{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:49:53Z","timestamp":1790952593993,"version":"4.1.0"},"reference-count":238,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA168717"],"award-info":[{"award-number":["CA168717"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The skeleton is heavily innervated by sympathetic nerves and represents a common site for breast cancer metastases, the latter being the main cause of morbidity and mortality in breast cancer patients. Progression and recurrence of breast cancer, as well as decreased overall survival in breast cancer patients, are associated with chronic stress, a condition known to stimulate sympathetic nerve outflow. Preclinical studies have demonstrated that sympathetic stimulation of \u03b2-adrenergic receptors in osteoblasts increases bone vascular density, adhesion of metastatic cancer cells to blood vessels, and their colonization of the bone microenvironment, whereas \u03b2-blockade prevented these events in mice with high endogenous sympathetic activity. These findings in preclinical models, along with clinical data from breast cancer patients receiving \u03b2-blockers, support the pathophysiological role of excess sympathetic nervous system activity in the formation of bone metastases, and the potential of commonly used, safe, and low-cost \u03b2-blockers as adjuvant therapy to improve the prognosis of bone metastases.<\/jats:p>","DOI":"10.3390\/cancers13122887","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T14:16:04Z","timestamp":1623248164000},"page":"2887","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Mechanisms Supporting the Use of Beta-Blockers for the Management of Breast Cancer Bone Metastasis"],"prefix":"10.3390","volume":"13","author":[{"given":"Maria-Bernadette","family":"Madel","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Elefteriou","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Baylor College of Medicine, Houston, TX 77030, USA"},{"name":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Manders, K., van de Poll-Franse, L.V., Creemers, G.-J., Vreugdenhil, G., van der Sangen, M.J., Nieuwenhuijzen, G.A., Roumen, R.M., and Voogd, A.C. (2006). Clinical management of women with metastatic breast cancer: A descriptive study according to age group. BMC Cancer, 6.","DOI":"10.1186\/1471-2407-6-179"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6243s","DOI":"10.1158\/1078-0432.CCR-06-0931","article-title":"Clinical features of metastatic bone disease and risk of skeletal morbidity","volume":"12","author":"Coleman","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1200\/JCO.2009.25.9820","article-title":"Metastatic Behavior of Breast Cancer Subtypes","volume":"28","author":"Kennecke","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/bjc.1998.52","article-title":"Clinical course and prognostic factors following bone recurrence from breast cancer","volume":"77","author":"Coleman","year":"1998","journal-title":"Br. J. Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/nm.2448","article-title":"Matrix-embedded cells control osteoclast formation","volume":"17","author":"Xiong","year":"2011","journal-title":"Nat. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/cncr.11132","article-title":"Mechanisms of osteolytic bone metastases in breast carcinoma","volume":"97","author":"Mundy","year":"2003","journal-title":"Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.mrrev.2011.05.002","article-title":"Initial steps of metastasis: Cell invasion and endothelial transmigration","volume":"728","author":"Krupitza","year":"2011","journal-title":"Mutat. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nrc2622","article-title":"Metastasis: From dissemination to organ-specific colonization","volume":"9","author":"Nguyen","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1475-2867-12-24","article-title":"Pathobiology of cancer metastasis: A short account","volume":"12","author":"Feller","year":"2012","journal-title":"Cancer Cell Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"8483","DOI":"10.1007\/s13277-014-2421-z","article-title":"Metastasis review: From bench to bedside","volume":"35","author":"Alizadeh","year":"2014","journal-title":"Tumour Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nrg2101","article-title":"Genetic determinants of cancer metastasis","volume":"8","author":"Nguyen","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1101\/gad.1636908","article-title":"Migratory neighbors and distant invaders: Tumor-associated niche cells","volume":"22","author":"Wels","year":"2008","journal-title":"Genes Dev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1056\/NEJMra0805239","article-title":"Molecular basis of metastasis","volume":"359","author":"Chiang","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/ijc.20153","article-title":"Cellular interactions in the tropism of prostate cancer to bone","volume":"110","author":"Sikes","year":"2004","journal-title":"Int. J. Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1535-6108(03)00132-6","article-title":"A multigenic program mediating breast cancer metastasis to bone","volume":"3","author":"Kang","year":"2003","journal-title":"Cancer Cell"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1172\/JCI22320","article-title":"Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors","volume":"115","author":"Minn","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/BF00319037","article-title":"Distribution of CGRP-, VIP-, D beta H-, SP-, and NPY-immunoreactive nerves in the periosteum of the rat","volume":"264","author":"Hill","year":"1991","journal-title":"Cell Tissue Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jbo.2016.03.003","article-title":"Role of sympathetic nerves in the establishment of metastatic breast cancer cells in bone","volume":"5","author":"Elefteriou","year":"2016","journal-title":"J. Bone Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00223-007-9015-3","article-title":"The new field of neuroskeletal biology","volume":"80","author":"Patel","year":"2007","journal-title":"Calcif. Tissue Int."},{"key":"ref_20","first-page":"77","article-title":"Noradrenergic and cholinergic innervation of the bone marrow","volume":"10","author":"Artico","year":"2002","journal-title":"Int. J. Mol. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0306-4522(02)00165-3","article-title":"Origins of skeletal pain: Sensory and sympathetic innervation of the mouse femur","volume":"113","author":"Mach","year":"2002","journal-title":"Neuroscience"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6231s","DOI":"10.1158\/1078-0432.CCR-06-0682","article-title":"Biology of bone cancer pain","volume":"12","author":"Goblirsch","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Lorenz, M.R., Brazill, J.M., Beeve, A.T., Shen, I., and Scheller, E.L. (2021). A neuroskeletal atlas: Spatial mapping and contextualization of axon subtypes innervating the long bones of C3H and B6 mice. J. Bone Miner. Res.","DOI":"10.1002\/jbmr.4273"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1038\/s41598-019-41779-w","article-title":"Innervation is higher above Bone Remodeling Surfaces and in Cortical Pores in Human Bone: Lessons from patients with primary hyperparathyroidism","volume":"9","author":"Sayilekshmy","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/00007632-199302000-00016","article-title":"Neuropeptide Y, tyrosine hydroxylase and vasoactive intestinal polypeptide-immunoreactive nerve fibers in the vertebral bodies, discs, dura mater, and spinal ligaments of the rat lumbar spine","volume":"18","author":"Ahmed","year":"1993","journal-title":"Spine"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s10735-010-9261-y","article-title":"Structural and cellular features in metaphyseal and diaphyseal periosteum of osteoporotic rats","volume":"41","author":"Fan","year":"2010","journal-title":"J. Mol. Histol."