance of human papillomavirus testing in paired urine and clinician-collected cervical samples among women aged over 30 years in Bhutan","volume":"14","author":"Tshomo","year":"2017","journal-title":"Virol. J."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/ijc.30092","article-title":"Urine testing to monitor the impact of HPV vaccination in Bhutan and Rwanda","volume":"139","author":"Franceschi","year":"2016","journal-title":"Int. J. Cancer"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"336","DOI":"10.4103\/ijc.IJC_188_18","article-title":"Prevalence and nonsexual transmission of human papilloma virus (HPV) in the adolescence girls from rural area of Maharashtra state, India","volume":"55","author":"Budukh","year":"2018","journal-title":"Indian J. Cancer"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/CEJ.0000000000000387","article-title":"Menstrual pad, a cervical cancer screening tool, a population-based study in rural India","volume":"27","author":"Budukh","year":"2018","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.3802\/jgo.2019.30.e17","article-title":"Cost effectiveness analysis of HPV primary screening and dual stain cytology triage compared with cervical cytology","volume":"30","author":"Termrungruanglert","year":"2019","journal-title":"J. Gynecol. Oncol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.anl.2016.07.015","article-title":"The influence of human papillomavirus on nasopharyngeal carcinoma in Japan","volume":"44","author":"Kano","year":"2017","journal-title":"Auris Nasus Larynx"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1002\/jmv.21826","article-title":"Prevalence and genotype distribution of cervical human papillomavirus infection in Macao","volume":"82","author":"Yip","year":"2010","journal-title":"J. Med. Virol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1525-1578(10)60499-0","article-title":"Performance assessment of eight high-throughput PCR assays for viral load quantitation of oncogenic HPV types","volume":"6","author":"Siegel","year":"2004","journal-title":"J. Mol. Diagn."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/j.prp.2018.08.032","article-title":"Human papillomavirus in tonsillectomy specimen from China and Pakistan\u2014Prevalence and genotype distribution","volume":"214","author":"Mujtaba","year":"2018","journal-title":"Pathol. Res. Pract."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/LGT.0000000000000408","article-title":"The variable characteristics of human papillomavirus in squamous cell carcinoma and adenocarcinoma of cervix in China","volume":"22","author":"Chen","year":"2018","journal-title":"J. Low. Genit. Tract Dis."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000497351","article-title":"Human papillomavirus in Thai women and men with anogenital warts","volume":"61","author":"Nilyanimit","year":"2019","journal-title":"Intervirology"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/jop.12800","article-title":"Prevalence of human papillomavirus in oral rinse samples from healthy individuals in northern Thailand","volume":"48","author":"Bumrungthai","year":"2019","journal-title":"J. Oral Pathol. Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4103\/0971-5916.178614","article-title":"Prevalence of human papillomavirus infection and cervical abnormalities in HIV-positive women in eastern India","volume":"143","author":"Chakravarty","year":"2016","journal-title":"Indian J. Med. Res."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1093\/jjco\/hyu112","article-title":"Human papillomavirus genotype distribution in cervical intraepithelial neoplasia grade 2\/3 and invasive cervical cancer in Japanese women","volume":"44","author":"Azuma","year":"2014","journal-title":"Jpn. J. Clin. Oncol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1111\/jog.13968","article-title":"Development and evaluation of a cervical cancer screening system in Cambodia: A collaborative project of the Cambodian Society of Gynecology and Obstetrics and Japan Society of Obstetrics and Gynecology","volume":"45","author":"Ueda","year":"2019","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Naizhaer, G., Yuan, J., Mijiti, P., Aierken, K., Abulizi, G., and Qiao, Y. (2020). Evaluation of multiple screening methods for cervical cancers in rural areas of Xinjiang, China. Medicine, 99.","DOI":"10.1097\/MD.0000000000019135"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"e13201","DOI":"10.1097\/MD.0000000000013201","article-title":"Human papillomavirus prevalence and behavioral risk factors among HIV-infected and HIV-uninfected men who have sex with men in Taiwan","volume":"97","author":"Lin","year":"2018","journal-title":"Medicine"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3855\/jidc.11162","article-title":"Human papillomavirus infection and anal cytology in Taiwanese homosexual men with and without HIV infection","volume":"13","author":"Wang","year":"2019","journal-title":"J. Infect. Dev. Ctries."