{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:25:37Z","timestamp":1791822337309,"version":"4.3.4"},"reference-count":305,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hungarian National Research Development and Innovation Office","award":["2019-1.1.1-PIACI-KFI-2019-00011"],"award-info":[{"award-number":["2019-1.1.1-PIACI-KFI-2019-00011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancers"],"abstract":"<jats:p>(1) Background: Hyperthermia in oncology conventionally seeks the homogeneous heating of the tumor mass. The expected isothermal condition is the basis of the dose calculation in clinical practice. My objective is to study and apply a heterogenic temperature pattern during the heating process and show how it supports radiotherapy. (2) Methods: The targeted tissue\u2019s natural electric and thermal heterogeneity is used for the selective heating of the cancer cells. The amplitude-modulated radiofrequency current focuses the energy absorption on the membrane rafts of the malignant cells. The energy partly \u201cnonthermally\u201d excites and partly heats the absorbing protein complexes. (3) Results: The excitation of the transmembrane proteins induces an extrinsic caspase-dependent apoptotic pathway, while the heat stress promotes the intrinsic caspase-dependent and independent apoptotic signals generated by mitochondria. The molecular changes synergize the method with radiotherapy and promote the abscopal effect. The mild average temperature (39\u201341 \u00b0C) intensifies the blood flow for promoting oxygenation in combination with radiotherapy. The preclinical experiences verify, and the clinical studies validate the method. (4) Conclusions: The heterogenic, molecular targeting has similarities with DNA strand-breaking in radiotherapy. The controlled energy absorption allows using a similar energy dose to radiotherapy (J\/kg). The two therapies are synergistically combined.<\/jats:p>","DOI":"10.3390\/cancers14040901","type":"journal-article","created":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T20:32:30Z","timestamp":1644784350000},"page":"901","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Heterogeneous Heat Absorption Is Complementary to Radiotherapy"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4939-1183","authenticated-orcid":false,"given":"Andras","family":"Szasz","sequence":"first","affiliation":[{"name":"Biotechnics Department, Szent Istvan University, H-2040 Budaors, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-642-57858-8_1","article-title":"A Historical Perspective on Hyperthermia in Oncology","volume":"Volume 1","author":"Seegenschmiedt","year":"1995","journal-title":"Thermoradiotherapy and Thermochemotherapy"},{"key":"ref_2","first-page":"157","article-title":"Metabolic status and reaction to heat of normal and tumor tissue","volume":"Volume 1","author":"Seegenschmiedt","year":"1995","journal-title":"Thermoradiotherapy and Thermochemiotherapy"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1016\/0360-3016(86)90137-9","article-title":"Specific absorption rate and tissue temperature in local hyperthermia","volume":"12","author":"Griffiths","year":"1986","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"790","DOI":"10.3109\/02656736.2013.822993","article-title":"Magnetic nanoparticle heating and heat transfer on a microscale: Basic principles, realities and physical limitations of hyperthermia for tumour therapy","volume":"29","author":"Dutz","year":"2013","journal-title":"Int. J. Hyperth."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.ijrobp.2015.12.361","article-title":"Hyperthermia and Radiation Therapy in Locoregional Recurrent Breast Cancers: A Systematic Review and Meta-analysis","volume":"94","author":"Datta","year":"2016","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3109\/02656736.2015.1099746","article-title":"Hyperthermia and radiotherapy in the management of head and neck cancers: A systematic review and meta-analysis","volume":"32","author":"Datta","year":"2016","journal-title":"Int. J. Hyperth."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1080\/02656736.2016.1195924","article-title":"Hyperthermia and radiotherapy with or without chemotherapy in locally advanced cervical cancer: A systematic review with conventional and network meta-analyses","volume":"32","author":"Datta","year":"2016","journal-title":"Int. J. Hyperth."},{"key":"ref_8","first-page":"109","article-title":"The addition of deep hyperthermia to gemcitabine-based chemoradiation may achieve enhanced survival in unresectable locally advanced adenocarcinoma of the pancreas","volume":"27","author":"Rogers","year":"2021","journal-title":"Clin. Transl. Radiat. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1001\/jamaoncol.2017.4996","article-title":"Effect of Neoadjuvant Chemotherapy Plus Regional Hyperthermia on Long-term Outcomes Among Patients with Localized High-Risk Soft Tissue Sarcoma","volume":"4","author":"Issels","year":"2018","journal-title":"JAMA Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/02656730150201552","article-title":"Hyperthermia in oncology: Invited Review","volume":"17","author":"Falk","year":"2001","journal-title":"Int. J. Hyperth."},{"key":"ref_11","unstructured":"Streffer, C., van Beuningen, D., Dietzel, F., R\u00f6ttinger, E., Robinson, J.E., Scherer, E., Seeber, S., and Trott, K.R. (1978). Cancer Therapy by Hyperthermia and Radiation, Urban and Schwarzenberg."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Seegenschmiedt, M.H., Fessenden, P., and Vernon, C.C. (1996). Thermoradiotherapy and Thermochemotherapy, Volume 2: Clinical Applications, Springer.","DOI":"10.1007\/978-3-642-60938-1"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Kosaka, M., Sugahara, T., Schmidt, K.L., and Simon, E. (2001). Thermotherapy for Neoplasia, Inflammation, and Pain, Springer.","DOI":"10.1007\/978-4-431-67035-3"},{"key":"ref_14","unstructured":"Matsuda, T. (1993). Cancer Treatment by Hyperthermia, Radiation and Drugs, Taylor & Francis."},{"key":"ref_15","unstructured":"Urano, M., and Douple, E. (1992). Hyperthermia and Oncology: Volume 2, Biology of Thermal Potentiation of Radiotherapy, VSP BV."},{"key":"ref_16","first-page":"295","article-title":"Current and potential role of thermoradiotherapy for solid tumors","volume":"26","author":"Hehr","year":"2003","journal-title":"Onkologie"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S0140-6736(00)02059-6","article-title":"Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumors: A prospective, randomised, multicentre trial","volume":"355","author":"Gonzalez","year":"2000","journal-title":"Lancet"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S1470-2045(02)00818-5","article-title":"Hyperthermia in combined treatment of cancer","volume":"3","author":"Wust","year":"2002","journal-title":"Lancet Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S0140-6736(95)90463-8","article-title":"Randomised trial of hyperthermia as adjuvant to radiotherapy for recurrent or metastatic malignant melanoma","volume":"345","author":"Overgaard","year":"1995","journal-title":"Lancet"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/0360-3016(88)90237-4","article-title":"Low-dose reirradiation in combination with hyperthermia: A palliative treatment for patients with breast cancer recurring in previously irradiated areas","volume":"15","author":"The","year":"1988","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0140-6736(91)93384-L","article-title":"Hyperthermia with low-dose radiotherapy for recurrent breast carcinoma","volume":"337","author":"Vernon","year":"1991","journal-title":"Lancet"},{"key":"ref_22","first-page":"116","article-title":"Thermotherapy with curative intent\u2013breast, head, and neck, and prostate tumours","volume":"38","author":"Bicher","year":"2006","journal-title":"Dtsch. Z. Fur Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3389\/fonc.2017.00132","article-title":"Integrating Hyperthermia into Modern Radiation Oncology: What Evidence Is Necessary?","volume":"7","author":"Peeken","year":"2017","journal-title":"Front. Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.clon.2007.03.015","article-title":"Hyperthermia: A Potent Enhancer of Radiotherapy","volume":"19","author":"Horsman","year":"2007","journal-title":"Clin. Oncol."},{"key":"ref_25","first-page":"183","article-title":"Hyperthermia\u2014The actual role in radiation oncology and future prospects","volume":"168","author":"Molls","year":"1992","journal-title":"Strahlenther. Oncol."},{"key":"ref_26","first-page":"560","article-title":"Hyperthermia\u2013Its actual role is radiation oncology","volume":"171","author":"Seegenschmiedt","year":"1995","journal-title":"Strahlenther. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/0360-3016(95)02137-X","article-title":"Phase III study of interstitial thermoradiotherapy compared with interstitial radiotherapy alone in the treatment of recurrent or persistent human tumours: A prospectively controlled randomized study by radiation therapy oncology group","volume":"34","author":"Emami","year":"1996","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_28","first-page":"110","article-title":"Radio-Thermotherapy in Multimodal Surgical Treatment Concepts","volume":"18","author":"Wust","year":"1995","journal-title":"Oncologie"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/0360-3016(89)90470-7","article-title":"The current and potential role of hyperthermia in radiotherapy","volume":"16","author":"Overgaard","year":"1989","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Bauer, K.H. (1964). Das Krebsproblem, Springer.","DOI":"10.1007\/978-3-642-86062-1"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4236\/ojbiphy.2021.111002","article-title":"Approaching Complexity: Hyperthermia Dose and Its Possible Measurement in Oncology","volume":"11","author":"Szasz","year":"2021","journal-title":"Open J. Biophys."