},{"key":"ref_27","first-page":"1","article-title":"Distribution of nerve endings and sensory neuropeptides in rat synovium, meniscus and bone","volume":"14","author":"Hukkanen","year":"1992","journal-title":"Int. J. Tissue React."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/jor.1100150120","article-title":"Calcitonin gene-related peptide, substance P, and tyrosine hydroxylase-immunoreactive innervation of rat bone marrows: An immunohistochemical and ultrastructural investigation on possible efferent and afferent mechanisms","volume":"15","author":"Imai","year":"1997","journal-title":"J. Orthop. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuroscience.2018.01.047","article-title":"The Changing Sensory and Sympathetic Innervation of the Young, Adult and Aging Mouse Femur","volume":"387","author":"Chartier","year":"2018","journal-title":"Neuroscience"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.neuroscience.2011.01.039","article-title":"The majority of myelinated and unmyelinated sensory nerve fibers that innervate bone express the tropomyosin receptor kinase A","volume":"178","author":"Bloom","year":"2011","journal-title":"Neuroscience"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neulet.2007.08.055","article-title":"Organization of a unique net-like meshwork of CGRP+ sensory fibers in the mouse periosteum: Implications for the generation and maintenance of bone fracture pain","volume":"427","author":"Martin","year":"2007","journal-title":"Neurosci. Lett."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.bone.2009.09.013","article-title":"A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: Therapeutic opportunity for treating skeletal pain","volume":"46","author":"Mantyh","year":"2010","journal-title":"Bone"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1016\/j.celrep.2016.08.002","article-title":"NGF-TrkA Signaling by Sensory Nerves Coordinates the Vascularization and Ossification of Developing Endochondral Bone","volume":"16","author":"Tomlinson","year":"2016","journal-title":"Cell Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"E3632","DOI":"10.1073\/pnas.1701054114","article-title":"NGF-TrkA signaling in sensory nerves is required for skeletal adaptation to mechanical loads in mice","volume":"114","author":"Tomlinson","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.2217\/fon.10.142","article-title":"Impact of stress on cancer metastasis","volume":"6","author":"Lutgendorf","year":"2010","journal-title":"Future Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1016\/S0889-1591(02)00076-4","article-title":"Examining psychosocial factors related to cancer incidence and progression: In search of the silver lining","volume":"17","author":"Heffner","year":"2003","journal-title":"Brain. Behav. Immun."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Clouston, S.A.P., Kuan, P., Kotov, R., Mukherjee, S., Thompson-Carino, P., Bromet, E.J., and Luft, B.J. (2019). Risk factors for incident prostate cancer in a cohort of world trade center responders. BMC Psychiatry, 19.","DOI":"10.1186\/s12888-019-2383-1"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"40363","DOI":"10.1038\/srep40363","article-title":"Perceived Stress and Colorectal Cancer Incidence: The Japan Collaborative Cohort Study","volume":"7","author":"Kikuchi","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00127-009-0068-7","article-title":"What do predict anxiety and depression in breast cancer patients? A follow-up study","volume":"45","author":"Vahdaninia","year":"2010","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1097\/01.psy.0000238216.88515.e5","article-title":"Depression and stress reactivity in metastatic breast cancer","volume":"68","author":"Wilhelm","year":"2006","journal-title":"Psychosom. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1093\/jnci\/djn229","article-title":"Mapping pathways from stress to cancer progression","volume":"100","author":"Ross","year":"2008","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1136\/bmj.38343.670868.D3","article-title":"Depression and anxiety in women with early breast cancer: Five year observational cohort study","volume":"330","author":"Burgess","year":"2005","journal-title":"BMJ"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0006-3223(03)00566-3","article-title":"Depression and cancer: Mechanisms and disease progression","volume":"54","author":"Spiegel","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/ncponc1134","article-title":"Do stress-related psychosocial factors contribute to cancer incidence and survival?","volume":"5","author":"Chida","year":"2008","journal-title":"Nat. Clin. Pract. Oncol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1200\/JCO.2010.33.4441","article-title":"Beta-blocker use is associated with improved relapse-free survival in patients with triple-negative breast cancer","volume":"29","author":"Lei","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"628","DOI":"10.18632\/oncotarget.197","article-title":"Beta-blocker drug therapy reduces secondary cancer formation in breast cancer and improves cancer specific survival","volume":"1","author":"Powe","year":"2010","journal-title":"Oncotarget"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1200\/JCO.2010.33.5422","article-title":"Beta blockers and breast cancer mortality: A population- based study","volume":"29","author":"Barron","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s10549-013-2654-3","article-title":"Therapeutic effect of \u03b2-blockers in triple-negative breast cancer postmenopausal women","volume":"140","author":"Botteri","year":"2013","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s00432-014-1658-7","article-title":"Meta-analysis of the effects of beta blocker on survival time in cancer patients","volume":"140","author":"Choi","year":"2014","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1152\/physrev.00014.2017","article-title":"Impact of the Autonomic Nervous System on the Skeleton","volume":"98","author":"Elefteriou","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1210\/en.2010-0881","article-title":"\u03b22-Adrenergic receptor signaling in osteoblasts contributes to the catabolic effect of glucocorticoids on bone","volume":"152","author":"Ma","year":"2011","journal-title":"Endocrinology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s00223-013-9752-4","article-title":"Control of bone remodeling by the peripheral sympathetic nervous system","volume":"94","author":"Elefteriou","year":"2014","journal-title":"Calcif. Tissue Int."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/nm1447","article-title":"Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma","volume":"12","author":"Thaker","year":"2006","journal-title":"Nat. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1006\/brbi.1994.1002","article-title":"An interleukin-1 beta-induced noradrenaline release in the spleen is mediated by brain corticotropin-releasing factor: An in vivo microdialysis study in conscious rats","volume":"8","author":"Shimizu","year":"1994","journal-title":"Brain Behav. Immun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev.pa.35.040195.002221","article-title":"Catecholamine influences and sympathetic neural modulation of immune responsiveness","volume":"35","author":"Madden","year":"1995","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1006\/phrs.1996.0036","article-title":"Evidence for functional beta-adrenoceptor subtypes in CG-5 breast cancer cell","volume":"33","author":"Badino","year":"1996","journal-title":"Pharmacol. