{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:16:08Z","timestamp":1790525768808,"version":"4.1.0"},"reference-count":61,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-17-EURE-000"],"award-info":[{"award-number":["ANR-17-EURE-000"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["17-EURE-0003"],"award-info":[{"award-number":["17-EURE-0003"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"FRM","doi-asserted-by":"publisher","award":["SPF20150934074"],"award-info":[{"award-number":["SPF20150934074"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"name":"LIGUE SAVOIE","award":["2017"],"award-info":[{"award-number":["2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The inflammatory gene NLRP7 is the major gene responsible for recurrent complete hydatidiform moles (CHM), an abnormal pregnancy that can develop into gestational choriocarcinoma (CC). However, the role of NLRP7 in the development and immune tolerance of CC has not been investigated. Three approaches were employed to define the role of NLRP7 in CC development: (i) a clinical study that analyzed human placenta and sera collected from women with normal pregnancies, CHM or CC; (ii) an in vitro study that investigated the impact of NLRP7 knockdown on tumor growth and organization; and (iii) an in vivo study that used two CC mouse models, including an orthotopic model. NLRP7 and circulating inflammatory cytokines were upregulated in tumor cells and in CHM and CC. In tumor cells, NLRP7 functions in an inflammasome-independent manner and promoted their proliferation and 3D organization. Gravid mice placentas injected with CC cells invalidated for NLRP7, exhibited higher maternal immune response, developed smaller tumors, and displayed less metastases. Our data characterized the critical role of NLRP7 in CC and provided evidence of its contribution to the development of an immunosuppressive maternal microenvironment that not only downregulates the maternal immune response but also fosters the growth and progression of CC.<\/jats:p>","DOI":"10.3390\/cancers13122999","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T11:00:33Z","timestamp":1623754833000},"page":"2999","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["NLRP7 Promotes Choriocarcinoma Growth and Progression through the Establishment of an Immunosuppressive Microenvironment"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6968-4215","authenticated-orcid":false,"given":"Deborah","family":"Reynaud","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Inserm U1292, Universit\u00e9 Grenoble-Alpes, 38000 Grenoble, France"},{"name":"Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), Biosciences and Biotechnology Institute of Grenoble, CEDEX 9, 38054 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8767-6462","authenticated-orcid":false,"given":"Roland","family":"Abi Nahed","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Inserm U1292, Universit\u00e9 Grenoble-Alpes, 38000 Grenoble, France"},{"name":"Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), Biosciences and Biotechnology Institute of Grenoble, CEDEX 9, 38054 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Lemaitre","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Inserm U1292, Universit\u00e9 Grenoble-Alpes, 38000 Grenoble, France"},{"name":"Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), Biosciences and Biotechnology Institute of Grenoble, CEDEX 9, 38054 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4988-9723","authenticated-orcid":false,"given":"Pierre-Adrien","family":"Bolze","sequence":"additional","affiliation":[{"name":"Department of Gynecological Surgery and Oncology, Obstetrics, French Reference Center for Gestational Trophoblastic Diseases, University Hospital Lyon Sud, University of Lyon 1, 69000 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Traboulsi","sequence":"additional","affiliation":[{"name":"Laboratory for Immuno-Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 2005, 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Molecular Biology Department, CHU Clermont-Ferrand, 63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houssine","family":"Boufettal","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, Ibn Rochd University Hospital, Hassan 2 University, Faculty of Medicine and Pharmacy, 20360 Casablanca, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Inserm U1292, Universit\u00e9 Grenoble-Alpes, 38000 Grenoble, France"},{"name":"Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), Biosciences and Biotechnology Institute of Grenoble, CEDEX 9, 38054 Grenoble, France"},{"name":"Centre Hospitalo-Universitaire Grenoble Alpes, Service Obst\u00e9trique, CS 10217, Universit\u00e9 Grenoble Alpes, CEDEX 9, 38043 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Touria","family":"Aboussaouira","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department, Ibn Rochd University Hospital, Hassan 2 University, Faculty of Medicine and Pharmacy, 20360 Casablanca, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2535-5134","authenticated-orcid":false,"given":"Padma","family":"Murthi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Monash Biomedicine Discovery Institute, Monash, Clayton, VIC 3168, Australia"},{"name":"Department of Obstetrics and Gynecology, The University of Melbourne, Parkville, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4060-2159","authenticated-orcid":false,"given":"Rima","family":"Slim","sequence":"additional","affiliation":[{"name":"Departments of Human Genetics and Obstetrics and 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