{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:43:16Z","timestamp":1790959396989,"version":"4.1.0"},"reference-count":205,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T00:00:00Z","timestamp":1644451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>The plant Cannabis sativa has been in use medicinally for several thousand years. It has over 540 metabolites thought to be responsible for its therapeutic effects. Two of the key phytocannabinoids are cannabidiol (CBD) and tetrahydrocannabinol (THC). Unlike THC, CBD does not have potentially intoxicating effects. Preclinical and clinical research indicates that CBD has a wide range of therapeutic effects, and many of them are relevant to the management of cancer. In this article, we explore some of the potential mechanisms of action of CBD in cancer, and evidence of its efficacy in the integrative management of cancer including the side effects associated with its treatment, demonstrating its potential for integration with orthodox cancer care.<\/jats:p>","DOI":"10.3390\/cancers14040885","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T02:37:46Z","timestamp":1644547066000},"page":"885","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Cannabidiol (CBD) in Cancer Management"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6227-6860","authenticated-orcid":false,"given":"Kylie","family":"O\u2019Brien","sequence":"first","affiliation":[{"name":"Adelaide Campus, Torrens University, Adelaide, SA 5000, Australia"},{"name":"NICM Health Research Centre, Western Sydney University, Westmead, Sydney, NSW 2145, Australia"},{"name":"Releaf Group Ltd., St Kilda, VIC 3182, Australia"},{"name":"International College of Cannabinoid Medicine, iccm.co, London N1 7GU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4488","DOI":"10.1002\/cncr.30879","article-title":"Cannabis use among patients at a comprehensive cancer center in a state with legalized medicinal and recreational use","volume":"123","author":"Pergam","year":"2017","journal-title":"Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/cncr.33906","article-title":"A Coala-T-Cannabis Survey Study of breast cancer patients\u2019 use of cannabis before, during, and after treatment","volume":"128","author":"Weiss","year":"2021","journal-title":"Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Seltzer, E.S., Watters, A.K., MacKenzie, J.D., Granat, L.M., and Zhang, D. 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