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"R37","DOI":"10.1152\/ajpregu.00668.2006","article-title":"Thermoregulation: Some concepts have changed. Functional architecture of the thermoregulatory system","volume":"292","author":"Romanovsky","year":"2007","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_33","unstructured":"Vaupel, P.W., and Hammersen, F. (1983). Mikrozirkulation in malignen Tumoren. 6. Jahrestagung der Gesellschaft f\u00fcr Mikrozirkulation e.V., M\u00fcnchen, November 1982, Karger."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"603","DOI":"10.4065\/78.5.603","article-title":"Skin Blood Flow in Adult Human Thermoregulation: How It Works, When It Does Not, and Why","volume":"78","author":"Charkoudian","year":"2003","journal-title":"Mayo Clin. Proc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1073\/pnas.1616255114","article-title":"A hypothalamic circuit that controls body temperature","volume":"114","author":"Zhao","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1093\/carcin\/16.10.2373","article-title":"Normal human cells at confluence get heat resistance by efficient accumulation of HSP72 in nucleus","volume":"16","author":"Watanabe","year":"1995","journal-title":"Carcinogenesis"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/02656730600765072","article-title":"Prospective thermal dosimetry: The key to hyperthermia\u2019s future","volume":"22","author":"Jones","year":"2006","journal-title":"Int. J. Hyperth."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3747\/co.27.6233","article-title":"Radiotherapy Side Effects: Integrating a Survivorship Clinical Lens to Better Serve Patients","volume":"27","author":"Chaput","year":"2020","journal-title":"Curr. Oncol."},{"key":"ref_39","unstructured":"Majeed, H., and Gupta, V. (2021, December 11). Adverse Effects of Radiation Therapy, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/33085406\/."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.3390\/cancers3043799","article-title":"Combined Hyperthermia and Radiotherapy for the Treatment of Cancer","volume":"3","author":"Kaur","year":"2011","journal-title":"Cancers"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1615\/CritRevBiomedEng.v38.i1.80","article-title":"A Review of Hyperthermia Combined with Radiotherapy\/Chemotherapy on Malignant Tumors","volume":"38","author":"Rao","year":"2010","journal-title":"Crit. Rev. Biomed. Eng."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Elming, P.B., Sorensen, B.S., Oei, A.L., Franken, N.A.P., Crezee, J., Overgaard, J., and Horsman, M.R. (2019). Hyperthermia: The optimal treatment to overcome radiation resistant hypoxia. Cancers, 11.","DOI":"10.3390\/cancers11010060"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/PL00000707","article-title":"Heat shock effects on cell cycle progression","volume":"57","author":"Rensing","year":"2000","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"ref_44","unstructured":"Urano, M., and Douple, E. (1988). The effects of hyperthermia on cellular macromolecules. Hyperthermia and Oncology Volume 1, Thermal Effects on Cells and Tissues, VSP."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1615\/CritRevEukarGeneExpr.v19.i3.50","article-title":"Molecular parameters of hyperthermia for radiosensitization","volume":"19","author":"Pandita","year":"2009","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Kosaka, M., Sugahara, T., Schmidt, K.L., Kosaka, M., Sugahara, T., and Simon, E. (2001). Heat inactivation of DNA-dependent protein kinase: Possible mechanism of hyperthermic radiosensitization. Thermotherapy for Neoplasia, Inflammation, and Pain, Springer.","DOI":"10.1007\/978-4-431-67035-3"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/02656730310001619514","article-title":"Physiological mechanisms underlying heat-induced radiosensitization","volume":"20","author":"Vujaskovic","year":"2004","journal-title":"Int. J. Hyperth."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/02656730902744171","article-title":"Tumour oxygenation is increased by hyperthermia at mild temperatures","volume":"25","author":"Song","year":"2009","journal-title":"Int. J. Hyperth."},{"key":"ref_49","first-page":"605","article-title":"Differential response of normal and tumor microcirculation to hyperthermia","volume":"44","author":"Dudar","year":"1984","journal-title":"Cancer Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1109\/TBME.1984.325364","article-title":"Implication of blood-flow in hyperthermic treatment of tumors","volume":"31","author":"Song","year":"1984","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"ref_51","first-page":"1","article-title":"Effect of heat on blood-flow","volume":"Volume 2","author":"Anghileri","year":"1986","journal-title":"Hyperthermia in Cancer Treatment"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Gautherie, M. (1990). Pathophysiological mechanism of hyperthermia in cancer therapy. Methods of Hyperthermia Control, Clinical Thermology, Springer.","DOI":"10.1007\/978-3-642-74636-9"},{"key":"ref_53","first-page":"36","article-title":"Optimization of temperature distributions for regional hyperthermia based on a nonlinear heat transfer model","volume":"858","author":"Erdmann","year":"1998","journal-title":"Ann. NYAS"},{"key":"ref_54","first-page":"6449","article-title":"Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumours: A review","volume":"49","author":"Vaupel","year":"1989","journal-title":"Cancer Res."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Kosaka, M., Sugahara, T., Schmidt, K.L., and Simon, E. (2001). Thermal responses of microcirculation and modification of tumour blood flow in treating the tumours. Theoretical and Experimental Basis of Hyperthermia. Thermotherapy for Neoplasia, Inflammation, and Pain, Springer.","DOI":"10.1007\/978-4-431-67035-3"},{"key":"ref_56","first-page":"139","article-title":"Microvasculature and perfusion in normal tissues and tumours","volume":"Volume 1","author":"Seegenschmiedt","year":"1995","journal-title":"Thermoradiometry and Thermochemotherapy"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Kosaka, M., Sugahara, T., Schmidt, K.L., and Simon, E. (2001). Theoretical and experimental basis of hyperthermia. Thermotherapy for Neoplasia, Inflammation, and Pain, Springer.","DOI":"10.1007\/978-4-431-67035-3"},{"key":"ref_58","unstructured":"Lindholm, C.E. (1992). Hyperthermia and Radiotherapy. [Ph.D. Thesis, Lund University]."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1200\/JCO.1991.9.12.2091","article-title":"Regional hyperthermic perfusion with melphalan after surgery for recurrent malignant melanoma of the extremities","volume":"9","author":"Rudenstam","year":"1991","journal-title":"J. Clin. Oncol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1148\/123.2.463","article-title":"Cellular Responses to Combinations of Hyperthermia and Radiation","volume":"123","author":"Dewey","year":"1977","journal-title":"Radiology"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Kim, W., Lee, S., Seo, D., Kim, D., Kim, K., Kim, E., Kang, J., Seong, K.M., Youn, H., and Youn, B. (2019). Cellular Stress Responses in Radiotherapy. Cells, 8.","DOI":"10.3390\/cells8091105"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Walleczek, J. (2000). Self-Organized Biological Dynamics & Nonlinear Control, Cambridge University Press.","DOI":"10.1017\/CBO9780511535338"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/0265673031000119006","article-title":"Basic principles of thermal dosimetry and thermal thresholds for tissue damage from hyperthermia","volume":"19","author":"Dewhirst","year":"2003","journal-title":"Int. J. Hyperth."},{"key":"ref_64","first-page":"4818","article-title":"Thermal dose expression in clinical hyperthermia and correlation with tumor response\/control","volume":"44","author":"Perez","year":"1984","journal-title":"Cancer Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3109\/02656739409009351","article-title":"Arrhenius relationships from the molecule and cell to the clinic","volume":"10","author":"Dewey","year":"1994","journal-title":"Int. J. Hyperth."},{"key":"ref_66","unstructured":"Gellerman, J. (2006, January 22\u201323). Nichtinvasive Thermometrie bei lokoregionaler Tiefenhyperthermie, Noninvasive thermometry in loco-regional deep hyperthermia. Proceedings of the Oncothermia Symphosia, 2016, Cologne, Germany."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"60","DOI":"10.4236\/ojbiphy.2012.23009","article-title":"On the Dynamic Equilibrium in Homeostasis","volume":"2","author":"Hegyi","year":"2012","journal-title":"Open J. Biophys."},{"key":"ref_68","first-page":"627","article-title":"Oncological hyperthermia: The correct dosing in clinical applications","volume":"54","author":"Lee","year":"2018","journal-title":"Int. J. Oncol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/02656730110039449","article-title":"A phase II trial testing the thermal dose parameter CEM43\u00b0 T90 as a predictor of response in soft tissue sarcomas treated with pre-operative thermorasiotherapy","volume":"17","author":"Maguire","year":"2001","journal-title":"Int. J. Hyperth."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1080\/02656730500271668","article-title":"Re-setting the biologic rationale for thermal therapy","volume":"21","author":"Dewhirst","year":"2005","journal-title":"Int. J. Hyperth."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/0360-3016(95)02260-0","article-title":"Radiation plus local hyperthermia versus radiation plus the combination of local and whole-body hyperthermia in canine sarcomas","volume":"34","author":"Thrall","year":"1996","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/02656730310001637316","article-title":"Whole-body hyperthermia in the scope of von Ardenne\u2019s systemic cancer multistep therapy (sCMT) combined with chemotherapy in patients with metastatic colorectal cancer: A phase I\/II study","volume":"20","author":"Hildebrandt","year":"2004","journal-title":"Int. J. Hyperth."