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"5843","DOI":"10.7314\/APJCP.2013.14.10.5843","article-title":"HPV genotyping linear assay test comparison in cervical cancer patients: Implications for HPV prevalence and molecular epidemiology in a limited-resource area in Bandung, Indonesia","volume":"14","author":"Panigoro","year":"2013","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1002\/jmv.25025","article-title":"Comparison of the digene hybrid capture 2 and Roche cobas 4800 HPV tests for detection of CIN2+ in a referral population in Japan","volume":"90","author":"Sasagawa","year":"2018","journal-title":"J. Med. Virol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S2055-6640(20)30063-7","article-title":"The feasibility and acceptability of self-sampling and HPV testing using cepheid Xpert\u00ae HPV in a busy primary care facility","volume":"5","author":"Woo","year":"2019","journal-title":"J. Virus Erad."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ygyno.2003.12.015","article-title":"Prevalence of single and multiple HPV types in cervical carcinomas in Jakarta, Indonesia","volume":"93","author":"Schellekens","year":"2004","journal-title":"Gynecol. Oncol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/sj.bjc.6604417","article-title":"Prevalence of human papillomavirus in Indonesia: A population-based study in three regions","volume":"99","author":"Vet","year":"2008","journal-title":"Br. J. Cancer"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"387","DOI":"10.4103\/0019-509X.200668","article-title":"Human papillomavirus\/p16 positive head and neck cancer in India: Prevalence, clinical impact, and influence of tobacco use","volume":"53","author":"Murthy","year":"2016","journal-title":"Indian J. Cancer"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1002\/jmv.21847","article-title":"Distribution of human papillomavirus genotypes among cervical intraepithelial neoplasia and invasive cancers in Macao","volume":"82","author":"Hlaing","year":"2010","journal-title":"J. Med. Virol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.cmi.2020.03.033","article-title":"Commercially available molecular tests for human papillomaviruses: A global overview","volume":"26","author":"Poljak","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"5934","DOI":"10.1128\/JVI.78.11.5934-5945.2004","article-title":"Human papillomavirus type 16 E6 amino acid 83 variants enhance E6-mediated MAPK signaling and differentially regulate tumorigenesis by notch signaling and oncogenic ras","volume":"78","author":"Chakrabarti","year":"2004","journal-title":"J. Virol."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Zhao, P., Liu, S., Zhong, Z., Hou, J., Lin, L., Weng, R., Su, L., Lei, N., Hou, T., and Yang, H. (2018). Prevalence and genotype distribution of human papillomavirus infection among women in northeastern Guangdong Province of China. BMC Infect. Dis., 18.","DOI":"10.1186\/s12879-018-3105-x"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Chuerduangphui, J., Proyrungroj, K., Pientong, C., Hinkan, S., Budkaew, J., Pimson, C., Chumworathayi, B., Hanond, P., and Ekalaksananan, T. (2018). Prevalence and anatomical sites of human papillomavirus, Epstein-Barr virus and herpes simplex virus infections in men who have sex with men, Khon Kaen, Thailand. BMC Infect. Dis., 18.","DOI":"10.1186\/s12879-018-3406-0"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Yuan, X., Li, Y.-J., Qiu, Q., Luo, Z., and Zhao, X. (2019). Prevalence and genotype distribution of human papillomavirus among 9945 women from the Nanhai area of Foshan. BMC Infect. Dis., 19.","DOI":"10.1186\/s12879-019-3687-y"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Li, J., Wang, Y.Y., Nan, X., Tian, X.F., Yan, T., Wang, P., Yin, Y., Liu, Y., Yuan, R., and Wang, G.Q. (2016). Prevalence of human papillomavirus genotypes among women with cervical lesions in the Shaanxi Province of China. Genet. Mol. Res., 15.","DOI":"10.4238\/gmr.15017181"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"419","DOI":"10.7883\/yoken.JJID.2018.206","article-title":"Human papillomavirus genotypes and hpv16 e6\/e7 variants among patients with genital cancers in Vietnam","volume":"71","author":"Pham","year":"2018","journal-title":"Jpn. J. Infect. Dis."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/1751-2980.12605","article-title":"Esophageal squamous cell carcinomas in a Malaysian cohort show a lack of association with human papillomavirus","volume":"19","author":"Cheah","year":"2018","journal-title":"J. Dig. Dis."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1128\/JCM.00989-09","article-title":"Evaluation of a newly developed GenoArray human papillomavirus (HPV) genotyping assay and comparison with the Roche linear array HPV genotyping assay","volume":"48","author":"Liu","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"28502","DOI":"10.18632\/oncotarget.16093","article-title":"Human papillomavirus subtypes distribution among 2309 cervical cancer patients in West China","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/jmv.24899","article-title":"Prevalence and genotype distribution of human papillomavirus among females in the suburb of Shanghai, China","volume":"90","author":"Zhang","year":"2018","journal-title":"J. Med. Virol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"62411","DOI":"10.18632\/oncotarget.11498","article-title":"Prevalence of human papillomavirus infection and genotyping for population-based cervical screening in developed regions in China","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"e17293","DOI":"10.1097\/MD.0000000000017293","article-title":"The prevalence and genotype distribution of human papillomaviruses among women in Taizhou, China","volume":"98","author":"Jin","year":"2019","journal-title":"Medicine"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"96","DOI":"10.7883\/yoken.JJID.2019.181","article-title":"Prevalence and genotype distribution of high-risk human papillomavirus among chinese women in Sichuan Province","volume":"73","author":"Li","year":"2020","journal-title":"Jpn. J. Infect. Dis."