{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T02:53:51Z","timestamp":1768877631928,"version":"3.49.0"},"reference-count":33,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Neoadjuvant concurrent radiochemotherapy makes it possible to increase the breast conservation rate. This study reports the long term outcome of this treatment. Methods: From 2001 to 2003, 59 women with T2\u20133 N0\u20132 M0 invasive breast cancer (BC) not amenable to upfront breast conserving treatment (BCS) were included in this prospective, non-randomized phase II study. Chemotherapy (CT) consisted of four cycles of continuous 5-FU infusion and Vinorelbine. Starting concurrently with the second CT cycle, normofractionated RT was delivered to the breast and LN. Breast surgery was then performed. Results: Median follow-up (FU) was 13 years [3\u201318]. BCS was performed in 41 (69%) patients and mastectomy in 18 patients, with pathological complete response rate of 27%. Overall and distant-disease free survivals rates at 13 years were 70.9% [95% CI 59.6\u201384.2] and 71.5% [95% CI 60.5\u201384.5] respectively. Loco regional and local controls rates were 83.4% [95% CI 73.2\u201395.0] and 92.1% [95% CI 83.7\u2013100], respectively. Late toxicity (CTCAE-V3) was assessed in 51 patients (86%) with a median follow-up of 13 years. Fifteen presented grade 2 fibrosis (29.4%), 8 (15.7%) had telangiectasia, and 1 had radiodermatitis. Conclusions: This combined treatment provided high long-term local control rates with limited side-effects.<\/jats:p>","DOI":"10.3390\/cancers13205107","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T04:51:57Z","timestamp":1634100717000},"page":"5107","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Neoadjuvant Concurrent Radiotherapy and Chemotherapy in Early Breast Cancer Patients: Long-Term Results of a Prospective Phase II Trial"],"prefix":"10.3390","volume":"13","author":[{"given":"Diane","family":"Jornet","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Institut Curie, 75005 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Loap","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Institut Curie, 75005 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Yves","family":"Pierga","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Institut Curie, 75005 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Laki","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Institut Curie, 75005 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5754-5771","authenticated-orcid":false,"given":"Anne","family":"Vincent-Salomon","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institut Curie, 75005 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1795-7509","authenticated-orcid":false,"given":"Youlia M.","family":"Kirova","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Institut Curie, 75005 Paris, France"},{"name":"Faculty of Medicine, University Versailles St Quentin, 78000 St Quentin, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Fourquet","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Institut Curie, 75005 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Early Breast Cancer Trialists\u2019 Collaborative Group (EBCTCG) (2005). 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