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"7288","DOI":"10.1200\/jco.2004.22.90140.7288","article-title":"Randomized trial with ICE (ifosfamide, carboplatin, etoposide) plus whole body hyperthermia versus ICE chemotherapy for malignant pleural mesothelioma","volume":"22","author":"Bakhshandeh","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s00066-010-2146-x","article-title":"Evaluation of CEM43\u00b0CT90 thermal dose in superficial hyperthermia: A retrospective analysis","volume":"186","year":"2010","journal-title":"Strahlenther. Onkol. Radiother. Oncol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/02656730110116704","article-title":"A phase I study of fever-range whole body hyperthermia (FR-WBH) in patients with advanced solid tumors: Correlation with mouse models","volume":"18","author":"Kraybill","year":"2002","journal-title":"Int. J. Hyperth."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3109\/02656739709023548","article-title":"Long-duration, mild whole body hyperthermia with cisplatin: Tumour response and kinetics of apoptosis and necrosis in a metastatic rat mammary adenocarcinoma","volume":"13","author":"Toyota","year":"1997","journal-title":"Int. J. Hyperth."},{"key":"ref_77","first-page":"2223","article-title":"Therapeutic efficacy of long duration-low temperature whole body hyperthermia when combined with tumor necrosis factor and carboplatin in rats","volume":"54","author":"Sakaguchi","year":"1994","journal-title":"Cancer Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3109\/08820130009062297","article-title":"Use of mild, whole body hyperthermia in cancer therapy","volume":"29","author":"Ostberg","year":"2000","journal-title":"Immunol. Investig."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"International Collaborative Hyperthermia Group, Vernon, C.C., Hand, J.W., Field, S.B., Machin, D., Whaley, J.B., van der Zee, J., van Putten, W.L., van Rhoon, G.C., and van Dijk, J.D. (1996). Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: Results from five randomized controlled trials. Int. J. Radiat. Oncol. Biol. Phys., 35, 731\u2013744.","DOI":"10.1016\/0360-3016(96)00154-X"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0360-3016(97)00333-7","article-title":"Relationship between thermal dose and outcome in thermoradiotherapy treatments for superficial recurrences of breast cancer: Data from a phase III trial","volume":"39","author":"Sherar","year":"1997","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_81","first-page":"151","article-title":"A prospective randomized study of local hyperthermia as a supplement and radiosensitiser in the treatment of carcinoma of the cervix with radiotherapy","volume":"5","author":"Sharma","year":"1989","journal-title":"Endocurietherapy\/Hyperth. Oncol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ijrobp.2004.04.057","article-title":"Regional hyperthermia combined with radiotherapy for uterine cervical cancers: A multi-institutional prospective randomized trial of the international atomic energy agency","volume":"61","author":"Vasanthan","year":"2005","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1080\/02656730903092018","article-title":"A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma","volume":"25","author":"Harima","year":"2009","journal-title":"Int. J. Hyperth."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1080\/02656736.2018.1447696","article-title":"A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma of Yoko Harima et al. (2001): Multiple biases and no advantage of hyperthermia","volume":"34","author":"Roussakow","year":"2018","journal-title":"Int. J. Hyperth."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1080\/02656736.2018.1460768","article-title":"A randomised clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma of Yoko, Harima et al. (2001): A response letter to the editor of comments from Dr. Roussakow","volume":"34","author":"Harima","year":"2018","journal-title":"Int. J. Hyperth."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.radonc.2013.04.011","article-title":"HDR brachytherapy combined with interstitial hyperthermia in locally advanced cervical cancer patients initially treated with concomitant radiochemotherapy\u2013A phase III study","volume":"109","author":"Piotrokowicz","year":"2013","journal-title":"Radiother. Oncol."},{"key":"ref_87","first-page":"115","article-title":"Thermoradiotherapy in the treatment of locally advanced nonsmall cell lung cancer","volume":"14","author":"Kay","year":"1996","journal-title":"Radiat. Oncol. J."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s10147-006-0647-5","article-title":"Regional hyperthermia combined with radiotherapy for locally advanced non-small cell lung cancers: A multi-institutional prospective randomized trial of the International Atomic Energy Agency","volume":"12","author":"Mitsumori","year":"2007","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1200\/JCO.2005.05.520","article-title":"Randomized trial of hyperthermia and radiation for superficial tumors","volume":"23","author":"Jones","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/jso.2930530302","article-title":"What happened to hyperthermia and what is its current status in cancer treatment?","volume":"53","author":"Storm","year":"1993","journal-title":"J. Surg. Oncol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1093\/annonc\/mdf280","article-title":"Heating the patient: A promising approach?","volume":"13","year":"2002","journal-title":"Ann. Oncol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3389\/fonc.2020.00819","article-title":"Integrating Loco-Regional Hyperthermia into the Current Oncology Practice: SWOT and TOWS Analyses","volume":"10","author":"Datta","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"495003","DOI":"10.1088\/0022-3727\/47\/49\/495003","article-title":"On the reliable measurement of specific absorption rates and intrinsic loss parameters in magnetic hyperthermia materials","volume":"47","author":"Wildeboer","year":"2014","journal-title":"J. Phys. D Appl. Phys."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Szasz, A., Szasz, N., and Szasz, O. (2010). Oncothermia: Principles and Practices, Springer Science.","DOI":"10.1007\/978-90-481-9498-8"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4172\/0974-8369.1000247","article-title":"Nanoheating without Artificial Nanoparticles Part II. Experimental support of the nanoheating concept of the modulated electro-hyperthermia method, using U937 cell suspension model","volume":"7","author":"Andocs","year":"2015","journal-title":"Biol. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3109\/02656736.2011.562873","article-title":"Toward establishment of temperature thresholds for immunological impact of heat exposure in humans","volume":"27","author":"Beachy","year":"2011","journal-title":"Int. J. Hyperth."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/0360-3016(94)90571-1","article-title":"Influence of elevated temperature on natural killer cell activity, lymphokine-activated killer cell activity and lectin-dependent cytotoxicity of human umbilical cord blood and adult blood cells","volume":"29","author":"Shen","year":"1994","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_98","first-page":"555","article-title":"Restoring natural killer cell cytotoxicity after hyperthermia alone or combined with radiotherapy","volume":"36","author":"Hietanen","year":"2016","journal-title":"Anticancer. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1080\/0265673021000036531","article-title":"Physiological consequences of hyperthermia: Heat, heat shock proteins and the immune response","volume":"18","author":"Repasky","year":"2002","journal-title":"Int. J. Hyperth."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/jrcr.jrcr_25_18","article-title":"Thermal and nonthermal effects of radiofrequency on living state and applications as an adjuvant with radiation therapy","volume":"10","author":"Szasz","year":"2019","journal-title":"J. Radiat. Cancer Res."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Krenacs, T., Meggyeshazi, N., Forika, G., Kiss, E., Hamar, P., Szekely, T., and Vancsik, T. (2020). Modulated Electro-Hyperthermia-Induced Tumor Damage Mechanisms Revealed in Cancer Models. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21176270"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4236\/ojbiphy.2018.83008","article-title":"Similarities of modulation by temperature and by electric field","volume":"8","author":"Vincze","year":"2018","journal-title":"Open J. Biophys."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1073\/pnas.0636434100","article-title":"An approach to electrical modeling of single and multiple cells","volume":"100","author":"Gowrishankar","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/1521-186X(200007)21:5<385::AID-BEM7>3.0.CO;2-F","article-title":"Theoretical evaluation of the distributed power dissipation in biological cells exposed to electric fields","volume":"21","author":"Kotnik","year":"2000","journal-title":"Bioelectromagnetics"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4236\/ojbiphy.2017.74016","article-title":"Energy absorption by the membrane rafts in the modulated electro-hyperthermia (mEHT)","volume":"7","author":"Papp","year":"2017","journal-title":"Open J. Biophys."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"The Physical Sciences-Oncology Centers Network, Agus, D.B., Alexander, J.F., Arap, W., Ashili, S., Aslan, J., Austin, R.H., Backman, V., Bethel, K., and Bonneau, R. (2013). A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci. Rep., 3, 01449.","DOI":"10.1038\/srep01449"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1515\/zpch-1889-0416","article-title":"On the reaction rate of the inversion of non-refined sugar upon souring","volume":"4","author":"Arrhenius","year":"1889","journal-title":"Z Phys. Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"252","DOI":"10.4236\/ojbiphy.2021.113010","article-title":"The Capacitive Coupling Modalities for Oncological Hyperthermia","volume":"11","author":"Szasz","year":"2021","journal-title":"Open J. Biophys."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1081\/JBC-120024620","article-title":"An Energy Analysis of Extracellular Hyperthermia","volume":"22","author":"Szasz","year":"2003","journal-title":"Electromagn. Biol. Med."