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"572","DOI":"10.15537\/smj.2018.6.22132","article-title":"Genotype patterns and prevalence of human papilloma virus in non-vaccinated women in Zunyi, China","volume":"39","author":"Zhao","year":"2018","journal-title":"Saudi Med. J."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1128\/jcm.34.3.745-747.1996","article-title":"Comprehensive study of several general and type-specific primer pairs for detection of human papillomavirus DNA by PCR in paraffin-embedded cervical carcinomas","volume":"34","author":"Baay","year":"1996","journal-title":"J. Clin. Microbiol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/infdis\/jiy160","article-title":"Prevalence and epidemiologic profile of oral infection with alpha, beta, and gamma papillomaviruses in an asian Chinese population","volume":"218","author":"Wong","year":"2018","journal-title":"J. Infect. Dis."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jfma.2018.03.013","article-title":"Prevalence of current oral HPV infection among 100 betel nut chewers or cigarette smokers in Northern Taiwan","volume":"118","author":"Wang","year":"2019","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jmii.2018.02.002","article-title":"Human papillomavirus infection is not associated with laryngeal squamous cell carcinoma in Taiwan","volume":"53","author":"Huang","year":"2020","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3346\/jkms.2014.29.1.32","article-title":"Human papillomavirus prevalence and genotype distribution among HIV-infected women in Korea","volume":"29","author":"Park","year":"2014","journal-title":"J. Korean Med. Sci."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"12556","DOI":"10.1038\/s41598-019-49060-w","article-title":"Carcinogenic risk of human papillomavirus (HPV) genotypes and potential effects of HPV vaccines in Korea","volume":"9","author":"Park","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.pvr.2018.10.001","article-title":"Single type infection of human papillomavirus as a cause for high-grade cervical intraepithelial neoplasia and invasive cancer in Japan","volume":"6","author":"Sakamoto","year":"2018","journal-title":"Papillomavirus Res."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/jmv.25611","article-title":"The prevalence of VAIN, CIN, and related HPV genotypes in Japanese women with abnormal cytology","volume":"92","author":"Zhang","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"169","DOI":"10.2174\/1874357901004010169","article-title":"Comparison of the DiagCor GenoFlow human papillomavirus array test and roche linear array HPV genotyping test","volume":"4","author":"Wong","year":"2015","journal-title":"Open Virol. J."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Nopmaneepaisarn, T., Tangjaturonrasme, N., Rawangban, W., Vinayanuwattikun, C., Keelawat, S., and Bychkov, A. (2019). Low prevalence of p16-positive HPV-related head-neck cancers in Thailand: Tertiary referral center experience. BMC Cancer, 19.","DOI":"10.1186\/s12885-019-6266-0"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1097\/OLQ.0000000000000372","article-title":"Prevalence of anal human papillomavirus vaccine types in the Bangkok men who have sex with men cohort study","volume":"42","author":"Cranston","year":"2015","journal-title":"Sex. Transm. Dis."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S2055-6640(20)31146-8","article-title":"Cervical cytological abnormalities and HPV infection in perinatally HIV-infected adolescents","volume":"1","author":"Ananworanich","year":"2015","journal-title":"J. Virus Erad."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s10552-019-01173-3","article-title":"Soy and tea intake on cervical cancer risk: The Singapore Chinese health study","volume":"30","author":"Paul","year":"2019","journal-title":"Cancer Causes Control"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1177\/0956462415587226","article-title":"Prevalence and concordance of human papillomavirus infection at multiple anatomic sites among HIV-infected women from Chennai, India","volume":"27","author":"Menezes","year":"2016","journal-title":"Int. J. STD AIDS"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1111\/tmi.13309","article-title":"DNA-HPV transition rate and related factors in HPV-infected women in Can Tho city, Vietnam","volume":"24","author":"Duong","year":"2019","journal-title":"Trop. Med. Int. Health"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1128\/JCM.40.3.779-787.2002","article-title":"GP5+\/6+ PCR followed by reverse line blot analysis enables rapid and high-throughput identification of human papillomavirus genotypes","volume":"40","author":"Pol","year":"2002","journal-title":"J. Clin. Microbiol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1373\/clinchem.2005.052381","article-title":"Multiplex human papillomavirus serology based on in situ-purified glutathione S-transferase fusion proteins","volume":"51","author":"Waterboer","year":"2005","journal-title":"Clin. Chem."