{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:32:43Z","timestamp":1790728363046,"version":"4.1.0"},"reference-count":56,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background In previous studies, patient-reported outcomes (PROs) have been shown to improve survival in cancer patients. The aim of the present study was to assess symptoms potentially related to adverse events experienced by cancer outpatients treated by oral anticancer agents (OAAs) using PROs. Methods Between September 2018 and May 2019, outpatients starting OAAs were included in a 12-week follow-up to assess 15 symptoms listed in the National Cancer Institute PRO Common Terminology Criteria for Adverse Events, using a 5-point scale of severity or frequency. Patients were requested to alert a referral nurse or pharmacist when they self-assessed high-level (level 3 or 4) symptoms. Results 407 questionnaires were completed by 63 patients in which 2333 symptoms were reported. Almost three-quarters (74.6%) reported at least one high-level symptom. The symptoms that were most commonly experienced were fatigue (&gt;9 in 10 patients; 13.2% of symptoms declared), various psychological disorders (&gt;9 in 10 patients; 28.6% of symptoms declared) and general pain (&gt;8 in 10 patients; 9.4% of symptoms declared). Conclusion PROs are appropriate to detect potential adverse events in cancer outpatients treated by OAAs. This study is the first step for integrating the patient\u2019s perspective in a digital e-health device in routine oncology care.<\/jats:p>","DOI":"10.3390\/cancers14030660","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T01:41:59Z","timestamp":1643420519000},"page":"660","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Assessment of Patient Reported Outcomes (PROs) in Outpatients Taking Oral Anticancer Drugs Included in the Real-Life Oncoral Program"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9950-406X","authenticated-orcid":false,"given":"Bastien","family":"Collomb","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Pharmacie Clinique Oncologique, Groupement Hospitalier Sud, Hospices Civils de Lyon, 69495 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9679-0187","authenticated-orcid":false,"given":"Am\u00e9lie","family":"Dubromel","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Pharmacie Clinique Oncologique, Groupement Hospitalier Sud, Hospices Civils de Lyon, 69495 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Ga\u00eblle","family":"Caffin","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Pharmacie Clinique Oncologique, Groupement Hospitalier Sud, Hospices Civils de Lyon, 69495 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Herledan","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Pharmacie Clinique Oncologique, Groupement Hospitalier Sud, Hospices Civils de Lyon, 69495 Lyon, France"},{"name":"CICLY Centre pour l\u2019Innovation en Canc\u00e9rologie de Lyon, Universit\u00e9 Lyon 1-EA 3738, 69921 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Larbre","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Pharmacie Clinique Oncologique, Groupement Hospitalier Sud, Hospices Civils de Lyon, 69495 Lyon, France"},{"name":"CICLY Centre pour l\u2019Innovation en Canc\u00e9rologie de Lyon, Universit\u00e9 Lyon 1-EA 3738, 69921 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Baudouin","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Pharmacie Clinique Oncologique, Groupement Hospitalier Sud, Hospices Civils de Lyon, 69495 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Cerutti","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Pharmacie Clinique Oncologique, Groupement Hospitalier Sud, Hospices Civils de Lyon, 69495 Lyon, 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Ghesquieres","sequence":"additional","affiliation":[{"name":"Department of Hematology, Groupement Hospitalier Sud, Hospices Civils de Lyon, 69495 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Salles","sequence":"additional","affiliation":[{"name":"Department of Hematology, Groupement Hospitalier Sud, Hospices Civils de Lyon, 69495 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Couraud","sequence":"additional","affiliation":[{"name":"CICLY Centre pour l\u2019Innovation en Canc\u00e9rologie de Lyon, Universit\u00e9 Lyon 1-EA 3738, 69921 Lyon, France"},{"name":"Department of Pneumology, Groupement Hospitalier Sud, Hospices Civils de Lyon, 69495 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3177-8857","authenticated-orcid":false,"given":"Benoit","family":"You","sequence":"additional","affiliation":[{"name":"CICLY Centre pour l\u2019Innovation en Canc\u00e9rologie de Lyon, Universit\u00e9 Lyon 1-EA 3738, 69921 Lyon, France"},{"name":"Department of Oncology, Groupement Hospitalier Sud, Hospices Civils de Lyon, 69495 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Freyer","sequence":"additional","affiliation":[{"name":"CICLY Centre pour l\u2019Innovation en Canc\u00e9rologie de Lyon, Universit\u00e9 Lyon 1-EA 3738, 69921 Lyon, France"},{"name":"Department of Oncology, Groupement Hospitalier Sud, Hospices Civils de Lyon, 69495 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Trillet-Lenoir","sequence":"additional","affiliation":[{"name":"CICLY Centre pour l\u2019Innovation 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