{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:38:41Z","timestamp":1792417121277,"version":"4.4.0"},"reference-count":43,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T00:00:00Z","timestamp":1625270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Awake surgery with cognitive monitoring has increasingly been implemented to preserve brain networks and functionality. More recently, not only surgery in the left but also in the right hemisphere, i.c., the parietal lobe, was associated with potential risk for deficits in cognitive functions, such as cognitive flexibility. In this explorative pilot study, we compare cognitive performance more than three months after surgery with baseline measurements and explore the association between cognitive decline and subcortical tracts that may have been severed during surgery in the right hemisphere. Twenty-two patients who underwent surgery for a right parietal low-grade glioma were assessed pre- and postoperatively using the Trail Making Test and the Stroop task to administer set-shifting abilities and inhibition. Volume measurements and lesion\u2013symptom mapping analyses were performed on postoperative MRI scans. Careful interpretation of the results shows a change in TMT performance and not on the Stroop Task when the lateral part of the arcuate fasciculus is damaged, indicating that disconnection of the lateral part of the dorsal stream might be correlated specifically with impaired set-shifting and not with inhibition. More importantly, this study underlines the need for international concertation to allow larger studies to increase power and perform more detailed analyses.<\/jats:p>","DOI":"10.3390\/cancers13133337","type":"journal-article","created":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T22:34:36Z","timestamp":1625438076000},"page":"3337","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Impaired Set-Shifting from Dorsal Stream Disconnection: Insights from a European Series of Right Parietal Lower-Grade Glioma Resection"],"prefix":"10.3390","volume":"13","author":[{"given":"Suzanne L.","family":"Hartung","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Mandonnet","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Lariboisiere Hospital, 75010 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2988-8544","authenticated-orcid":false,"given":"Philip","family":"de Witt Hamer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Location VUmc, Cancer Center Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5553-7911","authenticated-orcid":false,"given":"Martin","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology and Brain Tumor Center Amsterdam at Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Wager","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Poitiers University Hospital, 86021 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Rech","sequence":"additional","affiliation":[{"name":"CHRU-Nancy, Service de Neurochirurgie, Universit\u00e9 de Lorraine, F-54000 Nancy, France"},{"name":"CNRS, CRAN, Universit\u00e9 de Lorraine, F-54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Pallud","sequence":"additional","affiliation":[{"name":"Department of Neursurgery, Saint-Anne Hospital, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Pessanha Viegas","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital Garcia de Orta, 2805-267 Almada, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Ille","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, School of Medicine, Klinikum rechts der Isar, Technical University Munich, 80333 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4050-1531","authenticated-orcid":false,"given":"Sandro M.","family":"Krieg","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, School of Medicine, Klinikum rechts der Isar, Technical University Munich, 80333 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7845-6196","authenticated-orcid":false,"given":"Pierre A.","family":"Robe","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine J. E.","family":"van Zandvoort","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands"},{"name":"Department of Experimental Psychology, Utrecht University, 3584 CS Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.cortex.2020.08.021","article-title":"Network-level causal analysis of set-shifting during trail making test part B: A multimodal analysis of a glioma surgery case","volume":"132","author":"Mandonnet","year":"2020","journal-title":"Cortex"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jocn.2019.08.091","article-title":"Glioma surgery: From preservation of motor skills to conservation of cognitive functions","volume":"70","author":"Altieri","year":"2019","journal-title":"J. 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