{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:21:33Z","timestamp":1760235693793,"version":"build-2065373602"},"reference-count":34,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>There have been conflicting results regarding the association between diabetes and the risk of hematologic malignancies, and its interaction with obesity is unknown. This study determined the risk of hematologic malignancies according to the glycemic status in a population-based study involving health screening 9,774,625 participants. The baseline glycemic status of the participants was categorized into no diabetes, impaired fasting glucose (IFG), newly detected diabetes, diabetes duration &lt;5 years, and diabetes duration \u22655 year groups. The risks of overall and specific hematologic malignancies were estimated using a Cox regression analysis. During a median follow up of 7.3 years, 14,733 hematologic malignancies developed. The adjusted hazard ratio (aHR) for the risk of all the hematologic malignancies was 0.99 (95% confidence interval (CI) 0.95\u20131.02) for IFG, 0.99 (95% CI 0.91\u20131.08) for newly detected diabetes, 1.03 (95% CI 0.96\u20131.11) for diabetes duration &lt;5 years, and 1.11 (95% CI 1.03, 1.20) for diabetes duration \u22655 year groups. The association was independent from obesity. The risk of non-Hodgkin\u2019s lymphoma (NHL) increased according to the progression of dysglycemia towards a longer diabetes duration, while Hodgkin\u2019s lymphoma did not. This study in Korea demonstrated diabetes to be associated with an increased risk of hematologic malignancies independent of obesity. The NHL risk increased with the diabetes duration.<\/jats:p>","DOI":"10.3390\/cancers13194760","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T09:59:15Z","timestamp":1632391155000},"page":"4760","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Obesity-Independent Association between Glycemic Status and the Risk of Hematologic Malignancy: A Nationwide Population-Based Longitudinal Cohort Study"],"prefix":"10.3390","volume":"13","author":[{"given":"Jihun","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan 49267, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Man","family":"Jin","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2776-4401","authenticated-orcid":false,"given":"Seok Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dahye","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, The Catholic University of Korea, Seoul 03083, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyungdo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Statistics and Actuarial Science, Soongsil University, Seoul 06978, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Min","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Boramae Medical Center, Seoul Metropolitan Government-Seoul National University, Seoul 07061, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JiWon","family":"Chang","sequence":"additional","affiliation":[{"name":"Supportive Care Center, Samsung Medical Center, Seoul 06351, Korea"},{"name":"Department of Family Medicine, Samsung Medical Center, Seoul 06351, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0119-5818","authenticated-orcid":false,"given":"Sang Youl","family":"Rhee","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul 02453, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taewoong","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Hematologic Malignancies and Cellular Therapy, Duke University Medical Center, Durham, NC 27710, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Wook","family":"Shin","sequence":"additional","affiliation":[{"name":"Supportive Care Center, Samsung Medical Center, Seoul 06351, Korea"},{"name":"Department of Family Medicine, Samsung Medical Center, Seoul 06351, Korea"},{"name":"Department of Clinical Research Design & Evaluation\/Department of Digital Health, Samsung Advanced Institute for Health Science & Technology (SAIHST), Sungkyunkwan University, Seoul 06351, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1053\/j.gastro.2003.10.065","article-title":"Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma","volume":"126","author":"Tran","year":"2004","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s00125-007-0681-5","article-title":"Diabetes mellitus and risk of endometrial cancer: A meta-analysis","volume":"50","author":"Friberg","year":"2007","journal-title":"Diabetologia"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"264","DOI":"10.2337\/dc14-1996","article-title":"Cancer risk among people with type 1 and type 2 diabetes: Disentangling true associations, detection bias, and reverse causation","volume":"38","author":"Harding","year":"2014","journal-title":"Diabetes Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s10654-011-9617-y","article-title":"Diabetes mellitus and incidence and mortality of colorectal cancer: A systematic review and meta-analysis of cohort studies","volume":"26","author":"Jiang","year":"2011","journal-title":"Eur. 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