{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:11:12Z","timestamp":1789049472682,"version":"build-2803163510"},"reference-count":52,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The aim was to establish prevalence of bile acid malabsorption (BAM) and management in patients who underwent treatment for malignancy. Retrospective evaluation of data in patients seen within six months (August 2019\u2013January 2020) was carried out. Demographic, nuclear medicine (Selenium Homocholic Acid Taurine (SeHCAT) scan result), clinical (previous malignancy, type of intervention (medication, diet), response to intervention) and laboratory (vitamin D, vitamin B12 serum levels) data were searched. In total, 265 consecutive patients were reviewed. Out of those, 87\/265 (33%) patients (57 females, 66%) were diagnosed with BAM. Mean age was 59 +\/\u2212 12 years. The largest group were females with gynaecological cancer (35), followed by haematology group (15), colorectal\/anal (13), prostate (9), upper gastrointestinal cancer (6), another previous malignancy (9). Severe BAM was most common in haematology (10\/15; 67%) and gynaecological group (21\/35; 60%). Medication and low-fat diet were commenced in 65\/87 (75%), medication in 10\/87 (11%), diet in 6\/87 (7%). Colesevelam was used in 71\/75 (95%). Symptoms improved in 74\/87 (85%) patients. Vitamin D insufficiency\/deficiency was diagnosed in 62\/87 (71%), vitamin B12 deficiency in 39\/87 (45%). BAM is a common condition in this cohort however treatments are highly effective.<\/jats:p>","DOI":"10.3390\/cancers13246213","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T02:07:18Z","timestamp":1639102038000},"page":"6213","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Bile Acid Malabsorption as a Consequence of Cancer Treatment: Prevalence and Management in the National Leading Centre"],"prefix":"10.3390","volume":"13","author":[{"given":"Caroline","family":"Gee","sequence":"first","affiliation":[{"name":"The Royal Marsden Hospital NHS Foundation Trust, Fulham Road, Chelsea, London SW3 6JJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Fleuret","sequence":"additional","affiliation":[{"name":"The Royal Marsden Hospital NHS Foundation Trust, Fulham Road, Chelsea, London SW3 6JJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Wilson","sequence":"additional","affiliation":[{"name":"The Royal Marsden Hospital NHS Foundation Trust, Fulham Road, Chelsea, London SW3 6JJ, UK"},{"name":"St Marks Hospital, Watford Road, Harrow, Middlesex, London HA1 3UJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Levine","sequence":"additional","affiliation":[{"name":"The Royal Marsden Hospital NHS Foundation Trust, Fulham Road, Chelsea, London SW3 6JJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramy","family":"Elhusseiny","sequence":"additional","affiliation":[{"name":"The Royal Marsden Hospital NHS Foundation Trust, Fulham Road, Chelsea, London SW3 6JJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Muls","sequence":"additional","affiliation":[{"name":"The Royal Marsden Hospital NHS Foundation Trust, Fulham Road, Chelsea, London SW3 6JJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cunningham","sequence":"additional","affiliation":[{"name":"The Royal Marsden Hospital NHS Foundation Trust, Fulham Road, Chelsea, London SW3 6JJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darina","family":"Kohoutova","sequence":"additional","affiliation":[{"name":"The Royal Marsden Hospital NHS Foundation Trust, Fulham Road, Chelsea, London SW3 6JJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0016-5085(67)80140-9","article-title":"The syndrome of ileal disease and the broken enterohepatic circulation: Cholerheic enteropathy","volume":"52","author":"Hofmann","year":"1967","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.5604\/01.3001.0010.5493","article-title":"Bile Acid Physiology","volume":"16","author":"Garruti","year":"2017","journal-title":"Ann. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1007\/s11894-011-0219-3","article-title":"New insights into bile acid malabsorption","volume":"13","author":"Johnston","year":"2011","journal-title":"Curr. Gastroenterol. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/1389200216666151103115454","article-title":"Bile Acids in Physiology, Pathology and Pharmacology","volume":"17","author":"Marin","year":"2015","journal-title":"Curr. Drug Metab."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1146\/annurev-food-041715-033159","article-title":"Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health","volume":"7","author":"Joyce","year":"2016","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev.biochem.72.121801.161712","article-title":"The enzymes, regulation, and genetics of bile acid synthesis","volume":"72","author":"Russell","year":"2003","journal-title":"Annu. Rev. Biochem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1042\/BST20120077","article-title":"Cholesterol, an essential molecule: Diverse roles involving cytochrome P450 enzymes","volume":"40","author":"McLean","year":"2012","journal-title":"Biochem. Soc. Trans."