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10544-020-00522-3","article-title":"Self-assembled silver nanoparticle-DNA on a dielectrode microdevice for determination of gynecologic tumors","volume":"22","author":"Li","year":"2020","journal-title":"Biomed. Microdevices"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12951-020-0577-9","article-title":"Early-stage cervical cancer diagnosis based on an ultra-sensitive electrochemical DNA nanobiosensor for HPV-18 detection in real samples","volume":"18","author":"Mahmoodi","year":"2020","journal-title":"J. Nanobiotechnol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.canep.2018.03.005","article-title":"Prevalence and age-wise distribution of human papillomavirus type 16\/18 infections among hospital screened women of a peri-urban area in West Bengal: Impact of socio-demographic factors","volume":"54","author":"Bhattacharya","year":"2018","journal-title":"Cancer Epidemiol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.meegid.2018.04.029","article-title":"Prevalence of human papilloma virus with risk of cervical cancer among south Indian women: A genotypic study with meta-analysis and molecular dynamics of HPV E6 oncoprotein","volume":"62","author":"Husain","year":"2018","journal-title":"Infect. Genet. Evol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1128\/JCM.00991-09","article-title":"Abundance of multiple high-risk human papillomavirus (HPV) infections found in cervical cells analyzed by use of an ultrasensitive HPV genotyping assay","volume":"48","author":"Schmitt","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/inthealth\/ihw015","article-title":"Spousal migration and human papillomavirus infection among women in rural western Nepal","volume":"8","author":"Johnson","year":"2016","journal-title":"Int. Health"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"888","DOI":"10.7326\/M20-2849","article-title":"Prevalence of human papillomavirus and estimation of human papillomavirus vaccine effectiveness in Thimphu, Bhutan, in 2011\u20132012 and 2018","volume":"173","author":"Baussano","year":"2020","journal-title":"Ann. Intern. Med."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"e016309","DOI":"10.1136\/bmjopen-2017-016309","article-title":"Cervical cancer screening in rural Bhutan with the care HPV test on self-collected samples: An ongoing cross-sectional, population-based study (REACH-Bhutan)","volume":"7","author":"Baussano","year":"2017","journal-title":"BMJ Open"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1128\/JCM.01064-12","article-title":"Comparison of PapType to digene hybrid capture 2, roche linear array, and amplicor for detection of high-risk human papillomavirus genotypes in women with previous abnormal pap smears","volume":"50","author":"Tabrizi","year":"2012","journal-title":"J. Clin. Microbiol."},{"key":"ref_191","first-page":"48","article-title":"Comparison of HPV genotyping assays and hybrid capture 2 for detection of high-risk HPV in cervical specimens","volume":"41","author":"Um","year":"2011","journal-title":"Ann. Clin. Lab. Sci."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.vaccine.2019.01.069","article-title":"Efficacy, safety, and immunogenicity of a quadrivalent HPV vaccine in Japanese men: A randomized, phase 3, placebo-controlled study","volume":"37","author":"Mikamo","year":"2019","journal-title":"Vaccine"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/S1473-3099(16)30120-7","article-title":"Efficacy, safety, and immunogenicity of the human papillomavirus 16\/18 AS04-adjuvanted vaccine in women older than 25 years: 7-year follow-up of the phase 3, double-blind, randomised controlled VIVIANE study","volume":"16","author":"Wheeler","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"14000","DOI":"10.1007\/s11356-018-1623-0","article-title":"Infections after photodynamic therapy in Condyloma acuminatum patients: Incidence and management","volume":"25","author":"Yu","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/jnci\/djz074","article-title":"Efficacy, safety, and immunogenicity of an escherichia coli-produced bivalent human papillomavirus vaccine: An interim analysis of a randomized clinical trial","volume":"112","author":"Qiao","year":"2020","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s12275-015-5150-0","article-title":"Therapeutic potential of an AcHERV-HPV L1 DNA vaccine","volume":"53","author":"Lee","year":"2015","journal-title":"J. Microbiol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1016\/j.drudis.2019.07.011","article-title":"Cervical cancer and HPV infection: Ongoing therapeutic research to counteract the action of E6 and E7 oncoproteins","volume":"24","author":"Almeida","year":"2019","journal-title":"Drug Discov. Today"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/gt.2017.38","article-title":"Coinjection of IL2 DNA enhances E7-specific antitumor immunity elicited by intravaginal therapeutic HPV DNA vaccination with electroporation","volume":"24","author":"Sun","year":"2017","journal-title":"Gene Ther."