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1093\/carcin\/10.9.1753","article-title":"Regulation of cell proliferation by beta-adrenergic receptors in a human lung adenocarcinoma cell line","volume":"10","author":"Schuller","year":"1989","journal-title":"Carcinogenesis"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41413-021-00137-1","article-title":"Sympathetic activity in breast cancer and metastasis: Partners in crime","volume":"9","author":"Sousa","year":"2021","journal-title":"Bone Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1001\/archpsyc.64.1.109","article-title":"Prospective study of posttraumatic stress disorder symptoms and coronary heart disease in the Normative Aging Study","volume":"64","author":"Kubzansky","year":"2007","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1001\/archgenpsychiatry.2009.149","article-title":"Posttraumatic stress disorder and health-related quality of life in patients with coronary heart disease: Findings from the Heart and Soul Study","volume":"66","author":"Cohen","year":"2009","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/aje\/kwp104","article-title":"Psychosocial stress and change in weight among US adults","volume":"170","author":"Block","year":"2009","journal-title":"Am. J. Epidemiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1097\/01.psy.0000143637.63508.47","article-title":"Cortisol, hunger, and desire to binge eat following a cold stress test in obese women with binge eating disorder","volume":"66","author":"Gluck","year":"2004","journal-title":"Psychosom. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/00365520903401967","article-title":"Stressful psychosocial factors and symptoms of gastroesophageal reflux disease: A population-based study in Norway","volume":"45","author":"Jansson","year":"2010","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1053\/j.gastro.2007.12.010","article-title":"The effect of auditory stress on perception of intraesophageal acid in patients with gastroesophageal reflux disease","volume":"134","author":"Fass","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1111\/j.1572-0241.2000.02012.x","article-title":"Stress and exacerbation in ulcerative colitis: A prospective study of patients enrolled in remission","volume":"95","author":"Levenstein","year":"2000","journal-title":"Am. J. Gastroenterol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/01.PSY.0000106907.24881.F2","article-title":"Impact of depressive mood on relapse in patients with inflammatory bowel disease: A prospective 18-month follow-up study","volume":"66","author":"Mittermaier","year":"2004","journal-title":"Psychosom. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1111\/j.1572-0241.2006.00798.x","article-title":"Psychobiological subtypes of ulcerative colitis: pANCA status moderates the relationship between disease activity and psychological distress","volume":"101","author":"Maunder","year":"2006","journal-title":"Am. J. Gastroenterol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s11657-012-0105-0","article-title":"The relationship of depression, anxiety and stress with low bone mineral density in post-menopausal women","volume":"7","author":"Erez","year":"2012","journal-title":"Arch. Osteoporos."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1055\/s-0030-1252020","article-title":"Depression and osteoporosis: A research synthesis with meta-analysis","volume":"42","author":"Cizza","year":"2010","journal-title":"Horm. Metab. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/smi.2806","article-title":"Post-traumatic stress disorder and risk of osteoporosis: A nationwide longitudinal study","volume":"34","author":"Huang","year":"2018","journal-title":"Stress Health"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.jad.2017.11.058","article-title":"Physical health conditions associated with full and subthreshold PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study","volume":"227","author":"Blaney","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jad.2015.11.048","article-title":"Depression as a risk factor for fracture in women: A 10 year longitudinal study","volume":"192","author":"Williams","year":"2016","journal-title":"J. Affect. Disord."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.biopsych.2009.03.016","article-title":"Major depression is a risk factor for low bone mineral density: A meta-analysis","volume":"66","author":"Yirmiya","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1007\/s00198-004-1730-2","article-title":"Depression and bone mineral density: Is there a relationship in elderly Asian men? Results from Mr. Os (Hong Kong)","volume":"16","author":"Wong","year":"2005","journal-title":"Osteoporos. Int."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1176\/ajp.151.11.1691","article-title":"Low lumbar bone mineral density in patients with major depression","volume":"151","author":"Schweiger","year":"1994","journal-title":"Am. J. Psychiatry"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.pnpbp.2005.01.009","article-title":"Effects of antidepressant treatment and of gender on serum leptin levels in patients with major depression","volume":"29","author":"Esel","year":"2005","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1056\/NEJM199610173351602","article-title":"Bone mineral density in women with depression","volume":"335","author":"Michelson","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1742-1241.2006.01276.x","article-title":"Relation of cortisol levels and bone mineral density among premenopausal women with major depression","volume":"61","author":"Altindag","year":"2007","journal-title":"Int. J. Clin. Pract."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.bone.2013.04.011","article-title":"Determinants of stress fracture risk in United States Military Academy cadets","volume":"55","author":"Cosman","year":"2013","journal-title":"Bone"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/BF01612908","article-title":"Functional beta-adrenergic receptors in breast cancer cells","volume":"116","author":"Vandewalle","year":"1990","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s10549-011-1348-y","article-title":"\u03b2-Adrenergic receptors (\u03b2-AR) regulate VEGF and IL-6 production by divergent pathways in high \u03b2-AR-expressing breast cancer cell lines","volume":"130","author":"Madden","year":"2011","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s10549-011-1371-z","article-title":"Alpha- and beta-adrenergic receptor (AR) protein expression is associated with poor clinical outcome in breast cancer: An immunohistochemical study","volume":"130","author":"Powe","year":"2011","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0092-8674(02)01049-8","article-title":"Leptin regulates bone formation via the sympathetic nervous system","volume":"111","author":"Takeda","year":"2002","journal-title":"Cell"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nature03398","article-title":"Leptin regulation of bone resorption by the sympathetic nervous system and CART","volume":"434","author":"Elefteriou","year":"2005","journal-title":"Nature"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1084\/jem.20102608","article-title":"Genetic determination of the cellular basis of the sympathetic regulation of bone mass accrual","volume":"208","author":"Kajimura","year":"2011","journal-title":"J. Exp. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1001\/jama.292.11.1326","article-title":"Use of beta-blockers and risk of fractures","volume":"292","author":"Schlienger","year":"2004","journal-title":"JAMA"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1007\/s00198-007-0354-8","article-title":"Beta-blocker use and risk of fractures in men and women from the general population: The MONICA\/KORA Augsburg cohort study","volume":"18","author":"Meisinger","year":"2007","journal-title":"Osteoporos. Int."