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bbrc.2010.02.140","article-title":"Cerebrotendinous xanthomatosis: An inborn error in bile acid synthesis with defined mutations but still a challenge","volume":"396","author":"Hansson","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1194\/jlr.R006338","article-title":"Genetic connections between neurological disorders and cholesterol metabolism","volume":"51","author":"Leoni","year":"2010","journal-title":"J. Lipid Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.steroids.2014.04.016","article-title":"Bile acids are nutrient signaling hormones","volume":"86","author":"Zhou","year":"2014","journal-title":"Steroids"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11894-018-0615-z","article-title":"Update on Bile Acid Malabsorption: Finally Ready for Prime Time?","volume":"20","author":"Vijayvargiya","year":"2018","journal-title":"Curr. Gastroenterol. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1172\/JCI110668","article-title":"Hepatic Uptake of Bile Acids in Man","volume":"70","author":"Angelin","year":"1982","journal-title":"J. Clin. Investig."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"9124","DOI":"10.1021\/acs.jafc.8b07306","article-title":"Review on Bile Acids: Effects of the Gut Microbiome, Interactions with Dietary Fiber, and Alterations in the Bioaccessibility of Bioactive Compounds","volume":"67","author":"Singh","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/bmb\/ldp032","article-title":"Recent advances in the understanding of bile acid malabsorption","volume":"92","author":"Pattni","year":"2009","journal-title":"Br. Med. Bull."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1172\/JCI106644","article-title":"Colonic secretion of water and electrolytes induced by bile acids: Perfusion studies in man","volume":"50","author":"Mekjian","year":"1971","journal-title":"J. Clin. Investig."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/0016-5085(81)90257-2","article-title":"Factors in the mechanism of diarrhea in bile acid malabsorption: Fecal pH\u2014a key determinant","volume":"80","author":"McJunkin","year":"1981","journal-title":"Gastroenterology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1111\/apt.12684","article-title":"Systematic review: The management of chronic diarrhoea due to bile acid malabsorption","volume":"39","author":"Wilcox","year":"2014","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0300-5089(21)00739-2","article-title":"Bile acid-induced diarrhoea","volume":"15","author":"Fromm","year":"1986","journal-title":"Clin. Gastroenterol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1002\/ibd.21502","article-title":"Bile acid malabsorption in inflammatory bowel disease: Assessment by serum markers","volume":"17","author":"Lenicek","year":"2011","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1155\/2013\/485631","article-title":"Bile acid malabsorption in chronic diarrhea: Pathophysiology and treatment","volume":"27","author":"Barkun","year":"2013","journal-title":"Can. J. Gastroenterol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1097\/00007611-198710000-00015","article-title":"Bile acids in radiation-induced diarrhea","volume":"80","author":"Arlow","year":"1987","journal-title":"South. Med. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"332","DOI":"10.5009\/gnl14397","article-title":"Bile Acid diarrhea: Prevalence, pathogenesis, and therapy","volume":"9","author":"Camilleri","year":"2015","journal-title":"Gut Liver"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.cgh.2009.04.024","article-title":"A new mechanism for bile acid diarrhea: Defective feedback inhibition of bile acid biosynthesis","volume":"7","author":"Walters","year":"2009","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1080\/003655201750422693","article-title":"Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption","volume":"36","author":"Montagnani","year":"2001","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/gut.34.4.476","article-title":"Gastrointestinal function in chronic radiation enteritis\u2014effects of loperamide-N-oxide","volume":"34","author":"Yeoh","year":"1993","journal-title":"Gut"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1053\/j.gastro.2019.11.301","article-title":"Differences in Fecal Microbiomes and Metabolomes of People With vs Without Irritable Bowel Syndrome and Bile Acid Malabsorption","volume":"158","author":"Jeffery","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1136\/gutjnl-2017-315909","article-title":"Guidelines for the investigation of chronic diarrhoea in adults: British Society of Gastroenterology, 3rd edition","volume":"67","author":"Arasaradnam","year":"2018","journal-title":"Gut"},{"key":"ref_28","first-page":"720","article-title":"Se-75-labeled bile acid analogs, new radiopharmaceuticals for investigating the enterohepatic circulation","volume":"22","author":"Boyd","year":"1981","journal-title":"J. Nucl. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2097359","DOI":"10.1155\/2018\/2097359","article-title":"Pros and Cons of the SeHCAT Test in Bile Acid Diarrhea: A More Appropriate Use of an Old Nuclear Medicine Technique","volume":"2018","author":"Fani","year":"2018","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e137","DOI":"10.1016\/j.ejim.2011.08.013","article-title":"Bile acid malabsorption investigated by selenium-75-homocholic acid taurine ((75)SeHCAT) scans: Causes and treatment responses to cholestyramine in 298 patients with chronic watery diarrhoea","volume":"22","author":"Borghede","year":"2011","journal-title":"Eur. J. Intern. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.1365-2036.2009.04081.x","article-title":"Systematic review: The prevalence of idiopathic bile acid malabsorption as diagnosed by SeHCAT scanning in patients with diarrhoea-predominant irritable bowel syndrome","volume":"30","author":"Wedlake","year":"2009","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jhep.2012.08.002","article-title":"Bile acid transporters and regulatory nuclear receptors in the liver and beyond","volume":"58","author":"Halilbasic","year":"2013","journal-title":"J. Hepatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/2040622313510730","article-title":"Radiation-induced small bowel disease: Latest developments and clinical guidance","volume":"5","author":"Stacey","year":"2014","journal-title":"Ther. Adv. Chronic Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1136\/gut.32.10.1180","article-title":"Chronic diarrhoea after radiotherapy for gynaecological cancer: Occurrence and aetiology","volume":"32","author":"Danielsson","year":"1991","journal-title":"Gut"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1182\/blood-2014-06-583302","article-title":"Lenalidomide-induced diarrhea in patients with myeloma is caused by bile acid malabsorption that responds to treatment","volume":"124","author":"Pawlyn","year":"2014","journal-title":"Blood"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nrgastro.2017.126","article-title":"Acute graft-versus-host disease of the gut: Considerations for the gastroenterologist","volume":"14","author":"Naymagon","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1365-2141.2011.09014.x","article-title":"Bile acid malabsorption in patients with graft-versus-host disease of the gastrointestinal tract","volume":"157","author":"Joshi","year":"2012","journal-title":"Br. J. Haematol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1056\/NEJM196908212810801","article-title":"Cholestyramine treatment of diarrhea associated with ileal resection","volume":"281","author":"Hofmann","year":"1969","journal-title":"N. Engl. J. Med."},{"key":"ref_39","unstructured":"(2021, October 12). NICE Guidelines. Available online: https:\/\/bnf.nice.org.uk\/drug\/colesevelam-hydrochloride.html."},{"key":"ref_40","first-page":"779","article-title":"Colesevelam HCl: A non-systemic lipid-altering drug","volume":"4","author":"Bays","year":"2003","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1007\/s00520-015-2653-5","article-title":"Outcomes from treating bile acid malabsorption using a multidisciplinary approach","volume":"23","author":"Gupta","year":"2015","journal-title":"Support. Care Cancer"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"412","DOI":"10.7861\/clinmedicine.17-5-412","article-title":"The efficacy of a low-fat diet to manage the symptoms of bile acid malabsorption\u2014outcomes in patients previously treated for cancer","volume":"17","author":"Jackson","year":"2017","journal-title":"Clin. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"536","DOI":"10.7861\/clinmedicine.15-6-536","article-title":"Management of bile acid malabsorption using low-fat dietary interventions: A useful strategy applicable to some patients with diarrhoea-predominant irritable bowel syndrome?","volume":"15","author":"Watson","year":"2015","journal-title":"Clin. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1177\/1756283X10377126","article-title":"Managing bile acid diarrhoea","volume":"3","author":"Walters","year":"2010","journal-title":"Therap. Adv. Gastroenterol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1136\/gut.10.9.717","article-title":"Effect of cholestyramine on the absorption of vitamin D3 and calcium","volume":"10","author":"Thompson","year":"1969","journal-title":"Gut"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1016\/j.clnu.2019.12.028","article-title":"Vitamin D: A magic bullet or a myth?","volume":"39","author":"Reijven","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_47","first-page":"19","article-title":"Vitamin K deficiency and bleeding after long-term use of cholestyramine","volume":"61","author":"Vroonhof","year":"2003","journal-title":"Neth. J. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"145","DOI":"10.7861\/clinmedicine.15-2-145","article-title":"Vitamin B12 deficiency\u2014A 21st century perspective","volume":"15","author":"Shipton","year":"2015","journal-title":"Clin. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/00365529109111222","article-title":"Intrinsic factor secretion and cobalamin absorption. Physiology and pathophysiology in the gastrointestinal tract","volume":"188","author":"Festen","year":"1991","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nrgastro.2014.46","article-title":"Radiation enteropathy\u2014Pathogenesis, treatment and prevention","volume":"11","author":"Denham","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/apt.13333","article-title":"Systematic review: Bile acids and intestinal inflammation-luminal aggressors or regulators of mucosal defence?","volume":"42","author":"Pavlidis","year":"2015","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1017\/S0029665118000101","article-title":"Nutritional strategies to prevent gastrointestinal toxicity during pelvic radiotherapy","volume":"77","author":"Wedlake","year":"2018","journal-title":"Proc. Nutr. Soc."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/13\/24\/6213\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:44:34Z","timestamp":1760168674000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/13\/24\/6213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,10]]},"references-count":52,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["cancers13246213"],"URL":"https:\/\/doi.org\/10.3390\/cancers13246213","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,10]]}}}