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/bem.2250030109","article-title":"What are non-thermal electric biological effects?","volume":"3","year":"1982","journal-title":"Bioelectromagnetics"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"314","DOI":"10.4236\/ojbiphy.2021.113011","article-title":"Therapeutic Basis of Electromagnetic Resonances and Signal-Modulation","volume":"11","author":"Szasz","year":"2021","journal-title":"Open J. Biophys."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.brs.2021.03.008","article-title":"Kilohertz-frequency stimulation of the nervous system: A review of underlying mechanisms","volume":"14","author":"Neudorfer","year":"2021","journal-title":"Brain Stimul."},{"key":"ref_113","unstructured":"Szasz, A. (2020). Time-fractal modulation of modulated electro-hyperthermia (mEHT). Book Challenges and Solutions of Oncological Hyperthermia, Cambridge Scholars."},{"key":"ref_114","unstructured":"Rec. ITU-R SM.1056-1. 1 RECOMMENDATION ITU-R SM.1056-1 (2021, October 31). Limitation of Radiation from Industrial, Scientific and Medical (ISM) Equipment (Question ITU-R 70\/1). Available online: https:\/\/www.itu.int\/dms_pubrec\/itu-r\/rec\/sm\/R-REC-SM.1056-1-200704-I!!PDF-E.pdf."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3892\/etm.2015.2567","article-title":"Definitive radiotherapy with concurrent oncothermia for stage IIIB non-small-cell lung cancer: A case report","volume":"10","author":"Yeo","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3389\/fonc.2020.00254","article-title":"Putative Abscopal Effect in Three Patients Treated by Combined Radiotherapy and Modulated Electrohyperthermia","volume":"10","author":"Chi","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_117","first-page":"40","article-title":"Fractal physiology","volume":"11","author":"Deering","year":"1992","journal-title":"IEEE Comput. Graph. Appl."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"West, B.J. (1990). Fractal Physiology and Chaos in Medicine, World Scientific.","DOI":"10.1142\/1025"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Bassingthwaighte, J.B., Leibovitch, L.S., and West, B.J. (1994). Fractal Physiology, Oxford University Press.","DOI":"10.1007\/978-1-4614-7572-9"},{"key":"ref_120","unstructured":"Musha, T., and Sawada, Y. (1994). Physics of the Living State, IOS Press."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1016\/j.bios.2008.09.033","article-title":"Detecting effects of low levels of cytochalasin B in 3T3 fibroblast cultures by analysis of electrical noise obtained from cellular micromotion","volume":"24","author":"Lovelady","year":"2009","journal-title":"Biosens. Bioelectron."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"041908","DOI":"10.1103\/PhysRevE.76.041908","article-title":"Distinguishing cancerous from noncancerous cells through analysis of electrical noise","volume":"76","author":"Lovelady","year":"2007","journal-title":"Phys. Rev. E"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"6416","DOI":"10.1103\/PhysRevA.39.6416","article-title":"Effects of oscillations and energy-driven fluctuations on the dynamics of enzyme catalysis and free-energy transduction","volume":"39","author":"Astumian","year":"1989","journal-title":"Phys. Rev. A"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1073\/pnas.92.9.3740","article-title":"Rectification and signal averaging of weak electric fields by biological cells","volume":"92","author":"Astumian","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1109\/51.816251","article-title":"Rectification in Biological Membranes","volume":"19","author":"Sabah","year":"2000","journal-title":"IEEE Eng. Med. Biol."},{"key":"ref_126","unstructured":"Nagy, G., Meggyeshazi, N., and Szasz, O. (2012, January 12\u201314). Deep temperature measurements in oncothermia processes. Proceedings of the Conference of the International Clinical Hyperthermia Society 2012, Budapest, Hungary."},{"key":"ref_127","unstructured":"Szasz, A. (2020). Phantom measurements with the EHY-2030 device. Challenges and Solutions of Oncological Hyperthermia, Cambridge Scholars."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s12541-016-0033-9","article-title":"Simulation and experimental evaluation of selective heating characteristics of 13.56 MHz radiofrequency hyperthermia in phantom models","volume":"17","author":"Hossain","year":"2016","journal-title":"Int. J. Precis. Eng. Manuf."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.1038\/s41598-019-40595-6","article-title":"Quantitative estimation of the equivalent radiation dose escalation using radiofrequency hyperthermia in mouse xenograft models of human lung cancer","volume":"9","author":"Prasad","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.4103\/0973-1482.197561","article-title":"Temperature increase induced by modulated electrohyperthermia (onco-thermia\u00ae) in the anesthetized pig liver","volume":"12","author":"Balogh","year":"2016","journal-title":"J. Cancer Res. Ther."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Kim, J.K., Prasad, B., and Kim, S. (2017). Temperature mapping and thermal dose calculation in combined radiation therapy and 13.56 MHz radiofrequency hyperthermia for tumor treatment. SPIE 10047, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXVI, Proceedings of the SPIE Conferences and Exhibitions, San Francisco, CA, USA, 28 January\u20132 February 2017, SPIE.","DOI":"10.1117\/12.2253163"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1080\/02656736.2018.1423709","article-title":"The effect of modulated electro-hyperthermia on temperature and blood flow in human cervical carcinoma","volume":"34","author":"Lee","year":"2018","journal-title":"Int. J. Hyperth."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"84082","DOI":"10.18632\/oncotarget.11444","article-title":"In vitro comparison of conventional hyperthermia and modulated electro-hyperthermia","volume":"7","author":"Yang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Forika, G., Balogh, A., Vancsik, T., Zalatnai, A., Petovari, G., Benyo, Z., and Krenacs, T. (2020). Modulated Electro-Hyperthermia Resolves Radioresistance of Panc1 Pancreas Adenocarcinoma and Promotes DNA Damage and Apoptosis In Vitro. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21145100"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s00066-009-1903-1","article-title":"Strong synergy of heat and modulated electro- magnetic field in tumor cell killing, Study of HT29 xenograft tumors in a nude mice model","volume":"185","author":"Andocs","year":"2009","journal-title":"Strahlenther. Onkol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"16039","DOI":"10.1038\/cddiscovery.2016.39","article-title":"Comparison of biological effects of modulated electro-hyperthermia and conventional heat treatment in human lymphoma U937 cells","volume":"2","author":"Andocs","year":"2016","journal-title":"Cell Death Discov."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.1158\/0008-5472.CAN-04-0083","article-title":"Disruption of Cancer Cell Replication by Alternating Electric Fields","volume":"64","author":"Kirson","year":"2004","journal-title":"Cancer Res."},{"key":"ref_138","first-page":"1514","article-title":"Reorganization of actin filaments and microtubules by outside electric field","volume":"8","author":"Vincze","year":"2015","journal-title":"J. Adv. Biol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1039\/b901963d","article-title":"Vesicles in electric fields: Some novel aspects of membrane behavior","volume":"5","author":"Dimova","year":"2009","journal-title":"Soft Matter"},{"key":"ref_140","first-page":"249","article-title":"Nanoheating without Artificial Nanoparticles","volume":"7","author":"Vincze","year":"2015","journal-title":"Biol. Med."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Lajtha, A., and Mikoshiba, K. (2009). Calcium and Apoptosis. Handbook of Neurochemistry and Molecular Neurobiology, Springer.","DOI":"10.1007\/978-0-387-30370-3"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"784","DOI":"10.3109\/02656736.2015.1069411","article-title":"Electro-hyperthermia inhibits glioma tumorigenicity through the induction of E2F1-mediated apoptosis","volume":"31","author":"Cha","year":"2015","journal-title":"Int. J. Hyperth."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1101\/gad.283317.116","article-title":"E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response","volume":"30","author":"Li","year":"2016","journal-title":"Genes Dev."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"13488","DOI":"10.1038\/s41598-020-69561-3","article-title":"Non-thermal effects of radiofrequency electromagnetic fields","volume":"10","author":"Wust","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_145","first-page":"264","article-title":"Tumor specific stress and immune response induced by modulated electrohyperthermia in relation to tumor metabolic profiles","volume":"20","author":"Krenacs","year":"2017","journal-title":"Oncothermia J."},{"key":"ref_146","first-page":"228","article-title":"The efficiency of modulated electro-hyperthermia may correlate with the tumor metabolic profiles","volume":"20","author":"Forika","year":"2017","journal-title":"Oncothermia J."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/bem.20051","article-title":"On the thermal noise limit of cellular membranes","volume":"26","author":"Vincze","year":"2004","journal-title":"Bioelectromagnetics"},{"key":"ref_148","first-page":"90","article-title":"Elevated apoptosis and tumor stem cell destruction in a radioresistant pancreatic adenocarcinoma cell line when radiotherapy is combined with modulated electrohyperthermia","volume":"26","author":"Forika","year":"2019","journal-title":"Oncothermia J."},{"key":"ref_149","first-page":"S131","article-title":"Modulated electro-hyperthermia induced programmed cell death in HT29 colorectal carcinoma xenograft","volume":"461","author":"Meggyeshazi","year":"2012","journal-title":"Virchows Arch."