{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:28:35Z","timestamp":1790706515368,"version":"4.1.0"},"reference-count":35,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T00:00:00Z","timestamp":1637539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Research on the relationship between the geriatric nutritional risk index (GNRI) and postoperative complications\/oncological outcomes in elderly colorectal cancer (CRC) patients is limited. This study investigated the prognostic value of the GNRI in aged CRC patients. We retrospectively analyzed 1206 consecutive CRC patients aged over 75 years who underwent curative-intent surgery from January 2008 to December 2015 and categorized them into high GNRI (\u226598) and low GNRI (&lt;98) groups according to a receiver operating characteristic (ROC) curve analysis. Uni- and multivariate logistic regression analysis were used to explore the association of the GNRI with postoperative complications. Kaplan\u2013Meier survival analyses and the Cox proportional hazard model were used to explore the association between GNRI and survival. We discovered that GNRI is an independent risk factor for postoperative complications (HR: 1.774, p = 0.037). Surgical site infection, wound dehiscence and pneumonia were more common in patients with GNRI &lt; 98. Survival analysis showed significantly worse overall survival and disease-free survival in the low GNRI group (both p &lt; 0.001). In the multivariate analysis, GNRI &lt; 98 was an independent risk factor for OS (HR: 1.329, p = 0.031) and DFS (HR: 1.312, p = 0.034). Thus, preoperative GNRI can be effectively used to predict postoperative complications and long-term survival in elderly CRC patients after curative surgery.<\/jats:p>","DOI":"10.3390\/cancers13225852","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T02:55:17Z","timestamp":1637636117000},"page":"5852","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The Clinical Utility of the Geriatric Nutritional Risk Index in Predicting Postoperative Complications and Long-Term Survival in Elderly Patients with Colorectal Cancer after Curative Surgery"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7497-4444","authenticated-orcid":false,"given":"Chun-Kai","family":"Liao","sequence":"first","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou, Taoyuan 333423, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yih-Jong","family":"Chern","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou, Taoyuan 333423, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3068-8999","authenticated-orcid":false,"given":"Yu-Jen","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou, Taoyuan 333423, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7052-8896","authenticated-orcid":false,"given":"Yueh-Chen","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou, Taoyuan 333423, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3909-1715","authenticated-orcid":false,"given":"Yen-Lin","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Keelung Branch, Keelung City 204201, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jy-Ming","family":"Chiang","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou, Taoyuan 333423, Taiwan"},{"name":"School of Medicine, Chang Gung University, Taoyuan 333323, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Yuh","family":"Yeh","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou, Taoyuan 333423, Taiwan"},{"name":"School of Medicine, Chang Gung University, Taoyuan 333323, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeng-Fu","family":"You","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou, Taoyuan 333423, Taiwan"},{"name":"School of Medicine, Chang Gung University, Taoyuan 333323, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3322\/caac.21601","article-title":"Colorectal cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jgo.2015.12.002","article-title":"Comorbidity in older adults with cancer","volume":"7","author":"Williams","year":"2016","journal-title":"J. Geriatr. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/j.ejon.2005.09.001","article-title":"Cancer-associated malnutrition: An introduction","volume":"9","year":"2005","journal-title":"Eur. J. Oncol. Nurs."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/cncr.32437","article-title":"High prevalence of malnutrition and nutrition impact symptoms in older patients with cancer: Results of a Brazilian multicenter study","volume":"126","author":"Martucci","year":"2020","journal-title":"Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s11912-019-0829-8","article-title":"Malnutrition in older adults with cancer","volume":"21","author":"Zhang","year":"2019","journal-title":"Curr. Oncol. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.clnu.2007.06.009","article-title":"Postoperative complications in gastrointestinal cancer patients: The joint role of the nutritional status and the nutritional support","volume":"26","author":"Bozzetti","year":"2007","journal-title":"Clin. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.jgo.2019.03.002","article-title":"Malnutrition and overall survival in older adults with cancer: A systematic review and meta-analysis","volume":"10","author":"Zhang","year":"2019","journal-title":"J. Geriatr. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/ajcn\/82.4.777","article-title":"Geriatric nutritional risk index: A new index for evaluating at-risk elderly medical patients","volume":"82","author":"Bouillanne","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.clnu.2013.12.005","article-title":"The validity of geriatric nutrition risk index: Simple tool for prediction of nutritional-related complication of hospitalized elderly patients. Comparison with mini nutritional assessment","volume":"33","author":"Amin","year":"2014","journal-title":"Clin. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.clnu.2008.07.005","article-title":"Geriatric nutritional risk index and overall-cause mortality prediction in institutionalised elderly: A 3-year survival analysis","volume":"27","author":"Cereda","year":"2008","journal-title":"Clin. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.clnu.2014.01.017","article-title":"The geriatric nutritional risk index predicts hospital length of stay and in-hospital weight loss in elderly patients","volume":"34","author":"Cereda","year":"2015","journal-title":"Clin. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.21873\/invivo.11430","article-title":"The preoperative geriatric nutritional risk index predicts postoperative complications in elderly patients with gastric cancer undergoing gastrectomy","volume":"32","author":"Kushiyama","year":"2018","journal-title":"In Vivo"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Bo, Y., Wang, K., Liu, Y., You, J., Cui, H., Zhu, Y., Lu, Q., and Yuan, L. (2016). The geriatric nutritional risk index predicts survival in elderly esophageal squamous cell carcinoma patients with radiotherapy. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0155903"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"12561","DOI":"10.1038\/s41598-018-30906-8","article-title":"Geriatric nutritional risk index predicts prognosis after hepatectomy in elderly patients with hepatitis B virus-related hepatocellular carcinoma","volume":"8","author":"Li","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/ejcts\/ezaa066","article-title":"Utility of geriatric nutritional risk index in patients with lung cancer undergoing surgery","volume":"58","author":"Hino","year":"2020","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"10744","DOI":"10.1038\/s41598-020-67285-y","article-title":"The geriatric nutritional risk index predicts postoperative complications and prognosis in elderly patients with colorectal cancer after curative surgery","volume":"10","author":"Sasaki","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2147\/CMAR.S234688","article-title":"The value of geriatric nutritional risk index in evaluating postoperative complication risk and long-term prognosis in elderly colorectal cancer patients","volume":"12","author":"Tang","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1080\/01635581.2012.670743","article-title":"Malnutrition is high and underestimated during chemotherapy in gastrointestinal cancer: An AGEO prospective cross-sectional multicenter study","volume":"64","author":"Attar","year":"2012","journal-title":"Nutr. Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.5455\/medarh.2014.68.263-267","article-title":"Malnutrition at the time of surgery affects negatively the clinical outcome of critically ill patients with gastrointestinal cancer","volume":"68","author":"Shpata","year":"2014","journal-title":"Med. Arch."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"110769","DOI":"10.1016\/j.nut.2020.110769","article-title":"Malnutrition is associated with poor health-related quality of life in surgical patients with gastrointestinal cancer","volume":"75\u201376","author":"Maia","year":"2020","journal-title":"Nutrition"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00384-010-1113-4","article-title":"Low preoperative serum albumin in colon cancer: A risk factor for poor outcome","volume":"26","author":"Lai","year":"2011","journal-title":"Int. J. Colorectal Dis."},{"key":"ref_23","first-page":"147","article-title":"A new prognostic strategy for gastric carcinoma: Albumin level and metastatic lymph node ratio","volume":"69","author":"Isik","year":"2014","journal-title":"Minerva Chir."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1007\/s00432-014-1714-3","article-title":"The prognostic significance of the prognostic nutritional index in cancer: A systematic review and meta-analysis","volume":"140","author":"Sun","year":"2014","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/s00595-011-0061-0","article-title":"The prognostic nutritional index can be a prognostic indicator in colorectal carcinoma","volume":"42","author":"Nozoe","year":"2012","journal-title":"Surg. Today"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s10120-018-0818-x","article-title":"Body mass index and mortality in patients with gastric cancer: A large cohort study","volume":"21","author":"Lee","year":"2018","journal-title":"Gastric Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1245\/s10434-014-4281-6","article-title":"Sarcopenia is a negative prognostic factor after curative resection of colorectal cancer","volume":"22","author":"Miyamoto","year":"2015","journal-title":"Ann. Surg. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Choi, Y., Oh, D.Y., Kim, T.Y., Lee, K.H., Han, S.W., Im, S.A., Kim, T.Y., and Bang, Y.J. (2015). Skeletal muscle depletion predicts the prognosis of patients with advanced pancreatic cancer undergoing palliative chemotherapy, independent of body mass index. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0139749"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1038\/s41430-020-0629-0","article-title":"Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: Systematic review, narrative synthesis and meta-analysis","volume":"74","author":"Bullock","year":"2020","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Reber, E., Gomes, F., Vasiloglou, M.F., Schuetz, P., and Stanga, Z. (2019). Nutritional Risk Screening and Assessment. J. Clin. Med., 20.","DOI":"10.3390\/jcm8071065"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1186\/s12935-020-01628-7","article-title":"Geriatric nutritional risk index as a predictor of complications and long-term outcomes in patients with gastrointestinal malignancy: A systematic review and meta-analysis","volume":"20","author":"Xie","year":"2020","journal-title":"Cancer Cell Int."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1002\/jso.25270","article-title":"Primary tumor location in stage III colon cancer has prognostic impact on subsequent liver metastasis","volume":"118","author":"Liao","year":"2018","journal-title":"J. Surg. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1245\/s10434-017-6142-6","article-title":"The relationship between clavien-dindo morbidity classification and oncologic outcomes after colorectal cancer resection","volume":"25","author":"Duraes","year":"2018","journal-title":"Ann. Surg. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/jso.20329","article-title":"Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer","volume":"91","author":"Walsh","year":"2005","journal-title":"J. Surg. Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1007\/s00268-013-2156-9","article-title":"Prognostic nutritional index predicts postoperative outcome in colorectal cancer","volume":"37","author":"Mohri","year":"2013","journal-title":"World J. Surg."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/13\/22\/5852\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:33:53Z","timestamp":1760168033000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/13\/22\/5852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,22]]},"references-count":35,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["cancers13225852"],"URL":"https:\/\/doi.org\/10.3390\/cancers13225852","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,22]]}}}