{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:10:46Z","timestamp":1782321046599,"version":"3.54.5"},"reference-count":41,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Mastocytosis is a rare disorder due to the abnormal proliferation of clonal mast cells. Mast cells exist in most tissues, mature in situ from hematopoietic stem cells and develop unique characteristics of local effector cells. Mastocytosis develops by activation mutation of the KIT surface receptor which is involved in the proliferation of a number of cell lines such as mast cells, germ cells, melanocytes, and hematopoietic cells. It manifests as two main categories: cutaneous mastocytosis and systemic mastocytosis. Imaging can play an important role in detection and characterization of the disease manifestation, not only by radiography and bone scans, but also magnetic resonance imaging and computed tomography, which can be more sensitive in the assessment of distinctive disease patterns. Radiologists should be aware of various appearances of this disease to better facilitate diagnosis and patient management. Accordingly, this review will discuss the clinical presentation, pathophysiology, and role of imaging in detection and extent estimation of the systemic involvement of the disease, in addition to demonstration of appearance on varying imaging modalities. Familiarity with the potential imaging findings associated with mastocytosis can aid in early disease diagnosis and classification and accordingly can lead directing further work up and better management.<\/jats:p>","DOI":"10.3390\/cancers13205102","type":"journal-article","created":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T08:09:32Z","timestamp":1634026172000},"page":"5102","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Mastocytosis\u2014A Review of Disease Spectrum with Imaging Correlation"],"prefix":"10.3390","volume":"13","author":[{"given":"Ahmed","family":"Elsaiey","sequence":"first","affiliation":[{"name":"Houston Methodist Hospital, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagar S.","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Yale New Haven Health at 1939 Bridgeport Hospital, Bridgeport, CT 06610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey T.","family":"Jensen","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center, Department of Diagnostic Imaging, University of Texas, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Klimkowski","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center, Department of Diagnostic Imaging, University of Texas, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Taher","sequence":"additional","affiliation":[{"name":"Transitional Year Residency Program, Trinity Health Midatlantic, Nazareth Hospital, Philadelphia, PA 19152, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3371-2632","authenticated-orcid":false,"given":"Humaira","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Department of Radiology, The State University of New Jersey, Piscataway, NJ 08854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajaykumar C.","family":"Morani","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center, Department of Diagnostic Imaging, University of Texas, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo K.","family":"Wong","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center, Department of Diagnostic Imaging, University of Texas, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1982-1429","authenticated-orcid":false,"given":"Usama I.","family":"Salem","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center, Department of Diagnostic Imaging, University of Texas, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M.","family":"Palmquist","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center, Department of Diagnostic Imaging, University of Texas, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled M.","family":"Elsayes","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center, Department of Diagnostic Imaging, University of Texas, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"key":"ref_1","first-page":"283","article-title":"Epidemiology, Prognosis, and Risk Factors in Mastocytosis","volume":"34","author":"Brockow","year":"2014","journal-title":"Immunol. 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