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1016\/S0140-6736(15)00239-1","article-title":"Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2\/3: A randomised, double-blind, placebo-controlled phase 2b trial","volume":"386","author":"Trimble","year":"2015","journal-title":"Lancet"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1080\/13697137.2019.1600500","article-title":"Recurrent disease after treatment for cervical pre-cancer: Determining whether prophylactic HPV vaccination could play a role in prevention of secondary lesions","volume":"22","author":"Velentzis","year":"2019","journal-title":"Climacteric"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ijgo.2015.07.038","article-title":"World Health Organization guidelines for treatment of cervical intraepithelial neoplasia 2\u20133 and screen-and-treat strategies to prevent cervical cancer","volume":"132","author":"Santesso","year":"2016","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.ajog.2007.07.050","article-title":"2006 consensus guidelines for the management of women with cervical intraepithelial neoplasia or adenocarcinoma in situ","volume":"197","author":"Wright","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ijgo.2009.09.012","article-title":"Cryotherapy for HPV clearance in women with biopsy-confirmed cervical low-grade squamous intraepithelial lesions","volume":"108","author":"Chumworathayi","year":"2010","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3802\/jgo.2009.20.2.91","article-title":"Factors associated with HPV persistence after conization in patients with negative margins","volume":"20","author":"Nam","year":"2009","journal-title":"J. Gynecol. Oncol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1067\/mob.2001.112589","article-title":"Value of human papillomavirus deoxyribonucleic acid testing after conization in the prediction of residual disease in the subsequent hysterectomy specimen","volume":"184","author":"Lin","year":"2001","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"72.e1","DOI":"10.1016\/j.ajog.2010.01.063","article-title":"Significance of human papillomavirus genotyping with high-grade cervical intraepithelial neoplasia treated by a loop electrosurgical excision procedure","volume":"203","author":"Kang","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Ghelardi, A., Marrai, R., Bogani, G., Sopracordevole, F., Bay, P., Tonetti, A., Lombardi, S., Bertacca, G., and Joura, E.A. (2021). Surgical treatment of vulvar HSIL: Adjuvant HPV vaccine reduces recurrent disease. Vaccines, 9.","DOI":"10.3390\/vaccines9020083"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ygyno.2013.04.050","article-title":"Is vaccination with quadrivalent HPV vaccine after loop electrosurgical excision procedure effective in preventing recurrence in patients with high-grade cervical intraepithelial neoplasia (CIN2\u20133)?","volume":"130","author":"Kang","year":"2013","journal-title":"Gynecol. Oncol."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Bogani, G., Raspagliesi, F., Sopracordevole, F., Ciavattini, A., Ghelardi, A., Simoncini, T., Petrillo, M., Plotti, F., Lopez, S., and Casarin, J. (2020). Assessing the long-term role of vaccination against hpv after loop electrosurgical excision procedure (Leep): A propensity-score matched comparison. Vaccines, 8.","DOI":"10.3390\/vaccines8040717"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jphotobiol.2019.03.012","article-title":"5-aminolevulinic acid photodynamic therapy reduces HPV viral load via autophagy and apoptosis by modulating Ras\/Raf\/MEK\/ERK and PI3K\/AKT pathways in HeLa cells","volume":"194","author":"Xie","year":"2019","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s10147-003-0354-4","article-title":"Eradication and reinfection of human papillomavirus after photodynamic therapy for cervical intraepithelial neoplasia","volume":"8","author":"Ichimura","year":"2003","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1002\/jmv.24281","article-title":"Human papillomavirus prevalence and genotypes distribution among female outpatients in Qingdao, East China","volume":"87","author":"Bi","year":"2015","journal-title":"J. Med. Virol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jfma.2016.03.005","article-title":"Induction chemotherapy with dose-modified docetaxel, cisplatin, and 5-fluorouracil in Asian patients with borderline resectable or unresectable head and neck cancer","volume":"116","author":"Wang","year":"2017","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"312","DOI":"10.4103\/jcrt.JCRT_889_17","article-title":"Nimotuzumab plus chemotherapy with docetaxel, cisplatin, 5-fluorouracil for locally advanced head and neck squamous cell carcinoma: A clinical study","volume":"15","author":"Wang","year":"2019","journal-title":"J. Cancer Res. Ther."