{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:07:09Z","timestamp":1760551629428,"version":"build-2065373602"},"reference-count":33,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JASTRO","award":["not vailable"],"award-info":[{"award-number":["not vailable"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>We evaluated the efficacy and toxicity of reirradiation of nasal cavity or paranasal sinus tumors. We collected and analyzed multi-institutional data of reirradiation cases. Seventy-eight patients with nasal or paranasal sinus tumors underwent reirradiation. The median survival time was 20 months with a medial follow-up of 10.7 months. The 2-year local control and overall survival rates were 43% and 44%, respectively. Tumor volume (\u226425 cm3), duration between previous radiotherapy and reirradiation (\u226412 months), histology (squamous cell carcinoma), male sex, and lymph node involvement were predisposing factors for poor survival. Distant metastasis was observed in 20 patients (25.6%). Grade \u2265 3 adverse events were observed in 22% of the patients, including five grade 4 (8.6%) cases and one grade 5 (1.2%) case. Tumor location adjacent to the optic pathway was a significant predisposing factor for grade \u22653 visual toxicity. Reirradiation of nasal and paranasal sinus tumors is feasible and effective. However, adverse events, including disease-related toxicities, were significant. Prognostic factors emerge from this study to guide multidisciplinary approaches and clinical trial designs.<\/jats:p>","DOI":"10.3390\/cancers13246315","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T11:27:36Z","timestamp":1639654056000},"page":"6315","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Reirradiation for Nasal Cavity or Paranasal Sinus Tumor\u2014A Multi-Institutional Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7508-7217","authenticated-orcid":false,"given":"Hideya","family":"Yamazaki","sequence":"first","affiliation":[{"name":"Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajiicho Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajiicho Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6018-468X","authenticated-orcid":false,"given":"Gen","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajiicho Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6595-0205","authenticated-orcid":false,"given":"Norihiro","family":"Aibe","sequence":"additional","affiliation":[{"name":"Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajiicho Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4340-9338","authenticated-orcid":false,"given":"Makoto","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajiicho Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroya","family":"Shiomi","sequence":"additional","affiliation":[{"name":"CyberKnife Center, Soseikai General Hospital, Kyoto 612-8473, Japan"},{"name":"Department of Radiation Oncology, Miyakojima IGRT Clinic, Osaka 534-0021, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7633-0669","authenticated-orcid":false,"given":"Ryoong-Jin","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Miyakojima IGRT Clinic, Osaka 534-0021, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kansai Medical University, Hirakata 573-1191, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoaki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kansai Medical University, Hirakata 573-1191, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Konishi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikio","family":"Ogita","sequence":"additional","affiliation":[{"name":"Radiotherapy Department, Fujimoto Hayasuzu Hospital, Miyakonojo 885-0055, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1002\/1097-0142(20011215)92:12<3012::AID-CNCR10131>3.0.CO;2-E","article-title":"Nasal and paranasal sinus carcinoma: Are we making progress? 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