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00198-013-2498-z","article-title":"\u03b2-Adrenergic receptor antagonists and fracture risk: A meta-analysis of selectivity, gender, and site-specific effects","volume":"25","author":"Toulis","year":"2014","journal-title":"Osteoporos. Int."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e10388","DOI":"10.1002\/jbm4.10388","article-title":"Association of Beta Blocker Use With Bone Mineral Density in the Framingham Osteoporosis Study: A Cross-Sectional Study","volume":"4","author":"Lary","year":"2020","journal-title":"JBMR Plus"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/01.blo.0000200242.52802.6d","article-title":"Beta-blockers increase bone mineral density","volume":"443","author":"Turker","year":"2006","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1359\/jbmr.0301214","article-title":"Geelong Osteoporosis Study Beta-adrenergic blockers reduce the risk of fracture partly by increasing bone mineral density: Geelong Osteoporosis Study","volume":"19","author":"Pasco","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/01.hjh.0000203845.26690.cb","article-title":"Treatment with beta-blockers, ACE inhibitors, and calcium-channel blockers is associated with a reduced fracture risk: A nationwide case-control study","volume":"24","author":"Rejnmark","year":"2006","journal-title":"J. Hypertens."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.bone.2007.01.006","article-title":"Protective effect of beta blockers in postmenopausal women: Influence on fractures, bone density, micro and macroarchitecture","volume":"40","author":"Bonnet","year":"2007","journal-title":"Bone"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.1172\/JCI122151","article-title":"Sympathetic \u03b21-adrenergic signaling contributes to regulation of human bone metabolism","volume":"128","author":"Khosla","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/pros.22564","article-title":"Use of \u03b2-blockers is associated with prostate cancer-specific survival in prostate cancer patients on androgen deprivation therapy","volume":"73","author":"Grytli","year":"2013","journal-title":"Prostate"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.eururo.2013.01.007","article-title":"Association between use of \u03b2-blockers and prostate cancer-specific survival: A cohort study of 3561 prostate cancer patients with high-risk or metastatic disease","volume":"65","author":"Grytli","year":"2014","journal-title":"Eur. Urol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1002\/cncr.29392","article-title":"Clinical impact of selective and nonselective beta-blockers on survival in patients with ovarian cancer","volume":"121","author":"Watkins","year":"2015","journal-title":"Cancer"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1093\/annonc\/mds616","article-title":"Improved survival outcomes with the incidental use of beta-blockers among patients with non-small-cell lung cancer treated with definitive radiation therapy","volume":"24","author":"Wang","year":"2013","journal-title":"Ann. Oncol. Off. J. Eur. Soc. Med. Oncol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1023\/B:CACO.0000036152.58271.5e","article-title":"Antihypertensive drug use and the risk of prostate cancer (Canada)","volume":"15","author":"Perron","year":"2004","journal-title":"Cancer Causes Control"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1158\/1055-9965.EPI-11-0249","article-title":"\u03b2-Blockers and survival among Danish patients with malignant melanoma: A population-based cohort study","volume":"20","author":"Lemeshow","year":"2011","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"6109","DOI":"10.7314\/APJCP.2013.14.10.6109","article-title":"Does beta-blocker therapy improve the survival of patients with metastatic non-small cell lung cancer?","volume":"14","author":"Aydiner","year":"2013","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.mayocp.2013.09.001","article-title":"Effect of \u03b2-blockers and other antihypertensive drugs on the risk of melanoma recurrence and death","volume":"88","author":"Gandini","year":"2013","journal-title":"Mayo Clin. Proc."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1093\/ije\/dyt196","article-title":"Beta-blocker usage and breast cancer survival: A nested case-control study within a UK clinical practice research datalink cohort","volume":"42","author":"Cardwell","year":"2013","journal-title":"Int. J. Epidemiol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1038\/bjc.2015.133","article-title":"Stress hormones reduce the efficacy of paclitaxel in triple negative breast cancer through induction of DNA damage","volume":"112","author":"Reeder","year":"2015","journal-title":"Br. J. Cancer"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"219","DOI":"10.4161\/cc.23368","article-title":"Pharmacological blockade of a \u03b2(2)AR-\u03b2-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model","volume":"12","author":"Hara","year":"2013","journal-title":"Cell Cycle"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nature10368","article-title":"A stress response pathway regulates DNA damage through \u03b22-adrenoreceptors and \u03b2-arrestin-1","volume":"477","author":"Hara","year":"2011","journal-title":"Nature"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/ncomms2413","article-title":"Src activation by \u03b2-adrenoreceptors is a key switch for tumour metastasis","volume":"4","author":"Allen","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s10549-010-0822-2","article-title":"The \u03b22-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells","volume":"125","author":"Shi","year":"2011","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"7196","DOI":"10.1158\/1078-0432.CCR-09-0585","article-title":"Protein kinase A activation confers resistance to trastuzumab in human breast cancer cell lines","volume":"15","author":"Gu","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"ref_110","first-page":"874","article-title":"Behavioral stress accelerates prostate cancer development in mice","volume":"123","author":"Hassan","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"14094","DOI":"10.1074\/jbc.M611370200","article-title":"Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation","volume":"282","author":"Sastry","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1038\/bjc.2013.205","article-title":"\u03b2-blockers increase response to chemotherapy via direct antitumour and anti-angiogenic mechanisms in neuroblastoma","volume":"108","author":"Pasquier","year":"2013","journal-title":"Br. J. Cancer"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"161","DOI":"10.18632\/oncotarget.1083","article-title":"Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma","volume":"5","author":"Wolter","year":"2014","journal-title":"Oncotarget"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1023\/A:1024491219366","article-title":"Effects of neurotransmitters on the chemokinesis and chemotaxis of MDA-MB-468 human breast carcinoma cells","volume":"80","author":"Drell","year":"2003","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_115","first-page":"4514","article-title":"Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines","volume":"9","author":"Lutgendorf","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"29919","DOI":"10.1074\/jbc.M611539200","article-title":"Stress hormones regulate interleukin-6 expression by human ovarian carcinoma cells through a Src-dependent mechanism","volume":"282","author":"Nilsson","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/ijc.20410","article-title":"Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs","volume":"112","author":"Lang","year":"2004","journal-title":"Int. J. Cancer"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/j.1476-5381.2011.01791.x","article-title":"Involvement