},{"key":"ref_215","first-page":"CD012301","article-title":"Extended-field radiotherapy for locally advanced cervical cancer","volume":"10","author":"Thamronganantasakul","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1007\/s00066-017-1122-0","article-title":"Salvage-radiotherapie mit oder ohne gleichzeitige chemotherapie bei beckenrezidiv nach alleiniger hysterektomie im fr\u00fchen stadium des geb\u00e4rmutterhalskrebses","volume":"193","author":"Kim","year":"2017","journal-title":"Strahlenther. Onkologie"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.21873\/invivo.11652","article-title":"Local radiotherapy or chemotherapy for oligo-recurrent cervical cancer in patients with prior pelvic irradiation","volume":"33","author":"Kobayashi","year":"2019","journal-title":"In Vivo"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1002\/cncr.33062","article-title":"Optimization of therapeutic strategy for p16-positive oropharyngeal squamous cell carcinoma: Multi-institutional observational study based on the national head and neck cancer registry of Japan","volume":"126","author":"Saito","year":"2020","journal-title":"Cancer"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1007\/s10147-019-01394-1","article-title":"Radiotherapy alone as a possible de-intensified treatment for human papillomavirus-related locally advanced oropharyngeal squamous cell carcinoma","volume":"24","author":"Yamamoto","year":"2019","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"13404","DOI":"10.1038\/s41598-019-49771-0","article-title":"HPV-positive status associated with inflamed immune microenvironment and improved response to anti-PD-1 therapy in head and neck squamous cell carcinoma","volume":"9","author":"Wang","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1111\/cas.13480","article-title":"Pembrolizumab in Asia-Pacific patients with advanced head and neck squamous cell carcinoma: Analyses from KEYNOTE-012","volume":"109","author":"Tahara","year":"2018","journal-title":"Cancer Sci."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/hed.23707","article-title":"Platinum-based chemotherapy plus cetuximab first-line for Asian patients with recurrent and\/or metastatic squamous cell carcinoma of the head and neck: Results of an open-label, single-arm, multicenter trial","volume":"37","author":"Guo","year":"2015","journal-title":"Head Neck"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1111\/cas.14148","article-title":"Efficacy and safety of nivolumab in Japanese patients with uterine cervical cancer, uterine corpus cancer, or soft tissue sarcoma: Multicenter, open-label phase 2 trial","volume":"110","author":"Tamura","year":"2019","journal-title":"Cancer Sci."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.oraloncology.2018.04.008","article-title":"Nivolumab vs. investigator\u2019s choice in recurrent or metastatic squamous cell carcinoma of the head and neck: 2-year long-term survival update of CheckMate 141 with analyses by tumor PD-L1 expression","volume":"81","author":"Ferris","year":"2018","journal-title":"Oral Oncol."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"e173776","DOI":"10.1001\/jamaoncol.2017.3776","article-title":"Association of ipilimumab with safety and antitumor activity in women with metastatic or recurrent human papillomavirus-related cervical carcinoma","volume":"4","author":"Lheureux","year":"2018","journal-title":"JAMA Oncol."},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Cho, H.-W., Park, Y.-C., Sung, M.-H., Park, J.S., Kim, T.J., Seong, S.J., Cho, C.H., and Lee, J.K. (2019). Short-term clinical and immunologic effects of poly-gamma-glutamic acid (\u03b3-PGA) in women with cervical intraepithelial neoplasia 1 (CIN 1): A multicenter, randomized, double blind, phase II trial. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0217745"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3802\/jgo.2019.30.e88","article-title":"A phase 1\/2a, dose-escalation, safety and preliminary efficacy study of oral therapeutic vaccine in subjects with cervical intraepithelial neoplasia 3","volume":"30","author":"Park","year":"2019","journal-title":"J. Gynecol. Oncol."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.micinf.2015.10.004","article-title":"A randomized open-label clinical trial of an anti-HPV biological dressing (JB01-BD) administered intravaginally to treat high-risk HPV infection","volume":"18","author":"Guo","year":"2016","journal-title":"Microbes Infect."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/hiv.12432","article-title":"Human papillomavirus 16 (HPV16) and HPV52 E6-specific immunity in HIV-infected adults on combination antiretroviral therapy","volume":"18","author":"Leng","year":"2017","journal-title":"HIV Med."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jinf.2017.02.007","article-title":"Human papillomavirus infection and cervical lesions in HIV infected women on antiretroviral treatment in Thailand","volume":"74","author":"Delory","year":"2017","journal-title":"J. Infect."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/ijgo.13385","article-title":"REBACIN\u00ae is an optional intervention for persistent high-risk human papillomavirus infection: A retrospective analysis of 364 patients","volume":"152","author":"Yang","year":"2021","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s40261-018-0712-7","article-title":"Safety and plasma concentrations of a cyclin-dependent kinase 9 (CDK9) inhibitor, FIT039, administered by a single adhesive skin patch applied on normal skin and cutaneous warts","volume":"39","author":"Sumi","year":"2019","journal-title":"Clin. Drug Investig."