{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T05:31:08Z","timestamp":1771306268306,"version":"3.50.1"},"reference-count":40,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Research Foundation (DFG)","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/501100002839","name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100002839","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Optic nerve sheath meningiomas (ONSM) are rare but can lead to irreversible blindness. Hybrid imaging may enhance tumor delineation and diagnostic accuracy via receptor binding. However, relevant clinical data for ONSM are lacking. We evaluated the feasibility of receptor-based hybrid imaging prior to robotic radiosurgery (RRS). We retrospectively analyzed all of our institution\u2019s patients with suspected ONSM who underwent combined positron emission tomography and magnetic resonance imaging (PET\/MRI) with gallium-68-labeled (DOTA0-Phe1-Tyr3) octreotide (Ga68-DOTATOC) before RRS between 2018 and 2019. Eight patients with ten suspected ONSM (female = 7; median age, 51.2 years; IQR, 43.0\u201366.0) were included. Nine out of ten ONSM were deemed PET-positive with a median standard uptake value (SUV) max of 5.6 (IQR, 2.6\u20137.8). For all nine ONSM that presented 68Ga-DOTATOC uptake, hybrid PET\/MRI was used for target volume contouring prior to RSS. At a median follow-up of 11.7 months (IQR, 9.4\u201316.4), tumor control was achieved in all patients. Radiosurgery resulted in the improvement of visual acuity in two of eight patients, whereas six showed stable vision. Ga68-DOTATOC-PET\/MRI can be used for target volume contouring prior to RRS for ONSM as it enables safe treatment planning and improves diagnostic accuracy.<\/jats:p>","DOI":"10.3390\/cancers13133305","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T05:00:10Z","timestamp":1625115610000},"page":"3305","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["68Ga-DOTATOC-PET\/MRI\u2014A Secure One-Stop Shop Imaging Tool for Robotic Radiosurgery Treatment Planning in Patients with Optic Nerve Sheath Meningioma"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6641-1070","authenticated-orcid":false,"given":"Josefine","family":"Graef","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Charite\u0301\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, Berlin Institute of Health, 13353 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7302-7886","authenticated-orcid":false,"given":"Christian","family":"Furth","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Charite\u0301\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, Berlin Institute of Health, 13353 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Kathrin","family":"Kluge","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, Berlin Institute of Health, 13353 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8946-6426","authenticated-orcid":false,"given":"Gueliz","family":"Acker","sequence":"additional","affiliation":[{"name":"Berlin Institute of Health at Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, BIH Academy, Clinician Scientist Program, 10117 Berlin, Germany"},{"name":"Department of Neurosurgery, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, Berlin Institute of Health, 10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melina","family":"Kord","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, Berlin Institute of Health, 13353 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoe","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, Berlin Institute of Health, 13353 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4414-0657","authenticated-orcid":false,"given":"Holger","family":"Amthauer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Charite\u0301\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, Berlin Institute of Health, 13353 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Makowski","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, School of Medicine, Technical University of Munich, 81675 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Loebel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, Berlin Institute of Health, 10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Vajkoczy","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, Berlin Institute of Health, 10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Budach","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, Berlin Institute of Health, 13353 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7700-4657","authenticated-orcid":false,"given":"Carolin","family":"Senger","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, Berlin Institute of Health, 13353 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0039-6257(92)90135-G","article-title":"Optic nerve sheath meningiomas","volume":"37","author":"Dutton","year":"1992","journal-title":"Surv. Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"168","DOI":"10.47102\/annals-acadmedsg.V35N3p168","article-title":"New concepts in the management of optic nerve sheath meningiomas","volume":"35","author":"Berman","year":"2006","journal-title":"Ann. Acad. Med. Singap."