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Danics, L., Schvarcz, C.A., Viana, P., Vancsik, T., Kren\u00e1cs, T., Beny\u00f3, Z., Kaucs\u00e1r, T., and Hamar, P. (2020). Exhaustion of Protective Heat Shock Response Induces Significant Tumor Damage by Apoptosis after Modulated Electro-Hyperthermia Treatment of Triple Negative Breast Cancer Isografts in Mice. Cancers, 12.","DOI":"10.3390\/cancers12092581"},{"key":"ref_151","first-page":"329","article-title":"Modulated electrohyperthermia causes caspase independent programmed cell death in HT29 colon cancer xenografts","volume":"463","author":"Meggyeshazi","year":"2013","journal-title":"Virchows Arch."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s00066-014-0617-1","article-title":"DNA fragmentation and caspase-independent programmed cell death by modulated electrohyperthermia","volume":"190","author":"Andocs","year":"2014","journal-title":"Strahlenther. Onkol."},{"key":"ref_153","first-page":"249563","article-title":"Early changes in mRNA and protein expression related to cancer treatment by modulated electro-hyperthermia","volume":"2013","author":"Meggyeshazi","year":"2013","journal-title":"Hindawi Publ. Corp. Conf. Pap. Med."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1080\/02656736.2016.1186290","article-title":"Electro-hyperthermia up-regulates tumour suppressor Septin 4 to induce apoptotic cell death in hepatocellular carcinoma","volume":"32","author":"Jeon","year":"2016","journal-title":"Int. J. Hyperth."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"16608","DOI":"10.1038\/s41598-018-34712-0","article-title":"First in vitro evidence of modulated electro-hyperthermia treatment performance in combination with megavoltage radiation by clonogenic assay","volume":"8","author":"McDonald","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_156","first-page":"455","article-title":"Radiotherapy and modulated electro-hyperthermia effect on Panc1 and Capan1 pancreas adenocarcinoma cell lines","volume":"24","author":"Forika","year":"2018","journal-title":"Oncothermia J."},{"key":"ref_157","first-page":"103","article-title":"Apoptotic response and DNA damage of the radioresistant Panc1 pancreas adenocarcinoma to combined modulated electro hyperthermia and radiotherapy","volume":"29","author":"Forika","year":"2020","journal-title":"Oncothermia J."},{"key":"ref_158","first-page":"68","article-title":"Radiosensitization effect of novel cancer therapy, oncothermia toward overcoming treatment resistance","volume":"25","author":"Yoshikata","year":"2019","journal-title":"Oncothermia J."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jtherbio.2018.04.007","article-title":"Effect of tumor properties on energy absorption, temperature mapping, and thermal dose in 13.56-MHz radiofrequency hyperthermia","volume":"74","author":"Prasad","year":"2018","journal-title":"J. Therm. Biol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1021\/acsabm.9b00453","article-title":"Presence of Gold Nanoparticles in Cells Associated with the Cell-Killing Effect of Modulated Electro-Hyperthermia","volume":"2","author":"Chen","year":"2019","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Besztercei, B., Vancsik, T., Benedek, A., Major, E., Thomas, M.J., Schvarcz, C.A., Kren\u00e1cs, T., Beny\u00f3, Z., and Balogh, A. (2019). Stress-Induced, p53-Mediated Tumor Growth Inhibition of Melanoma by Modulated Electrohyperthermia in Mouse Models without Major Immunogenic Effects. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20164019"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s13014-015-0462-0","article-title":"Effects of hyperthermia on DNA repair pathways: One treatment to inhibit them all","volume":"10","author":"Oei","year":"2015","journal-title":"Radiat. Oncol."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Thomas, M.B., Major, E., Benedek, A., Horv\u00e1th, I., M\u00e1th\u00e9, D., Bergmann, R., Szasz, A.M., Krenacs, T., and Benyo, Z. (2020). Suppression of metastatic melanoma growth in lung by modulated electro-hyperthermia monitored by a minimally invasive heat stress testing approach in mice. Cancers, 12.","DOI":"10.3390\/cancers12123872"},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Schvarcz, C., Danics, L., Kren\u00e1cs, T., Viana, P., B\u00e9res, R., Vancsik, T., Nagy, \u00c1., Gyenesei, A., Kun, J., and Fonovi\u0107, M. (2021). Modulated Electro-Hyperthermia Induces a Prominent Local Stress Response and Growth Inhibition in Mouse Breast Cancer Isografts. Cancers, 13.","DOI":"10.3390\/cancers13071744"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s12192-014-0523-6","article-title":"Upregulation of heat shock proteins and the promotion of damage-associated molecular pattern signals in a colorectal cancer model by modulated electrohyperthermia","volume":"20","author":"Andocs","year":"2014","journal-title":"Cell Stress Chaperones"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41416-020-0942-3","article-title":"Radiation-induced bystander and abscopal effects: Important lessons from preclinical models","volume":"123","author":"Daguenet","year":"2020","journal-title":"Br. J. Cancer"},{"key":"ref_167","unstructured":"Piana, R. (2021, December 12). The Abscopal Effect: A Reemerging Field of Interest. Available online: https:\/\/ascopost.com\/issues\/november-25-2018\/the-abscopal-effect-a-reemerging-field-of-interest\/."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s12609-017-0234-y","article-title":"The Abscopal Effect of Radiation Therapy: What Is It and How Can We Use It in Breast Cancer?","volume":"9","author":"Hu","year":"2017","journal-title":"Curr. Breast Cancer Rep."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"590764","DOI":"10.3389\/fonc.2021.590764","article-title":"Modulated Electro-Hyperthermia Facilitates NK-Cell Infiltration and Growth Arrest of Human A2058 Melanoma in a Xenograft Model","volume":"11","author":"Vancsik","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.3892\/or.2014.3500","article-title":"Modulated electro-hyperthermia enhances dendritic cell therapy through an abscopal effect in mice","volume":"32","author":"Qin","year":"2014","journal-title":"Oncol. Rep."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"201","DOI":"10.5468\/ogs.2014.57.3.201","article-title":"S100 expression in dendritic cells is inversely correlated with tumor grade in endometrial carcinoma","volume":"57","author":"Lee","year":"2014","journal-title":"Obstet. Gynecol. Sci."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Tsang, Y.W., Huang, C.C., Yang, K.L., Chi, M.-S., Chiang, H.-C., Wang, Y.-S., Andocs, G., Szasz, A., and Li, W.-T. (2015). Improving immunological tumor microenvironment using electro-hyperthermia followed by dendritic cell immunotherapy. BMC Cancer, 15.","DOI":"10.1186\/s12885-015-1690-2"},{"key":"ref_173","first-page":"277","article-title":"Inhibition of proliferation, induction of apoptotic cell death and immune response by modulated electro-hyperthermia in C26 colorectal cancer allografts, thermometry","volume":"20","author":"Vancsik","year":"2017","journal-title":"Oncothermia J."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"41","DOI":"10.7150\/jca.21520","article-title":"Modulated electro-hyperthermia induced loco-regional and systemic tumor destruction in colorectal cancer allografts","volume":"9","author":"Vancsik","year":"2018","journal-title":"J. Cancer"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1002\/cam4.2330","article-title":"Modulated electro-hyperthermia induced p53 driven apoptosis and cell cycle arrest additively support doxorubicin chemotherapy of colorectal cancer in vitro","volume":"8","author":"Vancsik","year":"2019","journal-title":"Cancer Med."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s11060-009-0093-0","article-title":"Transcranial electro-hyperthermia combined with alkylating chemotherapy in patients with relapsed high-grade gliomas: Phase I clinical results","volume":"98","author":"Wismeth","year":"2009","journal-title":"J. Neuro-Oncol."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Minnaar, C.A., Kotzen, J.A., Ayeni, O.A., Naidoo, T., Tunmer, M., Sharma, V., Vangu, M.-D.-T., and Baeyens, A. (2019). The effect of modulated electro-hyperthermia on local disease control in HIV-positive and -negative cervical cancer women in South Africa: Early results from a phase III randomized controlled trial. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0217894"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/02656736.2020.1737253","article-title":"Analysis of the effects of mEHT on the treatment-related toxicity and quality of life of HIV-positive cervical cancer patients","volume":"37","author":"Minnaar","year":"2020","journal-title":"Int. J. Hyperth."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3389\/fonc.2020.00376","article-title":"Potentiation of the Abscopal Effect by Modulated Electro-Hyperthermia in Locally Advanced Cervical Cancer Patients","volume":"10","author":"Minnaar","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_180","first-page":"122","article-title":"Possible potentiation of the abscopal effect of ionising radiation by modulated electro-hyperthermia in locally advanced cervical cancer patients","volume":"24","author":"Minnaar","year":"2018","journal-title":"Oncothermia J."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1016\/j.ejca.2019.01.068","article-title":"Modulated electro hyperthermia as an immune modulator with checkpoint inhibitors and radiotherapy","volume":"110","author":"Minnaar","year":"2019","journal-title":"Eur. J. Cancer"},{"key":"ref_182","first-page":"196","article-title":"Tumor-directed immunotherapy: Combined radiotherapy and oncothermia","volume":"24","author":"Chi","year":"2018","journal-title":"Oncothermia J."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.3389\/fonc.2019.01012","article-title":"Review of the clinical evidences of modulated electro-hyperthermia (mEHT) method: An update for the practicing oncologist","volume":"9","author":"Szasz","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_184","unstructured":"Szasz, A. (2020). 8-year observational study on naturopathic treatment with modulated electro-hyperthermia (mEHT): A single-centre experience. Challenges and Solutions of Oncological Hyperthermia, Cambridge Scholars."