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"e12836","DOI":"10.1111\/dth.12836","article-title":"Low dose isotretinoin as an adjuvant therapy for treatment of different clinical variants of warts: A case series","volume":"32","author":"Dave","year":"2019","journal-title":"Dermatol. Ther."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.anl.2016.01.005","article-title":"Intralesional cidofovir injection for recurrent respiratory papillomatosis in Japan","volume":"43","author":"Murono","year":"2016","journal-title":"Auris Nasus Larynx"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.pharep.2016.05.007","article-title":"Repositioning of anti-viral drugs as therapy for cervical cancer","volume":"68","author":"Sharma","year":"2016","journal-title":"Pharmacol. Rep."},{"key":"ref_236","doi-asserted-by":"crossref","unstructured":"Chauhan, N., Maher, D.M., Yallapu, M.M., Hafeez, B.B., Singh, M.M., Chauhan, S.C., and Jaggi, M. (2019). A triphenylethylene nonsteroidal SERM attenuates cervical cancer growth. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-46680-0"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"9089","DOI":"10.1007\/s13277-016-4789-4","article-title":"Mutation analysis of EGFR and its correlation with the HPV in Indian cervical cancer patients","volume":"37","author":"Qureshi","year":"2016","journal-title":"Tumor Biol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"e13065","DOI":"10.1111\/dth.13065","article-title":"Clinical efficacy of paiteling in the treatment of condyloma acuminatum infected with different subtypes of HPV","volume":"32","author":"Hu","year":"2019","journal-title":"Dermatol. Ther."},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Luo, M., Yu, J., Zhu, S., Huang, L., Chen, Y., and Wei, S. (2019). Detoxification therapy of traditional Chinese medicine for genital tract high-risk human papillomavirus infection: A systematic review and meta-analysis. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0213062"},{"key":"ref_240","doi-asserted-by":"crossref","unstructured":"Kwon, S.-B., Kim, M.-J., Yang, J.M., Lee, H.-P., Hong, J.T., Jeong, H.-S., Kim, E.S., and Yoon, D.-Y. (2016). Cudrania tricuspidata stem extract induces apoptosis via the extrinsic pathway in SiHa cervical cancer cells. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0150235"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1080\/21645515.2018.1547604","article-title":"Pleurotus ferulae polysaccharides improve the antitumor efficacy of therapeutic human papillomavirus dendritic cell-based vaccine","volume":"15","author":"Li","year":"2019","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_242","doi-asserted-by":"crossref","unstructured":"Shukla, D.P., Shah, K.P., Rawal, R.M., and Jain, N.K. (2016). Anticancer and cytotoxic potential of Turmeric (Curcuma longa), Neem (Azadirachta indica), Tulasi (Ocimum sanctum) and Ginger (Zingiber officinale) extracts on HeLa cell line. Int. J. Life Sci. Sci. Res., 2.","DOI":"10.21276\/ijlssr.2016.2.4.2"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jscs.2018.06.011","article-title":"Azadirachta indica leaves mediated green synthesized copper oxide nanoparticles induce apoptosis through activation of TNF-\u03b1 and caspases signaling pathway against cancer cells","volume":"23","author":"Dey","year":"2019","journal-title":"J. Saudi Chem. Soc."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"106332","DOI":"10.1016\/j.prostaglandins.2019.04.002","article-title":"Flax seed oil reduced tumor growth, modulated immune responses and decreased HPV E6 and E7 oncoprotein expression in a murine model of ectopic cervical cancer","volume":"143","author":"Deshpande","year":"2019","journal-title":"Prostaglandins Lipid Mediat."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.1038\/s41598-017-05696-0","article-title":"TALEN based HPV-E7 editing triggers necrotic cell death in cervical cancer cells","volume":"7","author":"Shankar","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s12038-020-00054-1","article-title":"CRISPR-mediated knockdown of miR-214 modulates cell fate in response to anti-cancer drugs in HPV-negative and HPV-positive cervical cancer cells","volume":"45","author":"Sen","year":"2020","journal-title":"J. Biosci."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/ijc.32709","article-title":"Effects of the antifungal agent ciclopirox in HPV-positive cancer cells: Repression of viral E6\/E7 oncogene expression and induction of senescence and apoptosis","volume":"146","author":"Braun","year":"2020","journal-title":"Int. J. Cancer"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1016\/j.ymthe.2018.07.019","article-title":"Nanoparticles based on poly (\u03b2-amino ester) and HPV16-targeting CRISPR\/shRNA as potential drugs for HPV16-related cervical malignancy","volume":"26","author":"Zhu","year":"2018","journal-title":"Mol. Ther."