{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:16:30Z","timestamp":1793322990411,"version":"4.5.0"},"reference-count":232,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Cancer cachexia is a debilitating multi-factorial wasting syndrome characterised by severe skeletal muscle wasting and dysfunction (i.e., myopathy). In the oncology setting, cachexia arises from synergistic insults from both cancer\u2013host interactions and chemotherapy-related toxicity. The majority of studies have surrounded the cancer\u2013host interaction side of cancer cachexia, often overlooking the capability of chemotherapy to induce cachectic myopathy. Accumulating evidence in experimental models of cachexia suggests that some chemotherapeutic agents rapidly induce cachectic myopathy, although the underlying mechanisms responsible vary between agents. Importantly, we highlight the capacity of specific chemotherapeutic agents to induce cachectic myopathy, as not all chemotherapies have been evaluated for cachexia-inducing properties\u2014alone or in clinically compatible regimens. Furthermore, we discuss the experimental evidence surrounding therapeutic strategies that have been evaluated in chemotherapy-induced cachexia models, with particular focus on exercise interventions and adjuvant therapeutic candidates targeted at the mitochondria.<\/jats:p>","DOI":"10.3390\/cancers13143615","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T10:07:37Z","timestamp":1626689257000},"page":"3615","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Chemotherapy-Induced Myopathy: The Dark Side of the Cachexia Sphere"],"prefix":"10.3390","volume":"13","author":[{"given":"Dean G.","family":"Campelj","sequence":"first","affiliation":[{"name":"Institute for Health and Sport, Victoria University, Melbourne, VIC 8001, Australia"},{"name":"Inherited and Acquired Myopathy Program, Australian Institute for Musculoskeletal Science (AIMSS), Victoria University, St Albans, VIC 3021, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5874-7743","authenticated-orcid":false,"given":"Craig A.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Inherited and Acquired Myopathy Program, Australian Institute for Musculoskeletal Science (AIMSS), Victoria University, St Albans, VIC 3021, Australia"},{"name":"Centre for Muscle Research (CMR), Department of Physiology, The University of Melbourne, Parkville, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4854-0036","authenticated-orcid":false,"given":"Emma","family":"Rybalka","sequence":"additional","affiliation":[{"name":"Institute for Health and Sport, Victoria University, Melbourne, VIC 8001, Australia"},{"name":"Inherited and Acquired Myopathy Program, Australian Institute for Musculoskeletal Science (AIMSS), Victoria University, St Albans, VIC 3021, Australia"},{"name":"Department of Medicine\u2014Western Health, Melbourne Medical School, The University of Melbourne, Melbourne, VIC 3021, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8643","DOI":"10.1158\/0008-5472.CAN-07-6611","article-title":"A history of cancer chemotherapy","volume":"68","author":"DeVita","year":"2008","journal-title":"Cancer Res."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Reuvers, T.G.A., Kanaar, R., and Nonnekens, J. 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