{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:44:58Z","timestamp":1761061498730,"version":"build-2065373602"},"reference-count":111,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T00:00:00Z","timestamp":1634169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006545","name":"National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["U54MD010706-CHH"],"award-info":[{"award-number":["U54MD010706-CHH"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010232","name":"NIDA","doi-asserted-by":"publisher","award":["1U01DA045300-01A1"],"award-info":[{"award-number":["1U01DA045300-01A1"]}],"id":[{"id":"10.13039\/501100010232","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>An emerging theory about racial differences in cancer risk and outcomes is that psychological and social stressors influence cellular stress responses; however, limited empirical data are available on racial differences in cellular stress responses among men who are at risk for adverse prostate cancer outcomes. In this study, we undertook a systems approach to examine molecular profiles and cellular stress responses in an important segment of African American (AA) and European American (EA) men: men undergoing prostate biopsy. We assessed the prostate transcriptome with a single biopsy core via high throughput RNA sequencing (RNA-Seq). Transcriptomic analyses uncovered impacted biological pathways including PI3K-Akt signaling pathway, Neuroactive ligand-receptor interaction pathway, and ECM-receptor interaction. Additionally, 187 genes mapping to the Gene Ontology (GO) terms RNA binding, structural constituent of ribosome, SRP-dependent co-translational protein targeting to membrane and the biological pathways, translation, L13a-mediated translational silencing of Ceruloplasmin expression were differentially expressed (DE) between EA and AA. This signature allowed separation of AA and EA patients, and AA patients with the most severe clinical characteristics. AA patients with elevated expression levels of this genomic signature presented with higher Gleason scores, a greater number of positive core biopsies, elevated dehydroepiandrosterone sulfate levels and serum vitamin D deficiency. Protein-protein interaction (PPI) network analysis revealed a high degree of connectivity between these 187 proteins.<\/jats:p>","DOI":"10.3390\/cancers13205143","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T09:10:49Z","timestamp":1634202649000},"page":"5143","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A Systems Approach to Interrogate Gene Expression Patterns in African American Men Presenting with Clinically Localized Prostate Cancer"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4558-0400","authenticated-orcid":false,"given":"Gary","family":"Hardiman","sequence":"first","affiliation":[{"name":"Department of Medicine, Medical University of South Carolina (MUSC), Charleston, SC 29425, USA"},{"name":"Faculty of Medicine, Health and Life Sciences, School of Biological Sciences and Institute for Global Food Security, Queens University Belfast, Stranmillis Road, Belfast BT9 5AG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Savage","sequence":"additional","affiliation":[{"name":"Department of Urology, Medical University of South Carolina (MUSC), Charleston, SC 29425, USA"},{"name":"Ralph H. Johnson VA Medical Center, Charleston, SC 29401, USA"},{"name":"Department of Radiation Oncology, Medical University of South Carolina (MUSC), Charleston, SC 29425, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4645-7642","authenticated-orcid":false,"given":"E. Starr","family":"Hazard","sequence":"additional","affiliation":[{"name":"Academic Affairs Faculty, Medical University of South Carolina (MUSC), Charleston, SC 29425, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6370-2884","authenticated-orcid":false,"given":"Willian A.","family":"da Silveira","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Health and Life Sciences, School of Biological Sciences and Institute for Global Food Security, Queens University Belfast, Stranmillis Road, Belfast BT9 5AG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Morgan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Health and Life Sciences, School of Biological Sciences and Institute for Global Food Security, Queens University Belfast, Stranmillis Road, Belfast BT9 5AG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Harris","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Health and Life Sciences, School of Biological Sciences and Institute for Global Food Security, Queens University Belfast, Stranmillis Road, Belfast BT9 5AG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie S.","family":"Jefferson","sequence":"additional","affiliation":[{"name":"Hollings Cancer Center, Medical University of South Carolina (MUSC), Charleston, SC 29425, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Medical University of South Carolina (MUSC), Charleston, SC 29425, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Caulder","sequence":"additional","affiliation":[{"name":"Ralph H. Johnson VA Medical Center, Charleston, SC 29401, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Ambrose","sequence":"additional","affiliation":[{"name":"Ralph H. Johnson VA Medical Center, Charleston, SC 29401, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis","family":"Frey","sequence":"additional","affiliation":[{"name":"Biomedical Informatics Center (BMIC), Medical University of South Carolina (MUSC), Charleston, SC 29425, USA"},{"name":"Department of Public Health Sciences, Medical University of South Carolina (MUSC), Charleston, SC 29425, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7124-5158","authenticated-orcid":false,"given":"Bethany","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences, Medical University of South Carolina (MUSC), Charleston, SC 29425, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastiano","family":"Gattoni-Celli","sequence":"additional","affiliation":[{"name":"Ralph H. Johnson VA Medical Center, Charleston, SC 29401, USA"},{"name":"Department of Radiation Oncology, Medical University of South Carolina (MUSC), Charleston, SC 29425, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanita","family":"Hughes Halbert","sequence":"additional","affiliation":[{"name":"Hollings Cancer Center, Medical University of South Carolina (MUSC), Charleston, SC 29425, USA"},{"name":"Department of Psychiatry & Behavioral Sciences, Medical University of South Carolina (MUSC), Charleston, SC 29425, USA"},{"name":"Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA 90032, USA"},{"name":"Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90033, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejphar.2008.02.050","article-title":"The As and Ds of stress: Metabolic, morphological and behavioral consequences","volume":"585","author":"Reagan","year":"2008","journal-title":"Eur. 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