{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:03:02Z","timestamp":1777564982774,"version":"3.51.4"},"reference-count":26,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The prognostic value of the CRP to albumin ratio (CAR) among older adults with cancer is not known. Six hundred and three older outpatients with cancer and undergoing geriatric assessment before therapeutic decisions were prospectively recruited from the PF-EC cohort study. Serum albumin levels, serum CRP levels and the CAR were prospectively recorded at baseline, and at each consultation thereafter, as follows: 1, 3, 6, 9, 12, 18, 24 and 36 months. Frailty was defined as a G8-index \u2264 14. The primary endpoint was longitudinal variation in the CAR during the study follow-up. Two clusters in the longitudinal trajectories of the CAR were identified, one favourable, with lower values and better overall survival (cluster A), and the second with higher values and less favourable overall survival (cluster B). The median CAR [95% CI] for clusters A and B were respectively: 0.17 [0.04\u20130.48] and 0.26 [0.04\u20130.79] at baseline (p = 0.01), and 0.18 [0.02\u20133.17] and 0.76 [0.03\u20136.87] during the study follow-up (p &lt; 0.0001). Cluster B was associated with the frailest patients with metastatic disease, mainly driven by a high CRP level at baseline, and low albumin during the study follow-up. Our study results suggest that the most risk-prone patients have a cancer-cachexia trajectory.<\/jats:p>","DOI":"10.3390\/cancers13225782","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T08:53:56Z","timestamp":1637225636000},"page":"5782","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prognostic Value of Prospective Longitudinal CRP to Albumin Ratio among Older Outpatients with Cancer"],"prefix":"10.3390","volume":"13","author":[{"given":"Fiamma","family":"Burgassi","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine G\u00e9riatrique, H\u00f4pital Avicenne, APHP, 93000 Bobigny, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5579-9927","authenticated-orcid":false,"given":"Elena","family":"Paillaud","sequence":"additional","affiliation":[{"name":"Service de G\u00e9riatrie, H\u00f4pital Europ\u00e9en Georges Pompidou, APHP, 75015 Paris, France"},{"name":"Faculty of Health, University of Paris, 75006 Paris, France"},{"name":"Clinical Epidemiology and Ageing, IMRB-UPEC\/Inserm U955, Universit\u00e9 Paris-Est Cr\u00e9teil, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanne","family":"Poisson","sequence":"additional","affiliation":[{"name":"Service de G\u00e9riatrie, H\u00f4pital Europ\u00e9en Georges Pompidou, APHP, 75015 Paris, France"},{"name":"Faculty of Health, University of Paris, 75006 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5594-6694","authenticated-orcid":false,"given":"Guilhem","family":"Bousquet","sequence":"additional","affiliation":[{"name":"Service d\u2019Oncologie M\u00e9dicale, H\u00f4pital Avicenne, APHP, 93000 Bobigny, France"},{"name":"Inserm UMR_S942, Cardiovascular Markers in Stressed Conditions, MASCOT, Universit\u00e9 Sorbonne Paris Nord, 93000 Bobigny, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Pamoukdjian","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine G\u00e9riatrique, H\u00f4pital Avicenne, APHP, 93000 Bobigny, France"},{"name":"Inserm UMR_S942, Cardiovascular Markers in Stressed Conditions, MASCOT, Universit\u00e9 Sorbonne Paris Nord, 93000 Bobigny, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and Classification of Cancer Cachexia: An International Consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1007\/s00535-013-0787-0","article-title":"Cancer Cachexia\u2014Pathophysiology and Management","volume":"48","author":"Suzuki","year":"2013","journal-title":"J. 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