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1534735420932648","article-title":"A Narrative Review of Regional Hyperthermia: Updates from 2010 to 2019","volume":"19","author":"Fiorentini","year":"2020","journal-title":"Integr. Cancer Ther."},{"key":"ref_186","first-page":"721","article-title":"A phase II clinical study on relapsed malignant gliomas treated with electro-hyperthermia","volume":"20","author":"Fiorentini","year":"2006","journal-title":"Vivo"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1055\/s-2007-986020","article-title":"Retrospective clinical study of adjuvant electro-hyperthermia treatment for advanced brain-gliomas","volume":"39","author":"Sahinbas","year":"2007","journal-title":"Dtsch. Z. F\u00fcr Onkol."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1200\/jco.2008.26.15_suppl.2047","article-title":"Prospective phase II trial for recurrent high-grade gliomas with capacitive coupled low radiofrequency (LRF) hyperthermia","volume":"26","author":"Hager","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref_189","first-page":"1","article-title":"Modulated Electrohyperthermia in Integrative Cancer Treatment for Relapsed Malignant Glioblastoma and Astrocytoma: Retrospective Multicenter Controlled Study","volume":"18","author":"Fiorentini","year":"2018","journal-title":"Integr. Cancer Ther."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ejmp.2016.07.042","article-title":"O34. Update on phase III randomized clinical trial investigating the effects of the addition of electro-hyperthermia to chemoradiotherapy for cervical cancer patients in South Africa","volume":"32","author":"Minnaar","year":"2016","journal-title":"Phys. Med."},{"key":"ref_191","first-page":"192435","article-title":"Treatment of advanced cervical cancer with complex chemoradio\u2013hyperthermia","volume":"2013","author":"Pesti","year":"2013","journal-title":"Hindawi Publ. Corp. Conf. Pap. Med."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jare.2020.03.004","article-title":"A randomized phase II trial of best supportive care with or without hyperthermia and vitamin C for heavily pretreated, advanced, refractory non-small-cell lung cancer","volume":"24","author":"Ou","year":"2020","journal-title":"J. Adv. Res."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"77","DOI":"10.5090\/kjtcs.2014.47.2.77","article-title":"Current Status of Oncothermia Therapy for Lung Cancer","volume":"47","author":"Szasz","year":"2014","journal-title":"Korean J. Thorac. Cardiovasc. Surg."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"677","DOI":"10.4149\/neo_2020_190623N538","article-title":"Feasibility of modulated electro-hyperthermia in preoperative treatment for locally-advanced rectal cancer: Early phase 2 clinical results","volume":"67","author":"You","year":"2019","journal-title":"Neoplasma"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4236\/crcm.2015.45033","article-title":"Results of Oncothermia Combined with Operation, Chemotherapy and Radiation Therapy for Primary, Recurrent and Metastatic Sarcoma","volume":"04","author":"Jeung","year":"2015","journal-title":"Case Rep. Clin. Med."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1534735419878505","article-title":"Modulated electro-hyperthermia as palliative treatment for pancreas cancer: A retrospective observational study on 106 patients","volume":"18","author":"Fiorentini","year":"2019","journal-title":"Integr. Cancer Ther."},{"key":"ref_197","first-page":"13","article-title":"Clinical study for advanced pancreas cancer treated by oncothermia","volume":"1","author":"Dani","year":"2008","journal-title":"Forum Hyperthermie"},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Ranieri, G., Ferrari, C., di Palo, A., Marech, I., Porcelli, M., Falagario, G., Ritrovato, F., Ramuni, L., Fanelli, M., and Rubini, G. (2017). Bevacizumab-Based Chemotherapy Combined with, Regional Deep Capacitive Hyperthermia in Metastatic Cancer Patients: A Pilot Study. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18071458"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1080\/02656736.2021.1877837","article-title":"Beneficial effects of modulated electro-hyperthermia during neoadjuvant treatment for locally advanced rectal cancer","volume":"38","author":"Kim","year":"2021","journal-title":"Int. J. Hyperth."},{"key":"ref_200","unstructured":"Szasz, A. (2020). Modulated electro-hyperthermia for the treatment of relapsed brain gliomas. Challenges and Solutions of Oncological Hyperthermia, Cambridge Scholars."},{"key":"ref_201","first-page":"9","article-title":"Combined treatment with modulated electro-hyperthermia and an autophagy inhibitor effectively inhibit ovarian and cervical cancer growth","volume":"36","author":"Wookyeom","year":"2018","journal-title":"Int. J. Hyperth."},{"key":"ref_202","unstructured":"Szasz, A. (2020). The position of modulated electro-hyperthermia (oncothermia) in combination with standard chemo- and radiotherapy in clinical practice\u2013Highlights of upcoming phase III clinical studies in hospital Universitario Marqu\u00e9s de Val-decilla (HUMV). Challenges and Solutions of Oncological Hyperthermia, Cambridge Scholars."},{"key":"ref_203","first-page":"1","article-title":"The induction of immunogenic cell death (ICD) during maintenance chemotherapy and subsequent multimodal immunotherapy for glioblastoma (GBM)","volume":"3","author":"Makalowski","year":"2018","journal-title":"Austin Oncol. Case Rep."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-4682-8-4","article-title":"The self-organizing fractal theory as a universal discovery method: The phenomenon of life","volume":"8","author":"Kurakin","year":"2011","journal-title":"Theor. Biol. Med Model."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1088\/0031-8949\/35\/3\/006","article-title":"Self-Organization and Information","volume":"35","author":"Haken","year":"1987","journal-title":"Phys. Scr."},{"key":"ref_206","unstructured":"Sornette, D. (2000). Chaos, Fractals, Self-Organization and Disorder: Concepts and Tools, Springer."},{"key":"ref_207","unstructured":"Sha, L., Ward, E.R., and Stroy, B. (2002, January 5\u20137). A Review of Dielectric Properties of Normal and Malignant Breast Tissue. Proceedings of the IEEE Southeast Con. 2002, Columbia, SC, USA."},{"key":"ref_208","first-page":"35","article-title":"On electrical impedance scanning-principles and simulations","volume":"68","author":"Scholz","year":"2000","journal-title":"Electromedica"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1088\/0967-3334\/24\/2\/302","article-title":"In vivo electrical conductivity of hepatic tumors","volume":"24","author":"Haemmerich","year":"2003","journal-title":"Physiol. Meas."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1109\/TBME.1986.325740","article-title":"Dielectric Properties of VX-2 Carcinoma Versus Normal Liver Tissue","volume":"33","author":"Smith","year":"1986","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.radonc.2010.07.015","article-title":"PET in radiotherapy planning: Particularly exquisite test or pending and experimental tool?","volume":"96","author":"Gregorie","year":"2010","journal-title":"Radiother. Oncol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02308900","article-title":"A review of the applications of solid state physics concepts to biological systems","volume":"3","author":"Cope","year":"1975","journal-title":"J. Biol. Phys."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1126\/science.171.3976.1151","article-title":"Tumor Detection by Nuclear Magnetic Resonance","volume":"171","author":"Damadian","year":"1971","journal-title":"Science"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/222747a0","article-title":"Evidence for the Existence of a Minimum of Two Phases of Ordered Water in Skeletal Muscle","volume":"222","author":"Hazlewood","year":"1969","journal-title":"Nature"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1029\/RS014i06Sp00005","article-title":"Descriptive summary: Radiofrequency radiation dosimetry handbook-Second edition","volume":"14","author":"Durney","year":"1979","journal-title":"Radio Sci."},{"key":"ref_216","first-page":"99","article-title":"The living state and cancer","volume":"12","year":"1980","journal-title":"Physiol. Chem. Phys."},{"key":"ref_217","unstructured":"Szent-Gy\u00f6rgyi, A. (1998). Electronic Biology and Cancer, Marcel Dekker."},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Szent-Gy\u00f6rgyi, A. (1968). Bioelectronics, a Study on Cellular Regulations, Defense and Cancer, Acadamic Press.","DOI":"10.1353\/pbm.1968.0030"},{"key":"ref_219","unstructured":"Pething, R. (1979). Dielectric and Electronic Properties of Biological Materials, John Wiley and Sons."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"078302","DOI":"10.1103\/PhysRevLett.99.078302","article-title":"Distinct Water Species Confined at the Interface of a Phospholipid Membrane","volume":"99","author":"Volkov","year":"2007","journal-title":"Phys. Rev. Lett."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/bem.2250160304","article-title":"Absorbed Energy Distribution from Radiofrequency Electromagnetic Radiation in a Mammalian Cell Model: Effect of Membrane-Bound Water","volume":"16","author":"Liu","year":"1995","journal-title":"Bioelectromagnetics"},{"key":"ref_222","doi-asserted-by":"crossref","unstructured":"Hendry, B. (1981). Membrane Physiology and Membrane Excitation, Croom Helm.","DOI":"10.1007\/978-1-4615-9766-7"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.3389\/fimmu.2017.01513","article-title":"Introducing Membrane Charge and Membrane Potential to T Cell Signaling","volume":"8","author":"Ma","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.bbamem.2008.02.012","article-title":"Membrane-associated stress proteins: More than simply chaperones","volume":"1778","author":"Multhoff","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1128\/MCB.26.1.313-323.2006","article-title":"Identifying Optimal Lipid Raft Characteristics Required to Promote Nanoscale Protein-Protein Interactions on the Plasma Membrane","volume":"26","author":"Nicolau","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.bbamem.2013.10.019","article-title":"The Fluid\u2014Mosaic Model of Membrane Structure: Still relevant to understanding the structure, function and dynamics of biological membranes after more than 40 years","volume":"1838","author":"Nicolson","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.bpj.2013.02.011","article-title":"Nanoscale Measurement of the Dielectric Constant of Supported Lipid Bilayers in Aqueous Solutions with Electrostatic Force Microscopy","volume":"104","author":"Gramse","year":"2013","journal-title":"J. Biophys."