{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:43:12Z","timestamp":1784198592805,"version":"3.55.0"},"reference-count":34,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Altered lipid metabolism has been described in some types of cancer. To analyse in depth the metabolic modifications in breast cancer patients, advanced 1H-nuclear magnetic resonance was performed in these patients. The main objective of this paper was to define a specific lipidomic signature for these cancer patients. Materials and methods: Serum from 240 women (171 breast cancer patients and 69 control women) were studied and analysed by nuclear magnetic resonance. Results: Triglyceride-enriched particles, specifically very low-density lipoprotein triglycerides, intermediate-density lipoprotein triglycerides, low-density lipoprotein triglycerides, and high-density lipoprotein triglycerides, were positively associated with breast cancer. Moreover, alanine, tyrosine, and branched amino acids were also associated with increased risk of breast cancer. Conclusions: Breast cancer patients showed a modified metabolome, giving a very interesting tool to draw different radar charts between control women and breast cancer patients. To our knowledge, this is the first time that advanced nuclear magnetic resonance profiling has been used to identify relevant and specifically altered lipid or amino acid metabolites in BC serum samples. The altered metabolic signature could be analysed for early and reliable BC patient diagnosis and prognosis.<\/jats:p>","DOI":"10.3390\/cancers13174281","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T00:19:26Z","timestamp":1629937166000},"page":"4281","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Altered Serum Metabolic Profile Assessed by Advanced 1H-NMR in Breast Cancer Patients"],"prefix":"10.3390","volume":"13","author":[{"given":"Josep","family":"Gum\u00e0","sequence":"first","affiliation":[{"name":"Department of Oncology, Hospital Universitari de Sant Joan, 43204 Reus, Spain"},{"name":"Center for R&D&I in Nutrition and Health, Institut de Investigaci\u00f3 Sanitaria Pere Virgili (IISPV), Avda. de la Universitat, 1\u2014Second Floor, 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4126-4809","authenticated-orcid":false,"given":"Jose","family":"Adri\u00e1-Cebri\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hospital Universitari de Sant Joan, 43204 Reus, Spain"},{"name":"Center for R&D&I in Nutrition and Health, Institut de Investigaci\u00f3 Sanitaria Pere Virgili (IISPV), Avda. de la Universitat, 1\u2014Second Floor, 43204 Reus, Spain"},{"name":"Research Unit on Lipids and Atherosclerosis, Institut de Investigaci\u00f3 Sanitaria Pere Virgili (IISPV), Universitat Rovira i Virgili, 43204 Reus, Spain"},{"name":"Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Institute of Health Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belen","family":"Ruiz-Aguado","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hospital Universitari de Sant Joan, 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinta","family":"Albacar","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hospital Universitari de Sant Joan, 43204 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6267-8779","authenticated-orcid":false,"given":"Josefa","family":"Girona","sequence":"additional","affiliation":[{"name":"Center for R&D&I in Nutrition and Health, Institut de Investigaci\u00f3 Sanitaria Pere Virgili (IISPV), Avda. de la Universitat, 1\u2014Second Floor, 43204 Reus, Spain"},{"name":"Research Unit on Lipids and Atherosclerosis, Institut de Investigaci\u00f3 Sanitaria Pere Virgili (IISPV), Universitat Rovira i Virgili, 43204 Reus, Spain"},{"name":"Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Institute of Health Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Rodr\u00edguez-Calvo","sequence":"additional","affiliation":[{"name":"Center for R&D&I in Nutrition and Health, Institut de Investigaci\u00f3 Sanitaria Pere Virgili (IISPV), Avda. de la Universitat, 1\u2014Second Floor, 43204 Reus, Spain"},{"name":"Research Unit on Lipids and Atherosclerosis, Institut de Investigaci\u00f3 Sanitaria Pere Virgili (IISPV), Universitat Rovira i Virgili, 43204 Reus, Spain"},{"name":"Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Institute of Health Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neus","family":"Mart\u00ednez-Micaelo","sequence":"additional","affiliation":[{"name":"Center for R&D&I in Nutrition and Health, Institut de Investigaci\u00f3 Sanitaria Pere Virgili (IISPV), Avda. de la Universitat, 1\u2014Second Floor, 43204 Reus, Spain"},{"name":"Research Unit on Lipids and Atherosclerosis, Institut de Investigaci\u00f3 Sanitaria Pere Virgili (IISPV), Universitat Rovira i Virgili, 43204 Reus, Spain"},{"name":"Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Institute of Health Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1274-3576","authenticated-orcid":false,"given":"Eric W. 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