{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:37:55Z","timestamp":1793407075388,"version":"4.5.0"},"reference-count":54,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T00:00:00Z","timestamp":1623283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Although awake resection using intraoperative cortico-subcortical functional brain mapping is the benchmark technique for diffuse gliomas within eloquent brain areas, it is still rarely proposed for IDH-wildtype glioblastomas. We have assessed the feasibility, safety, and efficacy of awake resection for IDH-wildtype glioblastomas. Methods: Observational single-institution cohort (2012\u20132018) of 453 adult patients harboring supratentorial IDH-wildtype glioblastomas who benefited from awake resection, from asleep resection, or from a biopsy. Case matching (1:1) criteria between the awake group and asleep group: gender, age, RTOG-RPA class, tumor side, location and volume and neurosurgeon experience. Results: In patients in the awake resection subgroup (n = 42), supratotal resections were more frequent (21.4% vs. 3.1%, p &lt; 0.0001) while partial resections were less frequent (21.4% vs. 40.1%, p &lt; 0.0001) compared to the asleep (n = 222) resection subgroup. In multivariable analyses, postoperative standard radiochemistry (aHR = 0.04, p &lt; 0.0001), supratotal resection (aHR = 0.27, p = 0.0021), total resection (aHR = 0.43, p &lt; 0.0001), KPS score &gt; 70 (HR = 0.66, p = 0.0013), MGMT promoter methylation (HR = 0.55, p = 0.0031), and awake surgery (HR = 0.54, p = 0.0156) were independent predictors of overall survival. After case matching, a longer overall survival was found for awake resection (HR = 0.47, p = 0.0103). Conclusions: Awake resection is safe, allows larger resections than asleep surgery, and positively impacts overall survival of IDH-wildtype glioblastoma in selected adult patients.<\/jats:p>","DOI":"10.3390\/cancers13122911","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T13:31:39Z","timestamp":1623331899000},"page":"2911","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Feasibility, Safety and Impact on Overall Survival of Awake Resection for Newly Diagnosed Supratentorial IDH-Wildtype Glioblastomas in Adults"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4569-5304","authenticated-orcid":false,"given":"Alessandro","family":"Moiraghi","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, GHU Site Sainte-Anne, F-75014 Paris, France"},{"name":"Universit\u00e9 de Paris, 102-108 rue de la Sant\u00e9, F-75014 Paris, France"},{"name":"Division of Neurosurgery, Geneva University Hospitals and Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland"},{"name":"Swiss Foundation for Innovation and Training in Surgery (SFITS), 1205 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Roux","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, GHU Site Sainte-Anne, F-75014 Paris, France"},{"name":"Universit\u00e9 de Paris, 102-108 rue de la Sant\u00e9, F-75014 Paris, France"},{"name":"Institut de Psychiatrie et Neurosciences de Paris (IPNP), UMR S1266, INSERM, IMA-BRAIN, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9548-644X","authenticated-orcid":false,"given":"Sophie","family":"Peeters","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of California, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Pelletier","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, CHU de Saint Etienne, 42270 Saint Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan","family":"Baroud","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, CHU Notre Dame de Secours, Byblos, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Trancart","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, GHU Site Sainte-Anne, F-75014 Paris, France"},{"name":"Universit\u00e9 de Paris, 102-108 rue de la Sant\u00e9, F-75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Oppenheim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, GHU Site Sainte-Anne, F-75014 Paris, France"},{"name":"Universit\u00e9 de Paris, 102-108 rue de la Sant\u00e9, F-75014 Paris, France"},{"name":"Department of Neuroradiology, GHU Site Sainte-Anne, F-75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanu\u00e8le","family":"Lechapt","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, 102-108 rue de la Sant\u00e9, F-75014 Paris, France"},{"name":"Department of Neuropathology, GHU Site Sainte-Anne, F-75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Benevello","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, GHU Site Sainte-Anne, F-75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Parraga","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, GHU Site Sainte-Anne, F-75014 Paris, France"},{"name":"Universit\u00e9 de Paris, 102-108 rue de la Sant\u00e9, F-75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Varlet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, 102-108 rue de la Sant\u00e9, F-75014 Paris, France"},{"name":"Institut de Psychiatrie et Neurosciences de Paris (IPNP), UMR S1266, INSERM, IMA-BRAIN, 75014 Paris, France"},{"name":"Department of Neuropathology, GHU Site Sainte-Anne, F-75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Chr\u00e9tien","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, 102-108 rue de la Sant\u00e9, F-75014 Paris, France"},{"name":"Department of Neuropathology, GHU Site Sainte-Anne, F-75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Dezamis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, GHU Site Sainte-Anne, F-75014 Paris, France"},{"name":"Universit\u00e9 de Paris, 102-108 rue de la Sant\u00e9, F-75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Zanello","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, GHU Site Sainte-Anne, F-75014 Paris, France"},{"name":"Universit\u00e9 de Paris, 102-108 rue de la Sant\u00e9, F-75014 Paris, France"},{"name":"Institut de Psychiatrie et Neurosciences de Paris (IPNP), UMR S1266, INSERM, IMA-BRAIN, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-9844","authenticated-orcid":false,"given":"Johan","family":"Pallud","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, GHU Site Sainte-Anne, F-75014 Paris, France"},{"name":"Universit\u00e9 de Paris, 102-108 rue de la Sant\u00e9, F-75014 Paris, France"},{"name":"Institut de Psychiatrie et Neurosciences de Paris (IPNP), UMR S1266, INSERM, IMA-BRAIN, 75014 Paris, 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