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1136\/bjo.86.11.1265","article-title":"Stereotactic fractionated irradiation of optic nerve sheath meningioma: A new treatment alternative","volume":"86","author":"Pitz","year":"2002","journal-title":"Br. J. Ophthalmol."},{"key":"ref_4","unstructured":"Patel, B.C., De Jesus, O., and Margolin, E. (2021, February 11). Optic Nerve Sheath Meningioma, Available online: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28613618."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.jocn.2013.03.008","article-title":"Diagnosis and management of optic nerve sheath meningiomas","volume":"20","author":"Shapey","year":"2013","journal-title":"J. Clin. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3389\/fonc.2018.00454","article-title":"The Use of 68Ga-DOTATATE PET\/CT in the Non-invasive Diagnosis of Optic Nerve Sheath Meningioma: A Case Report","volume":"8","author":"Yeboa","year":"2018","journal-title":"Front. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/01676830.2014.959185","article-title":"Ga-68-DOTA-TATE PET\/CT for Discrimination of Tumors of the Optic Pathway","volume":"34","author":"Klingenstein","year":"2014","journal-title":"Orbit"},{"key":"ref_8","first-page":"1053","article-title":"PET imaging of somatostatin receptors using [68GA]DOTA-D-Phe1-Tyr3-octreotide: First results in patients with meningiomas","volume":"42","author":"Henze","year":"2001","journal-title":"J. Nucl. Med."},{"key":"ref_9","first-page":"763","article-title":"Characterization of 68Ga-DOTA-D-Phe1-Tyr3-octreotide kinetics in patients with meningiomas","volume":"46","author":"Henze","year":"2005","journal-title":"J. Nucl. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.ejso.2009.01.007","article-title":"Clinical indications for Gallium-68 positron emission tomography imaging","volume":"35","author":"Khan","year":"2009","journal-title":"Eur. J. Surg. Oncol. (EJSO)"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Graef, J., Senger, C., Wetz, C., Baur, A.D.J., Kluge, A.K., Lukas, M., Rogasch, J.M.M., Walter-Rittel, T.C., Kohnert, D., and Makowski, M. (2020). Shortened Tracer Uptake Time in GA-68-DOTATOC-PET of Meningiomas Does Not Impair Diagnostic Accuracy and PET Volume Definition. Diagnostics, 10.","DOI":"10.3390\/diagnostics10121084"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1177\/107327480401100508","article-title":"Diagnosis and Treatment of Orbital Optic Nerve Sheath Meningioma","volume":"11","author":"Turbin","year":"2004","journal-title":"Cancer Control"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/cncr.22859","article-title":"Primary optic nerve sheath meningioma","volume":"110","author":"Jeremic","year":"2007","journal-title":"Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/08820530490884227","article-title":"Primary radiotherapy for optic nerve sheath meningioma","volume":"19","author":"Melian","year":"2004","journal-title":"Semin. Ophthalmol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1227\/NEU.0b013e31822932fe","article-title":"Multisession Radiosurgery for Optic Nerve Sheath Meningiomas\u2014An Effective Option","volume":"69","author":"Marchetti","year":"2011","journal-title":"Neurosurgery"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"E9","DOI":"10.3171\/2019.3.FOCUS1925","article-title":"Impact of 68Ga-DOTATOC PET\/MRI on robotic radiosurgery treatment planning in meningioma patients: First experiences in a single institution","volume":"46","author":"Acker","year":"2019","journal-title":"Neurosurg. Focus"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1007\/s00259-009-1270-2","article-title":"Potential impact of 68Ga-DOTATOC PET\/CT on stereotactic radiotherapy planning of meningiomas","volume":"37","author":"Nyuyki","year":"2009","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1002\/jmri.25711","article-title":"PET\/MRI: Where might it replace PET\/CT?","volume":"46","author":"Ehman","year":"2017","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1093\/neuonc\/nou131","article-title":"Comparison of 68Ga-DOTATOC-PET\/CT and PET\/MRI hybrid systems in patients with cranial meningioma: Initial results","volume":"17","author":"Wolf","year":"2015","journal-title":"Neuro-Oncology"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Senger, C., Kluge, A., Kord, M., Zimmermann, Z., Conti, A., Kufeld, M., Kreimeier, A., Loebel, F., Stromberger, C., and Budach, V. (2021). Effectiveness and Safety of Robotic Radiosurgery for Optic Nerve Sheath Meningiomas: A Single Institution Series. Cancers, 13.","DOI":"10.3390\/cancers13092165"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.7785\/tcrt.2012.500359","article-title":"Treatment and Technical Intervention Time Analysis of a Robotic Stereotactic Radiotherapy System","volume":"13","author":"Crop","year":"2014","journal-title":"Technol. Cancer Res. Treat."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1159\/000331193","article-title":"CyberKnife Radiosurgery for Brain Metastases","volume":"25","author":"Wowra","year":"2012","journal-title":"Prog. Neurol. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1177\/153303461000900502","article-title":"The CyberKnife Robotic Radiosurgery System in 2010","volume":"9","author":"Kilby","year":"2010","journal-title":"Technol. Cancer Res. Treat."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ijrobp.2010.10.078","article-title":"Simultaneous 68Ga-DOTATOC-PET\/MRI for IMRT Treatment Planning for Meningioma: First Experience","volume":"81","author":"Thorwarth","year":"2011","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.2967\/jnumed.110.074773","article-title":"Hybrid PET\/MRI of Intracranial Masses: Initial Experiences and Comparison to PET\/CT","volume":"51","author":"Boss","year":"2010","journal-title":"J. Nucl. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11307-019-01337-2","article-title":"The Impact of Positron Range on PET Resolution, Evaluated with Phantoms and PHITS Monte Carlo Simulations for Conventional and Non-conventional Radionuclides","volume":"22","author":"Carter","year":"2019","journal-title":"Mol. Imaging Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/WCO.0b013e32831fd9f5","article-title":"Primary optic nerve tumours","volume":"22","author":"Wilhelm","year":"2009","journal-title":"Curr. Opin. Neurol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.sjopt.2016.01.002","article-title":"An unusual radiological presentation of optic nerve sheath meningioma","volume":"30","author":"Samarawickrama","year":"2016","journal-title":"Saudi J. Ophthalmol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1001\/jamaneurol.2018.3989","article-title":"Diagnostic Errors in Initial Misdiagnosis of Optic Nerve Sheath Meningiomas","volume":"76","author":"Bruce","year":"2019","journal-title":"JAMA Neurol."},{"key":"ref_30","first-page":"1315","article-title":"Analyses on the misdiagnoses of 25 patients with unilateral optic nerve sheath meningioma","volume":"9","author":"Mao","year":"2016","journal-title":"Int. J. Ophthalmol."},{"key":"ref_31","first-page":"1","article-title":"Optic Nerve Sheath Meningioma Masquerading as Optic Neuritis","volume":"2016","author":"Alroughani","year":"2016","journal-title":"Case Rep. Neurol. Med."},{"key":"ref_32","first-page":"1","article-title":"Optic nerve sheath meningioma detected by single- photon emission computed tomography\/computed tomography somatostatin receptor scintigraphy: A case report","volume":"10","author":"Ahle","year":"2016","journal-title":"J. Med Case Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4103\/0972-3919.198487","article-title":"Somatostatin receptor SPECT\/CT using 99m TC labeled hynic-toc aids in diagnosis of primary optic nerve sheath meningioma","volume":"32","author":"Rangarajan","year":"2017","journal-title":"Indian J. Nucl. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s13014-019-1438-2","article-title":"Retrospective analysis of fractionated intensity-modulated radiotherapy (IMRT) in the interdisciplinary management of primary optic nerve sheath meningiomas","volume":"14","author":"Eckert","year":"2019","journal-title":"Radiat. Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1136\/bjo.2009.167346","article-title":"Long-term response to fractionated radiotherapy of presumed optic nerve sheath meningioma","volume":"94","author":"Lesser","year":"2009","journal-title":"Br. J. Ophthalmol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1007\/s00417-019-04424-w","article-title":"Efficacy of intensity-modulated radiation therapy for optic nerve sheath meningioma","volume":"257","author":"Sasano","year":"2019","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ijrobp.2010.01.034","article-title":"Fractionated Conformal Radiotherapy for Management of Optic Nerve Sheath Meningiomas: Long-Term Outcomes of Tumor Control and Visual Function at a Single Institution","volume":"80","author":"Metellus","year":"2011","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3171\/2010.7.GKS10869","article-title":"Long-term results of Gamma Knife surgery for optic nerve sheath meningioma","volume":"113","author":"Liu","year":"2010","journal-title":"J. Neurosurg."},{"key":"ref_39","first-page":"73","article-title":"Prolonged vision return after radiosurgery for an optic nerve-sheath meningioma","volume":"2012. 2","author":"Kooshkabadi","year":"2012","journal-title":"J. Radiosurg SBRT"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.semradonc.2015.11.008","article-title":"Dose-Response Modeling of the Visual Pathway Tolerance to Single-Fraction and Hypofractionated Stereotactic Radiosurgery","volume":"26","author":"Hiniker","year":"2016","journal-title":"Semin. Radiat. Oncol."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/13\/13\/3305\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:24:32Z","timestamp":1760163872000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/13\/13\/3305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,1]]},"references-count":40,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["cancers13133305"],"URL":"https:\/\/doi.org\/10.3390\/cancers13133305","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,1]]}}}