{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:11:52Z","timestamp":1789578712071,"version":"build-2803163510"},"reference-count":42,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 110-2622-8-038-003 SB"],"award-info":[{"award-number":["MOST 110-2622-8-038-003 SB"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["109-2314-B-038-072"],"award-info":[{"award-number":["109-2314-B-038-072"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004700","name":"Taipei Medical University","doi-asserted-by":"publisher","award":["TMU106-AE1-B05"],"award-info":[{"award-number":["TMU106-AE1-B05"]}],"id":[{"id":"10.13039\/501100004700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>Background: Atypical teratoid\/rhabdoid tumor (AT\/RT) is a rare, highly aggressive embryonal brain tumor most commonly presenting in young children. Methods: We performed a nationwide, population-based study of AT\/RT (ICD-O-3 code: 9508\/3) in Taiwan using the Taiwan Cancer Registry Database and the National Death Certificate Database. Results: A total of 47 cases (male\/female = 29:18; median age at diagnosis, 23.3 months (IQR: 12.5\u201387.9)) were diagnosed with AT\/RT between 1999 and 2014. AT\/RT had higher prevalence in males (61.70%), in children &lt; 36 months (55.32%), and at infratentorial or spinal locations (46.81%). Survival analyses demonstrated that patients \u2265 3 years of age (n = 21 (45%)) had a 5y-OS of 41% (p &lt; 0.0001), treatment with radiotherapy only (n = 5 (11%)) led to a 5y-OS of 60%, treatment with chemotherapy with or without radiotherapy (n = 27 (62%)) was associated with a 5y-OS of 45% (p &lt; 0.0001), and patients with a supratentorial tumor (n = 11 (23%)) had a 5y-OS of 51.95%. Predictors of better survival on univariate Cox proportional hazard modeling and confirmed with multivariate analysis included older age (\u22651 year), supratentorial sites, and the administration of radiotherapy, chemotherapy, or both. Gender had no effect on survival. Conclusion: Older age, supratentorial site, and treatment with radiotherapy, chemotherapy, or both significantly improves the survival of patients with AT\/RT.<\/jats:p>","DOI":"10.3390\/cancers14030668","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T01:41:59Z","timestamp":1643420519000},"page":"668","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Atypical Teratoid\/Rhabdoid Tumor in Taiwan: A Nationwide, Population-Based Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7571-3123","authenticated-orcid":false,"given":"Yen-Lin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Department of Pediatrics, Taipei Medical University Hospital, Taipei 110, Taiwan"},{"name":"Pediatric Brain Tumor Program, Taipei Cancer Center, Taipei Neurological Institute, Taipei Medical University, Taipei 110, Taiwan"},{"name":"TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Lan","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Department of Pediatrics, Taipei Medical University Hospital, Taipei 110, Taiwan"},{"name":"Pediatric Brain Tumor Program, Taipei Cancer Center, Taipei Neurological Institute, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3958-8342","authenticated-orcid":false,"given":"Chang-I","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Health Care Administration, College of Management, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8879-0462","authenticated-orcid":false,"given":"Noi","family":"Yar","sequence":"additional","affiliation":[{"name":"Department of Health Care Administration, College of Management, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Wen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Health Data Analytics and Statistics Center, Office of Data Science, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Lun","family":"Lee","sequence":"additional","affiliation":[{"name":"Pediatric Brain Tumor Program, Taipei Cancer Center, Taipei Neurological Institute, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Department of Radiation Oncology, Taipei Medical University Hospital, Taipei 110, Taiwan"},{"name":"Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Chun","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Health Care Administration, College of Management, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Department of Radiation Oncology, Taipei Medical University Hospital, Taipei 110, Taiwan"},{"name":"Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 110, Taiwan"},{"name":"Department of Radiation Oncology, Wan Fang Hospital, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Ling","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Department of Pediatrics, Taipei Medical University Hospital, Taipei 110, Taiwan"},{"name":"Pediatric Brain Tumor Program, Taipei Cancer Center, Taipei Neurological Institute, Taipei Medical University, Taipei 110, Taiwan"},{"name":"School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan"},{"name":"Department of Pediatrics, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7725-9019","authenticated-orcid":false,"given":"Kevin Li-Chun","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Pediatric Brain Tumor Program, Taipei Cancer Center, Taipei Neurological Institute, Taipei Medical University, Taipei 110, Taiwan"},{"name":"TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Department of Medical Imaging, Taipei Medical University Hospital, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Hui","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Taipei Medical University Hospital, Taipei 110, Taiwan"},{"name":"Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Miser","sequence":"additional","affiliation":[{"name":"Pediatric Brain Tumor Program, Taipei Cancer Center, Taipei Neurological Institute, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Department of Pediatrics, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA"},{"name":"Cancer Center, Taipei Medical University Hospital, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Yau","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Department of Pediatrics, Taipei Medical University Hospital, Taipei 110, Taiwan"},{"name":"Pediatric Brain Tumor Program, Taipei Cancer Center, Taipei Neurological Institute, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsi","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Department of Pediatrics, Taipei Medical University Hospital, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4075-6227","authenticated-orcid":false,"given":"Tai-Tong","family":"Wong","sequence":"additional","affiliation":[{"name":"Pediatric Brain Tumor Program, Taipei Cancer Center, Taipei Neurological Institute, Taipei Medical University, Taipei 110, Taiwan"},{"name":"TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Neuroscience Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan"},{"name":"Division of Pediatric Neurosurgery, Department of Neurosurgery, Taipei Medical University Hospital, Taipei Neuroscience Institute, Taipei Medical University, Taipei 110, 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