of \u03b12- and \u03b22-adrenoceptors on breast cancer cell proliferation and tumour growth regulation","volume":"166","author":"Bruzzone","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1023\/A:1006338232150","article-title":"Beta-adrenoceptor signaling and its control of cell replication in MDA-MB-231 human breast cancer cells","volume":"60","author":"Slotkin","year":"2000","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"10058","DOI":"10.18632\/oncotarget.2460","article-title":"Differential \u03b2\u2082-adrenergic receptor expression defines the phenotype of non-tumorigenic and malignant human breast cell lines","volume":"5","author":"Gargiulo","year":"2014","journal-title":"Oncotarget"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Liu, D., Deng, Q., Sun, L., Wang, T., Yang, Z., Chen, H., Guo, L., Liu, Y., Ma, Y., and Guo, N. (2015). A Her2-let-7-\u03b22-AR circuit affects prognosis in patients with Her2-positive breast cancer. BMC Cancer, 15.","DOI":"10.1186\/s12885-015-1869-6"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1111\/bcp.14030","article-title":"Prognostic significance of \u03b1- and \u03b22-adrenoceptor gene expression in breast cancer patients","volume":"85","author":"Rivero","year":"2019","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10549-019-05341-6","article-title":"\u03b22-Adrenergic receptor expression is associated with biomarkers of tumor immunity and predicts poor prognosis in estrogen receptor-negative breast cancer","volume":"177","author":"Kurozumi","year":"2019","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.clbc.2020.01.007","article-title":"Prognostic and Predictive Impact of Beta-2 Adrenergic Receptor Expression in HER2-Positive Breast Cancer","volume":"20","author":"Caparica","year":"2020","journal-title":"Clin. Breast Cancer"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/350350a0","article-title":"Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter","volume":"350","author":"Pacholczyk","year":"1991","journal-title":"Nature"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0361-9230(99)00063-5","article-title":"Desipramine treatment decreases 3H-nisoxetine binding and norepinephrine transporter mRNA in SK-N-SHSY5Y cells","volume":"49","author":"Zavosh","year":"1999","journal-title":"Brain Res. Bull."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399401003878","article-title":"Genetic or acquired deficits in the norepinephrine transporter: Current understanding of clinical implications","volume":"2001","author":"Tellioglu","year":"2001","journal-title":"Expert Rev. Mol. Med."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0959-4388(00)00088-X","article-title":"Biogenic amine transporters: Regulation in flux","volume":"10","author":"Blakely","year":"2000","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"30105","DOI":"10.1074\/jbc.M113.481309","article-title":"Extracellular norepinephrine clearance by the norepinephrine transporter is required for skeletal homeostasis","volume":"288","author":"Ma","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bonr.2018.11.002","article-title":"Cortical bone is an extraneuronal site of norepinephrine uptake in adult mice","volume":"9","author":"Zhu","year":"2018","journal-title":"Bone Rep."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"5537","DOI":"10.1172\/JCI129502","article-title":"\u03b22 adrenergic receptor-mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells","volume":"129","author":"Mohammadpour","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"7042","DOI":"10.1158\/0008-5472.CAN-10-0522","article-title":"The sympathetic nervous system induces a metastatic switch in primary breast cancer","volume":"70","author":"Sloan","year":"2010","journal-title":"Cancer Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.18632\/oncotarget.2887","article-title":"Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth","volume":"6","author":"Nagaraja","year":"2015","journal-title":"Oncotarget"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"610","DOI":"10.4049\/jimmunol.161.2.610","article-title":"Norepinephrine accelerates HIV replication via protein kinase A-dependent effects on cytokine production","volume":"161","author":"Cole","year":"1998","journal-title":"J. Immunol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.bbi.2006.01.005","article-title":"Adrenergic inhibition of innate anti-viral response: PKA blockade of Type I interferon gene transcription mediates catecholamine support for HIV-1 replication","volume":"20","author":"Sung","year":"2006","journal-title":"Brain Behav. Immun."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Inbar, S., Neeman, E., Avraham, R., Benish, M., Rosenne, E., and Ben-Eliyahu, S. (2011). Do stress responses promote leukemia progression? An animal study suggesting a role for epinephrine and prostaglandin-E2 through reduced NK activity. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0019246"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1097\/SLA.0b013e318211d7b5","article-title":"Improving postoperative immune status and resistance to cancer metastasis: A combined perioperative approach of immunostimulation and prevention of excessive surgical stress responses","volume":"253","author":"Goldfarb","year":"2011","journal-title":"Ann. Surg."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1158\/1078-0432.CCR-08-2966","article-title":"Surgical stress promotes tumor growth in ovarian carcinoma","volume":"15","author":"Lee","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.4049\/jimmunol.0903301","article-title":"Improving survival rates in two models of spontaneous postoperative metastasis in mice by combined administration of a beta-adrenergic antagonist and a cyclooxygenase-2 inhibitor","volume":"184","author":"Glasner","year":"2010","journal-title":"J. Immunol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1236361","DOI":"10.1126\/science.1236361","article-title":"Autonomic nerve development contributes to prostate cancer progression","volume":"341","author":"Magnon","year":"2013","journal-title":"Science"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Campbell, J.P., Karolak, M.R., Ma, Y., Perrien, D.S., Masood-Campbell, S.K., Penner, N.L., Munoz, S.A., Zijlstra, A., Yang, X., and Sterling, J.A. (2012). Stimulation of host bone marrow stromal cells by sympathetic nerves promotes breast cancer bone metastasis in mice. PLoS Biol., 10.","DOI":"10.1371\/journal.pbio.1001363"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.cell.2005.10.041","article-title":"Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow","volume":"124","author":"Katayama","year":"2006","journal-title":"Cell"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/FJC.0b013e318093ec8f","article-title":"Migration of endothelial progenitor cells mediated by stromal cell-derived factor-1alpha\/CXCR4 via PI3K\/Akt\/eNOS signal transduction pathway","volume":"50","author":"Zheng","year":"2007","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.abb.2008.03.016","article-title":"Regulation of bone remodeling by the central and peripheral nervous system","volume":"473","author":"Elefteriou","year":"2008","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.bbrc.2016.11.011","article-title":"Beta-adrenergic signaling affect osteoclastogenesis via osteocytic MLO-Y4 cells\u2019 RANKL production","volume":"488","author":"Yao","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"12593","DOI":"10.1038\/srep12593","article-title":"\u03b22-Adrenergic signal transduction plays a detrimental role in subchondral bone loss of temporomandibular joint in osteoarthritis","volume":"5","author":"Jiao","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1210\/edrv.18.1.0287","article-title":"The biology of vascular endothelial growth factor","volume":"18","author":"Ferrara","year":"1997","journal-title":"Endocr. Rev."