},{"key":"ref_228","unstructured":"Dharia, S. (2011). Spatially and Temporally Resolving Radio-Frequency Changes in Effective Cell Membrane Capacitance. [Ph.D. Thesis, University of Utah]."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1194\/jlr.R200021-JLR200","article-title":"Lipid rafts: Bringing order to chaos","volume":"44","author":"Pike","year":"2003","journal-title":"J. Lipid Res."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1146\/annurev.biophys.36.040306.132643","article-title":"Bilayer Thickness and Membrane Protein Function: An Energetic Perspective","volume":"36","author":"Andersen","year":"2007","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S1748-0132(07)70017-8","article-title":"Generating heat with metal nanoparticles","volume":"2","author":"Govorov","year":"2007","journal-title":"Nano Today"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1073\/pnas.1323433111","article-title":"On the dephasing of genetic oscillators","volume":"111","author":"Potoyan","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_233","doi-asserted-by":"crossref","unstructured":"Ptitsyn, A.A., Zvonic, S., and Gimble, J.M. (2007). Digital Signal Processing Reveals Circadian Baseline Oscillation in Majority of Mammalian Genes. PLOS Comput. Biol., 3.","DOI":"10.1371\/journal.pcbi.0030120"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.1016\/j.biomaterials.2012.02.029","article-title":"Biophysical control of invasive tumor cell behavior by extracellular matrix microarchitecture","volume":"33","author":"Carey","year":"2012","journal-title":"Biomaterials"},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"e13879","DOI":"10.7554\/eLife.13879","article-title":"Extracellular interactions and ligand degradation shape the nodal morphogen gradient","volume":"5","author":"Wang","year":"2016","journal-title":"Elife"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s002490100143","article-title":"Pink noise behaviour of the biosystems","volume":"30","author":"Szendro","year":"2001","journal-title":"Eur. Biophys. J."},{"key":"ref_237","first-page":"215","article-title":"Bio-response to white noise excitation","volume":"20","author":"Szendro","year":"2001","journal-title":"Electro- Magn."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/9475490","article-title":"Cells Electrical Characterization: Dielectric Properties, Mixture, and Modeling Theories","volume":"2020","author":"Nasir","year":"2020","journal-title":"J. Eng."},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Cole, K.S. (1968). Membranes, Ions and Impulses, University of California Press.","DOI":"10.1525\/9780520326514"},{"key":"ref_240","doi-asserted-by":"crossref","unstructured":"Schwan, H.P. (1963). Determination of biological impedances. Physical Techniques in Biological Research, Academic Press.","DOI":"10.1016\/B978-1-4831-6743-5.50013-7"},{"key":"ref_241","first-page":"459","article-title":"Dielectric behavior of biological cells and membranes","volume":"69","author":"Schwan","year":"1991","journal-title":"Bull. Inst. Chem. Res."},{"key":"ref_242","unstructured":"Anderson, J.C. (1964). Dielectrics, Chapman & Hall."},{"key":"ref_243","unstructured":"Grant, E.H., Sheppard, R.J., and South, S.P. (1978). Dielectric Behavior of Biological Molecules in Solution, Clarendon Press."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1021\/j100842a024","article-title":"Further observations on the electrical properties of hemoglobin-bound water","volume":"73","author":"Pennock","year":"1969","journal-title":"J. Phys. Chem."},{"key":"ref_245","doi-asserted-by":"crossref","unstructured":"Pethig, R.R. (2017). Dielectrophoresis: Theory, Methodology and Biological Applications, John Wiley & Sons.","DOI":"10.1002\/9781118671443"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0022-3093(02)01110-9","article-title":"Characterization of biological cells by dielectric spectroscopy","volume":"305","author":"Asami","year":"2002","journal-title":"J. Non-Cryst. Solids"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1515\/znb-1959-0213","article-title":"\u00dcber die Impedanz einer Suspension von kugelf\u00f6rmigen Teilchen mit einer Schale","volume":"14","author":"Pauly","year":"1959","journal-title":"Z. F\u00fcr Nat. B"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.bpj.2015.06.021","article-title":"Maxwell\u2019s Mixing Equation Revisited: Characteristic Impedance Equations for Ellipsoidal Cells","volume":"109","author":"Stubbe","year":"2015","journal-title":"Biophys. J."},{"key":"ref_249","unstructured":"Pliquett, F., and Pliquett, U. (1992, January 28\u201331). Tissue impedance, measured by pulse deformation. Proceedings of the 8th International Conference on Electrical Bio-impedance, University of Kuopio, Kuopio, Finland."},{"key":"ref_250","unstructured":"Loft, S.M., Conway, J., and Brown, B.H. (1992, January 28\u201331). Bioimpedance and cancer therapy. Proceedings of the 8th International Conference on Electrical Bio-impedance, University of Kuopio, Kuopio, Finland."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fphar.2017.00012","article-title":"Targeting membrane lipid a potential cancer cure?","volume":"8","author":"Tan","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/0921-4526(91)90621-K","article-title":"Hydrogen bonding in biological molecules\u2014An update","volume":"174","author":"Chidambaram","year":"1991","journal-title":"Phys. B Condens. Matter"},{"key":"ref_253","unstructured":"Meggyeshazi, N. (2015). Studies on Modulated Electrohyperthermia Induced Tumor Cell Death in a Colorectal Carcinoma Model. [Ph.D. Thesis, Pathological Sciences Doctoral School, Semmelweis University]."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1080\/02656736.2019.1692376","article-title":"Physical analysis of temperature-dependent effects of amplitude-modulated electromagnetic hyperthermia","volume":"36","author":"Wust","year":"2019","journal-title":"Int. J. Hyperth."},{"key":"ref_255","unstructured":"Szasz, A. (2020). Physics of hyperthermia\u2013Is physics really against us?. Challenges and Solutions of Oncological Hyperthermia, Cambridge Scholars."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"20170585","DOI":"10.1098\/rsif.2017.0585","article-title":"The interaction between electromagnetic fields at megahertz, gigahertz and terahertz frequencies with cells, tissues and organisms: Risks and potential","volume":"14","author":"Romanenko","year":"2017","journal-title":"J. R. Soc. Interface"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4236\/ojbiphy.2016.61002","article-title":"Heating, Efficacy and Dose of Local Hyperthermia","volume":"6","author":"Szasz","year":"2016","journal-title":"Open J. Biophys."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"98","DOI":"10.4236\/ojbiphy.2019.92008","article-title":"Bioelectromagnetic Paradigm of Cancer Treatment\u2014Modulated Electro-Hyperthermia (mEHT)","volume":"9","author":"Szasz","year":"2019","journal-title":"Open J. Biophys."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"8936","DOI":"10.1038\/s41598-020-65823-2","article-title":"Relationship between energy dosage and apoptotic cell death by modulated electro-hyperthermia","volume":"10","author":"Kao","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_260","doi-asserted-by":"crossref","unstructured":"Almeida, V.M., and Marana, S.R. (2019). Optimum temperature may be a misleading parameter in enzyme characterization and application. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0212977"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3109\/02656736.2012.695427","article-title":"Hyperthermia induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies","volume":"28","author":"Eppink","year":"2012","journal-title":"Int. J. Hyperth."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.radonc.2019.05.002","article-title":"Hyperthermia with radiotherapy reduces tumor alpha\/beta: Insights from trials of thermoradiotherapy vs radiotherapy alone","volume":"138","author":"Datta","year":"2019","journal-title":"Radiother. Oncol."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1259\/0007-1285-62-740-679","article-title":"The linear-quadratic formula and progress in fractionated radiotherapy","volume":"62","author":"Fowler","year":"1989","journal-title":"Br. J. Radiol."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.ijrobp.2013.11.212","article-title":"Quantifying the Combined Effect of Radiation Therapy and Hyperthermia in Terms of Equivalent Dose Distributions","volume":"88","author":"Kok","year":"2014","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_265","first-page":"1","article-title":"Biological effects of radiation on cancer cells","volume":"5","author":"Wang","year":"2018","journal-title":"Mil. Med. Res."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ctrv.2016.10.008","article-title":"Cell membrane modulation as adjuvant in cancer therapy","volume":"52","author":"Zalba","year":"2016","journal-title":"Cancer Treat. Rev."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1667\/0033-7587(2000)153[0186:HSPAWB]2.0.CO;2","article-title":"Heat-Shock Proteins Associated with Base Excision Repair Enzymes in HeLa Cells","volume":"153","author":"Mendez","year":"2000","journal-title":"Radiat. Res."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1242\/jeb.018960","article-title":"Differential roles of p38-MAPK and JNKs in mediating early protection or apoptosis in the hyperthermic perfused amphibian heart","volume":"211","author":"Gaitanaki","year":"2008","journal-title":"J. Exp. Biol."