{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:35:36Z","timestamp":1787027736212,"version":"build-2736575974"},"reference-count":42,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cusanuswerk, Bisch\u00f6fliche Studienf\u00f6rderung, Bonn, Germany","award":["Scholarship"],"award-info":[{"award-number":["Scholarship"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["395357507"],"award-info":[{"award-number":["395357507"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["36037240"],"award-info":[{"award-number":["36037240"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Limited availability of in vivo experimental models for invasive colorectal cancer (CRC) including metastasis and high tumor budding activity is a major problem in colorectal cancer research. In order to compare feline and human intestinal carcinomas, tumors of 49 cats were histologically subtyped, graded and further characterized according to the human WHO classification. Subsequently, feline tumors were compared to a cohort of 1004 human CRC cases. Feline intestinal tumors closely resembled the human phenotype on a histomorphological level. In both species, adenocarcinoma not otherwise specified (ANOS) was the most common WHO subtype. In cats, the second most common subtype of the colon (36.4%), serrated adenocarcinoma (SAC), was overrepresented compared to human CRC (8.7%). Mucinous adenocarcinoma (MAC) was the second most common subtype of the small intestine (12.5%). Intriguingly, feline carcinomas, particularly small intestinal, were generally of high tumor budding (Bd) status (Bd3), which is designated an independent prognostic key factor in human CRC. We also investigated the relevance of feline CTNNB1 exon 2 alterations by Sanger sequencing. In four cases of feline colonic malignancies (3 ANOS, 1 SAC), somatic missense mutations of feline CTNNB1 (p.D32G, p.D32N, p.G34R, and p.S37F) were detected, indicating that mutational alterations of the WNT\/\u03b2-catenin signaling pathway potentially play an essential role in feline intestinal tumorigenesis comparable to humans and dogs. These results indicate that spontaneous intestinal tumors of cats constitute a useful but so far underutilized model for human CRC. Our study provides a solid foundation for advanced comparative oncology studies and emphasizes the need for further (molecular) characterization of feline intestinal carcinomas.<\/jats:p>","DOI":"10.3390\/cancers13235941","type":"journal-article","created":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T22:19:16Z","timestamp":1638137956000},"page":"5941","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Bridging the Species Gap: Morphological and Molecular Comparison of Feline and Human Intestinal Carcinomas"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9049-9145","authenticated-orcid":false,"given":"Tanja","family":"Groll","sequence":"first","affiliation":[{"name":"Institute of Pathology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany"},{"name":"Comparative Experimental Pathology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany"},{"name":"Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, Ludwig-Maximilians-Universitaet (LMU), 80539 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Schopf","sequence":"additional","affiliation":[{"name":"Institute of Pathology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany"},{"name":"Comparative Experimental Pathology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Denk","sequence":"additional","affiliation":[{"name":"Institute of Pathology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany"},{"name":"Comparative Experimental Pathology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany"},{"name":"Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, Ludwig-Maximilians-Universitaet (LMU), 80539 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3400-7254","authenticated-orcid":false,"given":"Carolin","family":"Mogler","sequence":"additional","affiliation":[{"name":"Institute of Pathology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany"},{"name":"Comparative Experimental Pathology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Schwittlick","sequence":"additional","affiliation":[{"name":"LABOKLIN GmbH & Co. KG, 97688 Bad Kissingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Aupperle-Lellbach","sequence":"additional","affiliation":[{"name":"LABOKLIN GmbH & Co. KG, 97688 Bad Kissingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina Rim Jahan","family":"Sarker","sequence":"additional","affiliation":[{"name":"Institute of Pathology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany"},{"name":"Comparative Experimental Pathology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5977-5375","authenticated-orcid":false,"given":"Nicole","family":"Pfarr","sequence":"additional","affiliation":[{"name":"Institute of Pathology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilko","family":"Weichert","sequence":"additional","affiliation":[{"name":"Institute of Pathology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaspar","family":"Matiasek","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, Ludwig-Maximilians-Universitaet (LMU), 80539 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Jesinghaus","sequence":"additional","affiliation":[{"name":"Institute of Pathology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany"},{"name":"Department of Pathology, University Hospital Marburg, 35043 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7269-5433","authenticated-orcid":false,"given":"Katja","family":"Steiger","sequence":"additional","affiliation":[{"name":"Institute of Pathology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany"},{"name":"Comparative Experimental Pathology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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