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1073\/pnas.95.2.548","article-title":"Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)","volume":"95","author":"Achen","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"31273","DOI":"10.1074\/jbc.273.47.31273","article-title":"A novel type of vascular endothelial growth factor, VEGF-E (NZ-7 VEGF), preferentially utilizes KDR\/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain","volume":"273","author":"Ogawa","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/emboj\/18.2.363","article-title":"A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases","volume":"18","author":"Meyer","year":"1999","journal-title":"EMBO J."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199101033240101","article-title":"Tumor angiogenesis and metastasis\u2014Correlation in invasive breast carcinoma","volume":"324","author":"Weidner","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.bbi.2008.10.005","article-title":"Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: Implications for stress-related enhancement of tumor progression","volume":"23","author":"Yang","year":"2009","journal-title":"Brain Behav. Immun."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.psyneuen.2014.11.008","article-title":"The effect of chronic stress on anti-angiogenesis of sunitinib in colorectal cancer models","volume":"52","author":"Liu","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.oraloncology.2015.08.007","article-title":"Chronic stress promotes oral cancer growth and angiogenesis with increased circulating catecholamine and glucocorticoid levels in a mouse model","volume":"51","author":"Xie","year":"2015","journal-title":"Oral Oncol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature13145","article-title":"Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone","volume":"507","author":"Kusumbe","year":"2014","journal-title":"Nature"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nature17638","article-title":"Age-dependent modulation of vascular niches for haematopoietic stem cells","volume":"532","author":"Kusumbe","year":"2016","journal-title":"Nature"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1002\/jbmr.3133","article-title":"Skeletal Colonization by Breast Cancer Cells Is Stimulated by an Osteoblast and \u03b22AR-Dependent Neo-Angiogenic Switch","volume":"32","author":"Mulcrone","year":"2017","journal-title":"J. Bone Miner. Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jbo.2018.09.002","article-title":"\u03b22ARs stimulation in osteoblasts promotes breast cancer cell adhesion to bone marrow endothelial cells in an IL-1\u03b2 and selectin-dependent manner","volume":"13","author":"Mulcrone","year":"2018","journal-title":"J. Bone Oncol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1158\/0008-5472.CAN-15-1227","article-title":"Interleukin-6 Stimulates Defective Angiogenesis","volume":"75","author":"Gopinathan","year":"2015","journal-title":"Cancer Res."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1681\/ASN.2015101169","article-title":"IL-6 Trans-Signaling Links Inflammation with Angiogenesis in the Peritoneal Membrane","volume":"28","author":"Catar","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/path.2935","article-title":"Interleukin-6 signalling regulates vascular endothelial growth factor-C synthesis and lymphangiogenesis in human oral squamous cell carcinoma","volume":"225","author":"Shinriki","year":"2011","journal-title":"J. Pathol."},{"key":"ref_162","first-page":"2899","article-title":"Down-regulation of expression of interleukin-6 and its receptor results in growth inhibition of MCF-7 breast cancer cells","volume":"31","author":"Jiang","year":"2011","journal-title":"Anticancer Res."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"9087","DOI":"10.1158\/0008-5472.CAN-08-0400","article-title":"Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner","volume":"68","author":"Studebaker","year":"2008","journal-title":"Cancer Res."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ccell.2017.07.001","article-title":"Intravascular Survival and Extravasation of Tumor Cells","volume":"32","author":"Strilic","year":"2017","journal-title":"Cancer Cell"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1084\/jem.183.2.581","article-title":"Redirection of tumor metastasis by expression of E-selectin in vivo","volume":"183","author":"Biancone","year":"1996","journal-title":"J. Exp. Med."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"676731","DOI":"10.1155\/2012\/676731","article-title":"Cancer cell adhesion and metastasis: Selectins, integrins, and the inhibitory potential of heparins","volume":"2012","author":"Bendas","year":"2012","journal-title":"Int. J. Cell Biol."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12943-018-0937-3","article-title":"The functional role of integrins during intra- and extravasation within the metastatic cascade","volume":"18","author":"Schumacher","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_168","first-page":"962","article-title":"Proinflammatory activation pattern of human umbilical vein endothelial cells induced by IL-1\u03b2, TNF-\u03b1, and LPS","volume":"77","author":"Herczenik","year":"2010","journal-title":"Cytometry A"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/sj.jid.5700071","article-title":"Regulation of skin microvasculature angiogenesis, cell migration, and permeability by a specific inhibitor of PKCalpha","volume":"126","author":"Bokhari","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3389\/fimmu.2013.00177","article-title":"Unique Versus Redundant Functions of IL-1\u03b1 and IL-1\u03b2 in the Tumor Microenvironment","volume":"4","author":"Voronov","year":"2013","journal-title":"Front. Immunol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0002-9440(10)62048-2","article-title":"Characterization of the host proinflammatory response to tumor cells during the initial stages of liver metastasis","volume":"167","author":"Khatib","year":"2005","journal-title":"Am. J. Pathol."},{"key":"ref_172","first-page":"3233","article-title":"Involvement of very late activation antigen 4 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) in tumor necrosis factor alpha enhancement of experimental metastasis","volume":"54","author":"Okahara","year":"1994","journal-title":"Cancer Res."},{"key":"ref_173","first-page":"4771","article-title":"Interleukin 1-induced augmentation of experimental metastases from a human melanoma in nude mice","volume":"50","author":"Giavazzi","year":"1990","journal-title":"Cancer Res."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF00155590","article-title":"Interleukin-1 increases tumor cell adhesion to endothelial cells through an RGD dependent mechanism: In vitro and in vivo studies","volume":"8","author":"Lauri","year":"1990","journal-title":"Clin. Exp. Metastasis"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/ijc.2910520522","article-title":"Effect of IL-1 on experimental bone\/bone-marrow metastases","volume":"52","author":"Arguello","year":"1992","journal-title":"Int. J. Cancer"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1073\/pnas.0437939100","article-title":"IL-1 is required for tumor invasiveness and angiogenesis","volume":"100","author":"Voronov","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S8756-3282(99)00210-0","article-title":"Osteoblasts\/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor\/RANKL but not macrophage colony-stimulating factor: Receptor activator of NF-kappa B ligand","volume":"25","author":"Udagawa","year":"1999","journal-title":"Bone"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.cmet.2007.05.001","article-title":"Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction","volume":"5","author":"Tatsumi","year":"2007","journal-title":"Cell Metab."