{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:50:26Z","timestamp":1788915026811,"version":"build-2803163510"},"reference-count":48,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005888","name":"Uniwersytet Medyczny w Lodzi","doi-asserted-by":"publisher","award":["503\/1-153-05\/503-11-001"],"award-info":[{"award-number":["503\/1-153-05\/503-11-001"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The aim of the study was to validate thyroid US malignancy features, especially the nodule\u2019s shape, and selected Thyroid Imaging Reporting and Data Systems (EU-TIRADS; K-TIRADS; ACR-TIRADS, ATA guidelines) in patients with or without Hashimoto\u2019s thyroiditis (HT and non-HT groups). The study included 1188 nodules (HT: 358, non-HT: 830) with known final diagnoses. We found that the strongest indications of nodule\u2019s malignancy were microcalcifications (OR: 22.7) in HT group and irregular margins (OR:13.8) in non-HT group. Solid echostructure and macrocalcifications were ineffective in patients with HT. The highest accuracy of nodule\u2019s shape criterion was noted on transverse section, with the cut-off value of anteroposterior to transverse dimension ratio (AP\/T) close to 1.15 in both groups. When round nodules were regarded as suspicious in patients with HT (the cut-off value of AP\/T set to \u22651), it led to a three-fold increase in sensitivity of this feature, with a disproportionally lower decrease in specificity and similar accuracy. Such a modification was effective also for cancers other than PTC. The diagnostic effectiveness of analyzed TIRADS in patients with HT and without HT was similar. Changes in the threshold for AP\/T ratio influenced the number of nodules classified into the category of the highest risk, especially in the case of EU-TIRADS.<\/jats:p>","DOI":"10.3390\/cancers13194900","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:03:42Z","timestamp":1632960222000},"page":"4900","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Validation of Four Thyroid Ultrasound Risk Stratification Systems in Patients with Hashimoto\u2019s Thyroiditis; Impact of Changes in the Threshold for Nodule\u2019s Shape Criterion"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5617-0418","authenticated-orcid":false,"given":"Dorota","family":"S\u0142owi\u0144ska-Klencka","sequence":"first","affiliation":[{"name":"Department of Morphometry of Endocrine Glands, Medical University of Lodz, Pomorska Street 251, 92-213 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4581-0897","authenticated-orcid":false,"given":"Mariusz","family":"Klencki","sequence":"additional","affiliation":[{"name":"Department of Morphometry of Endocrine Glands, Medical University of Lodz, Pomorska Street 251, 92-213 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6339-1323","authenticated-orcid":false,"given":"Martyna","family":"Wojtaszek-Nowicka","sequence":"additional","affiliation":[{"name":"Department of Clinical Endocrinology, Medical University of Lodz, Pomorska Street 251, 92-213 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Wysocka-Konieczna","sequence":"additional","affiliation":[{"name":"Department of Morphometry of Endocrine Glands, Medical University of Lodz, Pomorska Street 251, 92-213 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Wo\u017aniak-Ose\u0142a","sequence":"additional","affiliation":[{"name":"Department of Morphometry of Endocrine Glands, Medical University of Lodz, Pomorska Street 251, 92-213 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u017cena","family":"Popowicz","sequence":"additional","affiliation":[{"name":"Department of Morphometry of Endocrine Glands, Medical University of Lodz, Pomorska Street 251, 92-213 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1159\/000478927","article-title":"European Thyroid Association Guidelines for Ultrasound Malignancy Risk Stratification of Thyroid Nodules in Adults: The EU-TIRADS","volume":"6","author":"Russ","year":"2017","journal-title":"Eur. 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