{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:29:29Z","timestamp":1792639769751,"version":"4.5.0"},"reference-count":218,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Cholangiocarcinoma accounts for approximately 10% of all hepatobiliary tumors and represents 3% of all new-diagnosed malignancies worldwide. Intrahepatic cholangiocarcinoma (i-CCA) accounts for 10% of all cases, perihilar (h-CCA) cholangiocarcinoma represents two-thirds of the cases, while distal cholangiocarcinoma accounts for the remaining quarter. Originally described by Klatskin in 1965, h-CCA represents one of the most challenging tumors for hepatobiliary surgeons, mainly because of the anatomical vascular relationships of the biliary confluence at the hepatic hilum. Surgery is the only curative option, with the goal of a radical, margin-negative (R0) tumor resection. Continuous efforts have been made by hepatobiliary surgeons in order to achieve R0 resections, leading to the progressive development of aggressive approaches that include extended hepatectomies, associating liver partition, and portal vein ligation for staged hepatectomy, pre-operative portal vein embolization, and vascular resections. i-CCA is an aggressive biliary cancer that arises from the biliary epithelium proximal to the second-degree bile ducts. The incidence of i-CCA is dramatically increasing worldwide, and surgical resection is the only potentially curative therapy. An aggressive surgical approach, including extended liver resection and vascular reconstruction, and a greater application of systemic therapy and locoregional treatments could lead to an increase in the resection rate and the overall survival in selected i-CCA patients. Improvements achieved over the last two decades and the encouraging results recently reported have led to liver transplantation now being considered an appropriate indication for CCA patients.<\/jats:p>","DOI":"10.3390\/cancers13153657","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T11:53:23Z","timestamp":1626868403000},"page":"3657","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Current Surgical Management of Peri-Hilar and Intra-Hepatic Cholangiocarcinoma"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6110-8582","authenticated-orcid":false,"given":"Andrea","family":"Lauterio","sequence":"first","affiliation":[{"name":"Department of General Surgery and Transplantation, Niguarda Ca\u2019 Granda Hospital, 20162 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3697-1653","authenticated-orcid":false,"given":"Riccardo","family":"De Carlis","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Transplantation, Niguarda Ca\u2019 Granda Hospital, 20162 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9371-7411","authenticated-orcid":false,"given":"Leonardo","family":"Centonze","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Transplantation, Niguarda Ca\u2019 Granda Hospital, 20162 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2225-543X","authenticated-orcid":false,"given":"Vincenzo","family":"Buscemi","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Transplantation, Niguarda Ca\u2019 Granda Hospital, 20162 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niccol\u00f2","family":"Incarbone","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Transplantation, Niguarda Ca\u2019 Granda Hospital, 20162 Milan, Italy"},{"name":"School of Medicine and Surgery, University of Milano-Bicocca, 20162 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4946-512X","authenticated-orcid":false,"given":"Ivan","family":"Vella","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Transplantation, Niguarda Ca\u2019 Granda Hospital, 20162 Milan, Italy"},{"name":"Department of Surgical Sciences, University of Pavia, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9133-8220","authenticated-orcid":false,"given":"Luciano","family":"De Carlis","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Transplantation, Niguarda Ca\u2019 Granda Hospital, 20162 Milan, Italy"},{"name":"School of Medicine and Surgery, University of Milano-Bicocca, 20162 Milan, Italy"},{"name":"International Center for Digestive Health, University of Milano-Bicocca, 20162 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1056\/NEJM199910283411807","article-title":"Biliary Tract Cancers","volume":"341","author":"Gores","year":"1999","journal-title":"N. 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