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1006\/bbrc.1999.1623","article-title":"Activated T lymphocytes support osteoclast formation in vitro","volume":"265","author":"Horwood","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1002\/1529-0131(200112)44:12<2768::AID-ART464>3.0.CO;2-I","article-title":"The osteoprotegerin\/receptor activator of nuclear factor kappaB\/receptor activator of nuclear factor kappaB ligand system in cartilage","volume":"44","author":"Komuro","year":"2001","journal-title":"Arthritis Rheum."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1093\/rheumatology\/kep300","article-title":"Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis","volume":"48","author":"Amiable","year":"2009","journal-title":"Rheumatology"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4248\/BR201301003","article-title":"Osteoclasts: New Insights","volume":"1","author":"Feng","year":"2013","journal-title":"Bone Res."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nature04524","article-title":"Regulation of cancer cell migration and bone metastasis by RANKL","volume":"440","author":"Jones","year":"2006","journal-title":"Nature"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/jcb.23009","article-title":"RANKL increases migration of human lung cancer cells through intercellular adhesion molecule-1 up-regulation","volume":"112","author":"Chen","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/pros.20678","article-title":"RANKL acts directly on RANK-expressing prostate tumor cells and mediates migration and expression of tumor metastasis genes","volume":"68","author":"Armstrong","year":"2008","journal-title":"Prostate"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1136\/jclinpath-2011-200312","article-title":"Receptor activator for nuclear factor \u03ba B expression predicts poor prognosis in breast cancer patients with bone metastasis but not in patients with visceral metastasis","volume":"65","author":"Zhang","year":"2012","journal-title":"J. Clin. Pathol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.clbc.2011.05.001","article-title":"Role of RANK, RANKL, OPG, and CXCR4 tissue markers in predicting bone metastases in breast cancer patients","volume":"11","author":"Ibrahim","year":"2011","journal-title":"Clin. Breast Cancer"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/nm.2452","article-title":"Evidence for osteocyte regulation of bone homeostasis through RANKL expression","volume":"17","author":"Nakashima","year":"2011","journal-title":"Nat. Med."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1002\/art.24781","article-title":"Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo","volume":"60","author":"Axmann","year":"2009","journal-title":"Arthritis Rheum."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S8756-3282(02)00915-8","article-title":"Interleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanism","volume":"32","author":"Kudo","year":"2003","journal-title":"Bone"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1359\/jbmr.1998.13.3.393","article-title":"IL-6 mediates the effects of IL-1 or TNF, but not PTHrP or 1,25(OH)2D3, on osteoclast-like cell formation in normal human bone marrow cultures","volume":"13","author":"Devlin","year":"1998","journal-title":"J. Bone Miner. Res."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1007\/s00018-005-5175-3","article-title":"Neuronal signaling and the regulation of bone remodeling","volume":"62","author":"Elefteriou","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.abb.2008.11.012","article-title":"Beta2-adrenoreceptor ligands regulate osteoclast differentiation in vitro by direct and indirect mechanisms","volume":"482","author":"Aitken","year":"2009","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0167-4889(03)00042-9","article-title":"Effects of beta-adrenergic agonists on bone-resorbing activity in human osteoclast-like cells","volume":"1640","author":"Arai","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1210\/endo.141.12.7849","article-title":"Extracellular calcium-sensing receptor expression and its potential role in regulating parathyroid hormone-related peptide secretion in human breast cancer cell lines","volume":"141","author":"Sanders","year":"2000","journal-title":"Endocrinology"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nrc867","article-title":"Metastasis to bone: Causes, consequences and therapeutic opportunities","volume":"2","author":"Mundy","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1172\/JCI118947","article-title":"Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis","volume":"98","author":"Guise","year":"1996","journal-title":"J. Clin. Investig."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrc3055","article-title":"Cancer to bone: A fatal attraction","volume":"11","author":"Weilbaecher","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.3390\/jcm4091741","article-title":"MicroRNAs and Osteolytic Bone Metastasis: The Roles of MicroRNAs in Tumor-Induced Osteoclast Differentiation","volume":"4","author":"Kagiya","year":"2015","journal-title":"J. Clin. Med."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4236\/abb.2013.410A4003","article-title":"Role of TGF-\u03b2 in breast cancer bone metastases","volume":"4","author":"Chiechi","year":"2013","journal-title":"Adv. Biosci. Biotechnol."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"24571","DOI":"10.1074\/jbc.M202561200","article-title":"Transforming growth factor-beta stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathways","volume":"277","author":"Kakonen","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s12307-011-0075-6","article-title":"TGF-\u03b2 in the Bone Microenvironment: Role in Breast Cancer Metastases","volume":"4","author":"Buijs","year":"2011","journal-title":"Cancer Microenviron."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1172\/JCI3523","article-title":"TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development","volume":"103","author":"Yin","year":"1999","journal-title":"J. Clin. Investig."},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Biswas, S., Nyman, J.S., Alvarez, J., Chakrabarti, A., Ayres, A., Sterling, J., Edwards, J., Rana, T., Johnson, R., and Perrien, D.S. (2011). Anti-transforming growth factor \u00df antibody treatment rescues bone loss and prevents breast cancer metastasis to bone. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0027090"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/1476-4598-9-122","article-title":"Targeting the Transforming Growth Factor-beta pathway inhibits human basal-like breast cancer metastasis","volume":"9","author":"Ganapathy","year":"2010","journal-title":"Mol. Cancer"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/nm.1943","article-title":"Imaging transforming growth factor-beta signaling dynamics and therapeutic response in breast cancer bone metastasis","volume":"15","author":"Korpal","year":"2009","journal-title":"Nat. Med."},{"key":"ref_207","first-page":"18","article-title":"Cancer and Bone*","volume":"19","author":"Guise","year":"1998","journal-title":"Endocr. Rev."},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Guise, T.A., and Chirgwin, J.M. (2003). Transforming growth factor-beta in osteolytic breast cancer bone metastases. Clin. Orthop. Relat. Res., S32\u2013S38.","DOI":"10.1097\/01.blo.0000093055.96273.69"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/nm.3961","article-title":"Excess TGF-\u03b2 mediates muscle weakness associated with bone metastases in mice","volume":"21","author":"Waning","year":"2015","journal-title":"Nat. Med."