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1016\/j.febslet.2013.06.027","article-title":"Temperature and the catalytic activity of enzymes: A fresh understanding","volume":"587","author":"Daniel","year":"2013","journal-title":"FEBS Lett."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1017\/S1460396918000456","article-title":"Quantification of DNA double-strand break induced by radiation in cervix cancer cells: In vitro study","volume":"18","author":"Vashum","year":"2019","journal-title":"J. Radiother. Pract."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/0955300032000093128","article-title":"Expression of phosphorylated histone H2AX in cultured cell lines following exposure to X-rays","volume":"79","author":"Macphail","year":"2003","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"7144","DOI":"10.1158\/0008-5472.CAN-04-1433","article-title":"Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines","volume":"64","author":"MacPhail","year":"2004","journal-title":"Cancer Res."},{"key":"ref_273","doi-asserted-by":"crossref","unstructured":"Mei, X., Ten Cate, R., van Leeuwen, C.M., Rodermond, H.M., de Leeuw, L., Dimitrakopoulou, D., Stalpers, L.J.A., Crezee, J., Kok, H.P., and Franken, N.A.P. (2020). Radiosensitization by hyperthermia: The effects of temperature, sequence, and time interval in cervical cell lines. Cancers, 12.","DOI":"10.3390\/cancers12030582"},{"key":"ref_274","first-page":"1","article-title":"A short time interval between radiotherapy and hyperthermia reduces in-filed recurrence and mortality in women with advanced cervical cancer","volume":"12","author":"Oei","year":"2017","journal-title":"Radiat. Oncol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1080\/02656736.2017.1320812","article-title":"Measurement and analysis of the impact of time interval temperature and radiation dose on tumor cell survival and its application in thermoradiotherapy plan evaluation","volume":"34","author":"Oei","year":"2018","journal-title":"Int. J. Hyperth."},{"key":"ref_276","first-page":"17","article-title":"Thermal radiosensitization in vitro","volume":"Volume 2","author":"Urano","year":"1994","journal-title":"Hyperthermia and Oncology"},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/0360-3016(80)90008-5","article-title":"Simultaneous and sequential hyperthermia and radiation treatment of an experimental tumor and its surrounding normal tissue in vivo","volume":"6","author":"Overgaard","year":"1980","journal-title":"Int. J. Radiat. Oncol."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3389\/fonc.2019.00134","article-title":"The Effect of the Time Interval Between Radiation and Hyperthermia on Clinical Outcome in 400 Locally Advanced Cervical Carcinoma Patients","volume":"9","author":"Kroesen","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"412","DOI":"10.3389\/fonc.2019.00412","article-title":"The Impact of the Time Interval Between Radiation and Hyperthermia on Clinical Outcome in Patients with Locally Advanced Cervical Cancer","volume":"9","author":"Crezee","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.3389\/fonc.2019.01387","article-title":"Commentary: The Impact of the Time Interval Between Radiation and Hyperthermia on Clinical Outcome in Patients with Locally Advanced Cervical Cancer","volume":"9","author":"Kroesen","year":"2019","journal-title":"Front. Oncol."},{"key":"ref_281","first-page":"113","article-title":"Thermal radiosensitization in animal tumors: The potential for therapeutic gain","volume":"Volume 2","author":"Urano","year":"1989","journal-title":"Hyperthermia and Oncology"},{"key":"ref_282","doi-asserted-by":"crossref","unstructured":"Aguilar, A., Ho, M., Chang, E., Carlson, K., Natarajan, A., Marciano, T., Bomzon, Z., and Patel, C. (2021). Permeabilizing Cell Membranes with Electric Fields. Cancers, 13.","DOI":"10.3390\/cancers13092283"},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1152\/physrev.00056.2017","article-title":"Voltage-Sensing Phosphatases: Biophysics, Physiology, and Molecular Engineering","volume":"98","author":"Okamura","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_284","unstructured":"Szasz, A. (2020). Guidelines for local hyperthermia treatment in oncology. Challenges and Solutions of Oncological Hyperthermia, Cambridge Scholars."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3109\/02656730903453546","article-title":"Mild temperature hyperthermia and radiation therapy: Role of tumor vascular thermotolerance and relevant physiological factors","volume":"26","author":"Griffin","year":"2010","journal-title":"Int. J. Hyperth."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1080\/02656736.2017.1335440","article-title":"Role of HIF-1\u03b1 in response of tumors to a combination of hyperthermia and radiation in vivo","volume":"34","author":"Kim","year":"2017","journal-title":"Int. J. Hyperth."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.3390\/cancers6021065","article-title":"The Double-Edged Sword: Conserved Functions of Extracellular Hsp90 in Wound Healing and Cancer","volume":"6","author":"Hance","year":"2014","journal-title":"Cancers"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"581374","DOI":"10.3389\/fnagi.2020.581374","article-title":"Molecular Chaperones: A Double-Edged Sword in Neurodegenerative Diseases","volume":"12","author":"Tittelmeier","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/jso.24653","article-title":"Heat shock protein 70 in pancreatic diseases: Friend or foe","volume":"116","author":"Giri","year":"2017","journal-title":"J. Surg. Oncol."},{"key":"ref_290","first-page":"86","article-title":"Cell Stress Proteins in Extracellular Fluids: Friend or Foe?","volume":"291","author":"Pockley","year":"2008","journal-title":"Ciba Found. Symp. Nat. Sleep"},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1379\/CSC-155R.1","article-title":"Antibodies against heat shock proteins in environmental stresses and diseases: Frend or foe?","volume":"11","author":"Wu","year":"2006","journal-title":"Cell Stress Chaper."},{"key":"ref_292","doi-asserted-by":"crossref","unstructured":"Taha, E.A., Ono, K., and Eguchi, T. (2019). Roles of Extracellular HSPs as Biomarkers in Immune Surveillance and Immune Evasion. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20184588"},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3389\/fimmu.2015.00505","article-title":"Radio-Immunotherapy-Induced Immunogenic Cancer Cells as Basis for Induction of Systemic Anti-Tumor Immune Responses\u2013Pre-Clinical Evidence and Ongoing Clinical Applications","volume":"6","author":"Derer","year":"2015","journal-title":"Front. Immunol."},{"key":"ref_294","unstructured":"Stagg, A.J., and Knight, S.C. (2020, October 07). Antigen-Presenting Cells, Nature. Available online: http:\/\/labs.icb.ufmg.br\/lbcd\/pages2\/bernardo\/Bernardo\/Artigos\/Antigen-presenting%20Cells.pdf."},{"key":"ref_295","doi-asserted-by":"crossref","unstructured":"Rapoport, B.L., and Anderson, R. (2019). Realizing the Clinical Potential of Immunogenic Cell Death in Cancer Chemotherapy and Radiotherapy. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20040959"},{"key":"ref_296","unstructured":"Szasz, A. (2020). Local treatment with systemic effect: Abscopal outcome. Challenges and Solutions of Oncological Hyperthermia, Cambridge Scholars."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1259\/0007-1285-26-305-234","article-title":"Whole body irradiation-radiology or medicine?","volume":"26","author":"Mole","year":"1953","journal-title":"Br. J. Radiol."},{"key":"ref_298","first-page":"e3860","article-title":"Abscopal Effect, From Myth to Reality: From Radiation Oncologists\u2019 Perspective","volume":"11","author":"Yilmaz","year":"2019","journal-title":"Cureus"},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.2217\/fon-2020-0994","article-title":"The abscopal effect of radiation therapy","volume":"17","author":"Craig","year":"2021","journal-title":"Future Oncol."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13045-018-0647-8","article-title":"Abscopal effect of radiotherapy combined with immune checkpoint inhibitors","volume":"11","author":"Liu","year":"2018","journal-title":"J. Hematol. Oncol."},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.ctrv.2015.03.011","article-title":"The abscopal effect of local radiotherapy: Using immunotherapy to make a rare event clinically relevant","volume":"41","author":"Reynders","year":"2015","journal-title":"Cancer Treat. Rev."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.1158\/1078-0432.CCR-09-0265","article-title":"Fractionated but not single dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody","volume":"15","author":"Dewan","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"ref_303","unstructured":"Szasz, A. (2020). Tumour-directed immunotherapy: Clinical results of radiotherapy with modulated electro-hyperthermia. Challenges and Solutions of Oncological Hyperthermia, Cambridge Scholars."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"e14571","DOI":"10.1200\/JCO.2016.34.15_suppl.e14571","article-title":"Immune effects by selective heating of membrane rafts of cancer-cells","volume":"34","author":"Dank","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"ref_305","first-page":"28","article-title":"Oncothermia treatment induced immunogenic cancer cell death","volume":"9","author":"Andocs","year":"2013","journal-title":"Oncothermia J."}],"container-title":["Cancers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/4\/901\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:17:50Z","timestamp":1760134670000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6694\/14\/4\/901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,11]]},"references-count":305,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["cancers14040901"],"URL":"https:\/\/doi.org\/10.3390\/cancers14040901","relation":{},"ISSN":["2072-6694"],"issn-type":[{"value":"2072-6694","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,11]]}}}