{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:26:29Z","timestamp":1779114389623,"version":"3.51.4"},"reference-count":32,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T00:00:00Z","timestamp":1631404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GZ: RI 2905\/3-1"],"award-info":[{"award-number":["GZ: RI 2905\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>In the context of quality assurance, the objectives were to describe the surgical treatment and postoperative morbidity (particularly renal insufficiency). A retrospective, multicentre study of patients who underwent cytoreductive surgery (CRS) with cisplatin-based HITOC was performed. The study was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation (GZ: RI 2905\/3-1)). Patients (n = 350) with malignant pleural mesothelioma (n = 261; 75%) and thymic tumours with pleural spread (n = 58; 17%) or pleural metastases (n = 31; 9%) were analyzed. CRS was accomplished by pleurectomy\/decortication (P\/D: n = 77; 22%), extended P\/D (eP\/D: n = 263; 75%) or extrapleural pneumonectomy (EPP: n = 10; 3%). Patients received cisplatin alone (n = 212; 61%) or cisplatin plus doxorubicin (n = 138; 39%). Low-dose cisplatin (\u2264125 mg\/m2 BSA) was given in 67% of patients (n = 234), and high-dose cisplatin (&gt;125 mg\/m2 BSA) was given in 33% of patients (n = 116). Postoperative renal insufficiency appeared in 12% of the patients (n = 41), and 1.4% (n = 5) required temporary dialysis. Surgical revision was necessary in 51 patients (15%). In-hospital mortality was 3.7% (n = 13). Patients receiving high-dose cisplatin were 2.7 times more likely to suffer from renal insufficiency than patients receiving low-dose cisplatin (p = 0.006). The risk for postoperative renal failure is dependent on the intrathoracic cisplatin dosage but was within an acceptable range.<\/jats:p>","DOI":"10.3390\/cancers13184580","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T21:45:57Z","timestamp":1631483157000},"page":"4580","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Hyperthermic Intrathoracic Chemotherapy (HITOC) after Cytoreductive Surgery for Pleural Malignancies\u2014A Retrospective, Multicentre Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2365-4803","authenticated-orcid":false,"given":"Michael","family":"Ried","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Ludwig-Maximilians-University of Munich, Asklepios Lung Clinic, 82131 Gauting, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Till","family":"Markowiak","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Center for Clinical Studies, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Huppertz","sequence":"additional","affiliation":[{"name":"Center for Clinical Studies, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Koller","sequence":"additional","affiliation":[{"name":"Center for Clinical Studies, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hauke","family":"Winter","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Thoraxklinik, University Hospital Heidelberg, 69126 Heidelberg, Germany"},{"name":"Translational Lung Research Center (TLRC) Heidelberg, Member of the German Center for Lung Research (DZL), 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura V.","family":"Klotz","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Thoraxklinik, University Hospital Heidelberg, 69126 Heidelberg, Germany"},{"name":"Translational Lung Research Center (TLRC) Heidelberg, Member of the German Center for Lung Research (DZL), 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Hatz","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Ludwig-Maximilians-University of Munich, Asklepios Lung Clinic, 82131 Gauting, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Ludwig-Maximilians-University of Munich, Asklepios Lung Clinic, 82131 Gauting, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernward","family":"Passlick","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Medical Center\u2014University of Freiburg, 79106 Freiburg im Breisgau, Germany"},{"name":"Faculty of Medicine, University of Freiburg, 79110 Freiburg im Breisgau, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8077-082X","authenticated-orcid":false,"given":"Severin","family":"Schmid","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Medical Center\u2014University of Freiburg, 79106 Freiburg im Breisgau, Germany"},{"name":"Faculty of Medicine, University of Freiburg, 79110 Freiburg im Breisgau, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5973-264X","authenticated-orcid":false,"given":"Mohamed","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Medical Center\u2014University of Freiburg, 79106 Freiburg im Breisgau, Germany"},{"name":"Faculty of Medicine, University of Freiburg, 79110 Freiburg im Breisgau, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin E.","family":"Eichhorn","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Thoraxklinik, University Hospital Heidelberg, 69126 Heidelberg, Germany"},{"name":"Translational Lung Research Center (TLRC) Heidelberg, Member of the German Center for Lung Research (DZL), 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Stefan","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, University Hospital Regensburg, 93053 Regensburg, Germany"},{"name":"Department of Thoracic Surgery, Hospital Barmherzige Br\u00fcder Regensburg, 93049 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1093\/ejcts\/ezs418","article-title":"Cytoreductive surgery and hyper-thermic intrathoracic chemotherapy perfusion for 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Cancers, 13.","DOI":"10.3390\/cancers13143637"}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/13\/18\/4580\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:01:19Z","timestamp":1760166079000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/13\/18\/4580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,12]]},"references-count":32,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["cancers13184580"],"URL":"https:\/\/doi.org\/10.3390\/cancers13184580","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,12]]}}}