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1002\/ijc.27485","article-title":"Human papillomavirus types in 115.789 HPV-positive women: A meta-analysis from cervical infection to cancer","volume":"131","author":"Guan","year":"2012","journal-title":"Int. J. Cancer"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/ijc.25396","article-title":"Human papillomavirus type distribution in 30.848 invasive cervical cancers worldwide: Variation by geographical region, histological type and year of publication","volume":"128","author":"Li","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref_251","doi-asserted-by":"crossref","unstructured":"Chan, P.K.S., Ho, W.C.S., Chan, M.C.W., Wong, M.C.S., Yeung, A.C.M., Chor, J.S.Y., and Hui, M. (2014). Meta-analysis on prevalence and attribution of human papillomavirus types 52 and 58 in cervical neoplasia worldwide. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0107573"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/jmv.23566","article-title":"E6 and E7 variants of human papillomavirus-16 and -52 in Japan, the Philippines, and Vietnam","volume":"85","author":"Ishizaki","year":"2013","journal-title":"J. Med. Virol."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH809>3.0.CO;2-C","article-title":"Human papillomavirus variants and squamous neoplasia of the cervix","volume":"193","author":"Giannoudis","year":"2001","journal-title":"J. Pathol."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1158\/1055-9965.EPI-05-0864","article-title":"Increased risk for cervical disease progression of French women infected with the human papillomavirus type 16 E6-350G variant: Table 1","volume":"15","author":"Grodzki","year":"2006","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1093\/infdis\/jiu310","article-title":"Geographical distribution and risk association of human papillomavirus genotype 52-variant lineages","volume":"210","author":"Zhang","year":"2014","journal-title":"J. Infect. Dis."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0304-3835(01)00570-5","article-title":"Analysis of E6 variants of human papillomavirus type 33, 52 and 58 in Japanese women with cervical intraepithelial neoplasia\/cervical cancer in relation to their oncogenic potential","volume":"170","author":"Xin","year":"2001","journal-title":"Cancer Lett."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1099\/jgv.0.001222","article-title":"Oncogenicitiy comparison of human papillomavirus type 52 E6 variants","volume":"100","author":"Lai","year":"2019","journal-title":"J. Gen. Virol."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1002\/ijc.27932","article-title":"Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations","volume":"132","author":"Chan","year":"2013","journal-title":"Int. J. Cancer"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1111\/jcmm.14059","article-title":"Oncogenic comparison of human papillomavirus type 58 E7 variants","volume":"23","author":"Law","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/JVI.00090-20","article-title":"Human papillomavirus 58 E7 T20I\/G63S variant isolated from an East Asian population possesses high oncogenicity","volume":"94","author":"Boon","year":"2020","journal-title":"J. Virol."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1080\/21645515.2017.1381811","article-title":"Factors involved in human papillomavirus (HPV) vaccine hesitancy among women in the South-East Asian Region (SEAR) and Western Pacific Region (WPR): A scoping review","volume":"14","author":"Santhanes","year":"2018","journal-title":"Hum. Vaccines Immunother."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.31557\/APJCP.2019.20.8.2429","article-title":"A qualitative study of parental knowledge and perceptions of human papillomavirus and cervical cancer prevention in rural central Java, Indonesia: Understanding community readiness for prevention interventions","volume":"20","author":"Spagnoletti","year":"2019","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12957-018-1308-7","article-title":"Effect of neoadjuvant chemotherapy and its correlation with HPV status, EGFR, Her-2-neu, and GADD45 expression in oral squamous cell carcinoma","volume":"16","author":"Pandey","year":"2018","journal-title":"World J. Surg. Oncol."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.4143\/crt.2015.379","article-title":"Predictors of distant metastasis after radical surgery followed by postoperative radiotherapy with or without chemotherapy for oropharyngeal cancer","volume":"48","author":"Chung","year":"2016","journal-title":"Cancer Res. Treat."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s40880-017-0191-x","article-title":"Californium-252 neutron brachytherapy combined with external pelvic radiotherapy plus concurrent chemotherapy for cervical cancer: A retrospective clinical study","volume":"36","author":"Qian","year":"2017","journal-title":"Chin. J. Cancer"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1158\/2326-6066.CIR-19-0315","article-title":"Myeloid cells orchestrate systemic immunosuppression, impairing the efficacy of immunotherapy against HPV\u00fe cancers","volume":"8","author":"Galliverti","year":"2020","journal-title":"Cancer Immunol. Res."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/13\/11\/2691\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:08:58Z","timestamp":1760162938000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/13\/11\/2691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,30]]},"references-count":266,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["cancers13112691"],"URL":"https:\/\/doi.org\/10.3390\/cancers13112691","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,30]]}}}