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"358","DOI":"10.3389\/fendo.2017.00358","article-title":"Osteolytic Breast Cancer Causes Skeletal Muscle Weakness in an Immunocompetent Syngeneic Mouse Model","volume":"8","author":"Regan","year":"2017","journal-title":"Front. Endocrinol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s11914-017-0344-5","article-title":"The Role of TGF\u03b2 in Bone-Muscle Crosstalk","volume":"15","author":"Regan","year":"2017","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.3389\/fimmu.2019.01408","article-title":"Immune Function and Diversity of Osteoclasts in Normal and Pathological Conditions","volume":"10","author":"Madel","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1002\/jbmr.2868","article-title":"Inflammatory Osteoclasts Prime TNF\u03b1-Producing CD4+ T Cells and Express CX3 CR1","volume":"31","author":"Ciucci","year":"2016","journal-title":"J. Bone Miner. Res."},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Buchwald, Z.S., Kiesel, J.R., DiPaolo, R., Pagadala, M.S., and Aurora, R. (2012). Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038199"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.4049\/jimmunol.0803897","article-title":"Cross-presentation by osteoclasts induces FoxP3 in CD8+ T cells","volume":"182","author":"Kiesel","year":"2009","journal-title":"J. Immunol."},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Madel, M.-B., Ib\u00e1\u00f1ez, L., Ciucci, T., Halper, J., Rouleau, M., Boutin, A., Hue, C., Duroux-Richard, I., Apparailly, F., and Garchon, H.-J. (2020). Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1. Elife, 9.","DOI":"10.7554\/eLife.54493"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1182\/blood-2016-03-707547","article-title":"Osteoclasts promote immune suppressive microenvironment in multiple myeloma: Therapeutic implication","volume":"128","author":"An","year":"2016","journal-title":"Blood"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.ccr.2013.09.008","article-title":"Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis","volume":"24","author":"Ell","year":"2013","journal-title":"Cancer Cell"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"20350","DOI":"10.1073\/pnas.0706901104","article-title":"MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression","volume":"104","author":"Lee","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/bcr2484","article-title":"MicroRNAs and their target gene networks in breast cancer","volume":"12","author":"Lal","year":"2010","journal-title":"Breast Cancer Res."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1136\/bmj.330.7494.769","article-title":"Recent developments in bisphosphonates for patients with metastatic breast cancer","volume":"330","author":"Gainford","year":"2005","journal-title":"BMJ"},{"key":"ref_222","first-page":"35","article-title":"Optimal management of bone metastases in breast cancer patients","volume":"3","author":"Wong","year":"2011","journal-title":"Breast Cancer"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1017\/S1462399408000616","article-title":"Molecular mechanisms and treatment of bone metastasis","volume":"10","author":"Clines","year":"2008","journal-title":"Expert Rev. Mol. Med."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"232","DOI":"10.4103\/IJPSYM.IJPSYM_512_17","article-title":"Tiamongla Stress and Quality of Life in Cancer Patients: Medical and Psychological Intervention","volume":"40","author":"Barre","year":"2018","journal-title":"Indian J. Psychol. Med."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1177\/2156587216676122","article-title":"Cancer and Cancer-Related Fatigue and the Interrelationships with Depression, Stress, and Inflammation","volume":"22","author":"Weber","year":"2017","journal-title":"J. Evid. Based Complement. Altern. Med."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/NMD.0000000000000276","article-title":"The complex role of personality in cancer treatment: Impact of dependency-detachment on health status, distress, and physician-patient relationship","volume":"203","author":"Porcerelli","year":"2015","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1007\/s00262-008-0485-6","article-title":"Immune, endocrine, and behavioral precursors to breast cancer recurrence: A case-control analysis","volume":"57","author":"Thornton","year":"2008","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4103\/0253-7176.101774","article-title":"The effect of anxiety on breast cancer patients","volume":"34","author":"Baqutayan","year":"2012","journal-title":"Indian J. Psychol. Med."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/14779072.2017.1307736","article-title":"Clinical utility of sympathetic blockade in cardiovascular disease management","volume":"15","author":"Park","year":"2017","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10549-005-9091-x","article-title":"A cohort study of antihypertensive medication use and breast cancer among Danish women","volume":"97","author":"Fryzek","year":"2006","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1002\/cncr.11663","article-title":"Relation between use of antihypertensive medications and risk of breast carcinoma among women ages 65\u201379 years","volume":"98","author":"Li","year":"2003","journal-title":"Cancer"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"10634","DOI":"10.1038\/ncomms10634","article-title":"Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination","volume":"7","author":"Le","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1093\/annonc\/mdx264","article-title":"Beta blockers and improved progression-free survival in patients with advanced HER2 negative breast cancer: A retrospective analysis of the ROSE\/TRIO-012 study","volume":"28","author":"Spera","year":"2017","journal-title":"Ann. Oncol. Off. J. Eur. Soc. Med. Oncol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"6446","DOI":"10.18632\/oncotarget.14119","article-title":"Use of non-selective \u03b2-blockers is associated with decreased tumor proliferative indices in early stage breast cancer","volume":"8","author":"Montoya","year":"2017","journal-title":"Oncotarget"},{"key":"ref_235","doi-asserted-by":"crossref","unstructured":"Pasquier, E., Ciccolini, J., Carre, M., Giacometti, S., Fanciullino, R., Pouchy, C., Montero, M.-P., Serdjebi, C., Kavallaris, M., and Andre, N. (2011). Propranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: Implication in breast cancer treatment. Oncotarget, 2.","DOI":"10.18632\/oncotarget.343"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/S2213-8587(17)30188-2","article-title":"Osteoporosis treatment: Recent developments and ongoing challenges","volume":"5","author":"Khosla","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1200\/jco.2013.31.15_suppl.1061","article-title":"Prognostic effect of beta blockers (BB) in triple-negative breast cancer (TNBC) patients","volume":"31","author":"Munzone","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.3389\/fonc.2020.01130","article-title":"The Influence of Pre-Existing Beta-Blockers Use on Survival Outcomes in HER2 Positive Advanced Breast Cancer: Pooled Analysis of Clinical Trial Data","volume":"10","author":"Modi","year":"2020","journal-title":"Front. Oncol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/13\/12\/2887\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:12:24Z","timestamp":1760163144000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/13\/12\/2887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,9]]},"references-count":238,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["cancers13122887"],"URL":"https:\/\/doi.org\/10.3390\/cancers13122887","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,9]]}}}