{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:46:48Z","timestamp":1792090008523,"version":"4.4.0"},"reference-count":71,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/01847; PI20\/00602; CB16\/12\/00273;"],"award-info":[{"award-number":["PI17\/01847; PI20\/00602; CB16\/12\/00273;"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Radiomics is a developing new discipline that analyzes conventional medical images to extract quantifiable data that can be mined for new biomarkers that show the biology of pathological processes at microscopic levels. These data can be converted into image-based signatures to improve diagnostic, prognostic and predictive accuracy in cancer patients. The combination of radiomics and molecular data, called radiogenomics, has clear implications for cancer patients\u2019 management. Though some studies have focused on radiogenomics signatures in hepatocellular carcinoma patients, only a few have examined colorectal cancer metastatic lesions in the liver. Moreover, the need to differentiate between liver lesions is fundamental for accurate diagnosis and treatment. In this review, we summarize the knowledge gained from radiomics and radiogenomics studies in hepatic metastatic colorectal cancer patients and their use in early diagnosis, response assessment and treatment decisions. We also investigate their value as possible prognostic biomarkers. In addition, the great potential of image mining to provide a comprehensive view of liver niche formation is examined thoroughly. Finally, new challenges and current limitations for the early detection of the liver premetastatic niche, based on radiomics and radiogenomics, are also discussed.<\/jats:p>","DOI":"10.3390\/cancers13215547","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T10:33:09Z","timestamp":1636108389000},"page":"5547","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Radiogenomics: Hunting Down Liver Metastasis in Colorectal Cancer Patients"],"prefix":"10.3390","volume":"13","author":[{"given":"Carolina","family":"de la Pinta","sequence":"first","affiliation":[{"name":"Radiation Oncology Department, Ram\u00f3n y Cajal University Hospital, IRYCIS, Alcal\u00e1 University, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda E.","family":"Castillo","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Ram\u00f3n y Cajal University Hospital, IRYCIS, Alcal\u00e1 University, 28034 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Cancer (CIBERONC), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Collado","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Ram\u00f3n y Cajal University Hospital, IRYCIS, Alcal\u00e1 University, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Galindo-Pumari\u00f1o","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Ram\u00f3n y Cajal University Hospital, IRYCIS, Alcal\u00e1 University, 28034 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Cancer (CIBERONC), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4406-8640","authenticated-orcid":false,"given":"Cristina","family":"Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Ram\u00f3n y Cajal University Hospital, IRYCIS, Alcal\u00e1 University, 28034 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Cancer (CIBERONC), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.ejso.2019.12.003","article-title":"Systematic review and meta-analysis of local ablative therapies for resectable colorectal liver metastases","volume":"46","author":"Rompianesi","year":"2020","journal-title":"Eur. 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